Journal of Cutaneous Pathology最新文献_第5页

Storiform Collagenomas With Unusual Morphology: Expanding the Histologic Spectrum in Two Molecularly Proven Cases. 具有异常形态的故事状胶原瘤：在两个分子证实的病例中扩大组织学谱。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-20 DOI: 10.1111/cup.70218

Amanda Scopelliti, Pranav Dorwal, Alison Cheah

引用次数: 0

Acute Myeloid Leukemia Involving the Skin. 累及皮肤的急性髓性白血病。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-20 DOI: 10.1111/cup.70219

Anna Sarah Erem, Alejandro A Gru

引用次数: 0

Pediatric Superficial Malignant Perineurioma/Perineuriomatous Malignant Peripheral Nerve Sheath Tumor of the Groin With NF1 Loss: A Case Report and Focused Review of the Literature. 小儿腹股沟浅表恶性会阴瘤/会阴瘤恶性周围神经鞘肿瘤伴NF1缺失1例报告及文献综述

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-17 DOI: 10.1111/cup.70215

Arthur William Passos Raetsch, Richard C K Jordan, Steven D Billings, Laura B Pincus

{"title":"Pediatric Superficial Malignant Perineurioma/Perineuriomatous Malignant Peripheral Nerve Sheath Tumor of the Groin With NF1 Loss: A Case Report and Focused Review of the Literature.","authors":"Arthur William Passos Raetsch, Richard C K Jordan, Steven D Billings, Laura B Pincus","doi":"10.1111/cup.70215","DOIUrl":"https://doi.org/10.1111/cup.70215","url":null,"abstract":"Malignant perineurioma, also referred to as perineuriomatous malignant peripheral nerve sheath tumor (MPNST), is an exceptionally rare neoplasm with limited clinicopathologic characterization, particularly in children. We report a 12-year-old boy with a 3.0-cm superficial right groin lesion. Histopathologic examination showed a spindle cell neoplasm with fascicular-to-swirling architecture in myxoid to collagenous stroma, moderate cytologic atypia and nuclear variability, mitotic activity, focal necrosis, and admixed inflammation. Epithelial membrane antigen, GLUT1, and claudin-1 positivity supported perineurial differentiation, while a broad negative immunohistochemical panel helped exclude potential mimics. Tumor-only sequencing demonstrated 17q loss with focal homozygous NF1 deletion, a BRCA2 frameshift, and low tumor mutational burden (3.4 mutations/Mb); RNA sequencing identified no pathogenic gene fusion. These molecular findings were interpreted as adjunctive rather than independently diagnostic. The tumor extended to the inked specimen edge, and subsequent management and follow-up information was unavailable. To our knowledge, this is the first reported superficial cutaneous malignant perineurioma/perineuriomatous MPNST in a pediatric patient.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Annular, Indurated Plaques During Mogamulizumab Therapy in Cutaneous T-Cell Lymphoma: A Clinicopathologic Pitfall. 莫加单抗治疗皮肤t细胞淋巴瘤期间出现新的环状硬化斑块：一个临床病理缺陷。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-14 DOI: 10.1111/cup.70209

Toan S Bui, Nicholas Urbanski, Damien Abreu, Jaroslaw Jedrych, Cole Sterling, Sima Rozati

{"title":"New Annular, Indurated Plaques During Mogamulizumab Therapy in Cutaneous T-Cell Lymphoma: A Clinicopathologic Pitfall.","authors":"Toan S Bui, Nicholas Urbanski, Damien Abreu, Jaroslaw Jedrych, Cole Sterling, Sima Rozati","doi":"10.1111/cup.70209","DOIUrl":"https://doi.org/10.1111/cup.70209","url":null,"abstract":"New annular, indurated plaques arising during mogamulizumab therapy for cutaneous T-cell lymphoma (CTCL) present a diagnostic challenge, as they may raise concern for treatment-related eruption or disease progression. We report two patients with darker skin types who developed plaques that were morphologically distinct from their baseline presentations during mogamulizumab therapy. These morphologic changes may be subtle, manifesting as increased induration, textural change, or plaque thickening, and can be easily overlooked if not assessed in the context of prior disease morphology. Despite clinical changes suggestive of alternative pathology, histopathologic evaluation in both cases demonstrated persistent or progressive mycosis fungoides. Immunophenotyping and T-cell receptor gene rearrangement studies further supported lymphoma involvement rather than drug-induced eruptions. These cases illustrate clinicopathologic discordance, in which changes in clinical morphology do not reliably reflect the underlying pathology. Accurate classification requires a structured, algorithmic approach incorporating repeat biopsy, histopathologic assessment, immunophenotyping, molecular studies, and comparison with prior clinical and pathologic findings over time as well as appropriate restaging. Recognition of this diagnostic pitfall, particularly in patients with darker skin types, is essential to guide appropriate management during mogamulizumab therapy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelioid Fibrous Histiocytoma With Bulbous Subcutaneous Extension and SQSTM1::ALK Fusion. 上皮样纤维组织细胞瘤伴球根状皮下扩张和SQSTM1::ALK融合。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-13 DOI: 10.1111/cup.70201

Hannah Moorman, Jennifer Crimmins, Joseph Gillam, Scott Turner, Mark C Mochel

引用次数: 0

Utility of IL-18 Immunohistochemistry in Distinguishing Dermatomyositis and Lupus Erythematosus in Skin Biopsies. IL-18免疫组织化学在皮肤活检中鉴别皮肌炎和红斑狼疮的应用。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-13 DOI: 10.1111/cup.70214

Steven M Hrycaj, Joseph S Durgin, Johann E Gudjonsson, J Michelle Kahlenberg, Gaidaa R Majari, Carole Bitar, Catherine G Chung, Rosalynn M Nazarian, May P Chan

{"title":"Utility of IL-18 Immunohistochemistry in Distinguishing Dermatomyositis and Lupus Erythematosus in Skin Biopsies.","authors":"Steven M Hrycaj, Joseph S Durgin, Johann E Gudjonsson, J Michelle Kahlenberg, Gaidaa R Majari, Carole Bitar, Catherine G Chung, Rosalynn M Nazarian, May P Chan","doi":"10.1111/cup.70214","DOIUrl":"https://doi.org/10.1111/cup.70214","url":null,"abstract":"Background: Distinction of dermatomyositis (DM) and cutaneous lupus erythematosus (LE) in skin biopsies is often difficult due to significant histopathologic overlap. Prior transcriptional analysis has identified upregulation of IL-18 in DM compared with LE. We aimed to assess its utility as an immunohistochemical marker in this differential diagnosis.Methods: Skin biopsies classified as DM (n = 35) or LE (n = 32) were immunostained with an IL-18 antibody. A positive IL-18 result was defined as presence of full-thickness epidermal staining of medium or strong intensity. Absent, weak, or partial-thickness staining was considered negative. Results were compared between groups by Fisher's exact test.Results: IL-18 expression in keratinocytes, when present, was consistently cytoplasmic with or without nuclear positivity. Twenty-eight (80%) DM cases and 11 (34%) LE cases were positive for IL-18 (p = 0.0002). A positive result had a sensitivity of 80% and a specificity of 66% for DM. Specifically, strong full-thickness staining was only observed in DM (five cases; p = 0.05), whereas complete absence of epidermal staining was seen exclusively in LE (five cases; p = 0.02).Conclusions: IL-18 immunohistochemistry can be a useful diagnostic adjunct in distinguishing DM and LE in a small subset of skin biopsies when staining is strong or completely absent. Correlation with clinical and histopathologic findings remains imperative.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary Indeterminate Cell Histiocytosis Presenting as a Reddish Nodule on the Abdomen of a 4-Year-Old Boy: Clinicopathologic Correlation and Electron Microscopy Findings. 孤立不确定细胞组织细胞增多症表现为4岁男孩腹部的红色结节：临床病理相关性和电镜检查结果。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-13 DOI: 10.1111/cup.70210

Seung-Soo Lee, Seok-Jong Lee, Weon Ju Lee, Dae-Lyong Ha

{"title":"Solitary Indeterminate Cell Histiocytosis Presenting as a Reddish Nodule on the Abdomen of a 4-Year-Old Boy: Clinicopathologic Correlation and Electron Microscopy Findings.","authors":"Seung-Soo Lee, Seok-Jong Lee, Weon Ju Lee, Dae-Lyong Ha","doi":"10.1111/cup.70210","DOIUrl":"https://doi.org/10.1111/cup.70210","url":null,"abstract":"Indeterminate cell histiocytosis (ICH) is a clonal proliferative disorder of mononuclear phagocyte cells that shows features of both dendritic and histiocytic cells. Only around 100 cases of ICH were reported, and among them, only 24% of reported cases involve pediatric patients, with a mean age at diagnosis of 50 years. We report an exceptionally rare case of solitary ICH in a 4-year-old boy. A 4-year-old visited our department presenting a solitary asymptomatic bean-sized reddish nodule on upper abdomen for 1 year. Initially thought to be keloid or dermatofibroma, an excisional biopsy was performed. Histopathological examination revealed dense cellular infiltration in the dermis, characterized by medium-sized mononuclear histiocytes displaying abundant glassy eosinophilic cytoplasm and indented or folded nuclei. Immunohistochemistry studies confirmed positivity for S-100 protein and CD1a, coupled with negativity for CD207/Langerin. Electron microscopy revealed the absence of Birbeck granules, leading to the diagnosis of ICH. With no remarkable findings in laboratory and imaging studies, the patient is undergoing regular follow-up to monitor any potential recurrence or development of related conditions. While most cases of skin-restricted ICH follow an indolent course, recognizing the reported association between ICH and other hematologic neoplasms is crucial. Therefore, awareness of ICH is essential, and in cases of suspicion, a skin biopsy should be performed for an accurate diagnosis.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Caseating Granulomatous Reaction to Red Tattoo Pigment in a Patient Receiving Immune Checkpoint Inhibitor Therapy. 接受免疫检查点抑制剂治疗的患者对红色纹身色素的非干酪化肉芽肿反应

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-10 DOI: 10.1111/cup.70213

Ashley Gochoco, Sushila A Toulmin, Christopher Iriarte, Joshua F Goldsmith

{"title":"Non-Caseating Granulomatous Reaction to Red Tattoo Pigment in a Patient Receiving Immune Checkpoint Inhibitor Therapy.","authors":"Ashley Gochoco, Sushila A Toulmin, Christopher Iriarte, Joshua F Goldsmith","doi":"10.1111/cup.70213","DOIUrl":"https://doi.org/10.1111/cup.70213","url":null,"abstract":"Cutaneous adverse reactions associated with tattoos exhibit various histopathologic patterns, ranging from allergic or interface dermatitis to sarcoid-like granulomatous inflammation. Immune checkpoint inhibitors (ICIs) are also well known to induce granulomatous cutaneous eruptions, usually with sarcoid-like features. Interestingly, ICIs can enhance immune responses at previous antigen exposure sites, including tattoos. Herein, we report a case of a non-caseating granulomatous tattoo reaction associated with red pigment in the context of ICI therapy. Histopathologically, the granulomas exhibited a tuberculoid architecture characterized by prominent peripheral lymphoplasmacytic inflammation rather than the relatively \"naked\" granulomas more typical of sarcoidal reactions. This case highlights the morphologic heterogeneity of granulomatous reactions arising within tattoos during ICI therapy and underscores the complex interaction between host immunity, tattoo pigment, and immunotherapy. Awareness of this pattern may help prevent misclassification as cutaneous sarcoidosis or infection and guide clinical care for patients on ICIs who develop such granulomatous reactions.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed-Type Hypersensitivity With Prominent Langerhans Cell Microabscesses in Response to a Dendritic Cell/AML Fusion Vaccine. 树突状细胞/AML融合疫苗对突出朗格汉斯细胞微脓肿的迟发型超敏反应

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-08 DOI: 10.1111/cup.70212

Ashley Gochoco, Steven R Tahan

引用次数: 0

Cutaneous Langerhans Cell Sarcoma Harboring BRAF V600E Mutation Followed by Chronic Myelomonocytic Leukemia and EBV-Positive Diffuse Large B-Cell Lymphoma. 含有BRAF V600E突变的皮肤朗格汉斯细胞肉瘤继发慢性髓细胞白血病和ebv阳性弥漫性大b细胞淋巴瘤。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-06 DOI: 10.1111/cup.70208

Seung Hyo Cho, Su Min Lee, Jee-Bum Lee, Sook Jung Yun

引用次数: 0