Journal of Current Ophthalmology最新文献

{"title":"Comparative Evaluation of Water Drinking Test Response in Advanced Glaucoma Patients with Prior Preserflo MicroShunt and Trabeculectomy Surgery.","authors":"Sharon Yet Xue Er, Puspha Raman","doi":"10.4103/joco.joco_302_25","DOIUrl":"10.4103/joco.joco_302_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the differences in intraocular pressure (IOP) response to the water drinking test (WDT) in advanced glaucoma patients following trabeculectomy or Preserflo MicroShunt implantation.</p><p><strong>Methods: </strong>This prospective study included 30 eyes from 29 advanced glaucoma patients: 15 underwent trabeculectomy, and 15 received the Preserflo MicroShunt. Baseline IOP was measured using Goldmann applanation tonometry, followed by WDT involving the consumption of 10 mL of water per kilogram of body weight over 5 min. IOP was measured at 15-min intervals until it returned to baseline. Outcomes included peak IOP, time to peak IOP, IOP fluctuation, and time to return to baseline.</p><p><strong>Results: </strong>Baseline IOP was comparable between groups (trabeculectomy: 14.83 ± 2.28 mmHg; Preserflo: 15 ± 1.23 mmHg, <i>P</i> = 0.515). The peak IOP and IOP fluctuation were also similar (<i>P</i> = 0.978 and <i>P</i> = 0.614, respectively). However, trabeculectomy patients exhibited a shorter time to peak IOP (27 ± 5.6 min vs. 36.25 ± 9.8 min, <i>P</i> = 0.017) and faster return to baseline (55 ± 4.8 min vs. 57.25 ± 9.8 min, <i>P</i> = 0.03).</p><p><strong>Conclusions: </strong>Both trabeculectomy and the Preserflo MicroShunt effectively controlled IOP during WDT, with the Preserflo MicroShunt demonstrating noninferiority in overall IOP control. Trabeculectomy exhibited superior dynamic outflow capacity, making it suitable for patients requiring aggressive IOP reduction.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"27-30"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous Tenon's Capsule Graft for Recurrent Retinal Detachment Associated with a Cavitary Optic Disc Anomaly following Failed Amniotic Membrane Grafting.","authors":"Nader Mohammadi, Amin Dehghani Sanij, Fatemeh Bazvand","doi":"10.4103/joco.joco_149_26","DOIUrl":"10.4103/joco.joco_149_26","url":null,"abstract":"<p><strong>Purpose: </strong>To report the successful use of an autologous Tenon's capsule graft for recurrent retinal detachment associated with a cavitary optic disc anomaly following failed amniotic membrane grafting.</p><p><strong>Methods: </strong>A 23-year-old woman presented with macula-off retinal detachment in the left eye caused by a large peripapillary break associated with a congenital optic disc anomaly. Initial pars plana vitrectomy with cryopreserved amniotic membrane grafting and silicone oil tamponade resulted in temporary reattachment. However, progressive shrinkage of two sequential amniotic membrane grafts led to recurrent retinal detachment complicated by proliferative vitreoretinopathy. Definitive repair was achieved through repeat vitrectomy, scleral buckling, removal of the residual amniotic membrane, and placement of a free autologous Tenon's capsule graft under perfluorocarbon liquid, followed by fluid-air exchange and 20% sulfur hexafluoride gas endotamponade.</p><p><strong>Results: </strong>The postoperative course was uncomplicated. The retina remained fully attached throughout the 6-month follow-up period, with the Tenon's capsule graft maintaining a stable position over the defect. Best-corrected visual acuity improved to 20/50 at the final visit.</p><p><strong>Conclusion: </strong>Autologous Tenon's capsule grafting may be a useful adjunct in selected cases of recurrent retinal detachment associated with cavitary optic disc anomalies after failed amniotic membrane grafting.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"111-115"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Choroidal Vascular Index Measurements in Pachychoroid Pigment Epitheliopathy using Manual ImageJ-Based Niblack and Protocol-Standardized Otsu Thresholding.","authors":"Doğukan Cömerter","doi":"10.4103/joco.joco_25_26","DOIUrl":"10.4103/joco.joco_25_26","url":null,"abstract":"<p><strong>Purpose: </strong>To compare choroidal vascular index (CVI) measurements obtained using manual ImageJ-based Niblack thresholding and protocol-standardized Otsu thresholding in patients with pachychoroid pigment epitheliopathy (PPE), employing a full-length choroidal region of interest (ROI) approach.</p><p><strong>Methods: </strong>This retrospective observational study included 30 eyes of 30 patients diagnosed with PPE. Enhanced depth imaging-optical coherence tomography (EDI-OCT) scans were acquired using Heidelberg Spectralis. Both horizontal and vertical fovea-centered B-scans were analyzed. The ROI was manually delineated on the OCT device using the polygon selection tool to include the entire visible choroid from the retinal pigment epithelium/Bruch's membrane complex to the choroidoscleral junction across the full scan width. CVI was calculated as the ratio of luminal area-to-total choroidal area. Manual ImageJ-based Niblack local thresholding was compared with protocol-standardized Otsu global thresholding using identical manually defined ROIs. Agreement was evaluated using paired <i>t</i>-tests, Pearson correlation, intraclass correlation coefficient (ICC), and Bland-Altman analysis.</p><p><strong>Results: </strong>A total of 60 OCT B-scans were analyzed. Mean CVI values were 0.615 ± 0.030 for ImageJ-Niblack and 0.626 ± 0.052 for Otsu thresholding. The mean intermethod difference was +0.011 ± 0.028, with no statistically significant difference between methods (<i>P</i> = 0.085). A strong linear association was observed (<i>r</i> = 0.90, <i>P</i> < 0.001), and ICC (2,1) demonstrated good agreement (0.76). Bland-Altman analysis showed a small mean bias (+0.012) with 95% limits of agreement from -0.049 to +0.073. Because no external reference standard or prespecified clinical equivalence margin was available, the findings support methodological consistency rather than interchangeability or accuracy equivalence.</p><p><strong>Conclusions: </strong>Protocol-standardized Otsu thresholding yielded CVI measurements that were directionally consistent with manual ImageJ-based Niblack analysis in PPE when a full-length choroidal ROI strategy was applied. This approach may support standardized group-level research analyses, but it should not be interpreted as establishing accuracy equivalence or full clinical interchangeability.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"55-60"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-Phenotype Correlation in Dominant Optic Atrophy due to OPA1 c.3011T>C (p.Leu1004Pro): A Family-Based Case Series.","authors":"Hasan Can Küçük, Nilüfer Koçak, Denizcan Özizmirliler, Suzan Doğruya, Ali Devebacak","doi":"10.4103/joco.joco_4_26","DOIUrl":"10.4103/joco.joco_4_26","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the structural, functional, and optical coherence tomography angigraphy (OCTA) phenotype associated with the OPA1 c3011T>C (p.Leu1004Pro) variant in a multigenerational family with autosomal dominant optic atrophy.</p><p><strong>Methods: </strong>In this retrospective familial case series, four affected female relatives across three generations underwent ophthalmic examination including best-corrected visual acuity (BCVA), peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) imaging, Humphrey 24-2 visual fields, and 6 mm × 6 mm swept-source OCTA (SS-OCTA). Quantitative OCTA assessed parafoveal vessel density in the superficial capillary plexus (SCP). Next-generation sequencing in the index case and intrafamilial Sanger sequencing confirmed segregation.</p><p><strong>Results: </strong>All subjects carried the heterozygous OPA1 c.3011T>C variant and showed a consistent optic neuropathy pattern with temporal disc pallor, selective temporal RNFL thinning, and macular GCC loss on a preserved outer retina without microcystic changes. BCVA ranged from 0.22 to 0.82 logMAR, indicating marked intrafamilial functional variability. Visual fields demonstrated central/centrocecal or paracentral defects with relative peripheral sparing, with more extensive central depression in the oldest case. On exploratory 6 mm × 6 mm SS-OCTA, parafoveal SCP vessel density values showed intercase variation without frank macular nonperfusion; findings are interpreted descriptively in the absence of device and age-matched internal controls.</p><p><strong>Conclusion: </strong>The OPA1 p.Leu1004Pro variant was associated with a stereotyped structural optic neuropathy pattern, whereas functional impairment showed marked intrafamilial variability. Exploratory SCP OCTA findings are descriptive only, given the absence of device and age-matched internal controls.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"79-86"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Centrifugal Retinal Vessel Realignment Documented by Fundus Autofluorescence over Three Years after Epiretinal Membrane Peeling: A Case Report.","authors":"Mateus Lins Dos Santos, Jessica Galvan, Ricardo Luz Leitão Guerra","doi":"10.4103/joco.joco_311_25","DOIUrl":"10.4103/joco.joco_311_25","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of progressive anatomical improvement documented over 3 years after epiretinal membrane (ERM) peeling and to describe how fundus autofluorescence (FAF) imaging contributed to the documentation and evaluation of this long-term recovery.</p><p><strong>Methods: </strong>A retrospective case report was conducted.</p><p><strong>Results: </strong>This case report describes a 70-year-old male patient with decreased visual acuity due to idiopathic ERM. Preoperative FAF demonstrated vessel displacement, and optical coherence tomography showed Grade 3 tractional changes. The patient underwent pars plana vitrectomy with ERM and internal limiting membrane peeling. Visual acuity improved rapidly, while FAF follow-up over 3 years demonstrated progressive centrifugal repositioning of retinal vessels toward their predisplacement locations.</p><p><strong>Conclusions: </strong>This finding illustrates the utility of FAF in documenting long-term anatomical recovery beyond macular thickness normalization. FAF may serve as a valuable complementary tool to monitor retinal remodeling and vessel realignment following membrane peeling, supporting its role in postoperative assessment of ERM surgery outcomes.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"38 1","pages":"102-104"},"PeriodicalIF":0.9,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Nicotine and Cannabis Use and Ocular Inflammatory Diseases and Complications: Results from the TriNetX Database.","authors":"Courtney Oliver, Paulina Liberman, Meghan K Berkenstock","doi":"10.4103/joco.joco_127_25","DOIUrl":"10.4103/joco.joco_127_25","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the incidence of ocular inflammatory diseases and related ocular complications in patients with and without a history of cigarette, cannabis, vaping, and chewing tobacco use or exposure to tobacco smoke.</p><p><strong>Methods: </strong>Patients aged 18 years and older with and without a history of cigarette, vape, cannabis, or chewing tobacco use, patients with and without a history of exposure to second-hand smoke, and patients with a diagnosis of an ocular inflammatory disease were included in our study. Odds ratios (ORs) were calculated to analyze the proportion of individuals who developed uveitis, scleritis, ocular mucous membrane pemphigoid (oMMP), and each ocular complication after cigarette, cannabis, vaping, and chewing tobacco use and exposure to tobacco smoke, compared to nonusers or those not exposed to tobacco smoke.</p><p><strong>Results: </strong>Compared to nonsmokers, the OR for developing uveitis was 1.459 times higher for cannabis users (<i>P</i> = 0.016, 95% confidence interval [CI]: 1.072-1.985) and 1.712 times higher for those exposed to tobacco smoke (<i>P</i> < 0.001, 95% CI: 1.366-2.146). The odds of developing scleritis were 2.596 times higher for cannabis users (<i>P</i> = 0.002, 95% CI: 1.389-4.853), 1.667 times higher for vape users (<i>P</i> = 0.008, 95% CI: 1.14-2.438), and 1.612 times higher for chewing tobacco users (<i>P</i> = 0.013, 95% CI: 1.102-2.357). The odds of developing oMMP were 1.923 times higher for cigarette users (<i>P</i> = 0.042, 95% CI: 1.011-3.657). The odds of developing glaucoma were 1.551 times higher for cigarette users (<i>P</i> < 0.001, 95% CI: 1.234-1.95), 1.547 times higher for vape users (<i>P</i> < 0.002, 95% CI: 1.223-1.956), 1.574 times higher for chewing tobacco users (<i>P</i> < 0.001, 95% CI: 1.25-1.982), and 1.707 times higher for those exposed to tobacco smoke (<i>P</i> = 0.001, 95% CI: 1.229-2.37). Finally, the odds of developing cataracts were 2.513 times higher for cigarette users (<i>P</i> < 0.001, 95% CI: 1.821-3.469), 1.923 times higher for cannabis users (<i>P</i> = 0.005, 95% CI: 1.204-3.069), 2.151 times higher for vape users (<i>P</i> < 0.001, 95% CI: 1.509-3.064), 2.162 times higher for chewing tobacco users (<i>P</i> < 0.001, 95% CI: 1.525-3.064), and 4.205 times higher for those exposed to tobacco smoke (<i>P</i> < 0.001, 95% CI: 2.89-6.068).</p><p><strong>Conclusions: </strong>History of cannabis use and exposure to second-hand smoke are significantly associated with an increased risk of uveitis, whereas a history of chewing tobacco, vape, and cannabis use is significantly associated with an increased risk of scleritis. Cigarette use is also associated with a significantly increased risk of oMMP.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 4","pages":"421-429"},"PeriodicalIF":0.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Hydroxypropyl Guar-Hyaluronic Acid Dual-Polymer Eye Drops on Inflammatory Cytokine Expression in Tears of Patients with Computer Vision Syndrome.","authors":"Shikha Pawaiya, Divya Singh, Vinod Sharma, Bhavya Mehta, Pooja Badgujar, Rahul Bhargava","doi":"10.4103/joco.joco_150_25","DOIUrl":"10.4103/joco.joco_150_25","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the impact of hydroxypropyl guar-hyaluronic acid (HPG-HA) dual-polymer eye drops on inflammatory cytokines in the tears of individuals experiencing computer vision syndrome.</p><p><strong>Methods: </strong>A randomized, double-masked, multi-center interventional study was conducted. One hundred and sixteen computer users with symptoms (using computers over 3 h daily for at least 1 year) were randomized into two groups; 56 patients received HPG-HA eye drops, and 60 patients received preserved saline drops, both twice daily for a duration of 3 months. The primary outcome was the reduction of inflammatory cytokines (interleukin-1 beta [IL-1β], IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, interferon-γ, and tumor necrosis factor-α) in conjunctiva and tears of computer users. The secondary outcomes encompassed alterations in dry eye symptom scores, Schirmer test results, tear breakup time (TBUT) values, and Nelson grade at the 3-month mark.</p><p><strong>Results: </strong>At baseline, tear inflammatory cytokines and tear film parameters were similar in both the supplement and placebo groups. Tear inflammatory cytokine levels showed no significant changes from baseline at 3 months postintervention in the tear supplement group, despite numerical reduction. However, the tear supplement group demonstrated a notable improvement in dry eye symptoms (<i>P</i> < 0.001), Schirmer test scores (<i>P</i> < 0.001), and TBUT scores (<i>P</i> < 0.001); however, there was no significant alteration in goblet cell counts or morphology of conjunctival epithelial cells.</p><p><strong>Conclusions: </strong>Treatment with HPG-HA dual-polymer eye drops for 3 months does alleviate dry eye symptoms and decrease tear evaporation rate in patients with computer vision syndrome. However, it does not alter tear inflammatory cytokines nor increase conjunctival goblet cell density.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 4","pages":"407-412"},"PeriodicalIF":0.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Choroidal Structure in Third-Trimester Pregnant Women.","authors":"Selda Celik Dulger, Sümeyra Koprubasi, Ertugrul Koylu, Sezin Erturk Aksakal, Huseyin Levent Keskin","doi":"10.4103/joco.joco_88_25","DOIUrl":"10.4103/joco.joco_88_25","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of pregnancy on choroidal vascularity index (CVI) and choroidal thickness (CT) in the third trimester.</p><p><strong>Methods: </strong>This prospective and cross-sectional study included 51 eyes of 51 healthy pregnant women in the third trimester and 50 eyes of 50 healthy age-matched participants as a control group. Full ophthalmologic examinations, including best-corrected visual acuity, intraocular pressure, slit-lamp biomicroscopy, axial length (AL), and anterior chamber depth (Lenstar LS900 HAAG-STREIT AG, Switzerland), and refractive error measurements were performed. CT was measured manually with optical coherence tomography at the fovea, 1500 μm temporal, and 1500 μm nasal to the fovea. The total choroidal area (TCA), luminal choroidal area (LCA), and stromal choroidal area (SCA) were evaluated by the binarization method. The ratio of the luminal area to the TCA was used as the CVI value.</p><p><strong>Results: </strong>There was no statistically significant difference in AL or age between the two groups (<i>P</i> < 0.05). The TCA, LCA, and SCA values were greater in the pregnant group (<i>P</i> = 0.007, 0.011, and <0.001, respectively). There were no statistically significant differences in terms of CVI and CT at three regions between the two groups (<i>P</i> = 0.080, <i>P</i> = 0.294, <i>P</i> = 0.287, and <i>P</i> = 0.107).</p><p><strong>Conclusion: </strong>Remarkable hemodynamic and hormonal changes take place during pregnancy. A significant increase in the total choroidal, luminal, and stromal areas was detected in pregnant women during the third trimester, although the CVI and CT demonstrated no difference between the groups.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 4","pages":"436-442"},"PeriodicalIF":0.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Pars Plana Vitrectomy and Panretinal Laser Photocoagulation on Ocular Blood Flow in Proliferative Diabetic Retinopathy.","authors":"Mehmet Barış Üçer, Zeliha Yazar, Mehmet Önen, Mutlu Gülbay","doi":"10.4103/joco.joco_265_24","DOIUrl":"10.4103/joco.joco_265_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of pars plana vitrectomy (PPV) versus panretinal photocoagulation (PRP) on ocular blood flow in patients with proliferative diabetic retinopathy (PDR).</p><p><strong>Methods: </strong>The blood flow parameters of the ophthalmic artery (OA), central retinal artery (CRA), central retinal vein (CRV), and posterior ciliary artery (PCA) of patients with PDR were evaluated with color Doppler ultrasonography (CDU), before and 6 months after PPV and PRP in 24 eyes of 24 patients. PRP alone was applied in the laser group, whereas PPV and PRP were applied to patients in the vitrectomy group.</p><p><strong>Results: </strong>CRA's peak systolic velocity, end-diastolic velocity, and CRV's mean velocity were significantly lower after PRP (<i>P</i> = 0.003, <i>P</i> = 0.003, and <i>P</i> = 0.050, respectively). A significant reduction in the resistivity index of CRA (<i>P</i> = 0.005) and OA (<i>P</i> = 0.013) was found in the vitrectomy group after PPV. Despite the application of PRP in the vitrectomy group, the decrease in postoperative flow velocities of the CRA, CRV, and PCA were lower than in the laser group.</p><p><strong>Conclusions: </strong>PRP treatment was associated with reduced flow velocities in the CRA and CRV; however, no comparable decline was observed when PPV was combined with PRP. Our findings suggest that PPV may counteract the flow-reducing effects of PRP by enhancing ocular blood flow velocities and decreasing vascular resistance. Given the limited sample size, this investigation should be considered a preliminary pilot study without definitive clinical conclusions.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 4","pages":"430-435"},"PeriodicalIF":0.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Evaluation of Inflammatory Cytokines in Tears of Individuals with Dry Eye Related to Prolonged Computer Use\".","authors":"Qing-Ping Xiang, Si-Jia Chen, Yu-Xin Mai, Min Liu","doi":"10.4103/joco.joco_30_26","DOIUrl":"10.4103/joco.joco_30_26","url":null,"abstract":"","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 4","pages":"472"},"PeriodicalIF":0.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}