Journal of Cutaneous Pathology最新文献

Syringomatous Tumor of the Nipple in an Adolescent Female: A Rare Cutaneous Adnexal Neoplasm With Distinct Histopathologic Features. 1例青春期女性乳头水疱瘤：一种具有独特组织病理特征的罕见皮肤附件肿瘤。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-10-03 DOI: 10.1111/cup.14865

Shilong Zhang, Jian Wu

引用次数: 0

Flashes of Light: From the Lab and Dermatopathology, to the World With Marty Mihm. 闪烁的光：从实验室和皮肤病理学，到世界与马蒂·米姆。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-29 DOI: 10.1111/cup.70000

R Rox Anderson, J Stuart Nelson, Thanh Nga Tran, Wenbin Tan

{"title":"Flashes of Light: From the Lab and Dermatopathology, to the World With Marty Mihm.","authors":"R Rox Anderson, J Stuart Nelson, Thanh Nga Tran, Wenbin Tan","doi":"10.1111/cup.70000","DOIUrl":"https://doi.org/10.1111/cup.70000","url":null,"abstract":"Martin C. (Marty) Mihm made multiple, pivotal contributions over four decades of discovery, innovation, and development leading to the world-wide application of lasers in dermatology. This started with trying to understand how pulses of light could be tailored to affect microscopic \"target\" structures in skin where the light is absorbed. There were many surprises, often first observed by light or electron microscopy. A host of new capabilities ensued, including laser treatments for microvascular and vascular malformations, non-melanoma pigmented lesions, tattoo and hair removal, rehabilitation of scars, improvement of photoaged skin, and lipid-targeting lasers for reduction of fat and acne. Dr. Mihm extended himself directly to patients, especially children with vascular anomalies. He contributed to the discovery that GLUT1, a glucose transporter expressed on vascular endothelium, is a defining diagnostic for infantile hemangiomas. He established a multispecialty vascular-anomalies clinic at the Massachusetts General Hospital, and co-founded the Vietnam Vascular Anomalies Center (VVAC) in Ho Chi Minh City. In Vietnam, topical radioactive phosphorus (32P) is applied as a misguided treatment for infantile hemangiomas, leading to radiation damage in uncounted thousands of children. By teaching the use of beta-adrenergic drug treatment, the use of 32P has been greatly reduced. Dr. Mihm pioneered the concept of pulsed dye laser (PDL) in combination with angiogenic inhibitors to improve the clinical efficacy of port wine stain (PWS) treatment. Moreover, he made seminal contributions to our understanding of the pathogenesis and spectrum of phenotypes of PWS lesions. The legacy of Martin C. Mihm extends to the entire world.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Scale Attention Fusion With Depthwise Separable Convolutions for Efficient Skin Cancer Detection. 基于深度可分卷积的多尺度注意力融合皮肤癌检测。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-25 DOI: 10.1111/cup.14870

Md Darun Nayeem, Md Anikur Rahman, Md Shakil Hossain, Mejdl Safran, Sultan Alfarhood, M F Mridha

{"title":"Multi-Scale Attention Fusion With Depthwise Separable Convolutions for Efficient Skin Cancer Detection.","authors":"Md Darun Nayeem, Md Anikur Rahman, Md Shakil Hossain, Mejdl Safran, Sultan Alfarhood, M F Mridha","doi":"10.1111/cup.14870","DOIUrl":"https://doi.org/10.1111/cup.14870","url":null,"abstract":"Skin cancer is a major global health concern, where early and accurate detection is crucial for improving patient outcomes. Traditional diagnostic methods, such as manual visual inspection and conventional machine learning models, often suffer from subjectivity, high computational costs, and limited annotated data. Althoug deep learning has improved automated skin cancer detection, existing models face challenges like overfitting, insufficient generalization, and complex architectures that limit real-time clinical application. To address these limitations, we propose MAF-DermNet, a deep learning framework that integrates Multi-Scale Attention Fusion (MAF) with depthwise separable convolutions for efficient and accurate skin cancer detection. Our approach enhances data diversity using DCGAN-based synthetic augmentation to improve model robustness. By leveraging multi-resolution inputs and a residual attention block, MAF-DermNet effectively captures subtle lesion features while preserving critical low-level information. Extensive experiments demonstrate exceptional performance, with accuracy exceeding 99.9% and macro F1 scores above 99.5%. In addition to its superior classification capabilities, MAF-DermNet offers enhanced interpretability and computational efficiency, making it well-suited for clinical deployment. Future work will focus on integrating clinical metadata and optimizing the model for diverse healthcare settings to further improve early diagnosis and treatment outcomes.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Overlapping Clinicopathological Presentations of Pityriasis Lichenoides and Mycosis Fungoides. 地衣样糠疹和蕈样真菌病的重叠临床病理表现。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-15 DOI: 10.1111/cup.14856

Olivia Pierog, Mariah Estill, Jaroslaw Jedrych, Sima Rozati, Rachel Marchalik

引用次数: 0

Decision Fatigue in Dermatopathology: Cognitive Load and Diagnostic Vulnerability. 皮肤病理学中的决策疲劳：认知负荷和诊断脆弱性。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-11 DOI: 10.1111/cup.14866

Cornelia Sigrid Lissi Müller

引用次数: 0

Chronological Changes in CD8⁺ T Cells and Granzyme B in Ulcerative Lesions During Mogamulizumab Therapy for Mycosis Fungoides. 莫加单抗治疗蕈样真菌病期间溃疡性病变中CD8+ T细胞和颗粒酶B的时间变化

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-10 DOI: 10.1111/cup.14860

Ryoko Kimura, Kazunari Sugita, Yuichi Yoshida

引用次数: 0

Cognitive Robustness in Dermatopathology-Diagnostic Thinking Beyond Rules and Routines. 超越规则和常规的皮肤病理诊断思维的认知稳健性。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-04 DOI: 10.1111/cup.14861

Cornelia Sigrid Lissi Müller

引用次数: 0

Novel Histopathologic Features of Extramammary Paget's Disease in Metastatic Primary Cutaneous Apocrine Carcinoma to the Esophagus. 原发性皮肤大汗腺癌转移至食道的乳腺外佩吉特病的新组织学特征。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-04 DOI: 10.1111/cup.14863

Dre Barnachea, Maki Yamamoto, Rupali Banker, Dong Ren, Bonnie Lee

{"title":"Novel Histopathologic Features of Extramammary Paget's Disease in Metastatic Primary Cutaneous Apocrine Carcinoma to the Esophagus.","authors":"Dre Barnachea, Maki Yamamoto, Rupali Banker, Dong Ren, Bonnie Lee","doi":"10.1111/cup.14863","DOIUrl":"https://doi.org/10.1111/cup.14863","url":null,"abstract":"Primary cutaneous apocrine carcinoma (PCAC) is an exceptionally rare cutaneous malignancy originating from apocrine glands, occurring most commonly in the axilla and anogenital regions. It typically follows a slow-growing clinical course, although aggressive behavior has been documented in select cases. While local recurrence and regional metastasis are not uncommon in PCAC, instances of distant metastases are rare, with only a handful of cases reported, including involvement of the liver, bone, and lung. We present a unique case of PCAC with pagetoid features arising in the groin and metastasizing to the esophagus, a highly unusual presentation not well described in the existing literature. PCAC manifesting as extramammary Paget's disease (EMPD), characterized by single malignant epithelial cells scattered throughout the epidermis, represents a rare and diagnostically challenging variant. Its ability to mimic metastatic carcinomas from various organs necessitates thorough clinical and pathological correlation for accurate diagnosis. This case report aims to illuminate the potentially aggressive behavior of PCAC and emphasizes the need for long-term surveillance and awareness of its less typical presentations.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carcinosarcoma Arising in an Eccrine Spiradenoma and Presenting With Metastasis: Case Report and Literature Review. 发生于内分泌螺旋腺瘤并有转移的癌肉瘤：病例报告及文献复习。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-02 DOI: 10.1111/cup.14867

Lisa M Marinelli, Jared M Orrock, Andrew L Folpe

{"title":"Carcinosarcoma Arising in an Eccrine Spiradenoma and Presenting With Metastasis: Case Report and Literature Review.","authors":"Lisa M Marinelli, Jared M Orrock, Andrew L Folpe","doi":"10.1111/cup.14867","DOIUrl":"https://doi.org/10.1111/cup.14867","url":null,"abstract":"Eccrine spiradenomas are benign sweat gland neoplasms that rarely undergo malignant transformation. Carcinosarcoma arising from an eccrine spiradenoma is exceptionally rare. A 41-year-old male presented with a rapidly growing neck/shoulder mass, progressive numbness, spasticity, and weakness. Further workup additionally revealed an epidural mass with spinal cord compression. Both masses were excised and predominantly showed morphologic features of high-grade osteosarcoma, with overtly malignant spindled cells producing lace-like osteoid. However, a single section from the upper back mass contained a roughly 2 mm focus of conventional eccrine spiradenoma, with an adjacent small focus having features of a poorly differentiated non-small cell carcinoma. The final diagnosis was that of a high-grade carcinosarcoma with heterologous osteosarcomatous differentiation, arising from a pre-existing eccrine spiradenoma, with metastasis to the T4-5 epidural region. The patient experienced rapid regrowth of the spinal mass and underwent radiotherapy but had unresectable metastatic disease at 2 months follow-up. We describe what is to our knowledge only the 21st example of carcinosarcoma arising from eccrine spiradenoma, mimicking metastatic osteosarcoma. Awareness of this very rare entity, careful sampling, close microscopic examination, and, in selected cases, ancillary immunohistochemistry are the keys to making this challenging diagnosis.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous FUS::TFCP2-Rearranged Rhabdomyosarcoma Initially Misdiagnosed as ALK-Rearranged Mesenchymal Neoplasm: A Case Report. 皮肤FUS: tfcp2重排横纹肌肉瘤最初误诊为alk -重排间质肿瘤1例。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-02 DOI: 10.1111/cup.14869

Daigo Shiraishi, Kenji Murata, Junya Shimizu, Yasutaka Murahashi, Taro Sugawara, Shintaro Sugita, Makoto Emori, Atsushi Teramoto

引用次数: 0