Age-Related Macular Degeneration Prevalence and its Risk Factors in Iran: A Systematic Review and Meta-Analysis Study.

IF 1.2 Q3 OPHTHALMOLOGY

Journal of Current Ophthalmology Pub Date : 2024-08-10 eCollection Date: 2023-10-01 DOI:10.4103/joco.joco_40_23

Parsa Panahi, Ali Kabir, Khalil Ghasemi Falavarjani

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引用次数: 0

Abstract

Purpose: To estimate the prevalence of age-related macular degeneration (AMD) and determine its risk factors in Iran.

Methods: A comprehensive electronic search was conducted in PubMed, Scopus, Web of Science, and Google Scholar, with no restrictions on time or language of publication. Eleven studies meeting the eligibility criteria were included. Six studies with a total sample size of 9930 were included in the meta-analysis to calculate the overall prevalence of AMD in Iran. Meta-analysis was performed using Stata/MP version 15.0. Risk of bias assessment was carried out based on the Newcastle-Ottawa Scale.

Results: All participants in the studies were over 40 years old. The pooled prevalence of AMD was estimated to be 9.9% (95% confidence interval [CI]: 6.3%-13.5%). After accounting for publication bias, this estimated decreased to 6.4% (95% CI: 4%-10.2%). Smoking (odds ratio [OR]: 1.781; 95% CI: 1.152-2.756), hypertension (HTN) (OR: 1.512; 95% CI: 1.119-2.044), diabetes mellitus (DM) (OR: 1.545; 95% CI: 1.088-2.194), and hyperlipidemia (OR: 1.512; 95% CI: 1.055-2.165) were identified as AMD risk factors.

Conclusion: Based on the results of the present review, the prevalence of AMD in the Iranian population over 40 years of age is estimated to be 6.4%, and having a history of smoking, HTN, DM, and hyperlipidemia are identified as risk factors of AMD in Iran. Further original studies are needed to draw more accurate conclusions.

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伊朗老年性黄斑变性患病率及其风险因素：系统回顾与元分析研究》。

目的：估算伊朗老年性黄斑变性（AMD）的患病率并确定其风险因素：在 PubMed、Scopus、Web of Science 和 Google Scholar 上进行了全面的电子检索，对发表时间或语言没有限制。共纳入了 11 项符合资格标准的研究。荟萃分析纳入了六项研究，样本量共计 9930 个，以计算伊朗 AMD 的总体患病率。荟萃分析使用 Stata/MP 15.0 版进行。根据纽卡斯尔-渥太华量表进行了偏倚风险评估：所有研究的参与者年龄都在 40 岁以上。据估计，AMD 的总患病率为 9.9%（95% 置信区间 [CI]：6.3%-13.5%）。在考虑了发表偏倚后，这一估计值降至 6.4%（95% 置信区间：4%-10.2%）。吸烟（几率比 [OR]：1.781；95% CI：1.152-2.756）、高血压 (HTN)（OR：1.512；95% CI：1.119-2.044）、糖尿病 (DM)（OR：1.545；95% CI：1.088-2.194）和高脂血症（OR：1.512；95% CI：1.055-2.165）被确定为老年痴呆症的风险因素：根据本综述的结果，伊朗 40 岁以上人群的老年性视网膜病变患病率估计为 6.4%，吸烟史、高血压、糖尿病和高脂血症被认为是伊朗老年性视网膜病变的风险因素。要得出更准确的结论，还需要进一步的原始研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Current Ophthalmology OPHTHALMOLOGY-

CiteScore

2.50

自引率

6.70%

发文量

审稿时长

8 weeks

期刊介绍： Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.