Journal of Cutaneous Pathology最新文献

CIC-DUX4 Sarcoma of the Skin: A Rare Case Report and Literature Review. CIC-DUX4 皮肤肉瘤：罕见病例报告和文献综述。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-18 DOI: 10.1111/cup.14748

Daniella F Faden, Olaf Rodriguez, Mark Abdelmalek, Carrie Kovarik

{"title":"CIC-DUX4 Sarcoma of the Skin: A Rare Case Report and Literature Review.","authors":"Daniella F Faden, Olaf Rodriguez, Mark Abdelmalek, Carrie Kovarik","doi":"10.1111/cup.14748","DOIUrl":"https://doi.org/10.1111/cup.14748","url":null,"abstract":"CIC::DUX4 fusion sarcoma represents a rare and aggressive subtype of undifferentiated small round blue cell tumors. We report on a 23-year-old African male who developed a rapidly enlarging inferolateral left buttock nodule with ulceration. After debulking excision of the lesion, histologic sections demonstrated sheets and lobules of atypical round blue cells with significant cytologic atypia. Prominent foci of atypical mitotic figures and tissue necrosis were present. Tumoral cells stained strongly and diffusely using MDM2, vimentin, WT1 and CD99 immunohistochemical (IHC) markers. Molecular testing was performed and highlighted CIC::DUX4 gene fusion positivity, making the diagnosis of a CIC::DUX4 sarcoma (CDS). Post-surgical excision, the patient showed no disease on imaging and underwent five cycles of adjuvant chemotherapy with no recurrence observed at the eight-month follow-up. With fewer than 200 cases reported in the literature and somewhat nonspecific clinicopathologic characteristics, CIC::DUX4 sarcoma presents a diagnostic challenge. This case underlines the importance of molecular diagnostics in undifferentiated sarcomas and presents a rare primary cutaneous manifestation of CIC::DUX4 fusion sarcoma. Additionally, we provide a review of the literature to aid in recognition, diagnosis, and treatment of this rare entity.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pseudoinflammatory Pattern Revisited. 假性炎症模式再探讨

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-17 DOI: 10.1111/cup.14737

Christopher R Shea

引用次数: 0

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria. 黑色素细胞增生症分级：最新组织病理学标准。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-12 DOI: 10.1111/cup.14744

Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell

引用次数: 0

Frequent Occurrence of High-Risk Basal Cell Carcinoma in Xeroderma Pigmentosum: A Histopathological Insight From an Indian Cohort. 色素性皮肤病中高风险基底细胞癌的频繁发生：来自印度队列的组织病理学启示

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-11 DOI: 10.1111/cup.14753

Shafaque Imran, Shivangi Dagar, Rhea Ahuja, Devesh Kumar Jag Swaroop, Somesh Gupta, Sudheer Arava, Kaushal K Verma, Neetu Bhari

{"title":"Frequent Occurrence of High-Risk Basal Cell Carcinoma in Xeroderma Pigmentosum: A Histopathological Insight From an Indian Cohort.","authors":"Shafaque Imran, Shivangi Dagar, Rhea Ahuja, Devesh Kumar Jag Swaroop, Somesh Gupta, Sudheer Arava, Kaushal K Verma, Neetu Bhari","doi":"10.1111/cup.14753","DOIUrl":"https://doi.org/10.1111/cup.14753","url":null,"abstract":"Background: Xeroderma pigmentosum (XP) is a genodermatosis, characterized both by premature aging and significantly increased risk of non-melanoma and melanoma skin cancers at an early age. However, limited literature is available on the common histopathological subtypes of basal cell carcinoma (BCC) in these patients.Methods: In this ambispective case series, we recruited patients of XP who had either a currently present skin tumor or previously excised one, provided their histopathological sections were available. Cytogenetic analysis was performed in all the patients. The histopathological findings were recorded by two trained dermatopathologists.Results: Of 22 recruited patients with XP, 12 patients had 41 BCCs, and 23 (56.09%) of them showed a high-risk histopathological subtype. Basosquamous carcinoma (10, 24.39%) was the most frequent high-risk tumor followed by infiltrative variant (7, 17.07%). Mixed-histopathological subtypes were noted in six (14.63%) cases, and all of them had a high-risk component. The low-risk subtypes included nodular (n = 17, 41.46%) and superficial BCC (1, 2.43%). Though a deep dermal involvement was seen in 27 (65.85%) lesions, none showed a perineural invasion or necrosis. Three (7.31%) lesions showed ulceration, while 10 (24.39%) showed presence of pigmentation.Conclusions: A frequent occurrence of high-risk basal cell carcinoma was noted in patients with XP-mandating creation of appropriate treatment and follow-up strategies in these patients.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perineuriomatous Melanocytic Nevi: A Case Series of Four Cases. 毛周黑素细胞痣：四例病例系列

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-07 DOI: 10.1111/cup.14749

Aya Almashad, Miki Lindsey, Nicholas Zoumberos, Sara C Shalin

{"title":"Perineuriomatous Melanocytic Nevi: A Case Series of Four Cases.","authors":"Aya Almashad, Miki Lindsey, Nicholas Zoumberos, Sara C Shalin","doi":"10.1111/cup.14749","DOIUrl":"https://doi.org/10.1111/cup.14749","url":null,"abstract":"Background: Melanocytic tumors with perineuriomatous differentiation may pose diagnostic challenges. This study explores characteristics of perineuriomatous melanocytic nevi, an entity merging features of perineurioma and melanocytic nevi. The aim is to elucidate histopathological features of perineuriomatous nevi to allow dermatopathologists to recognize them and differentiate them from other spindle cell lesions.Method: This study reviews four cases (2020-2023) of melanocytic nevi with perineuriomatous components.Results: All cases comprised adults (median age: 64.50, mean age: 60.25), with a female predominance, and exhibited clinical features characterized by irregular brown macules or papules on the trunk and extremities. Histopathologically, all lesions were compound, and biphasic patterns were evident, encompassing superficial nevoid and deeper spindled populations arranged in whorled fascicles and embedded in a sclerotic or myxoid stroma. Immunohistochemistry revealed expression of at least one perineuriomatous marker in deeper cells. Cases were assessed and compared with previously published cases for comprehensive insights. Three of our four cases demonstrated the presence of a junctional component that was smaller than the dermal component. We suggest that this unusual feature, which we term the \"reverse shoulder\", may allow dermatopathologists to help consider perineurial differentiation in the appropriate setting.Conclusion: Perineuriomatous nevi can pose diagnostic challenges. This study contributes to the growing body of literature on perineuriomatous nevi, emphasizing their unique features and the importance of accurate diagnosis to avoid unnecessary interventions.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms-An Analysis of 70 Cases. 靶向测序在 Spitz 黑素细胞肿瘤常规诊断中的作用--对 70 例病例的分析。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-07 DOI: 10.1111/cup.14750

Daja Šekoranja, Andrej Zupan, Alenka Matjašič, Emanuela Boštjančič, Eduardo Calonje, Jože Pižem

{"title":"Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms-An Analysis of 70 Cases.","authors":"Daja Šekoranja, Andrej Zupan, Alenka Matjašič, Emanuela Boštjančič, Eduardo Calonje, Jože Pižem","doi":"10.1111/cup.14750","DOIUrl":"https://doi.org/10.1111/cup.14750","url":null,"abstract":"Background: There is growing evidence that the Spitz group of melanocytic neoplasms should be restricted to those harboring kinase receptor fusions and HRAS mutations/11p15 amplification. The presence of genomic alterations characteristic of conventional melanomas (BRAF and NRAS mutations) precludes a diagnosis of a Spitz neoplasm. It is often challenging to distinguish Spitz neoplasms from conventional melanomas with spitzoid morphology on histopathological grounds alone.Methods: We report a series of 70 consecutive melanocytic tumors in which targeted sequencing was indicated to distinguish Spitz from spitzoid neoplasms and to classify Spitz neoplasms along the biological spectrum.Results: Final diagnoses incorporating molecular results included 12 conventional melanomas (nine of which with NRAS mutations), five Spitz melanomas, 35 atypical Spitz tumors, eight Spitz nevi, three melanocytic tumors with a MAP2K1 mutation, and seven desmoplastic Spitz nevi/tumors. There were significant discrepancies between initial diagnoses and final diagnoses after incorporating molecular results in 24 (34%) cases, including nine conventional melanomas favored to be Spitz neoplasms and nine Spitz neoplasms favored to be conventional melanomas.Conclusions: It is often not possible to reliably distinguish Spitz neoplasms from spitzoid melanocytic tumors without identifying their driver genomic alterations. Applying next-generation sequencing in diagnostically problematic tumors improves diagnostic accuracy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases. 43 例系列病例中盘状红斑狼疮与毛囊性真菌病的组织病理学比较。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-06 DOI: 10.1111/cup.14752

Camilla A Cascardo, Meghan R Mansour, Sandra Oska, Uma Sundram

{"title":"Histopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases.","authors":"Camilla A Cascardo, Meghan R Mansour, Sandra Oska, Uma Sundram","doi":"10.1111/cup.14752","DOIUrl":"10.1111/cup.14752","url":null,"abstract":"Background: Folliculotropic mycosis fungoides (FMF) is a rare cutaneous malignancy that can be mistaken for inflammatory diseases, such as discoid lupus erythematosus (DLE), due to the variability of histopathological findings.Methods: This study aims to provide dermatopathologists with evidence-based histopathologic criteria to distinguish DLE from FMF by reporting overlapping and distinguishing microscopic features. Forty-three biopsies from patients with a confirmed diagnosis of DLE or FMF were graded for the presence or absence of 18 histopathologic features.Results: The main histopathologic findings present in nearly all DLE and FMF biopsies were folliculocentric and folliculotropic patterns. Comedones, granulomas, and folliculitis were not prominent. Follicular hyperplasia, follicular plugging, interstitial mucin, lichenoid/interface dermatitis, and plasma cells were significantly more common in DLE biopsies, while follicular mucinosis and eosinophils were significantly more common in FMF samples. Cytologic atypia ranged from none to mild in DLE and mild to moderate in FMF. Rarely, both sets of biopsies contained epidermotropism, spongiosis, or peri-eccrine infiltration.Conclusion: While many histopathological features present in DLE overlap with features found in FMF, such as folliculocentrism and folliculotropism, significant differences do exist. Therefore, when diagnosing FMF, it is important to follow established criteria that differentiate this malignancy from inflammatory conditions such as DLE.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Expression Patterns in a Congenital Neurocristic Hamartoma With Multiple Proliferative Nodules. 伴有多发性增殖结节的先天性神经肉芽肿的基因表达模式

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-06 DOI: 10.1111/cup.14745

Jefferson Terry

引用次数: 0

A Legacy of Life and Science: Personal Reflections on the TITAN. 生命与科学的遗产：关于 TITAN 的个人思考。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-06 DOI: 10.1111/cup.14739

Abdul-Ghani Kibbi

引用次数: 0

Kaposi Sarcoma in the Context of Post-Modified Radical Mastectomy: A New Case Report and Brief Review. 改良根治性乳房切除术后的卡波西肉瘤：新病例报告和简要回顾。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-04 DOI: 10.1111/cup.14751

Rasha Mahmoud Genedy, Naglaa Mohamed El Sayed

{"title":"Kaposi Sarcoma in the Context of Post-Modified Radical Mastectomy: A New Case Report and Brief Review.","authors":"Rasha Mahmoud Genedy, Naglaa Mohamed El Sayed","doi":"10.1111/cup.14751","DOIUrl":"https://doi.org/10.1111/cup.14751","url":null,"abstract":"Kaposi sarcoma is a human herpesvirus 8-associated angio-proliferative tumor arising from lymphatic endothelial cells. Four clinical subtypes are known: classic, epidemic, endemic, and iatrogenic. The development of Kaposi sarcoma and lymphedema may be interlinked, where each condition could potentially support the progression of the other. Post-mastectomy lymphedema is a commonly recognized complication following radical mastectomy. Angiosarcoma is the most frequently reported neoplasm in such a situation. We present a 72-year-old female who developed Kaposi sarcoma on the same side of mastectomy 9 years following her initial diagnosis and treatment for cancer breast. The diagnosis of Kaposi sarcoma was based on the histopathologic findings and was confirmed with immunohistochemical staining for human herpes virus 8 and D2-40. Lymphedema may be associated with local immune suppression manifested in the form of defective cell-mediated immunity and antigen-presenting cell migration defect which may facilitate development of neoplasms. It is important to differentiate Kaposi sarcoma from other vascular tumors which may have a much worse prognosis. Patients with lymphedema should receive appropriate management and undergo long-term follow-up for early detection of any potential malignancies.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0