Liquid Biopsy and Ocular Tumors: A Review.

IF 0.9 Q3 OPHTHALMOLOGY

Journal of Current Ophthalmology Pub Date : 2025-09-18 eCollection Date: 2024-10-01 DOI:10.4103/joco.joco_88_24

Celine Chaaya, Andrea Sarkis, Georges El Haddad, Ernest Diab, Alexandre Schakal

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引用次数: 0

Abstract

Purpose: To explore the various applications of liquid biopsy (LB) in ophthalmology and provide a comprehensive discussion on its utility in the field.

Methods: A thorough exploration of the literature was conducted, and a total of 47 articles were included.

Results: In RB, where conventional tumor biopsies carry risks of spreading the tumor beyond the eye, LB, particularly from the aqueous humor, emerges as a promising alternative. It provides a secure means of detecting cfDNA. In addition, LB is effective in uveal melanoma, particularly through digital droplet PCR, in mutation detection and predicting disease progression. Moreover, vitreous LB proves highly effective in diagnosing vitreoretinal lymphoma, exhibiting greater sensitivity than traditional cytopathological methods. This noninvasive approach not only enhances diagnostic accuracy but also holds potential for guiding biologically targeted therapies, showcasing the ongoing advancements in LB technology poised to redefine and revolutionize the field.

Conclusion: These findings offer valuable insights for personalized treatment strategies in ocular malignancies.

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液体活检与眼部肿瘤：综述。

目的：探讨液体活检（LB）在眼科中的各种应用，并对其在该领域的应用进行全面的探讨。方法：深入查阅文献，共纳入47篇。结果：在RB中，传统的肿瘤活检有肿瘤扩散到眼睛以外的风险，LB，特别是房水LB，是一种有希望的替代方法。它提供了一种安全的检测cfDNA的方法。此外，LB在葡萄膜黑色素瘤中，特别是通过数字液滴PCR，在突变检测和预测疾病进展方面是有效的。此外，玻璃体LB对诊断玻璃体视网膜淋巴瘤非常有效，表现出比传统细胞病理学方法更高的敏感性。这种非侵入性方法不仅提高了诊断准确性，而且具有指导生物靶向治疗的潜力，展示了LB技术的持续进步，有望重新定义和彻底改变该领域。结论：这些发现为眼科恶性肿瘤的个性化治疗策略提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Current Ophthalmology OPHTHALMOLOGY-

CiteScore

2.50

自引率

6.70%

发文量

审稿时长

8 weeks

期刊介绍： Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.