Mohammadreza Akhlaghi, Alireza Dehghani, Farzan Kianersi, Mohammad Reza Khalili, Mohammad Tohidi, Hamidreza Jahanbani-Ardakani
{"title":"Effect of Eplerenone Treatment in Patients with Central Serous Retinopathy: A Double-Blind Randomized Clinical Trial.","authors":"Mohammadreza Akhlaghi, Alireza Dehghani, Farzan Kianersi, Mohammad Reza Khalili, Mohammad Tohidi, Hamidreza Jahanbani-Ardakani","doi":"10.4103/joco.joco_13_22","DOIUrl":"10.4103/joco.joco_13_22","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of eplerenone in central serous chorioretinopathy (CSCR) patients in a clinical trial design.</p><p><strong>Methods: </strong>In this double-blind clinical trial, naive acute. CSCR patients were divided into two groups: treatment with eplerenone 25 mg daily in the 1<sup>st</sup> week followed by 50 mg for the next 3 weeks and placebo group. Best-corrected visual acuity (BCVA), central macular thickness (CMT), macular volume (MV), and choroidal thickness (CT) were measured before and after 1 month of the intervention using the optical coherence tomography technique.</p><p><strong>Results: </strong>Thirty-one CSCR (male: 23, female: 8) and 25 CSCR patients (male: 18, female: 7) with the mean age of 35.65 ± 5.94 and 37.08 ± 6.41 years were recruited and divided randomly into treatment and placebo groups, respectively. BCVA improved significantly in the treatment group (from 0.28 ± 0.26 to 0.11 ± 0.14, <i>P</i> = 0.002) compared with the placebo group (from 0.31 ± 0.26 to 0.21 ± 0.14, <i>P</i> = 0.052). Although CT, CMT, and MV improved significantly in each group, there were no significant differences between the groups.</p><p><strong>Conclusion: </strong>In this study, we found favorable short-term clinical effects of eplerenone in acute CSCR patients, showing the pivotal role of mineralocorticoid receptors in the retina.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"61-65"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diffuse Unilateral Subacute Neuroretinitis: A Case Report Documenting Transretinal Migration of Nematodes.","authors":"Hassan Behboudi, Yousef Alizadeh, Maryam Dourandeesh, Ali Sanaye Abbasi, Ehsan Najibzadeh, Amin Nabavi","doi":"10.4103/joco.joco_345_22","DOIUrl":"10.4103/joco.joco_345_22","url":null,"abstract":"<p><strong>Purpose: </strong>To report two cases of diffuse unilateral subacute neuroretinitis (DUSN) from northern Iran and to present the sequential imaging.</p><p><strong>Methods: </strong>Two patients with large subretinal nematodes were evaluated and managed in our clinic. Serial fundus photography and optical coherence tomography (OCT) imaging were used to document the course of the disease. Laser photocoagulation was administered to manage the patients.</p><p><strong>Results: </strong>The migration of the nematodes from subinternal limiting membrane space to subretinal space was documented in one case, coinciding with the onset of inflammatory and destructive processes. Both patients were successfully managed using laser photocoagulation alone. Follow-up examinations revealed partial recovery of the outer retinal layers and improvement in visual acuity. Nevertheless, some persistent atrophy in the retinal nerve fiber layer and ellipsoid layer was noted in the final examination.</p><p><strong>Conclusions: </strong>We presented two cases of DUSN from northern Iran, with OCT documentation of transretinal migration in one case. Photocoagulation laser alone is an effective treatment modality in the early stage. The suboptimal final visual acuity appears to be linked to both inner and outer retinal layers' damage.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"107-110"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myopia Controlling using Low Dose Atropine Eye Drop.","authors":"Zhale Rajavi, Bahareh Kheiri, Kourosh Sheibani, Hamideh Sabbaghi","doi":"10.4103/joco.joco_344_22","DOIUrl":"10.4103/joco.joco_344_22","url":null,"abstract":"<p><strong>Purpose: </strong>To determine myopic progression, axial length elongation, best-corrected visual acuity (BCVA), pupil dilation, and accommodation amplitude following 24 months of Atropine 0.01% usage among progressive myopic patients.</p><p><strong>Methods: </strong>Fifty-one progressive myopic patients (age range, 3.5-17 years) were included in the present study. Fifteen patients were excluded due to loss to follow-up (eight patients) and Atropine complications (seven patients) and 36 patients continued therapy. Myopic progression, axial length, far and near BCVA, pupil diameter, and accommodation amplitude were measured at baseline examination and repeated every 6 months up to 2 years. All patients were recommended to instill one drop of Atropine 0.01% in each eye every night. Absolute success of therapy was defined as myopic progression ≤0.50 diopter (D) and axial length growth ≤0.2 mm per year.</p><p><strong>Results: </strong>Mean myopic progression was 0.16 and 1.28 D and mean axial length change was 0.05 and 0.69 mm at months 12 and 24, respectively. Pupil dilation was 1.26 and 1.84 mm and accommodation reduction was 3.38 and 3.37 D at the same follow-ups, while BCVA was not changed. Absolute success rate for myopic progression control was 56.8% at 12 months and 70.8% at 24 months follow-up. In addition, the success rate in respect to axial length changes was 44.4% and 58.3% at the same time points.</p><p><strong>Conclusions: </strong>Atropine 0.01% can slow myopic progression and axial length elongation at least in 50% of myopic cases at 12- and 24-month follow-up with no significant complications. Therefore, Atropine therapy is recommended in cases of progressive myopia in children and teenagers.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"82-88"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selman Belviranli, Refik Oltulu, Enver Mirza, Mehmet Adam, Ali Osman Gundogan
{"title":"Can Inactivated Coronavirus Disease 2019 Vaccine Cause Bilateral Neurotrophic Keratopathy?","authors":"Selman Belviranli, Refik Oltulu, Enver Mirza, Mehmet Adam, Ali Osman Gundogan","doi":"10.4103/joco.joco_224_23","DOIUrl":"10.4103/joco.joco_224_23","url":null,"abstract":"<p><strong>Purpose: </strong>To present a case of bilateral neurotrophic keratopathy (NK) following an inactivated coronavirus disease 2019 (COVID-19) vaccine administration.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 46-year-old female patient was referred to our cornea department with unhealing corneal epithelial defects in both eyes. The patient's complaints, including ocular redness, sensitivity to light and blurred vision, started 1 week after the second dose of CoronaVac<sup>®</sup> vaccine and continued to increase for 2 months. Ophthalmological examination revealed mild ocular redness, epithelial defects in the central cornea, and decreased corneal sensitivity in both eyes. No pathology that could cause NK was detected in the patient's anamnesis and tests. Treatment including bandage contact lens application, autologous serum eye drops, preservative-free artificial tears, and oral doxycycline resulted in closure of the epithelial defect on the 10<sup>th</sup> day, and on the 2-month follow-up visit, it was observed that corneal sensitivity had increased.</p><p><strong>Conclusions: </strong>In the presented case, it is thought that bilateral NK may be associated with the vaccine due to the chronological relationship between the vaccine administration and the lack of any other explanatory etiology. A cure was achieved in a short time with appropriate treatment, and the increase in corneal sensitivity over time indicates that the corneal neuropathy was reversible. Nowadays, with the worldwide administration of COVID-19 vaccines, ophthalmologists should keep in mind that, although rare, NK manifestation may still be encountered after vaccination.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"99-102"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Oliver-Gutierrez, Cristina Pares-Alfonso, Natalia Anglada-Masferrer, Laia Bisbe
{"title":"Khodadoust Line Indicating Graft Rejection in Descemet's Stripping Automated Endothelial Keratoplasty: A Unique Case Report.","authors":"David Oliver-Gutierrez, Cristina Pares-Alfonso, Natalia Anglada-Masferrer, Laia Bisbe","doi":"10.4103/joco.joco_222_23","DOIUrl":"10.4103/joco.joco_222_23","url":null,"abstract":"<p><strong>Purpose: </strong>To highlight the rarity of the endothelial rejection line, also known as the Khodadoust line, as a manifestation following Descemet's stripping automated endothelial keratoplasty (DSAEK). The objective is to present a meticulously detailed case, including imaging and anterior optical coherence tomography (OCT), to enhance understanding and recognition of this phenomenon.</p><p><strong>Methods: </strong>A detailed case presentation involving a 50-year-old male, 3 years post-DSAEK transplantation for endothelial damage resulting from intraocular surgeries. The patient urgently sought consultation due to vision loss while under daily fluorometholone use. Clinical examination revealed acute graft rejection characterized by corneal edema, anterior chamber reaction, and the presence of keratic precipitates forming a Khodadoust line. The management approach included the initiation of a tapered dexamethasone regimen.</p><p><strong>Results: </strong>The identified acute graft rejection, marked by the presence of a Khodadoust line, demonstrated favorable responsiveness to the initiated tapered dexamethasone regimen. Corneal OCT and imaging played crucial roles in providing detailed insights into the manifestation.</p><p><strong>Conclusions: </strong>While the endothelial rejection line (Khodadoust line) is a rare occurrence following DSAEK, this case underscores its potential association with graft rejection. The successful management outlined in this report suggests the importance of prompt recognition and appropriate anti-inflammatory intervention in such cases to achieve positive outcomes.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"96-98"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Taher Rajabi, Melika Samadi, Sepide Ghods, Seyed Mohsen Rafizadeh
{"title":"Correlation between Orbital Computed Tomography Scan Measurements and Clinical Enophthalmos in Acute Isolated Orbital Floor Fractures.","authors":"Mohammad Taher Rajabi, Melika Samadi, Sepide Ghods, Seyed Mohsen Rafizadeh","doi":"10.4103/joco.joco_213_23","DOIUrl":"10.4103/joco.joco_213_23","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the correlation between orbital computed tomography (CT) scan measurements including the fracture area (FA), the fracture location, the soft-tissue herniation volume (HV), the fractured orbital volume ratio (OVR) to the normal orbit, and the clinical enophthalmos in acute isolated orbital floor fractures.</p><p><strong>Methods: </strong>We enrolled 100 patients with acute isolated unilateral orbital floor fractures from May 2017 to January 2021. Based on the CT scan findings, we measured the FA, HV, OVR, and fracture site. We assessed enophthalmos using both clinical (CE) and radiographic (RE) measurements. Additionally, we investigated the correlation between CE and the measured parameters, along with the relationship between the pattern of diplopia and the fracture site.</p><p><strong>Results: </strong>We identified enophthalmos in 81% and diplopia in 78% of the patients with an acute blowout orbital floor fracture. CE was moderately correlated with the FA (<i>R</i> <sup>2</sup> = 0.4341, <i>P</i> < 0.001). CE was weakly correlated with the HV (<i>R</i> <sup>2</sup> = 0.2861, <i>P</i> = 0.04). Anterior fractures caused diplopia in both vertical gazes, but posterior fractures were mostly associated with diplopia in the up gaze. OVR was strongly associated with RE (<i>R</i> <sup>2</sup> = 0.663, <i>P</i> < 0.0001) and moderately associated with CE (<i>R</i> <sup>2</sup> = 0.4378, <i>P</i> < 0.0001). The univariate regression analysis also showed that OVR could significantly predict CE and RE.</p><p><strong>Conclusions: </strong>OVR surpasses other CT scan measurements such as FA and HV in the prediction of clinical enophthalmos. Thus, OVR could be utilized to estimate clinical enophthalmos at the time of presentation, especially when the acute clinical setting prohibits the proper clinical evaluation.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"89-95"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celine Chaaya, Georges El Haddad, Fadi Abdul Karim, Sarah Abou Daher
{"title":"Adenoid Cystic Carcinoma of the Lacrimal Gland.","authors":"Celine Chaaya, Georges El Haddad, Fadi Abdul Karim, Sarah Abou Daher","doi":"10.4103/joco.joco_231_23","DOIUrl":"10.4103/joco.joco_231_23","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the various aspects of adenoid cystic carcinoma of the lacrimal gland (LACC), including its clinical features, presentations, genetic factors, as well as current and potential future treatment options.</p><p><strong>Methods: </strong>A thorough exploration of the literature was conducted by extensively searching the PubMed database. A total of 68 articles with a primary focus on adenoid cystic carcinoma were selected.</p><p><strong>Results: </strong>LACC is the most frequent malignant epithelial tumor of the lacrimal gland. It is characterized by the symptoms such as pain, progressive swelling of the eye, double vision, and bulging of the eye. Although LACC is a rare tumor, early detection and appropriate treatment are crucial due to its aggressive nature which includes high recurrence rate and a significant risk of mortality. The primary treatment options for LACC involve a wide range of surgical procedures, including orbitotomy, exenteration, and cranio-orbital resection. Neoadjuvant intra-arterial chemotherapy represents the paradigm shift in the treatment of LACC enhancing patient survival when compared to conventional treatments.</p><p><strong>Conclusion: </strong>The existing literature emphasizes the importance of identifying prognostic factors that can guide treatment decisions and enhance the outcomes for patients with LACC.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation and Comparison of the Knowledge Levels of Current Artificial Intelligence Programs on Retinal/Vitreous Diseases and Treatment Methods.","authors":"Eyupcan Sensoy, Mehmet Citirik","doi":"10.4103/joco.joco_192_23","DOIUrl":"10.4103/joco.joco_192_23","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the answers to multiple-choice questions about retina and vitreous diseases and treatment modalities of Chat Generative Pre-Trained Transformer (ChatGPT), Bard, and Bing artificial intelligence chatbots, examining the level of knowledge about these subjects, and investigating the existence of their superiority over each other.</p><p><strong>Methods: </strong>Forty-six questions related to retinal and vitreous diseases and treatment modalities were asked to ChatGPT, Bing, and Bard chatbots.</p><p><strong>Results: </strong>The Bing artificial intelligence chatbot correctly answered 76.1% of the questions. ChatGPT and Bard artificial intelligence chatbots correctly answered 60.9% of the questions. No statistically significant difference was observed between the rates of correct and incorrect answers to the questions on the three artificial intelligence chatbots (<i>P</i> = 0.206).</p><p><strong>Conclusions: </strong>Artificial intelligence chatbots can be used to access accurate information about retinal and vitreous diseases and treatment modalities. However, the information obtained may not always be correct, and care should be taken about its use and results.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"78-81"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siamak Zarei-Ghanavati, Marzieh Najjaran, Samira Hassanzadeh, Mehdi Khabazkhoob, Akilesh Gokul, Mohammed Ziaei
{"title":"Agreement of a Pyramidal Wavefront-Based Autorefraction with Dry, Cycloplegic, and Subjective Refraction in Myopic Refractive Surgery Candidates.","authors":"Siamak Zarei-Ghanavati, Marzieh Najjaran, Samira Hassanzadeh, Mehdi Khabazkhoob, Akilesh Gokul, Mohammed Ziaei","doi":"10.4103/joco.joco_261_23","DOIUrl":"10.4103/joco.joco_261_23","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the repeatability of a pyramidal wavefront-based refraction (WFR) measurement and its agreement with dry autorefraction (DR), cycloplegic autorefraction (CR), and subjective refraction (SR) in myopic refractive surgery candidates.</p><p><strong>Methods: </strong>One hundred eighty-nine eyes from 189 participants were evaluated. PERAMIS aberrometry (PERAMIS; SCHWIND eye-tech-solutions, Kleinostheim, Germany), DR, and CR, as well as SR, were completed for all candidates. The repeatability of PERAMIS measurements was assessed, and the Bland-Altman plots were used to test the agreement between different methods.</p><p><strong>Results: </strong>Repeatability of the PERAMIS aberrometer was very high in the measurement of all refractive elements (Sphere, cylinder, spherical equivalent [M], J0, and J45) (interclass correlation coefficient >0.980 for all). A significant myopic shift was found with WFR compared to CR (0.45 diopter [D]) and SR (0.28 D) (<i>P</i> < 0.05). For the M component, there was a significant difference between WFR and CR (<i>P</i> < 0.05). J0 component measured with WFR was significantly different from SR and CR (<i>P</i> < 0.05). For the J45 variable, all three refraction methods were comparable (all, <i>P</i> > 0.05). In M > 5.00 D, a difference of 0.79 D (limit of agreement: -3.50-1.90) was found between WFR and CR.</p><p><strong>Conclusions: </strong>In lower degrees of myopia, WFR was in good agreement with the manifest autorefraction. WFR, CR, and SR techniques were comparable in measuring astigmatism, especially in oblique astigmatism.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"54-60"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir Houshang Beheshtnejad, Mohammad Hani, Parya Abdolalizadeh, Fateme Alipour
{"title":"Corneal Epithelial Thickness in Normal Corneas with Low and High Toricity.","authors":"Amir Houshang Beheshtnejad, Mohammad Hani, Parya Abdolalizadeh, Fateme Alipour","doi":"10.4103/joco.joco_169_23","DOIUrl":"10.4103/joco.joco_169_23","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the corneal epithelial thickness along the flat and steep meridians of corneas with low and high toricity.</p><p><strong>Methods: </strong>This was a prospective observational comparative study on healthy subjects with normal corneas seeking preoperative evaluation for refractive surgery at a university-based hospital. Subjects with up to 2 diopters (D) of corneal with-the-rule astigmatism were defined as low corneal toricity (CT), whereas cylinder > two-dimensional was considered as high CT. The anterior segment optical coherence tomography was conducted to measure the epithelial thickness along the principle meridians of CT over a diameter of 9 mm. At the eye level, outcome variables (corneal and epithelial thicknesses in low- and high-astigmatism groups) were assessed using generalized estimating equation models.</p><p><strong>Results: </strong>Included were 98 eyes (49 subjects): 46 eyes (23 subjects) with low CT and 52 eyes (26 subjects) with high CT. Two groups were similar with respect to the age (<i>P</i> = 0.82), sex (<i>P</i> = 0.49), and spherical equivalent (<i>P</i> = 0.11). Although the corneal thickness at steep and flat meridians was not different between two groups, high-CT group had significantly thinner epithelium at inferior 2.5-3.5 and 3.5-4.5 mm zones (<i>P</i> = 0.01 and 0.04) as well as superior 2.5-3.5 mm zone (<i>P</i> = 0.03) along the steep meridian. Two groups were similar with respect to epithelial thickness of flat meridian (all <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>The epithelium of steep meridian was thinner in the high-CT group compared to the low-CT group.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"36 1","pages":"37-41"},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}