Journal of Current Ophthalmology最新文献

{"title":"Relationship between Central Corneal Thickness and Endothelial Cell Density in Individuals with Primary Glaucoma and the General Population Living at High Altitudes.","authors":"Robin Debbarma, Vinod Sharma, Vinay Gupta, Bhavya Mehta, Pooja Badgujar, Rahul Bhargava","doi":"10.4103/joco.joco_213_25","DOIUrl":"https://doi.org/10.4103/joco.joco_213_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of high-altitude living on central corneal thickness (CCT) and corneal endothelial cell density (ECD) in individuals diagnosed with primary glaucoma, compared to age-matched healthy controls.</p><p><strong>Methods: </strong>This prospective study was conducted in the Lesser Himalayan region, at an average altitude between 2800 and 4200 m above sea level. The study population consisted of 120 eyes from 120 patients diagnosed with primary glaucoma who were permanent residents above 2000 meters. Subgroup 1A included individuals with primary open-angle glaucoma, whereas Subgroup 1B comprised those with angle closure glaucoma. Age-matched healthy subjects constituted the control group (Group 2).</p><p><strong>Results: </strong>Individuals with glaucoma residing above 3800 m exhibited a mean CCT reduction of 11 ± 5.3 μm and a mean ECD decrease of 145 ± 22 cells/mm² compared to those living below 3800 m. Participants with primary glaucoma had lower CCT and ECD than healthy controls. In healthy controls (Group 2), there was a nonsignificant increase in CCT (<i>P</i> = 0.090) and nonsignificant reductions in ECD (<i>P</i> = 0.076) and hexagonality (<i>P</i> = 0.080) at altitudes above 3800 m. At altitudes above 3800 meters, Subgroups 1A and IB had significantly lower ECD, greater coefficient of variation, and reduced hexagonality (all <i>P</i> < 0.001) than those below 3800 m. A significant inverse correlation between ECD and age was found in Subgroup 1A (<i>P</i> = 0.008), Subgroup 1B (<i>P</i> < 0.001), and Group 2 (<i>P</i> = 0.001).</p><p><strong>Conclusions: </strong>High-altitude residence may exacerbate corneal changes in patients with primary glaucoma, with potential implications for disease progression and management. The findings highlight the need for altitude-specific considerations in glaucoma assessment and treatment and underscore the importance of regular corneal evaluation in these populations.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"321-327"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal Vascularity Index Alterations across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes.","authors":"Reza Zarei, Mandana Esfahani, Samin Ghasemi, Tahereh Mahmoudi, Ali Banafshe Afshan, Seyed Mehdi Tabatabaei, Mona Safizadeh","doi":"10.4103/joco.joco_167_25","DOIUrl":"https://doi.org/10.4103/joco.joco_167_25","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the macular choroidal vascularity index (CVI) among patients diagnosed with pseudoexfoliative glaucoma (PXG), pseudoexfoliation syndrome (PEX), and healthy individuals.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted involving 77 eyes with PXG, 28 with PEX, and 74 from healthy controls. Enhanced depth imaging optical coherence tomography scans of the macula were analyzed using ImageJ software. The CVI was obtained by calculating the proportion of the luminal area within the total choroidal area. Generalized linear models were employed for statistical evaluation.</p><p><strong>Results: </strong>Subjects in the PXG and PEX groups were significantly older than those in the control group (<i>P</i> < 0.001), and sex distribution also differed significantly (<i>P</i> < 0.05). Eyes with PXG exhibited a notably lower CVI than normal eyes (0.62 ± 0.03 vs. 0.64 ± 0.04, <i>P</i> = 0.001). The difference between the PEX and control groups was not statistically significant (<i>P</i> = 0.146). After adjusting for age, sex, and axial length<b>,</b> the difference in CVI between PXG and controls did not reach statistical significance (<i>P</i> = 0.094).</p><p><strong>Conclusions: </strong>PXG may be associated with reduced CVI in the macular region, suggesting potential choroidal vascular alterations. This warrants further investigation into the vascular aspects of PXG pathophysiology.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"298-303"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, Prevalence, and Ocular Comorbidities of Primary Vitreoretinal Lymphoma in the TriNetX Global Collaborative Network.","authors":"Annie Zhang, David Teplitsky, Meghan K Berkenstock","doi":"10.4103/joco.joco_148_25","DOIUrl":"https://doi.org/10.4103/joco.joco_148_25","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the epidemiology of primary vitreoretinal lymphoma (PVRL), a rare malignancy of the central nervous system (CNS) that presents with vitritis and chorioretinal infiltrates and is closely associated with primary CNS lymphoma. Limited literature describes an incidence between 0.023 and 0.46/100,000 that has been increasing. The epidemiology of PVRL remains poorly characterized in large-scale datasets. We evaluated the baseline demographics, incidence, and prevalence of PVRL and ocular comorbidities using the TriNetX Global Collaborative Network database.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using TriNetX using the 10^th revision of the International Classification of Diseases codes for chorioretinal inflammation (H30) and other nonfollicular lymphoma (C83.8) to identify cases of PVRL in the TriNetX database. Data collected included demographics and comorbid ocular complications. The ten-year cumulative prevalence was calculated using TriNetX software.</p><p><strong>Results: </strong>Among 152,281,229 patients in the TriNetX network, 175 were identified as probable PVRL cases. The 10-year cumulative prevalence was estimated at 0.076 per 100,000 persons. The mean age at diagnosis was 59.4 years (standard deviation: 15.6; range: 19-90), and 59.52% were Caucasian. Postdiagnosis comorbidities included glaucoma (15.0%), cystoid macular edema (13.6%), and low vision (13.2%).</p><p><strong>Conclusions: </strong>This study provides an updated, large population-based assessment of the 10-year cumulative prevalence of PVRL using a global electronic health record database. These findings contribute to the limited literature on PVRL prevalence and offer insights into disease burden across diverse international populations.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"335-338"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRESERFLO MicroShunt Implantation as a Repeat Surgery after Failed Ab Interno XEN45 Gel Stent Implantation: A Case-Matched Study.","authors":"David Kiessling, Jan Niklas Lüke, Alexandra Lappas, Thomas S Dietlein, Gernot F Roessler, Randolf A Widder","doi":"10.4103/joco.joco_256_25","DOIUrl":"https://doi.org/10.4103/joco.joco_256_25","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate through a case-matched analysis whether failed ab interno XEN45 Gel Stent implantation exerts an influence on the outcome after subsequent implantation of a Preserflo MicroShunt.</p><p><strong>Methods: </strong>In this retrospective study, 70 eyes from 70 participants who underwent Preserflo MicroShunt implantation were included. Thirty-five eyes each underwent primary stent implantation (control group) or had previously undergone failed XEN45 Gel Stent implantation (post-XEN group). The two groups were matched at a 1:1 ratio based on the following criteria: preoperative and maximum intraocular pressure (IOP), preoperative medication score, cup/disc-ratio, follow-up time, and age. Surgery was defined as either \"success\" or \"failure\" based on the following three scores: an IOP reduction of >20% and IOP at the longest follow-up <21 mmHg (Score A) or <18 mmHg (Score B) or IOP ≤15 mmHg and an IOP reduction ≥40% (Score C). In all scores, revision surgery was considered a failure. Furthermore, we compared postoperative IOP and medication score, side effects, and revision rate between both groups.</p><p><strong>Results: </strong>Mean IOP decreased from 28.9 to 12.2 mmHg in the post-XEN group and from 27.7 to 12.9 mmHg in the control group, while the mean medication score decreased from 2.1 in the post-XEN group and from 2.6 in the control group to 0.3, respectively. Comparative analyses between the two groups did not reveal a significant difference in postoperative IOP, medication score, side effects, revision, or success rate.</p><p><strong>Conclusion: </strong>Preserflo MicroShunt implantation can be considered a viable option for repeat surgery in patients with bleb failure after prior XEN45 Gel Stent implantation.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"304-309"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression from Bilateral Unifocal to Multifocal Choroidal Metastases: A Multimodal Imaging Case Report of Undiagnosed Lung Cancer.","authors":"Bilal Haj Najeeb, Noor Dean Bawarish, Roman Dunavoelgyi, Ursula Schmidt-Erfurth, Stefan Sacu","doi":"10.4103/joco.joco_184_25","DOIUrl":"https://doi.org/10.4103/joco.joco_184_25","url":null,"abstract":"<p><strong>Purpose: </strong>To report the first documented case of progression from bilateral unifocal to multifocal choroidal metastases in a patient with previously undiagnosed lung cancer.</p><p><strong>Methods: </strong>A single case report illustrated with multimodal imaging.</p><p><strong>Results: </strong>A 53-year-old Caucasian male presented with a drop of vision to 20/80 associated with a hyperopic shift from -3.0 to +3.5 diopters in the right eye. Fundus examination revealed subretinal hemorrhages and retinal stress lines caused by a large, creamy subfoveal mass in the right eye, in addition to a smaller, yellow, and asymptomatic lesion located temporal to the fovea in the left eye. A red-free image demonstrated retinal stress lines. Autofluorescence illustrated central hypoautofluorescence surrounded by hyperautofluorescence, while angiography exhibited central hypofluorescence with surrounding progressive hyperfluorescence. Optical coherence tomography exhibited dome-shaped lesions with thickening of the retinal pigment epithelium and choroid, accompanied by subretinal hyperreflective infiltration. Ultrasound examination depicted two choroidal lesions with medium-to-low reflectivity. A subsequent systemic evaluation by an oncologist confirmed primary lung cancer with metastases. An examination 8 weeks later revealed counting fingers in the right eye and 20/30 in the left eye, accompanied by the appearance of multiple new metastases in both eyes and an extensive serous retinal detachment with increased density of hyperreflective speckles.</p><p><strong>Conclusions: </strong>Early ophthalmologic signs may lead to the diagnosis of systemic cancer. A multimodal imaging approach enhances the interpretation of clinical features by providing a comprehensive view of the pathological changes in choroidal metastases.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"363-367"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Fasting on Anterior Segment Parameters: A Systematic Review.","authors":"Seyed-Hashem Daryabari, Ali Bahramifar, Behnam Hosseini Ahangar, Saeed Karimi, Neda Shajirat, Seyyed Morteza Hosseini Imeni","doi":"10.4103/joco.joco_175_25","DOIUrl":"https://doi.org/10.4103/joco.joco_175_25","url":null,"abstract":"<p><strong>Purpose: </strong>To ascertain the effect of Ramadan fasting on the anterior segment. Fasting can affect anterior segment parameters because of altered hydration and metabolism.</p><p><strong>Methods: </strong>We searched online databases such as PubMed, Cochrane Library, Web of Science, Scopus, Embase, and Google Scholar for relevant records by suitable keywords. Overall, 21 eligible articles were included for the final assessment. Outcomes included types of fasting, tear film, corneal biomechanics, anterior chamber parameters, refraction, and visual acuity.</p><p><strong>Results: </strong>All 21 articles were conducted after Ramadan fasting. The outcomes revealed that tear breakup time (TBUT) diminished and basal tear secretion (BTS) decreased. Predawn fluid intake temporarily improved tear production. A study revealed that ocular surface disease index (OSDI) scores degraded. Increases in tear osmolarity and inflammatory markers were reported. Transient corneal steepening and reduced corneal hysteresis suggested dehydration effects, while advanced imaging revealed posterior curvature changes. Furthermore, inconsistent results included diminished or augmented anterior chamber depth. No significant changes were reported in refraction or visual acuity.</p><p><strong>Conclusions: </strong>The results indicated that fasting could alter various ocular structures and functions in the eye. Fasting could change the ocular surface condition, especially during the hotter seasons and longer fasting periods, along with lower parameters such as TBUT, BTS, and result in higher ocular discomfort, as measured by indices such as the OSDI scores. In addition, although the refraction and visual acuity seem to be stable along the fasting period, fasting could alter keratometric values and intraocular lens calculation, leading to suboptimal refractive results after surgeries.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"284-291"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncomplicated Cataract Surgery and Neovascular Conversion of Age-Related Macular Degeneration: Fifteen-Year Follow-Up Study.","authors":"Komal Agarwal, Elham Sadeghi, Kunaal Mehrotra, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jay Chhablani","doi":"10.4103/joco.joco_207_25","DOIUrl":"https://doi.org/10.4103/joco.joco_207_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of cataract surgery on neovascular age-related macular degeneration (nAMD) conversion over a 15-year follow-up period.</p><p><strong>Methods: </strong>This 15-year retrospective study on dry AMD patients compared Group A (cataract surgery) and Group B (no surgery). It assessed nAMD conversion rates, mean logMAR best-corrected visual acuity (BCVA), and final central macular thickness (CMT) changes. Kaplan-Meier survival curves and log-rank tests evaluated the impact of cataract surgery on time to conversion.</p><p><strong>Results: </strong>This study included 73 eyes from 46 patients, with a mean baseline age of 68.78 ± 8.62 years. Among them, 31 (67.39%) were female. Final analyses comprised 43 eyes in Group A and 30 eyes in Group B. Group A had a higher baseline age (70.3 ± 8.58 vs. 65.6 ± 7.24; <i>P</i> = 0.01), but baseline BCVA was similar (0.26 ± 0.33 vs. 0.29 ± 0.40; <i>P</i> = 0.61). The nAMD conversion rate showed no difference (32.55% vs. 36.66%; <i>P</i> = 0.491), as well as mean age at conversion (77.5 ± 8.10 vs. 77 ± 3.66; <i>P</i> = 0.80). The mean interval of conversion from cataract surgery was 5.24 ± 3.22 years. Final logMAR BCVA (0.78 ± 0.73 vs. 0.8 ± 0.76; <i>P</i> = 0.61) and mean CMT at final follow-up (167.6 ± 77.26 vs. 187 ± 85.19; <i>P</i> = 0.90) were also similar. The log-rank test showed no association between cataract surgery and conversion rate (<i>P</i> = 0.789).</p><p><strong>Conclusions: </strong>The present study did not find a significant difference in conversion from dry to wet AMD between patients who underwent cataract surgery and who did not. No significant difference was noted in the age at the time of conversion between the two groups.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"346-351"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Trends in Childhood Blindness in Schools for the Visually Impaired in India: A Structured Literature Review.","authors":"Pradeep Agarwal, Lokesh Chauhan","doi":"10.4103/joco.joco_163_25","DOIUrl":"https://doi.org/10.4103/joco.joco_163_25","url":null,"abstract":"<p><strong>Purpose: </strong>To provide insights for targeted public health interventions and future research. This review synthesizes recent evidence on the causes of childhood blindness in Indian schools for the visually impaired, highlighting emerging trends, regional disparities, and the role of socioeconomic and genetic factors.</p><p><strong>Methods: </strong>A structured literature review of studies published from 2009 to 2023 was conducted across PubMed, Scopus, and IndMed. The review followed systematic literature search and study selection principles, with methodology aligned to Preferred Reporting Items for Systematic reviews and Meta-analyses guidelines where applicable. Eleven cross-sectional and observational studies conducted in blind schools across India were included, all employing World Health Organization/International Classification of Diseases criteria for classifying childhood blindness and severe visual impairment. Data on sample size, demographics, and anatomical/etiological causes of blindness were systematically extracted and compared.</p><p><strong>Results: </strong>Across the included studies (a total of 3051 children), the proportion of preventable blindness has declined, whereas genetic and congenital causes have risen. Whole globe anomalies (22%-40%) are most common in socioeconomically disadvantaged regions, whereas optic nerve disorders (18%-24%) and retinal dystrophies (14%-19%) predominate in areas with high consanguinity. Corneal scarring has decreased to 8%-26% due to public health programs, but lens pathologies (up to 30%) and untreated refractive errors (9%-17%) remain significant. Retinopathy of prematurity accounts for up to 15% of cases in urban Maharashtra.</p><p><strong>Conclusions: </strong>Childhood blindness in India is shifting from preventable to genetic and congenital causes, with clear regional patterns influenced by socioeconomic and cultural factors. Strengthening region-specific screening, genetic counseling, and early intervention programs is essential to further reduce the burden and meet VISION 2020 targets.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"292-297"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment \"Governing Self-Directed Adoption of New Ophthalmic Procedures\".","authors":"Jee-Ah Sarah Oh, Jie Zhang, Stephen Ng, James Mckelvie","doi":"10.4103/joco.joco_305_25","DOIUrl":"https://doi.org/10.4103/joco.joco_305_25","url":null,"abstract":"","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"379"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal Stem Cell-Derived Exosomes for Keratoconus: A Novel Therapeutic Approach.","authors":"Ali Hadi, Hesam Hashemian, Masoud Khorrami-Nejad, Foroozan Narooie-Noori","doi":"10.4103/joco.joco_202_25","DOIUrl":"https://doi.org/10.4103/joco.joco_202_25","url":null,"abstract":"<p><p>Keratoconus (KC) is a progressive corneal ectatic disorder with limited treatment options addressing its underlying pathophysiology. Current therapies, including corneal cross-linking and transplantation, focus on halting progression rather than reversing damage. Mesenchymal stem cell-derived exosomes (MSC-Exo) have emerged as promising cell-free therapeutic agents with regenerative, anti-inflammatory, and immunomodulatory properties. This short communication synthesizes current evidence on MSC-Exo for KC treatment. Preclinical studies demonstrate that MSC-Exo enhances keratocyte proliferation, reduces fibrosis and inflammation, modulates extracellular matrix proteins, and promotes epithelial wound healing. Exosomes from various MSC sources show therapeutic efficacy across <i>in vitro</i> and animal models. While clinical evidence remains limited, early studies support safety and feasibility for ocular applications. MSC-Exo represents a promising therapeutic approach capable of modulating key KC pathological mechanisms, warranting further clinical investigation.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 3","pages":"375-377"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}