Journal of Cutaneous Pathology最新文献_第5页

Metastatic Gastrointestinal Stromal Tumor to the Scalp: A Case Report Highlighting Diagnostic Challenges and Molecular Correlation 转移到头皮的胃肠道间质瘤：一个病例报告强调诊断挑战和分子相关性。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-21 DOI: 10.1111/cup.14829

Andrew C. Sanchez, Oyewale O. Shiyanbola, Xiaohua Qian, Di Yan, Kathleen M. Sheahon, Jennifer Y. Wang, Roberto A. Novoa, Kerri E. Rieger, Ryanne A. Brown

引用次数: 0

Subungual Epidermoid Inclusions–A Series of 8 Cases and a Review of Literature 甲下表皮样包涵体——附8例报告及文献复习。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-11 DOI: 10.1111/cup.14830

Sarah M. Alnaqshabandi, Anurag Sharma, Ahmed Bakhshwin, Shira Ronen, Jennifer S. Ko, Steven D. Billings

引用次数: 0

Review of Literature to Determine Recommended Application of HPV-42 Molecular Testing for Digital Papillary Adenocarcinoma 文献综述确定HPV-42分子检测在数字乳头状腺癌中的推荐应用。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-11 DOI: 10.1111/cup.14823

Michelle Y. Zhu, Leting Zhang, Mahyar Khazaeli

{"title":"Review of Literature to Determine Recommended Application of HPV-42 Molecular Testing for Digital Papillary Adenocarcinoma","authors":"Michelle Y. Zhu, Leting Zhang, Mahyar Khazaeli","doi":"10.1111/cup.14823","DOIUrl":"10.1111/cup.14823","url":null,"abstract":"<p>Digital Papillary Adenocarcinoma (DPA) is a rare tumor that can cause metastasis and death. It can morphologically mimic benign sweat gland tumors. In 2022, the novel association of HPV-42 and DPA was discovered by means of DNA sequencing. In this scoping review, we aimed to systematically evaluate alternatives to HPV-42 molecular sequencing. Of 87 articles on DPA identified in a PUBMED meta-search, eight met the inclusion criteria. We found that DNA sequencing for HPV-42 is most sensitive (94%). Comparable tests included HPV-42 in situ hybridization (ISH), which had 82% sensitivity, and p16 immunohistochemistry, which had 70%–75% sensitivity. We further evaluated the performance of HPV-42 ISH and performed a stratified analysis of HPV-42 ISH-negative DPA cases. There was a statistically significant difference in HPV-42 positivity in patients younger than and older than 60 years old (<i>p</i> = 0.02). We recommend HPV-42 ISH for cases with equivocal morphology from patients aged over 60 years. Tumors with equivocal morphology from patients under the age of 60 years should be sequenced for HPV-42. For cases with classic morphology, p16 can be used to support the diagnosis, but molecular testing for HPV-42 is unnecessary.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 9","pages":"590-594"},"PeriodicalIF":1.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14823","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Biopsy Revealing Langerhans Cell Histiocytosis During Therapy for T-Cell Acute Lymphoblastic Leukemia: A Fatal Outcome 皮肤活检显示朗格汉斯细胞组织细胞增生在治疗t细胞急性淋巴细胞白血病：一个致命的结果。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-05 DOI: 10.1111/cup.14831

Swetha Palla, Prateek Bhatia, Narender Kumar, Debajyoti Chatterjee, Rajender Kumar, Deepak Bansal

引用次数: 0

Primary Cutaneous SMARCA4-Deficient Tumor With Metastases 原发性伴有转移的皮肤smarca4缺陷肿瘤。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-04 DOI: 10.1111/cup.14828

Supriya Pradhan, Martha Lehman, Abdul Mohd Tahir, Michael Su, Steven Kossard, Renukadas Sakalkale

引用次数: 0

The Role of Gram Stain in Differentiating Superficial Cutaneous Fungal Organisms 革兰氏染色在皮肤表层真菌生物鉴别中的作用。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-04 DOI: 10.1111/cup.14827

Taylor M. Nolff, Lillianna D. Pedersen, Luisa Y. A. Watts, Mary K. Klassen-Fischer, Walter L. Rush, Jill I. Allbritton

引用次数: 0

Histochemistry Testing for Cutaneous Fungal Infections: A Meta-Analysis 皮肤真菌感染的组织化学检测：荟萃分析。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-04 DOI: 10.1111/cup.14826

Manisha V. Vadali, Melissa A. Gener, Garth R. Fraga

{"title":"Histochemistry Testing for Cutaneous Fungal Infections: A Meta-Analysis","authors":"Manisha V. Vadali, Melissa A. Gener, Garth R. Fraga","doi":"10.1111/cup.14826","DOIUrl":"10.1111/cup.14826","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Specialized histochemistry testing for cutaneous fungal infection is common, but the comparative diagnostic accuracy of different test modalities such as periodic acid-Schiff (PAS) and Grocott methenamine silver (GMS) remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a meta-analysis of 23 studies involving 4404 patients who underwent histochemical testing for onychomycosis and seven studies involving 1221 patients who underwent histochemical testing for deep fungal infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis revealed a sensitivity of 0.84 (95% CI: 0.78–0.88) for PAS detection of onychomycosis vs. 0.73 (95% CI: 0.67–0.78) for GMS detection of onychomycosis. Studies on onychomycosis did not include a separate reference standard, and specificity could not be calculated. PAS showed higher estimated sensitivity (0.73) for diagnosis of deep fungal infection than GMS (0.49), but results were associated with broad, overlapping confidence intervals. Methodological issues prevented reliable conclusions on their accuracy in this setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While the choice of test for onychomycosis depends on user preference, if all factors are equal, PAS should be selected over GMS. The existing literature on histochemistry testing for deep fungal infection does not allow for reliable conclusions on its accuracy, and there is a compelling need for well-designed diagnostic accuracy studies in this area.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 8","pages":"539-547"},"PeriodicalIF":1.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma 大型先天性黑素细胞痣与LMNA::NTRK1融合：扩大先天性痣和黑色素瘤的靶向治疗选择。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-03 DOI: 10.1111/cup.14822

Akanksha Nagarkar, Jackson Turbeville, Molly A. Hinshaw, Philip E. LeBoit, Jeffrey Gagan, Mark Raffeld, Kenneth Aldape, Niharika Shah, Frederic G. Barr, Liqiang Xi, Ina Lee, Christina K. Ferrone, Svetlana D. Pack, Rosandra Kaplan, Mary Frances Wedekind Malone, Marielle Yohe, Michael R. Sargen

{"title":"Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma","authors":"Akanksha Nagarkar, Jackson Turbeville, Molly A. Hinshaw, Philip E. LeBoit, Jeffrey Gagan, Mark Raffeld, Kenneth Aldape, Niharika Shah, Frederic G. Barr, Liqiang Xi, Ina Lee, Christina K. Ferrone, Svetlana D. Pack, Rosandra Kaplan, Mary Frances Wedekind Malone, Marielle Yohe, Michael R. Sargen","doi":"10.1111/cup.14822","DOIUrl":"10.1111/cup.14822","url":null,"abstract":"<p>Large congenital melanocytic nevi/nevus (LCMN) are caused by genetic events that activate the mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) pathway. Individuals with LCMN are prone to developing aggressive melanomas during childhood. Targeted therapies are needed to treat this form of melanoma and manage LCMN symptoms such as pruritus and pain, which significantly impact quality of life. Here, we present the first case of an LCMN with an <i>NTRK</i> fusion driver event. The patient presented with an atypical proliferative nodule arising in the background nevus. RNA sequencing of the proliferative nodule with background nevus identified a pathogenic <i>LMNA::NTRK1</i> fusion. The fusion resulted in constitutive expression of TrkA, demonstrated by strong cytoplasmic pan-TRK staining, along with activation of the MAPK/ERK pathway, as indicated by positive nuclear and cytoplasmic staining for phosphorylated ERK. The background nevus beneath the proliferative nodule also expressed pan-TRK and phosphorylated ERK, suggesting that the <i>NTRK1</i> fusion occurred prior to the formation of the proliferative nodule. This case broadens the spectrum of driver events for LCMN and suggests that screening for <i>TRK</i> fusions in LCMN should be considered when systemic therapy is being considered for melanoma or symptom management.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 8","pages":"523-527"},"PeriodicalIF":1.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14822","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant CRTC1::TRIM11 Cutaneous Tumor With Lethal Outcome: Histopathologic and Molecular Findings 恶性CRTC1::TRIM11皮肤肿瘤致死性结局：组织病理学和分子研究结果。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-06-02 DOI: 10.1111/cup.14824

Meghan E. Beatson, James W. Smithy, Dylan Domenico, Gunes Gundem, Elli Papaemmanouil, Andrea Moy, Joyce M. Chen, Melissa P. Pulitzer, Charlotte Ariyan, Klaus J. Busam

{"title":"Malignant CRTC1::TRIM11 Cutaneous Tumor With Lethal Outcome: Histopathologic and Molecular Findings","authors":"Meghan E. Beatson, James W. Smithy, Dylan Domenico, Gunes Gundem, Elli Papaemmanouil, Andrea Moy, Joyce M. Chen, Melissa P. Pulitzer, Charlotte Ariyan, Klaus J. Busam","doi":"10.1111/cup.14824","DOIUrl":"10.1111/cup.14824","url":null,"abstract":"<div>\u0000 \u0000 <p>While early reports of <i>CRTC1::TRIM11</i> cutaneous tumors suggested a predominantly indolent clinical course, a few cases have been documented with lymph node and distant metastases. We report herein a metastasizing tumor with a lethal outcome. It presented as a subcutaneous mass on the back of a 17-year-old teenager. Histopathologically, the tumor was subepidermal and composed of amelanotic spindle and epithelioid cells with nuclear pleomorphism. The tumor cells were immunoreactive for Sox10 and S100, focally positive for Melan-A, and negative for PRAME. Whole genome and whole transcriptome sequencing revealed a <i>CRTC1::TRIM11</i> fusion as well as a number of additional genetic and genomic aberrations. No <i>TERT</i> promoter gene mutation was identified. The patient developed metastases to the lung, lymph nodes, and soft tissue. The tumor was refractory to various treatments. The patient died of widely metastatic disease 18 months after clinical presentation. This case expands our knowledge of the clinical, pathologic, and molecular findings of <i>CRTC1::TRIM11</i> cutaneous tumors. In contrast to other reported cases, the tumor of our patient contained additional genomic aberrations. More cases are needed to assess what factors are relevant for the prognosis of <i>CRTC1::TRIM11</i> cutaneous tumors to help distinguish those with indolent from those with aggressive behavior.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 8","pages":"528-532"},"PeriodicalIF":1.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Presentation of Solid-Variant Aneurysmal Bone Cysts as Primary Digital Skin Lesions: A Case Series Emphasizing Radiologic and Dermatopathologic Correlation 实变动脉瘤性骨囊肿作为原发性手指皮肤病变的不寻常表现：一个强调放射学和皮肤病理学相关性的病例系列。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-05-29 DOI: 10.1111/cup.14821

Shuai Li, Christopher J. Huerter, John M. Gross, Andrew B. Siref

{"title":"Unusual Presentation of Solid-Variant Aneurysmal Bone Cysts as Primary Digital Skin Lesions: A Case Series Emphasizing Radiologic and Dermatopathologic Correlation","authors":"Shuai Li, Christopher J. Huerter, John M. Gross, Andrew B. Siref","doi":"10.1111/cup.14821","DOIUrl":"10.1111/cup.14821","url":null,"abstract":"<div>\u0000 \u0000 <p>Solid-variant aneurysmal bone cysts (ABC) are rare benign bone neoplasms that lack the characteristic prominent blood-filled cystic spaces of classic ABCs and can present in unusual locations, such as the distal extremities. We report three patients with an age range of 40–53 years (mean 48) of solid-variant ABCs presenting as skin-associated masses on the fingers, a highly unusual and diagnostically challenging presentation from both clinical and dermatopathologic standpoints. These lesions initially posed a diagnostic challenge due to their resemblance to more common dermatologic entities, such as pyogenic granuloma or giant cell tumor of the tendon sheath. Histopathologic findings in the initial shave biopsy of case 1 were composed of granulation tissue-like material consisting of bland spindle cells, admixed with sparse multinucleated giant cells and were nonspecific without corresponding radiologic imaging correlation, in which all three cases demonstrated distal phalanx lucencies with extraosseous extension into the dermis/subcutis. Evaluation of the surgical excision specimens of these cases revealed classic morphologic features of solid-variant ABC, including haphazard growth of bland (myo)fibroblastic spindle cells and multinucleated giant cells, set in a background of woven bone and hemorrhage. In summary, we emphasize the diagnostic value of radiologic correlation by the pathologist in our series of solid ABCs presenting as cutaneous masses, as initial shave biopsies may contain nonspecific histopathologic findings; thus, radiologic correlation is critical to avoid pitfalls and ensure proper clinical management.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 8","pages":"517-522"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0