Journal of Current Ophthalmology最新文献

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The Effect of Ocular Hypotensive Medications on Posterior Segment Blood Flow in Healthy Subjects: A Prospective, Randomized, and Interventional Study. 降眼压药物对健康受试者后段血流的影响:一项前瞻性、随机和介入性研究。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_236_24
Saeed Shokouhi Rad, Marzieh Ghannad, Nasser Shoeibi, Elham Bakhtiari, Hamid Reza Heidarzadeh
{"title":"The Effect of Ocular Hypotensive Medications on Posterior Segment Blood Flow in Healthy Subjects: A Prospective, Randomized, and Interventional Study.","authors":"Saeed Shokouhi Rad, Marzieh Ghannad, Nasser Shoeibi, Elham Bakhtiari, Hamid Reza Heidarzadeh","doi":"10.4103/joco.joco_236_24","DOIUrl":"10.4103/joco.joco_236_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the immediate impact of topical ocular hypotensive medications on peripapillary and macular blood flow in healthy adults from Northeast Iran.</p><p><strong>Methods: </strong>A prospective, randomized, and interventional study was conducted on 80 healthy volunteers, with each volunteer having one eye treated with either brimonidine, dorzolamide, latanoprost, or timolol, all of which are ocular hypotensive medications. The study included a placebo treatment for one eye of each participant to serve as a control. At the peak effect of the drugs, all participants underwent an optical coherence tomography angiography scan of their eyes. A total of 160 eyes were included in the study.</p><p><strong>Results: </strong>According to the findings, the use of ocular hypotensive drugs did not demonstrate any significant influence on the radial peripapillary capillary network. However, the results indicated that a single dose of dorzolamide could result in a significant increase in macular blood flow (<i>P</i> = 0.019). Conversely, treatment with timolol resulted in a significant decrease in macular blood flow (<i>P</i> = 0.002). Moreover, brimonidine significantly affected the thickness of the retinal nerve fiber layer (<i>P</i> = 0.02).</p><p><strong>Conclusions: </strong>According to our findings, dorzolamide was the most effective in enhancing young adults' full macular thickness and macular blood flow. Conversely, timolol treatment was found to decrease the macular blood flow, which in turn may cause visual field defects due to optic nerve head and macular ischemia in patients with low-tension glaucoma.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"194-201"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central Toxic Keratopathy after Photorefractive Keratectomy: Two-Year Follow-Up Case Report and Review of the Literature. 光屈光性角膜切除术后中枢性中毒性角膜病变:两年随访病例报告及文献回顾。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_125_25
Javad Sadeghi, Negareh Yazdani, Mohammad-Reza Sedaghat, Iman Varshovi-Jaghargh
{"title":"Central Toxic Keratopathy after Photorefractive Keratectomy: Two-Year Follow-Up Case Report and Review of the Literature.","authors":"Javad Sadeghi, Negareh Yazdani, Mohammad-Reza Sedaghat, Iman Varshovi-Jaghargh","doi":"10.4103/joco.joco_125_25","DOIUrl":"10.4103/joco.joco_125_25","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare case of central toxic keratopathy (CTK) after photorefractive keratectomy (PRK).</p><p><strong>Methods: </strong>A 22-year-old male underwent bilateral PRK for the correction of myopic astigmatism. Preoperative refraction measurements were -2.50 -1.00 × 65 in the right eye and -3.50 diopter (D) sphere in the left eye. The intended refractive correction was -3.25 -1.00 × 65 (in the right eye) and -4.25 D sphere in the left eye. Preoperative corneal thickness measured 489 μm (in the right eye) and 491 μm in the left eye, both values exceeding the minimum safe threshold for PRK.</p><p><strong>Results: </strong>At the 1-week postoperative evaluation, slit-lamp examination and optical coherence tomography (OCT) revealed significant central corneal haziness, thinning, and flattening, along with hyperopic astigmatism. These findings were consistent with CTK. The surgeon adopted a conservative approach, closely monitoring the patient without initiating pharmacological intervention. By the 6-month follow-up, the patient demonstrated reduced hyperopia and achieved a best-corrected visual acuity of 20/20. OCT imaging also confirmed increased central corneal and epithelial thickness, suggesting progressive recovery. Long-term follow-up over 2 years showed stable refraction and corneal thickness, with no further significant changes.</p><p><strong>Conclusions: </strong>CTK is a rare but vision-threatening complication of refractive surgery, occurring not only after laser <i>in situ</i> keratomileusis but also following other refractive surgery approaches. Enhancing clinical knowledge of both its presentation and differential diagnosis is essential to avoid any unnecessary interventions.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"259-262"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Two Different Antiglaucomatous Medications on Corneal Endothelium and Transparency: A Comparative Perspective. 两种不同的抗青光眼药物对角膜内皮和透明度的影响:比较视角。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_208_25
Mahmut Asfuroglu, Yonca Asfuroglu
{"title":"Impact of Two Different Antiglaucomatous Medications on Corneal Endothelium and Transparency: A Comparative Perspective.","authors":"Mahmut Asfuroglu, Yonca Asfuroglu","doi":"10.4103/joco.joco_208_25","DOIUrl":"10.4103/joco.joco_208_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of two topical antiglaucomatous agents, latanoprost and brimonidine, on corneal transparency and endothelial cell characteristics in eyes with open-angle glaucoma or ocular hypertension (OHT).</p><p><strong>Methods: </strong>This comparative cross-sectional study included 59 patients diagnosed with open-angle glaucoma or OHT, of whom 34 were on latanoprost and 25 were on brimonidine treatment. The control group consisted of 32 healthy eyes. Corneal densitometry (CD) and specular microscopy measurements were obtained, including endothelial cell density (ECD), coefficient of variation (CV), hexagonality (HEX), and central corneal thickness (CCT).</p><p><strong>Results: </strong>There was no statistically significant difference identified between the three groups with regard to ECD (<i>P</i> = 0.23), HEX (<i>P</i> = 0.54), and CV (<i>P</i> = 0.35). However, the CD values in the central layer (2-6 mm) and posterior layer (2-6 mm) were found to be significantly lower in the latanoprost-treated group. This difference reached statistical significance compared with the control group in the central layer, and with both the control and brimonidine groups in the posterior layer (<i>P</i> < 0.01). A significant reduction in CCT was also observed in the latanoprost group compared to the control group (<i>P</i> = 0.008).</p><p><strong>Conclusions: </strong>This is a preliminary investigation to conduct a comparative analysis of corneal clarity in patients who are under antiglaucomatous medication and in a healthy population. It can be postulated that a reduction in CD values in the latanoprost-treated group may contribute to an improvement in corneal transparency due to the remodeling effect of the drug on the cornea. It can also be inferred that the lower CCT observed in the latanoprost-treated group may be attributed to the lower CD measurements in these eyes.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"202-206"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The History of Trachoma in Iran. 伊朗沙眼的历史。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_119_25
Seyed-Farzad Mohammadi, Jamal Rezaei-Orimi, Najmeh Bahmanziari, Elham Ashrafi, Seyed-Mehrdad Mohammadi, Alireza Mahdavi, Marzieh Katibeh, Jalil Allami
{"title":"The History of Trachoma in Iran.","authors":"Seyed-Farzad Mohammadi, Jamal Rezaei-Orimi, Najmeh Bahmanziari, Elham Ashrafi, Seyed-Mehrdad Mohammadi, Alireza Mahdavi, Marzieh Katibeh, Jalil Allami","doi":"10.4103/joco.joco_119_25","DOIUrl":"10.4103/joco.joco_119_25","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The epidemic and eradication of trachoma in Iran during the past century reflects the evolution of modern medicine and the emergence of public health. To document these events, to recognize key contributions, and to synthesize lessons learned is a social responsibility.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;To develop a comprehensive and credible historical review, we assembled a multidisciplinary team including a medical historian (JRO), disease control authorities from the Ministry of Health (AM and SFM), expert faculty from diverse fields (SFM, EA, SMM, and NB), the principal investigator of the most recent field survey (MK), and a prominent contemporary figure in Iran's Trachoma control efforts (JA). We reviewed institutional records, government health reports, and medical faculty documents archived in the National Library and Archives of Iran; analyzed the published scientific papers; interviewed the late Professor Hormoz Chams on key events and milestones; and consulted Iran's 2019 official report on trachoma elimination. We conducted documentary analysis and organized historical developments chronologically. Key actors, institutions, and interventions were identified to reconstruct the evolution of clinical practice, community investigations, and public health programs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This review begins with a concise overview of the ancient and global history on trachoma, followed by a focused account of its history in Iran-more detailed from the late Qajar to the Pahlavi period, and less so for the post-1979 Iranian revolution era. Recognized institutional players include Dar ul-Funun; Majlis-e Hefz al-Sehheh; Farabi Hospital and its Ophthalmology Chair; urban trachoma clinics and ministerial offices; the Parasitology Chair and Research Department, later the Institute of Parasitology and Malariology at the Medical School and later the School of Public Health at the Tehran University; the Social Services Organization; and the National Consultative Assembly. The Anglo-Persian Oil Company and its hospitals, the Red Lion and Sun Society, school-based health, and eventually the national primary health network all played important roles over time. Developments in medical specialization (ophthalmology and microbiology) and vocational education (community health and nursing) contributed to the efforts. Early generations of ophthalmologists, schoolteachers, nurses, disease and environmental control officers, and later community health workers, worked alongside microbiologists and public health experts. The evolution of treatment is traced from eye irrigation and lunar caustic chemoablation, to diathermocoagulation, and finally antibiotic therapy. While Iran never implemented mass drug administration, widespread free access to tetracycline eye ointment may have had a meaningful impact in the final stages. The Construction Jihad's major initiatives in the 1980s provided a leap forward in access to safe water ","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"145-158"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Different Concentrations of Autologous Serum Eye Drops in the Treatment of Ocular Surface Diseases: A Systematic Review and Meta-Analysis. 不同浓度自体血清滴眼液治疗眼表疾病的疗效:系统综述和meta分析。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_2_25
Annisa Nindiana Pertiwi, Made Susiyanti
{"title":"Efficacy of Different Concentrations of Autologous Serum Eye Drops in the Treatment of Ocular Surface Diseases: A Systematic Review and Meta-Analysis.","authors":"Annisa Nindiana Pertiwi, Made Susiyanti","doi":"10.4103/joco.joco_2_25","DOIUrl":"10.4103/joco.joco_2_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of different autologous serum eye drop (ASED) concentrations in treating ocular surface diseases.</p><p><strong>Methods: </strong>All articles assessing the efficacy of 20%, 50%, or 100% ASED were retrieved from PubMed, Cochrane, ScienceDirect, and EBSCO electronic databases and checked for applicability. Efficacy was evaluated based on symptom scoring, corneal staining, and tear film stability, which includes tear break-up time (TBUT) and the Schirmer's test.</p><p><strong>Results: </strong>Seven randomized clinical trials, three cohort studies, and one prospective study were included in this review. ASED significantly improved subjective ocular symptoms (overall standardized mean differences [SMD]: -2.99; 95% confidence interval [CI]: -4.38 to -1.60), without significant difference between 20%, 50%, and 100% concentrations (<i>P</i> = 0.617). Overall, TBUT also showed a considerable increase (mean differences [MD]: 1.68 s; 95% CI: 0.43-2.94), remarkably with 20% ASED (MD: 2.80; 95% CI: 1.61-4.00). In contrast, the Schirmer's test showed no significant trend toward improvement (MD: 0.53; 95% CI: -0.78-1.84). A remarkable effect was observed in keratoepitheliopathy (overall SMD: -1.08; 95% CI: -1.85 to -0.32), especially in the 50% ASED subgroup (SMD: -1.54; 95% CI: -2.73 to -0.35). All outcomes showed high heterogeneity (<i>I</i> <sup>2</sup> = 79.6%-97.3%). Sensitivity analyses limited to randomized controlled trials showed consistent findings, supporting the robustness of the results.</p><p><strong>Conclusion: </strong>ASED was effective in improving subjective ocular symptoms, tear break-up time, and keratoepitheliopathy across different concentrations but did not significantly affect Schirmer's test.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"159-171"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barriers to Adherence with Corticosteroid Eye Drops in Patients with Uveitis. 葡萄膜炎患者坚持使用皮质类固醇滴眼液的障碍。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_239_24
Karen Sun, Rayna Marshall, Michael Frankland, Amal Taylor, Cynthia Montana, Eric Crowell, Karen R Armbrust, Laura Kopplin, Meghan Berkenstock
{"title":"Barriers to Adherence with Corticosteroid Eye Drops in Patients with Uveitis.","authors":"Karen Sun, Rayna Marshall, Michael Frankland, Amal Taylor, Cynthia Montana, Eric Crowell, Karen R Armbrust, Laura Kopplin, Meghan Berkenstock","doi":"10.4103/joco.joco_239_24","DOIUrl":"10.4103/joco.joco_239_24","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the patient barriers to adherence with corticosteroid eye drops in patients with ocular inflammatory disorders across the United States.</p><p><strong>Methods: </strong>This was a multicenter study of adult and pediatric patients with uveitis undergoing treatment with corticosteroid eye drops. Sites included the Johns Hopkins Wilmer Eye, the University of Texas at Austin, the University of Wisconsin-Madison, the University of Minnesota, the Minneapolis Veterans Administration Hospital, and the Washington University of St. Louis. Eligible patients completed a self-reporting survey to assess barriers to adherence with corticosteroid eye drops.</p><p><strong>Results: </strong>The survey was completed fully by 94 subjects and partially by 20 (115 in total), of whom were 66% White, 60% female, and 47% had a college or advanced degree. While some patients (5.5%, <i>n</i> = 6) self-reported never taking their corticosteroid eye drops as prescribed, most reported taking the drops as directed (54.1%, <i>n</i> = 59) or at least 90% of the time (29.4%, <i>n</i> = 32). Reasons for nonadherence were explored: 56% of patients used a corticosteroid eye drop more than once a day, and 13% found frequency a limitation to adherence. Many patients had polypharmacy, 43% took 4 or more medications, and 50% took 1 or more drops in addition to a corticosteroid eye drop. Patients also reported difficulty reading the writing on drop bottles (39%) and poor vision limiting application into the eye (17%). Almost a quarter (24%) of patients occasionally ran out of their drop before the next refill. Most patients did not report cost (98%) or insurance loss (97%) as a barrier to obtaining a refill.</p><p><strong>Conclusions: </strong>Barriers to corticosteroid eye drop treatments for ocular inflammatory disease include difficulty with medication frequency, polypharmacy, medication administration, missing refills, and running out of medication early. Addressing these barriers may improve adherence with corticosteroid eye drops to achieve treatment goals.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"240-246"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient Changes in Wide-Field Choroidal Thickness after Photorefractive Keratectomy for Myopia: A Case-Control Study. 近视光屈光性角膜切除术后宽视场脉络膜厚度的短暂变化:一项病例对照研究。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_120_24
Negareh Yazdani, Hosein Hoseini-Yazdi, Nasser Shoeibi, Ali Akbar Derakhshan, Abbas Azimi Khorasani, Asieh Ehsaei
{"title":"Transient Changes in Wide-Field Choroidal Thickness after Photorefractive Keratectomy for Myopia: A Case-Control Study.","authors":"Negareh Yazdani, Hosein Hoseini-Yazdi, Nasser Shoeibi, Ali Akbar Derakhshan, Abbas Azimi Khorasani, Asieh Ehsaei","doi":"10.4103/joco.joco_120_24","DOIUrl":"10.4103/joco.joco_120_24","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the longitudinal changes in choroidal thickness following photorefractive keratectomy (PRK) in young adult myopes.</p><p><strong>Methods: </strong>The study population (age: 28 ± 1 years) consisted of 14 myopic subjects who underwent PRK for myopia correction, and a control group of 13 myopic subjects who did not undergo PRK. Measures of choroidal thickness were obtained at baseline in the control group, and before PRK in the treatment group, and then following 1-week, 1-month, 3 and 6 months. Changes in choroidal thickness across different regions were analyzed over time and between groups using linear mixed models.</p><p><strong>Results: </strong>The mean spherical equivalent refraction was -3.36 ± 0.31 diopter (D) in the treatment and -2.58 ± 0.30 D in the control group (<i>P</i> > 0.05) at baseline. Longitudinal changes in choroidal thickness were significantly different between the two groups (group by time interaction, <i>P</i> < 0.001). The mean wide-field choroidal thickness increased 1-week post-PRK in the treatment group (8 ± 3 μm), with this change in choroidal thickness significantly greater than the change in the control group (-1 ± 3 μm; <i>P</i> = 0.04). However, changes in the mean wide-field choroidal thickness were not significantly different between the two groups in 1-, 3-and 6-month follow-up visits (all <i>P</i> > 0.05). The observed longitudinal changes were not different across the macular and extramacular regions (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>Small magnitude thickening of the choroid was found to occur uniformly across the wide-field region within 1 week following myopic PRK. However, this change in choroidal thickness was transient and no longer observed within 6 months post-PRK.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"221-227"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Glaucoma Treatment through Materials Science: A Bibliometric Analysis. 通过材料科学推进青光眼治疗:文献计量学分析。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-12-19 eCollection Date: 2025-04-01 DOI: 10.4103/joco.joco_116_25
Junran Li, Huijie Hao, Bo Yu, Muyao Xin, Yu Sun, Xiaoli Xing
{"title":"Advancing Glaucoma Treatment through Materials Science: A Bibliometric Analysis.","authors":"Junran Li, Huijie Hao, Bo Yu, Muyao Xin, Yu Sun, Xiaoli Xing","doi":"10.4103/joco.joco_116_25","DOIUrl":"10.4103/joco.joco_116_25","url":null,"abstract":"<p><strong>Purpose: </strong>To identify recent research trends on advancing glaucoma treatment through materials science and focus on publications from different countries, institutions, and authors.</p><p><strong>Methods: </strong>We retrieved and analyzed data from January 1, 2015, to October 24, 2024, on the advancing glaucoma treatment through materials science research field from the Web of Science Core Collection database. Microsoft Excel and VOSviewer were applied to perform visualization analysis and evaluate the trends.</p><p><strong>Results: </strong>A total of 936 publications were identified, and the annual global publications increased steadily, from 44 to 93, during this period. The United States (267 publications, 9934 citations), Egyptian Knowledge Bank (52 publications, 1262 citations), and Jui-Yang Lai (20 publications, 986 citations) were the most influential and productive countries, institutions, and authors, respectively. The top 100 keywords were classified into eight clusters: (1) surgical materials; (2) nanoparticle retinal protection; (3) eye drops; (4) drug delivery characteristics; (5) contact; (6) ocular drug delivery mechanisms; (7) bioavailability and optimization; and (8) release technologies. Regarding the average appearing years (AAYs) of the keywords, \"microshunt\" (AAY: 2023.25), \"MIGS\" (AAY: 2022), and \"d-optimal design\" (AAY: 2021.5) were recognized as the hotspots in the short run.</p><p><strong>Conclusions: </strong>This study highlights advancements in materials science for glaucoma treatment, including biomaterials, nanotechnology, and nanoengineering. These innovations enable better drug delivery, improved devices, and surgical materials, promising more effective, personalized, and minimally invasive therapies for improved patient outcomes.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 2","pages":"183-193"},"PeriodicalIF":0.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mature Cataracts with Rheumatoid Peripheral Ulcerative Keratitis Treated by One- and Left-Handed Surgery via the Inferior Nasal Site. 经下鼻部单左手手术治疗成熟白内障伴风湿性周围性溃疡性角膜炎。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-11-14 eCollection Date: 2025-01-01 DOI: 10.4103/joco.joco_175_24
Suguru Nakagawa, Yohei Nomoto, Kazuya Inamochi
{"title":"Mature Cataracts with Rheumatoid Peripheral Ulcerative Keratitis Treated by One- and Left-Handed Surgery via the Inferior Nasal Site.","authors":"Suguru Nakagawa, Yohei Nomoto, Kazuya Inamochi","doi":"10.4103/joco.joco_175_24","DOIUrl":"10.4103/joco.joco_175_24","url":null,"abstract":"<p><strong>Purpose: </strong>To apply one- and left-handed phacoemulsification from the inferior nasal site for a case of rheumatoid peripheral ulcerative keratitis complicated by peripheral corneal thinning, which presented difficulties for standard two-handed cataract surgery.</p><p><strong>Methods: </strong>A case report.</p><p><strong>Results: </strong>The patient was an 80-year-old Japanese woman with the progression of peripheral ulcerative keratitis in the periphery of both eyes and a history of rheumatoid arthritis. Both eyes exhibited peripheral ulcerative keratitis, with the right eye particularly affected around the entire circumference of the cornea, except for the inferior nasal site. The disease subsided with the use of soft contact lenses and betamethasone and cyclosporine administration. The cataract progressed to a mature stage, and the density of corneal endothelial cells decreased to approximately 600/mm<sup>2</sup>. A right-handed surgeon, positioned at the lower left corner of her face, performed phacoemulsification using a one- and left-handed technique, without performing paracentesis, through a sclerocorneal incision from the inferior nasal site of her right eye. Postoperatively, her best-corrected visual acuity improved to 20/25 from hand motion.</p><p><strong>Conclusions: </strong>A patient with almost total circumferential thinning of the cornea, which appeared to be a challenge for standard cataract surgery, could undergo successful cataract surgery with the selection of an appropriate incision site and technique. The findings of this case report may provide valuable insights for the development of safe surgical strategies for cataract surgery in cases characterized by severe, almost circumferential peripheral thinning of the cornea.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 1","pages":"124-128"},"PeriodicalIF":0.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inadequacies in Uveitis: About the Whimsical Terminology of Bacillary Layer Detachment. 葡萄膜炎的不足:关于细菌层脱离的异样术语。
IF 0.9
Journal of Current Ophthalmology Pub Date : 2025-11-14 eCollection Date: 2025-01-01 DOI: 10.4103/joco.joco_120_25
Masaru Takeuchi, Yoshihiko Usui, Ahmed Abu El Asrar, Toshikatsu Kaburaki, De-Kuang Hwang, Sagnik Sen, Ioannis Papasavvas, Carl P Herbort
{"title":"Inadequacies in Uveitis: About the Whimsical Terminology of Bacillary Layer Detachment.","authors":"Masaru Takeuchi, Yoshihiko Usui, Ahmed Abu El Asrar, Toshikatsu Kaburaki, De-Kuang Hwang, Sagnik Sen, Ioannis Papasavvas, Carl P Herbort","doi":"10.4103/joco.joco_120_25","DOIUrl":"10.4103/joco.joco_120_25","url":null,"abstract":"","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"37 1","pages":"141-143"},"PeriodicalIF":0.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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