Journal of Current Ophthalmology最新文献

{"title":"Choroidal Vascular Characteristics in Subclinical Cushing Syndrome: A Cross-Sectional Pilot Study using Enhanced Depth Imaging Optical Coherence Tomography and Optical Coherence Tomography Angiography.","authors":"Eyupcan Sensoy, Berrak Sekeryapan Gediz, Sevde Nur Firat, Pinar Cicek Kaya","doi":"10.4103/joco.joco_271_25","DOIUrl":"10.4103/joco.joco_271_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the potential choroidal vascular changes in newly diagnosed subclinical Cushing syndrome (SCS) patients and to assess whether choroidal parameters correlate with hormonal parameters.</p><p><strong>Methods: </strong>Twenty-one right eyes of 21 patients with SCS and 22 right eyes of 22 healthy individuals were included in the study. Results of the 1 mg dexamethasone suppression test, basal cortisol, basal adrenocorticotropic hormone, and 24-h urine-free cortisol levels were recorded from the patient files. Choroidal thicknesses (CTs) were measured from the subfoveal, 500 μm nasal, and 500 μm temporal quadrants with enhanced depth imaging-optical coherence tomography (OCT). The ImageJ program calculated the choroidal vascularity index (CVI). The choriocapillaris (CC) flow area was evaluated with OCT-angiography. The primary outcome measure was the CVI.</p><p><strong>Results: </strong>There were no significant differences in subfoveal, nasal, or temporal CT between groups (<i>P</i> > 0.05). In addition, there was no statistically significant difference between the SCS group and the control group in terms of total choroidal area, luminal area, stromal area, and CVI values (<i>P</i> = 0.827, <i>P</i> = 0.466, <i>P</i> = 0.343, and <i>P</i> = 0.065, respectively). The mean difference in subfoveal CVI between the groups was -1.78 (95% confidence interval: -3.8-0.2). No statistical difference was found between the SCS and control groups in terms of CC flow area, with a radius of 1, 2, and 3 mm (<i>P</i> > 0.05). No statistically significant correlation was detected between the examined choroidal and biochemical parameters (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>According to the results of this study, subclinical hormonal changes in newly diagnosed SCS patients do not affect choroidal vascular status.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"42-49"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine Intake Effects on Intraocular Pressure in Healthy and Glaucomatous Populations: A Systematic Review and Meta-Analysis.","authors":"Owen Paruhum Simanjuntak, Olivia Jocelyn, Kevin Tadeus Simanjuntak, Raniindra Khalisha Soediro Abidin, Astrianda Nadya Suryono","doi":"10.4103/joco.joco_43_26","DOIUrl":"10.4103/joco.joco_43_26","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of caffeine intake on intraocular pressure (IOP).</p><p><strong>Methods: </strong>The PubMed, Cochrane, Scopus, and ProQuest databases were searched for publications of randomized trials investigating the effect of caffeine consumption on IOP in healthy and glaucomatous populations until February 1, 2025. Outcomes at 30 min, 1, 1.5, 2, and 3 h were analyzed using a random-effects model. Subgroup analysis was done for different types of caffeine-containing beverages and different amounts of caffeine.</p><p><strong>Results: </strong>Sixteen studies, including 599 healthy participants and 63 glaucomatous patients (with primary open-angle glaucoma, ocular hypertension, and normotensive glaucoma), were included in this meta-analysis. The weighted mean difference (WMD) with 95% confidence intervals of IOP in the healthy population at 30 min, 1 h, 1.5 h, and 2 h were significant at 0.61 (0.07; 1.16), 0.87 (0.40; 1.33), 1.60 (0.40; 2.80), and 0.63 (0.03; 1.22), respectively. In glaucomatous patients, WMD at 1 and 1.5 h time points were significant at 1.51 (0.83; 2.18) and 1.39 (0.99; 1.78), respectively. Ingestion of >100 mg of caffeine significantly increased IOP at 30 min, 1, and 1.5 h, whereas ingestion of ≤100 mg did not significantly increase IOP in healthy populations. All included studies with glaucomatous populations used >100 mg of caffeine.</p><p><strong>Conclusion: </strong>Caffeine ingestion, especially of >100 mg, acutely elevates IOP in both healthy and glaucomatous populations.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"1-16"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral Rupture during Cryoretinopexy for Symptomatic Retinal Tears: A Case Series.","authors":"Asterios Diafas, Nikolaos Dervenis, Yannick N Liermann, Mohamed Oshallah, Hassan Elkayal, Benjamin Clarke","doi":"10.4103/joco.joco_293_25","DOIUrl":"10.4103/joco.joco_293_25","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical outcomes of patients who experienced scleral rupture following cryoretinopexy and to highlight potential risk factors, management strategies, and prognosis.</p><p><strong>Methods: </strong>This retrospective case series includes patients who developed scleral rupture during cryoretinopexy for symptomatic retinal tear(s) across multiple ophthalmology units in the United Kingdom and internationally, between September 2003 and May 2025. Data collected included patient demographics, medical and ocular history, clinical examination findings, surgical management, and postoperative outcomes.</p><p><strong>Results: </strong>Four cases of scleral perforation were included in this series. The median age was 61 years, with an equal distribution of males and females. All patients underwent scleral repair and pars plana vitrectomy (PPV) with silicone oil tamponade. Three patients achieved a final visual acuity of at least 20/25, while one patient had a final visual acuity of 20/200. None of the cases had a history of systemic disorders, while myopia was noted in three patients.</p><p><strong>Conclusions: </strong>Immediate scleral rupture repair combined with PPV and silicone oil tamponade is the preferred management approach and is associated with favorable postoperative outcomes. Comprehensive patient counseling and informed consent are crucial when planning cryoretinopexy.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"50-54"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of Choroidal Osteoma: A Case Series with Multimodal Imaging Update.","authors":"Jenyffer Mariela Barahona Campos, Carolina Fernández, Santiago Morales","doi":"10.4103/joco.joco_103_25","DOIUrl":"10.4103/joco.joco_103_25","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical progression of choroidal osteoma (CO) in seven eyes using multimodal imaging and to assess treatment outcomes.</p><p><strong>Methods: </strong>An observational case series.</p><p><strong>Results: </strong>Seven eyes were diagnosed with CO with lesions predominantly located in the macular region. Initial visual acuity ranged from 20/20 to 20/150, and most eyes exhibited choroidal neovascularization, including polypoidal choroidal vasculopathy in two cases. Antivascular endothelial growth factor (anti-VEGF) therapy was administered to 86% of the affected eyes, leading to visual acuity stabilization or improvement. One eye experienced choroidal neovascular recurrence. Final visual acuity ranged from 20/20 to counting fingers after a follow-up period of 2-10 years. Multimodal imaging approaches were tailored to clinical and healthcare system needs rather than applied uniformly across all cases; therefore, slight differences were observed in the types of imaging used for each case.</p><p><strong>Conclusions: </strong>COs can lead to vision-threatening complications, particularly choroidal neovascularization, which responds well to anti-VEGF therapy. Multimodal imaging is essential for accurate diagnosis and disease monitoring. Early recognition and long-term follow-up are crucial for optimizing visual outcomes.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"105-110"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogenic Corneal Iris Segment Implantation for Repair of Large Iris Defect: The Antep Procedure.","authors":"Necip Kara, Elif Sarsu Kocaaslan, Eren Arslan","doi":"10.4103/joco.joco_321_25","DOIUrl":"10.4103/joco.joco_321_25","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a novel technique for repairing large iris defects using an allogenic corneal iris segment (ACIS), referred to as the Antep procedure, and to present its application in two challenging clinical cases.</p><p><strong>Methods: </strong>Two cases with significant iris loss and photic symptoms underwent ACIS implantation. The ACIS was shaped into a crescent-shaped segment specifically designed to cover the iris defect and stained with trypan blue. It was then positioned in the anterior chamber and secured with three-point fixation at the nasal and temporal positions to the residual iris and superiorly to the sclera.</p><p><strong>Results: </strong>In both patients, ACIS implantation provided effective anatomical reconstruction of the iris defect and led to meaningful functional improvement, particularly in photic symptoms. The segments remained well positioned throughout follow-up, and no intraoperative or postoperative complications were observed.</p><p><strong>Conclusions: </strong>The Antep procedure offers a biologically integrated, low-cost, and technically feasible option for reconstruction of large iris defects. Further studies with longer follow-up are warranted to evaluate long-term outcomes and broader applicability.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"96-101"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Motor and Sensory Outcomes of Infantile Esotropia following Bilateral Medial Rectus Recession: A Survival Analysis and Real-World Results.","authors":"Umay Güvenç, Fatma Gül Yilmaz Çinar, Yasemin Topalak, Evin Şingar, Ayşe Burcu","doi":"10.4103/joco.joco_261_25","DOIUrl":"10.4103/joco.joco_261_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate long-term outcomes of bilateral medial rectus recession in infantile esotropia (IET) using survival analysis of real-world data to identify predictors of surgical failure.</p><p><strong>Methods: </strong>This retrospective study included 121 IET patients with ≥12 months of follow-up. Motor success was defined as alignment within ±10 prism diopters at 6 months (early) and final visit (late). Sensory success was defined as binocular single vision (BSV), including fusion with or without stereopsis. Long-term motor stability was evaluated using survival analysis and Cox regression, while sensory outcomes were analyzed using multivariable regression.</p><p><strong>Results: </strong>Median surgical age was 24 months; the mean follow-up was 77.8 ± 59.6 months. Motor success was 56.2% at 6 months and 52.9% at the final follow-up. Cumulative success declined from 95.9% at 1 year to 54.9% at 10 years (median survival: 130 months). Male sex (<i>P</i> = 0.009), larger initial deviation (<i>P</i> = 0.035), and recession ≥6 mm (<i>P</i> = 0.022) were independently associated with failure, whereas surgical timing within the age range represented in this cohort was not. At the last follow-up, 33.1% of patients were undercorrected and 14.0% overcorrected, with overcorrection more frequent in longer follow-up (<i>P</i> = 0.001). Stereopsis was achieved in 9.3% of patients, and 70.9% of patients demonstrated BSV. Amblyopia independently reduced the likelihood of achieving BSV (odds ratio = 0.26, <i>P</i> = 0.015).</p><p><strong>Conclusions: </strong>Long-term motor alignment is maintained in about half of IET patients, though stability declines over time. Male sex, larger deviation, and higher surgical dose predict failure. Peripheral fusion is frequent, fine stereopsis remains rare, and amblyopia adversely affects sensory outcome.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"87-95"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Coronavirus Disease 2019 Pandemic on Central Retinal Vein Occlusion.","authors":"Tetsuya Muto, Shigeki Machida, Shinichiro Imaizumi, Tetsuju Sekiryu","doi":"10.4103/joco.joco_310_25","DOIUrl":"10.4103/joco.joco_310_25","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the disease prevalence rate and clinical characteristics of central retinal vein occlusion (CRVO) among new patients before and after the declaration of a state of emergency due to coronavirus disease 2019 on April 7, 2020, in Japan.</p><p><strong>Methods: </strong>New patients and patients with newly diagnosed CRVO were categorized into \"Before\" and \"After\" groups based on the initial visit. The prevalence rate, sex ratio, and age of patients newly diagnosed with CRVO were compared between the groups. The prevalence rate of patients newly diagnosed with rhegmatogenous retinal detachment (RRD) and pseudoexfoliation glaucoma (PEX) was also examined in the before and after groups. The best-corrected visual acuity (BCVA) at the initial visit, retinal photocoagulation, and BCVA after treatment were compared among 232 eyes observed in 12 ± 2 months after treatment.</p><p><strong>Results: </strong>No significant differences in prevalence rates of CRVO among newly diagnosed patients (<i>P</i> = 0.232), patients with RRD (<i>P</i> = 0.560), or patients with PEX (<i>P</i> = 0.972) were observed in both groups. No significant differences in sex ratio and age were observed in both groups. Although BCVA at the initial visit (<i>P</i> = 0.142) and after treatment (<i>P</i> = 0.155) showed no significant differences, retinal photocoagulation (<i>P</i> < 0.01) significantly increased in the after group.</p><p><strong>Conclusion: </strong>Although the coronavirus disease 2019 pandemic did not affect the prevalence of CRVO among new patients compared with that of RRD and PEX, it may be associated with a greater need for retinal photocoagulation, suggesting changes in disease severity.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"61-71"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminative Abilities of Macular and Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis and Optic Neuritis.","authors":"Hassan Hashemi, Alireza Jamali, Morad Amir Ahmad, Abbasali Yekta, Reyhaneh Shariati-Moghaddam, Malihe-Sadat Razavi, Mehdi Khabazkhoob","doi":"10.4103/joco.joco_294_25","DOIUrl":"10.4103/joco.joco_294_25","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the discriminative abilities of macular and retinal nerve fiber layer (RNFL) thicknesses in multiple sclerosis (MS) from normal and to identify optic neuritis (ON) in MS patients.</p><p><strong>Methods: </strong>This cross-sectional case-control study included 133 participants aged 30-45 years: 66 definite MS patients (18 with ON) and 67 age- and sex-matched healthy controls. MS diagnosis was established ≥5 years before enrollment. Exclusion criteria were other neurological/retinal diseases, high refractive error (> ±6.00 diopter), media opacities, glaucoma, or intraocular surgery. All underwent spectral-domain optical coherence tomography (Cirrus High-Definition Optical Coherence Tomography) under pharmacologic mydriasis to measure RNFL and macular thicknesses.</p><p><strong>Results: </strong>MS patients without ON showed significantly reduced macular thickness in inner superior, outer inferior, outer superior, outer nasal, and outer temporal sectors versus controls. MS patients with ON had significantly thinner inner superior and outer superior macular sectors than those without ON. For distinguishing MS from controls, an average RNFL ≤94 μm yielded a sensitivity of 87.9%, a specificity of 70.2%, and the area under the receiver operating characteristic curve (AUC) of 0.836 (<i>P</i> < 0.001). For differentiating MS with versus without ON, the average RNFL ≤83 μm achieved the highest RNFL performance: AUC of 0.836, sensitivity of 72.2%, and specificity of 81.3%. Among macular subregions, outer nasal (AUC = 0.680) and outer superior (AUC = 0.670) sectors best distinguished MS from controls. For ON detection, the outer superior sector performed best (AUC = 0.736, sensitivity: 61.1%, and specificity: 79.2%).</p><p><strong>Conclusion: </strong>RNFL thinning is a robust structural biomarker for MS and prior ON, whereas average macular thickness has limited standalone diagnostic utility for ON, though specific outer macular sectors show moderate discriminative value.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"31-41"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Hyporeflective Micro-Elevations and Irregularity of the Ellipsoid Zone in Blunt Ocular Trauma.","authors":"Ekaterina K Gladisheva, Alexey N Kulikov, Dmitrii S Maltsev","doi":"10.4103/joco.joco_51_26","DOIUrl":"10.4103/joco.joco_51_26","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prevalence, clinical course, and prognostic significance of hyporeflective micro-elevations and irregularity of the ellipsoid zone (MEEZ) in blunt ocular trauma.</p><p><strong>Methods: </strong>Patients with blunt ocular trauma underwent standard ophthalmological examination and optical coherence tomography angiography. MEEZ was defined as small hyporeflective foci at the level of the ellipsoid and interdigitation zone, with disappearance of the thin hyporeflective band between these layers. The prevalence and spatial distribution of MEEZ, choriocapillaris perfusion, and associated findings were evaluated.</p><p><strong>Results: </strong>MEEZ was identified in 62 (40.3%) out of 154 eyes with blunt trauma, including nine eyes with MEEZ as the only form of posterior segment injury, and 53 eyes where MEEZ was found with other posterior segment injuries. Mean best-corrected visual acuity in eyes with MEEZ only was 0.0 logMAR (20/20 of Snellen equivalent). In eyes where MEEZ was associated with other posterior segment injuries, mean best-corrected visual acuity was 0.9 ± 0.64 logMAR (approximately 20/160 of Snellen equivalent). Choriocapillaris perfusion area in eyes with MEEZ only and healthy fellow eyes was 21.1 ± 1.3 and 20.4 ± 1.2 mm² (<i>P</i> > 0.05), respectively. During the follow-up, MEEZ showed complete resolution in all cases with available follow-up data (<i>n</i> = 15) after a median period of 34.0 days.</p><p><strong>Conclusions: </strong>MEEZ is an important part of the spectrum of traumatic retinal changes frequently observed in blunt ocular trauma. As the only manifestation of blunt ocular trauma, MEEZ is associated with a favorable prognosis.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"72-78"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Vitreoretinal Surgery for X-Linked Retinoschisis: A Systematic Review and Meta-Analysis of the Current Literature.","authors":"Ahmed Bakr, Marwan Tahoun, Maher Nassor, Usman Muhammad","doi":"10.4103/joco.joco_322_25","DOIUrl":"10.4103/joco.joco_322_25","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically review and meta-analyze the outcomes of vitreoretinal surgery for X-linked retinoschisis (XLRS)-related complications.</p><p><strong>Methods: </strong>A systematic search of PubMed, Cochrane Library, CINAHL, Web of Science, and OVID was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Studies reporting surgical outcomes in patients with XLRS-associated retinal detachment or schisis were included. Primary outcomes were anatomic success (primary and final reattachment rates) and best-corrected visual acuity (BCVA). Random-effects meta-analysis was performed using RevMan. Subgroup analyses by surgical approach and age group were prespecified, and their feasibility was assessed according to the number of contributing studies.</p><p><strong>Results: </strong>Fourteen studies comprising over 200 eyes were included. The pooled primary reattachment rate was 0.73 (95% confidence interval [CI]: 0.46-0.99; <i>I</i> ² = 83%), reflecting substantial heterogeneity across cohorts; formal subgroup analyses were not feasible given the small number of contributing studies. The pooled final reattachment rate was 0.89 (95% CI: 0.84-0.94; <i>I</i> ² = 0%). Reoperation was frequently required, with rates of 20%-40% across series, predominantly due to proliferative vitreoretinopathy. Visual outcomes are reported narratively; approximately 50%-80% of eyes demonstrated BCVA improvement, although recovery was often limited by preexisting macular pathology, chronic disease, and amblyopia.</p><p><strong>Conclusions: </strong>Vitreoretinal surgery for XLRS-related complications can achieve favorable final anatomical outcomes in most cases, although multiple procedures are frequently required and visual recovery is variable and often modest. Anatomical success does not guarantee functional recovery, underscoring the importance of realistic prognostic counseling. These findings should be interpreted with caution, given that all included studies are small, observational case series with significant clinical heterogeneity. Standardized, prospective, multicenter studies are needed to optimize surgical strategies in this population.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"17-26"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}