Journal of Cutaneous Pathology最新文献

Histopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases. 43 例系列病例中盘状红斑狼疮与毛囊性真菌病的组织病理学比较。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-06 DOI: 10.1111/cup.14752

Camilla A Cascardo, Meghan R Mansour, Sandra Oska, Uma Sundram

{"title":"Histopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases.","authors":"Camilla A Cascardo, Meghan R Mansour, Sandra Oska, Uma Sundram","doi":"10.1111/cup.14752","DOIUrl":"10.1111/cup.14752","url":null,"abstract":"Background: Folliculotropic mycosis fungoides (FMF) is a rare cutaneous malignancy that can be mistaken for inflammatory diseases, such as discoid lupus erythematosus (DLE), due to the variability of histopathological findings.Methods: This study aims to provide dermatopathologists with evidence-based histopathologic criteria to distinguish DLE from FMF by reporting overlapping and distinguishing microscopic features. Forty-three biopsies from patients with a confirmed diagnosis of DLE or FMF were graded for the presence or absence of 18 histopathologic features.Results: The main histopathologic findings present in nearly all DLE and FMF biopsies were folliculocentric and folliculotropic patterns. Comedones, granulomas, and folliculitis were not prominent. Follicular hyperplasia, follicular plugging, interstitial mucin, lichenoid/interface dermatitis, and plasma cells were significantly more common in DLE biopsies, while follicular mucinosis and eosinophils were significantly more common in FMF samples. Cytologic atypia ranged from none to mild in DLE and mild to moderate in FMF. Rarely, both sets of biopsies contained epidermotropism, spongiosis, or peri-eccrine infiltration.Conclusion: While many histopathological features present in DLE overlap with features found in FMF, such as folliculocentrism and folliculotropism, significant differences do exist. Therefore, when diagnosing FMF, it is important to follow established criteria that differentiate this malignancy from inflammatory conditions such as DLE.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Expression Patterns in a Congenital Neurocristic Hamartoma With Multiple Proliferative Nodules. 伴有多发性增殖结节的先天性神经肉芽肿的基因表达模式

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-06 DOI: 10.1111/cup.14745

Jefferson Terry

引用次数: 0

A Legacy of Life and Science: Personal Reflections on the TITAN. 生命与科学的遗产：关于 TITAN 的个人思考。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-06 DOI: 10.1111/cup.14739

Abdul-Ghani Kibbi

引用次数: 0

Kaposi Sarcoma in the Context of Post-Modified Radical Mastectomy: A New Case Report and Brief Review. 改良根治性乳房切除术后的卡波西肉瘤：新病例报告和简要回顾。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-04 DOI: 10.1111/cup.14751

Rasha Mahmoud Genedy, Naglaa Mohamed El Sayed

{"title":"Kaposi Sarcoma in the Context of Post-Modified Radical Mastectomy: A New Case Report and Brief Review.","authors":"Rasha Mahmoud Genedy, Naglaa Mohamed El Sayed","doi":"10.1111/cup.14751","DOIUrl":"https://doi.org/10.1111/cup.14751","url":null,"abstract":"Kaposi sarcoma is a human herpesvirus 8-associated angio-proliferative tumor arising from lymphatic endothelial cells. Four clinical subtypes are known: classic, epidemic, endemic, and iatrogenic. The development of Kaposi sarcoma and lymphedema may be interlinked, where each condition could potentially support the progression of the other. Post-mastectomy lymphedema is a commonly recognized complication following radical mastectomy. Angiosarcoma is the most frequently reported neoplasm in such a situation. We present a 72-year-old female who developed Kaposi sarcoma on the same side of mastectomy 9 years following her initial diagnosis and treatment for cancer breast. The diagnosis of Kaposi sarcoma was based on the histopathologic findings and was confirmed with immunohistochemical staining for human herpes virus 8 and D2-40. Lymphedema may be associated with local immune suppression manifested in the form of defective cell-mediated immunity and antigen-presenting cell migration defect which may facilitate development of neoplasms. It is important to differentiate Kaposi sarcoma from other vascular tumors which may have a much worse prognosis. Patients with lymphedema should receive appropriate management and undergo long-term follow-up for early detection of any potential malignancies.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma Diagnosis in the Mihm Era-And Beyond. 米姆时代及其后的黑色素瘤诊断。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-03 DOI: 10.1111/cup.14742

David E Elder

{"title":"Melanoma Diagnosis in the Mihm Era-And Beyond.","authors":"David E Elder","doi":"10.1111/cup.14742","DOIUrl":"https://doi.org/10.1111/cup.14742","url":null,"abstract":"During the illustrious career of Martin C. Mihm Jr., MD, the diagnosis of melanoma underwent significant changes, to which he made many contributions. In early descriptions, melanomas were fungating tumor masses that were obviously malignant, and highly lethal. In seminal work by Dr. Mihm and his mentor, Wallace H. Clark, Jr., MD, the early phases of development of these neoplasms were recognized and distinguished from the more advanced disease. It was generally believed that the early stage of melanoma, termed radial growth phase (RGP) and characterized by absence of vertical growth phase (VGP) and by favorable microstaging attributes could be recognized, excised, and cured, thus preventing the development of advanced disease. However, strenuous efforts in this direction over several decades have resulted in little or no change in mortality, leading to the recognition that many of these neoplasms, at least, may not be true biological malignancies, and to the conclusion that overdiagnosis commonly occurs in this disease, which is defined as representing diagnosis as melanoma of a neoplasm that would not have had the capacity to cause death or symptoms in the lifetime of the host. Although there may be other subsets of neoplasms in this category, an important category of overdiagnosis in melanomas is concentrated in T1a melanomas that lack VGP. If these neoplasms can be recognized with sensitive and specific criteria, which may already be available, changes in terminology may be appropriate, recognizing that some of them may have low malignant potential, whereas others may have no capacity at all for metastasis and may not warrant the use of the term \"melanoma.\"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquired Epidermodysplasia Verruciformis With HPV5 RNA Expression Using RNA Chromogenic In Situ Hybridization. 利用 RNA 染色原位杂交技术发现伴有 HPV5 RNA 表达的后天性疣状表皮增生症

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-03 DOI: 10.1111/cup.14746

Jonathan Lai, Jaroslaw Jedrych

引用次数: 0

Line-Field Confocal Optical Coherence Tomography Imaging of Psoriasis With Histopathology Correlation. 银屑病的线场共焦光学相干断层成像与组织病理学相关性。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-29 DOI: 10.1111/cup.14734

Anna Elisa Verzì, Francesco Lacarrubba, Maria Letizia Musumeci, Rosario Caltabiano, Giuseppe Micali

{"title":"Line-Field Confocal Optical Coherence Tomography Imaging of Psoriasis With Histopathology Correlation.","authors":"Anna Elisa Verzì, Francesco Lacarrubba, Maria Letizia Musumeci, Rosario Caltabiano, Giuseppe Micali","doi":"10.1111/cup.14734","DOIUrl":"https://doi.org/10.1111/cup.14734","url":null,"abstract":"Line-field confocal optical coherence tomography (LC-OCT) is a novel imaging technique for in vivo examination of the skin that has recently been introduced in the dermatologic armamentarium of non-invasive diagnostic tools. Its usefulness in the diagnosis and treatment monitoring of some neoplastic, inflammatory, and infectious skin conditions has been demonstrated. The aim of this study was to evaluate the LC-OCT features of psoriasis in a large number of psoriatic plaques along with their histopathologic correlation. In this retrospective study, the LC-OCT and the corresponding histopathologic images of 100 psoriatic plaques of the trunk, upper and lower arms from 60 patients that underwent both procedures were evaluated and correlated. The following microscopic findings, typical of plaque psoriasis, were observed at both LC-OCT and histopathology: hyperkeratosis, parakeratosis, acanthosis, papillomatosis and vascular changes, Munro microabscesses, and pustules of Kogoj. The LC-OCT findings perfectly matched with histopathology. Our study confirms the usefulness of this new imaging technique in the non-invasive visualization of the common diagnostic clues of psoriasis.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature. 与先天性白细胞介素 17A 受体阻断有关的脓皮病：两例病例的报告和文献综述。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-27 DOI: 10.1111/cup.14740

Cynthia M Magro, Neil Crowson, Taylor Kalomeris, Gerard Nuovo

{"title":"Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature.","authors":"Cynthia M Magro, Neil Crowson, Taylor Kalomeris, Gerard Nuovo","doi":"10.1111/cup.14740","DOIUrl":"https://doi.org/10.1111/cup.14740","url":null,"abstract":"Pyoderma gangrenosum (PG) is a rare necrotizing neutrophilic dermatosis driven by monokines and cytokines elaborated by monocytes and autoreactive T cells, respectively. Th1-mediated autoimmune disorders and myeloproliferative disease are among the potential disease associations. More recently, certain medications were implicated, including TNF-alpha inhibitors, rituximab, and IL-17A inhibitors, such as secukinumab, where the development of PG is held to represent a cutaneous immune adverse effect. We present two patients who developed an autoinflammatory syndrome resembling PG in the setting of drug therapy with agents exhibiting an IL-17A inhibitory effect. The drugs were erunumab in one and secukinumab in the other. One patient received the anti-calcitonin gene-related peptide targeted therapy, erenumab, for migraine prophylaxis. While this drug has not been previously implicated in the development of PG, it can cause IL-17A blockade. The other patient was on secukinumab, a monoclonal antibody that selectively targets IL-17A. We documented a microenvironment enriched in IL-17A, emphasizing that the blockade impacts the functionality of the receptor as opposed to a quantitative reduction in IL-17A production by T cells. Qualitative functional IL-17A blockade could result in a paradoxical increase in IL-23, a pro-inflammatory cytokine that may contribute to the influx of neutrophils pathogenetically implicated in PG.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spitz-Type Proliferative Nodules Arising Within a Large Congenital Melanocytic Nevus Harboring a Novel LMNA-RAF1 Fusion. 先天性黑色素细胞痣中出现的斯皮茨型增殖性结节，携带一种新型 LMNA-RAF1 融合体。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-26 DOI: 10.1111/cup.14741

Gautham Vellaichamy, Janet Poulik, Nallasivam Palanisamy, Olena Kis, Xiaolan Fang, Khaleel I Al-Obaidy, Tor A Shwayder, Ben J Friedman

引用次数: 0

Immunohistochemical Expression of Immune Regulatory Proteins in Interface Dermatoses. 界面皮肤病中免疫调节蛋白的免疫组化表达。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-25 DOI: 10.1111/cup.14736

Sarah Grace McAlpine, Donna Culton, Michael Duplisea, Zhi Liu, Si On Lim, Paul Googe

{"title":"Immunohistochemical Expression of Immune Regulatory Proteins in Interface Dermatoses.","authors":"Sarah Grace McAlpine, Donna Culton, Michael Duplisea, Zhi Liu, Si On Lim, Paul Googe","doi":"10.1111/cup.14736","DOIUrl":"https://doi.org/10.1111/cup.14736","url":null,"abstract":"Cutaneous immune-related adverse events (irAEs) of immunotherapies, such as anti-programmed cell death protein-1 (PD-1), suggest that immune checkpoint factors may contribute to the pathobiology of lichenoid interface dermatitis in immunotherapy-naïve patients. Our study aimed to describe innate and adaptive immune markers via immunohistochemical (IHC) staining of lichenoid interface dermatoses. We studied the staining patterns of PD-L1, STING, IL-36 gamma, CD8, PD-1, and LAG-3 in five interface dermatoses: oral lichen planus (LP) (n = 10), cutaneous LP (n = 10), chronic cutaneous lupus erythematosus (CLE) (n = 11), erythema multiforme (EM) (n = 11), and toxic epidermal necrolysis (TEN) (n = 13), by immunohistochemistry (IHC) analysis. Expression was evaluated semi-quantitively according to the percentage of keratinocytes and dermal lymphocytes stained compared to keratinocytes and resident pericapillary lymphocytes in normal human skin. All interface dermatoses evaluated showed increased expression of PD-L1 on keratinocytes and LAG-3 in lymphocytes. STING was increased on the keratinocytes of most specimens. Expression of IL-36 gamma, in basal layer keratinocytes was more extensive in oral LP and cutaneous LP and varied in CLE, EM, and TEN. Lymphocytic infiltration expressing PD-1 was elevated in oral LP, cutaneous LP, and CLE. Current thinking is that interface dermatitis is the result of a cell-mediated immune reaction involving cytotoxic CD8+ T-cell-mediated apoptosis of keratinocytes. The findings of this study suggest that in addition to cell-mediated immunity, innate immune factors may contribute to pathobiology.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0