Andrew C Sanchez, Oyewale O Shiyanbola, Xiaohua Qian, Di Yan, Kathleen M Sheahon, Jennifer Y Wang, Roberto A Novoa, Kerri E Rieger, Ryanne A Brown
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Metastatic Gastrointestinal Stromal Tumor to the Scalp: A Case Report Highlighting Diagnostic Challenges and Molecular Correlation.
Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal mesenchymal neoplasms. While the liver and peritoneum are the most common metastatic sites, skin involvement is rare. Nevertheless, recognizing skin metastases is crucial as it guides targeted treatment and indicates the possibility of widespread disease. Skin metastases pose diagnostic challenges due to histopathologic and clinical variability, often resembling other tumors. We present an 81-year-old female with metastatic GIST involving the scalp with corroborative molecular data. This case underscores the fundamental nature of clinicopathologic correlation and the role of molecular analysis in aiding diagnosis, guiding treatment decisions, and revealing the prognostic implications of rare metastatic patterns of GISTs.
期刊介绍:
Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.