Journal of Cutaneous Pathology最新文献

Minimum Pathology Reporting Elements for Melanoma: A Review of Reporting Guidelines and Proposal for Minimum Reporting Elements for a Quality Pathology Report by the Task Force of the American Society of Dermatopathology. 黑色素瘤的最低病理报告要素：美国皮肤病理学会工作组对报告指南和高质量病理报告最低报告要素的建议的回顾。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-31 DOI: 10.1111/cup.14848

Klaus J Busam, Lyn M Duncan, Pedram Gerami, Lori Lowe, Hina Sheikh, Michael Tetzlaff

{"title":"Minimum Pathology Reporting Elements for Melanoma: A Review of Reporting Guidelines and Proposal for Minimum Reporting Elements for a Quality Pathology Report by the Task Force of the American Society of Dermatopathology.","authors":"Klaus J Busam, Lyn M Duncan, Pedram Gerami, Lori Lowe, Hina Sheikh, Michael Tetzlaff","doi":"10.1111/cup.14848","DOIUrl":"https://doi.org/10.1111/cup.14848","url":null,"abstract":"Guidelines have been proposed for the pathology reporting of melanoma to ensure inclusion of data elements important for patient care. Compliance with guidelines has been made a yardstick for quality performance. However, there is controversy about how comprehensive a report must be, which is why the American Society of Dermatopathology has formed a task force with the goal of defining minimum data elements that should be included in a pathology report of a primary cutaneous melanoma. Importantly, additional information can or at times should be documented if a pathologist believes it is valuable to the clinical care team of a particular patient. The proposed minimum reporting guidelines outlined herein largely reflect core reporting elements by various professional organizations. Data elements must be included if they are needed for pathologic staging. Excisions require a margin status, but detailed margin metrics are not required for most cases. Furthermore, histopathologic subtyping of melanoma in situ is not routinely needed. Whether or not invasive melanoma should be subclassified depends on clinical relevance and whether the available evidence permits a definitive melanoma subclassification. When the minimum data elements are included, a pathology report should be considered compliant with quality reporting guidelines.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRAME Immunohistochemistry for Differentiating Pigmented Lesions of the Vulva and Perineum. PRAME免疫组织化学鉴别外阴和会阴色素病变。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-27 DOI: 10.1111/cup.14850

Kasey J McCollum, Maria Angelica Selim, Michelle Schneider

{"title":"PRAME Immunohistochemistry for Differentiating Pigmented Lesions of the Vulva and Perineum.","authors":"Kasey J McCollum, Maria Angelica Selim, Michelle Schneider","doi":"10.1111/cup.14850","DOIUrl":"https://doi.org/10.1111/cup.14850","url":null,"abstract":"Special site pigmented lesions often present a diagnostic challenge for clinicians and for pathologists. Lesions of the genital region present even further challenges due to the sensitivity of the anatomic location and preference to defer physical exam and biopsy. Even after biopsy, the diagnostic challenge persists owing to the frequent presence of atypical features in these sites and the technical difficulties associated with performing complete excisions. Immunohistochemistry plays a crucial role in the classification and categorization of these lesions. PRAME (PReferentially expressed Antigen in MElanoma) is a nuclear receptor and transcriptional regulator that regulates cell differentiation, growth, and apoptosis. Immunohistochemistry for PRAME has proven valuable in assisting pathologists to classify various cutaneous melanocytic proliferations all over the human body. Our study sought to investigate the use of PRAME in determining the biologic nature of pigmented lesions of the genital region. A search of medical records identified 53 cases of genital pigmented lesions for review. Each case received MART1 and PRAME IHC for evaluation and classification by two board certified dermatopathologists. The results found that PRAME was negative (zero nuclear staining) in a total of 32 benign lesions (i.e., melanosis including macules and lentigos as well as nevi). One dysplastic nevus showed focal weak PRAME expression in less than 10% of lesional melanocytes. PRAME was overwhelmingly positive (4+ staining, > 75% of nuclei) in 90% of the malignant lesions (i.e., invasive melanoma and melanoma in situ). Overall, we conclude that PRAME remains a valuable tool in the diagnostic workup of diagnosing pigmented lesions of the genital region.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pembrolizumab-Exacerbated Widespread Pigmented Purpuric Dermatosis in an Elderly Patient, a Potential Diagnostic Pitfall Mimicking Pigmented Purpuric Dermatosis-Like Mycosis Fungoides. 派姆单抗加重了老年患者的广泛性色素紫癜性皮肤病，一个潜在的诊断陷阱，模拟色素紫癜性皮肤病样真菌病。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-24 DOI: 10.1111/cup.14841

Nicole Chang, Yoni Hirsch, Krisztian Nemeth, Susan Pei

{"title":"Pembrolizumab-Exacerbated Widespread Pigmented Purpuric Dermatosis in an Elderly Patient, a Potential Diagnostic Pitfall Mimicking Pigmented Purpuric Dermatosis-Like Mycosis Fungoides.","authors":"Nicole Chang, Yoni Hirsch, Krisztian Nemeth, Susan Pei","doi":"10.1111/cup.14841","DOIUrl":"https://doi.org/10.1111/cup.14841","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic lymphocyte-associated antigen-4 (CTLA-4) have revolutionized cancer treatment but are associated with immune-related adverse events, particularly cutaneous toxicities. We report a rare case of pembrolizumab-exacerbated pigmented purpuric dermatosis (PPD) in a 77-year-old male with a history of metastatic non-small cell lung cancer. His rash, initially confined to the lower extremities, worsened and became widespread to involve the trunk after pembrolizumab initiation. Histopathology showed perivascular lymphocytic infiltrate with extravasated erythrocytes without vasculitis, compatible with PPD; however, due to some lymphocyte atypia and exocytosis, together with the clinically widespread lesions, there was initial concern for PPD-like mycosis fungoides (MF). Subsequent T-cell receptor gene rearrangement studies revealed no monoclonal lymphoid population, and the later resolution of the rash with treatments typical for PPD did not support MF. This represents only the second reported case of ICI-associated PPD and highlights a potential diagnostic pitfall with histopathology and clinical presentation mimicking PPD-like MF. Our case contributes to the expanding spectrum of ICI-related cutaneous reactions and underscores the importance of recognizing inflammatory dermatoses with atypical histopathologic features for dermatologists and dermatopathologists.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Dermal Myofibroblastoma Emphasizing the Diagnostic Utility of Immunohistochemical Loss of Rb Expression. 一例罕见的真皮肌成纤维细胞瘤，强调免疫组织化学Rb表达缺失的诊断价值。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-21 DOI: 10.1111/cup.14842

Ayana Crawl-Bey, Ryanne A Brown, Johanna B Moore

{"title":"A Rare Case of Dermal Myofibroblastoma Emphasizing the Diagnostic Utility of Immunohistochemical Loss of Rb Expression.","authors":"Ayana Crawl-Bey, Ryanne A Brown, Johanna B Moore","doi":"10.1111/cup.14842","DOIUrl":"https://doi.org/10.1111/cup.14842","url":null,"abstract":"A 74-year-old female presented with a progressively enlarging and intermittently tender hyperpigmented lesion beneath her left rib cage. Physical examination revealed a firm, telangiectatic linear plaque clinically suspected to represent a hypertrophic scar. A shave biopsy was performed. Histologic sections demonstrated a dermal proliferation of plump spindled cells without cytologic atypia, organized in short fascicles interspersed with hyalinized collagen bundles. Immunohistochemical stains revealed CD34, desmin, and smooth muscle actin expression in the lesional cells. SOX10, S100, and Melan-A were negative. Retinoblastoma 1 (Rb) staining demonstrated loss of nuclear expression in the spindle-shaped cells. The findings support a diagnosis of myofibroblastoma, which rarely occurs in the skin. Myofibroblastoma is an uncommon benign mesenchymal neoplasm composed of fibroblasts and myofibroblasts with recurrent monoallelic loss of the 13q14 region, where RB1 resides, with resultant loss of Rb expression. Although the differential diagnosis was vast, this case highlights the utility of Rb immunohistochemistry in the diagnosis of cutaneous myofibroblastoma.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Melanoma Arising in a BAP1-Inactivated Melanocytic Tumor With NRAS Mutation: A Report of Exceptional Case With Emphasis on Its Genomic Features and Review of the Literature. 侵袭性黑色素瘤发生在bap1失活的黑色素细胞肿瘤伴NRAS突变：一个特殊病例的报告，重点是其基因组特征和文献复习。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-21 DOI: 10.1111/cup.14839

Muath Alyahya, Nyi Nyi May-Phyo, Ami Wang, Shamini Selvarajah, Cuihong Wei, Calvin Tseng, Tao Wang, Tara Baetz, Zaid Saeed Kamil

{"title":"Invasive Melanoma Arising in a BAP1-Inactivated Melanocytic Tumor With NRAS Mutation: A Report of Exceptional Case With Emphasis on Its Genomic Features and Review of the Literature.","authors":"Muath Alyahya, Nyi Nyi May-Phyo, Ami Wang, Shamini Selvarajah, Cuihong Wei, Calvin Tseng, Tao Wang, Tara Baetz, Zaid Saeed Kamil","doi":"10.1111/cup.14839","DOIUrl":"https://doi.org/10.1111/cup.14839","url":null,"abstract":"BAP1-inactivated melanocytic tumor is a distinct entity with loss of BAP1 protein and epithelioid morphology. It shares histopathologic features with Spitz nevus and nevoid melanoma, and it can occur sporadically or with germline BAP1 predisposition syndrome. These lesions typically have tumor-infiltrating lymphocytes and infrequent mitoses. They are generally indolent, though melanoma can arise in both germline and sporadic cases. Most show BRAF V600E and BAP1 mutations. We describe four tumors in one patient diagnosed with BAP1-tumor predisposition syndrome (BAP1-TPDS): two invasive melanomas arising in BIMT and two BIMTs with uncertain malignant potential. Molecular analysis and fluorescence in situ hybridization (FISH) revealed BAP1 and NRAS mutations in melanoma and BAP1-inactivated melanocytic tumor components, with a gain of 6p25 (RREB1) in the melanoma component only. The patient completed pembrolizumab adjuvant therapy with no evidence of metastasis. This is a rare presentation of BIMT with BAP1 and NRAS mutations, absence of BRAF V600 mutation, and loss of BAP1 immunoreactivity in all lesional cells. Our case adds to the understanding of the histomorphologic and mutational spectrum in BAP1-inactivated melanocytic tumors.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraneoplastic Erythroderma: A Rare, but Important Cause of Mixed Pattern Dermatitis. 副肿瘤性红皮病：一种罕见但重要的混合型皮炎病因。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-21 DOI: 10.1111/cup.14851

Gabriela Fonseca, Hana Ahmed, Lauren Graham, Carly Elston

引用次数: 0

Congenital Spitz Melanocytoma With Activating ZKSCAN1::MET Kinase Fusion. 激活ZKSCAN1::MET激酶融合的先天性Spitz黑色素细胞瘤

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-15 DOI: 10.1111/cup.14846

Tzah Feldman, Hiba Zaaroura, Hanaa Haj Abaya, Yaniv Zohar, Reuven Bergman

引用次数: 0

Proliferative Neurocristic Hamartoma Arising From a Congenital Melanocytic Nevus: A Case Report. 由先天性黑素细胞痣引起的增殖性神经系统错构瘤1例报告。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-15 DOI: 10.1111/cup.14847

Aizlynn Anne J Robledo, Yu-Hung Wu

引用次数: 0

Linear IgA Vasculitis: Cutaneous Small-Vessel Leukocytoclastic Vasculitis, in Association With Linear IgA Disease-Type Immunoreactant Deposition Along Epidermal Basement Membrane Zone. 线性IgA血管炎：皮肤小血管白细胞破裂性血管炎，与线性IgA病型免疫反应物沿表皮基底膜区沉积有关。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-13 DOI: 10.1111/cup.14843

Michael Murphy, Timothy Klufas, Joseph Beauchemin, Shannon Hanggodo, Albert Zhou

引用次数: 0

Hematoxylin-Eosin Histology for Detection of Dermatophytosis: A Retrospective Cohort Selection Diagnostic Accuracy Study. 苏木精-伊红组织学检测皮肤癣：一项回顾性队列选择诊断准确性研究。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-13 DOI: 10.1111/cup.14840

Jack Hulse, Tatiana Movchan, Richard Galbraith, Garth R Fraga

{"title":"Hematoxylin-Eosin Histology for Detection of Dermatophytosis: A Retrospective Cohort Selection Diagnostic Accuracy Study.","authors":"Jack Hulse, Tatiana Movchan, Richard Galbraith, Garth R Fraga","doi":"10.1111/cup.14840","DOIUrl":"https://doi.org/10.1111/cup.14840","url":null,"abstract":"Background: Dermatophytes can be identified in hematoxylin-eosin (H&E) histologic preparations, but the diagnostic accuracy of this approach and the relative need for ancillary periodic acid-Schiff (PAS) testing are unknown.Methods: A cohort selection cross-sectional study with repeated measures was utilized to measure the accuracy of four blinded assessors at different levels of experience and training in detecting fungal hyphae in H&E slides from 100 consecutive cases selected based on prior PAS testing to exclude dermatophytosis.Results: Dermatopathology training was associated with an accuracy of 0.97 (95% CI: 0.93, 1.00), a sensitivity of 0.78 (95% CI: 0.50, 1.00), and a specificity of 0.99 (95% CI: 0.96, 1.00). Accuracy for non-dermatopathologist assessors improved after completing an educational module (from 0.64 to 0.84) but was limited by low sensitivity. False positive classifications by the dermatopathology assessor were only seen in nail clipping specimens. False negative classifications were seen in cases with low fungal burdens, topical corticosteroid treatments, and comorbid conditions.Conclusions: Experienced dermatopathologists can usually identify dermatophytosis with H&E staining. These findings indicate that PAS testing should be selectively applied to cases with suspected dermatophytosis where no organisms are visible on H&E, on nail clips where H&E may be unreliable, and in evaluations by non-dermatopathologists.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0