Journal of Cutaneous Pathology最新文献

Histopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases. 43 例系列病例中盘状红斑狼疮与毛囊性真菌病的组织病理学比较。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-06 DOI: 10.1111/cup.14752

Camilla A Cascardo, Meghan R Mansour, Sandra Oska, Uma Sundram

{"title":"Histopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases.","authors":"Camilla A Cascardo, Meghan R Mansour, Sandra Oska, Uma Sundram","doi":"10.1111/cup.14752","DOIUrl":"10.1111/cup.14752","url":null,"abstract":"Background: Folliculotropic mycosis fungoides (FMF) is a rare cutaneous malignancy that can be mistaken for inflammatory diseases, such as discoid lupus erythematosus (DLE), due to the variability of histopathological findings.Methods: This study aims to provide dermatopathologists with evidence-based histopathologic criteria to distinguish DLE from FMF by reporting overlapping and distinguishing microscopic features. Forty-three biopsies from patients with a confirmed diagnosis of DLE or FMF were graded for the presence or absence of 18 histopathologic features.Results: The main histopathologic findings present in nearly all DLE and FMF biopsies were folliculocentric and folliculotropic patterns. Comedones, granulomas, and folliculitis were not prominent. Follicular hyperplasia, follicular plugging, interstitial mucin, lichenoid/interface dermatitis, and plasma cells were significantly more common in DLE biopsies, while follicular mucinosis and eosinophils were significantly more common in FMF samples. Cytologic atypia ranged from none to mild in DLE and mild to moderate in FMF. Rarely, both sets of biopsies contained epidermotropism, spongiosis, or peri-eccrine infiltration.Conclusion: While many histopathological features present in DLE overlap with features found in FMF, such as folliculocentrism and folliculotropism, significant differences do exist. Therefore, when diagnosing FMF, it is important to follow established criteria that differentiate this malignancy from inflammatory conditions such as DLE.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"126-131"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual, Symmetric Rash on Both Forearms in a 94-Year-Old Patient A Clinicopathological Challenge and Diagnostic Pitfall. 94岁患者双前臂不寻常的对称皮疹：临床病理挑战和诊断缺陷。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1111/cup.14764

Anna-Maria Forster, Beda Muehleisen

引用次数: 0

VEXAS Syndrome: Histiocytoid Cells With Feathery Cytoplasm as a Clue to the Diagnosis. VEXAS综合征：具有羽状细胞质的组织细胞样细胞是诊断的线索。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-28 DOI: 10.1111/cup.14757

Christine J Ko, Ian Odell, Jeffrey R Gehlhausen, Jonathan Leventhal, Jennifer M McNiff, Amanda Zubek

引用次数: 0

Kaposi Sarcoma in the Context of Post-Modified Radical Mastectomy: A New Case Report and Brief Review. 改良根治性乳房切除术后的卡波西肉瘤：新病例报告和简要回顾。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-04 DOI: 10.1111/cup.14751

Rasha Mahmoud Genedy, Naglaa Mohamed El Sayed

{"title":"Kaposi Sarcoma in the Context of Post-Modified Radical Mastectomy: A New Case Report and Brief Review.","authors":"Rasha Mahmoud Genedy, Naglaa Mohamed El Sayed","doi":"10.1111/cup.14751","DOIUrl":"10.1111/cup.14751","url":null,"abstract":"Kaposi sarcoma is a human herpesvirus 8-associated angio-proliferative tumor arising from lymphatic endothelial cells. Four clinical subtypes are known: classic, epidemic, endemic, and iatrogenic. The development of Kaposi sarcoma and lymphedema may be interlinked, where each condition could potentially support the progression of the other. Post-mastectomy lymphedema is a commonly recognized complication following radical mastectomy. Angiosarcoma is the most frequently reported neoplasm in such a situation. We present a 72-year-old female who developed Kaposi sarcoma on the same side of mastectomy 9 years following her initial diagnosis and treatment for cancer breast. The diagnosis of Kaposi sarcoma was based on the histopathologic findings and was confirmed with immunohistochemical staining for human herpes virus 8 and D2-40. Lymphedema may be associated with local immune suppression manifested in the form of defective cell-mediated immunity and antigen-presenting cell migration defect which may facilitate development of neoplasms. It is important to differentiate Kaposi sarcoma from other vascular tumors which may have a much worse prognosis. Patients with lymphedema should receive appropriate management and undergo long-term follow-up for early detection of any potential malignancies.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"80-84"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CIC-DUX4 Sarcoma of the Skin: A Rare Case Report and Literature Review. CIC-DUX4 皮肤肉瘤：罕见病例报告和文献综述。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-18 DOI: 10.1111/cup.14748

Daniella F Faden, Olaf Rodriguez, Mark Abdelmalek, Carrie Kovarik

{"title":"CIC-DUX4 Sarcoma of the Skin: A Rare Case Report and Literature Review.","authors":"Daniella F Faden, Olaf Rodriguez, Mark Abdelmalek, Carrie Kovarik","doi":"10.1111/cup.14748","DOIUrl":"10.1111/cup.14748","url":null,"abstract":"CIC::DUX4 fusion sarcoma represents a rare and aggressive subtype of undifferentiated small round blue cell tumors. We report on a 23-year-old African male who developed a rapidly enlarging inferolateral left buttock nodule with ulceration. After debulking excision of the lesion, histologic sections demonstrated sheets and lobules of atypical round blue cells with significant cytologic atypia. Prominent foci of atypical mitotic figures and tissue necrosis were present. Tumoral cells stained strongly and diffusely using MDM2, vimentin, WT1 and CD99 immunohistochemical (IHC) markers. Molecular testing was performed and highlighted CIC::DUX4 gene fusion positivity, making the diagnosis of a CIC::DUX4 sarcoma (CDS). Post-surgical excision, the patient showed no disease on imaging and underwent five cycles of adjuvant chemotherapy with no recurrence observed at the eight-month follow-up. With fewer than 200 cases reported in the literature and somewhat nonspecific clinicopathologic characteristics, CIC::DUX4 sarcoma presents a diagnostic challenge. This case underlines the importance of molecular diagnostics in undifferentiated sarcomas and presents a rare primary cutaneous manifestation of CIC::DUX4 fusion sarcoma. Additionally, we provide a review of the literature to aid in recognition, diagnosis, and treatment of this rare entity.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"92-98"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Expression Patterns in a Congenital Neurocristic Hamartoma With Multiple Proliferative Nodules. 伴有多发性增殖结节的先天性神经肉芽肿的基因表达模式

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-06 DOI: 10.1111/cup.14745

Jefferson Terry

{"title":"Gene Expression Patterns in a Congenital Neurocristic Hamartoma With Multiple Proliferative Nodules.","authors":"Jefferson Terry","doi":"10.1111/cup.14745","DOIUrl":"10.1111/cup.14745","url":null,"abstract":"Cutaneous neurocristic hamartoma (CNH) is a rare lesion composed of neural crest derivatives, thought to arise from aberrant migration and differentiation of neural crest cells. Recognition of CNH may be difficult, as they may resemble giant congenital nevus, and development of proliferative nodules (PNs) may raise concern for malignant transformation. Assessment of gene expression in CNH and PNs derived from CNH may offer insight into pathogenesis and suggest clinically useful biomarkers to identify these entities. This study investigates gene expression patterns in a congenital CNH and three separate PNs derived from that CNH with giant congenital nevus and malignant melanoma as comparator groups. Comparison of PN to CNH demonstrates downregulation of WIF1, which encodes as a tumor suppressor, and loss of WIF1 expression might explain the progression from CNH to PN. Comparison of gene expression in PN and CNH with giant congenital nevus and malignant melanoma shows relative overexpression of IGF2 and H19 in CNH and PN, suggesting that abnormal imprinting and IGF2 overexpression may have integral functions in the foundation of CNH.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"85-91"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiosarcoma of the Scalp Mimicking an Inflammatory Scarring Alopecia and Diagnosed on Horizontal Histologic Sections. 头皮血管肉瘤模仿炎症性疤痕性脱发并通过水平组织学切片确诊

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.1111/cup.14766

Divya M Shan, Mary-Margaret B Noland, Julio A Diaz-Perez, Sosipatros A Boikos, Mark C Mochel

{"title":"Angiosarcoma of the Scalp Mimicking an Inflammatory Scarring Alopecia and Diagnosed on Horizontal Histologic Sections.","authors":"Divya M Shan, Mary-Margaret B Noland, Julio A Diaz-Perez, Sosipatros A Boikos, Mark C Mochel","doi":"10.1111/cup.14766","DOIUrl":"10.1111/cup.14766","url":null,"abstract":"While most forms of alopecia neoplastica are attributable to cutaneous metastases from visceral primary malignancies, rarely a diffuse primary skin cancer may present as alopecia. Herein, we present a case of angiosarcoma which clinically mimicked an inflammatory alopecia and was diagnosed by examination of alopecia-protocol horizontal histologic sections. A 72-year-old female presented to her dermatologist with a chief complaint of hair loss and pruritus. She was noted to have alopecia with erythema of the scalp and was diagnosed clinically with lichen planopilaris. However, when multiple topical treatments were unsuccessful, her dermatologist performed a scalp biopsy to guide further alopecia therapy. Horizontally oriented histologic sections were prepared from the biopsy in standard alopecia fashion. Histopathologic examination revealed a proliferation of dissecting vascular channels lined by atypical endothelial cells, diagnostic of angiosarcoma. The patient underwent radiation and chemotherapy with clinical response and had stable disease for several years thereafter. This case highlights the importance of considering unexpected malignancies in the clinical and pathologic examination of cases of suspected inflammatory alopecia.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"104-107"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An exceptional case of imatinib mesylate inducing both psoriasis and lichenoid reaction: A case report. 甲磺酸伊马替尼同时诱发银屑病和苔藓样反应的特殊病例：病例报告。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-08-20 DOI: 10.1111/cup.14703

Kaoutar Belharti, Hasnae Saddouk, Nassiba Zerrouki, Siham Dikhaye, Nada Zizi

引用次数: 0

Chronic Leg Ulcerations and Subcutaneous Panniculitis due to Dermal Herpes Zoster in an Immunosuppressed Woman. 免疫抑制妇女皮肤带状疱疹引起的慢性腿部溃疡和皮下泛膜炎。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-12-03 DOI: 10.1111/cup.14767

Yasir Al-Dojaily, Wilson Omesiete, R Hal Flowers, Sarah E Gradecki, Olivia V Lim

引用次数: 0

Study of Microsatellite Instability by Immunohistochemistry in a Cohort of Patients With Melanoma. 用免疫组化方法研究黑色素瘤患者队列中的微卫星不稳定性

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-24 DOI: 10.1111/cup.14758

Rodolfo David Palacios Diaz, Blanca de Unamuno Bustos, Mónica Pozuelo Ruiz, Margarita Llavador Ros, Sarai Palanca Suela, Rafael Botella Estrada

{"title":"Study of Microsatellite Instability by Immunohistochemistry in a Cohort of Patients With Melanoma.","authors":"Rodolfo David Palacios Diaz, Blanca de Unamuno Bustos, Mónica Pozuelo Ruiz, Margarita Llavador Ros, Sarai Palanca Suela, Rafael Botella Estrada","doi":"10.1111/cup.14758","DOIUrl":"10.1111/cup.14758","url":null,"abstract":"Background: Microsatellite instability (MSI) has prognostic value and impacts therapy strategies in several malignancies. Data regarding MSI in melanoma are scarce. The aim of this study was to assess MSI through the analysis of MMR protein expression in patients with melanoma.Methods: An observational retrospective single-center study was designed based on patients with primary melanoma. We assessed MSI through immunohistochemical staining with anti-MLH1, anti-MSH2, anti-MSH6, and anti-PMS2 on full-thickness excision tissue.Results: Ninety-three patients were included in this study. The complete absence of nuclear staining in tumoral cells was extremely rare, with only one melanoma not expressing MSH6. Most melanomas showed an expression index for MLH1 (77.7%), MSH2 (87.2%), and PMS2 (78.6%) ≥ 75%. Most melanomas (57.8%) exhibited an MSH6 expression index in the range of 1%-74%. A low MSH6 expression index and a reduced combined MMR protein expression index (MMR-e) were significantly associated with higher melanoma-specific survival. A mild PMS2 staining intensity was significantly associated with a higher melanoma-specific survival. The patients with high MMR-e who received immunotherapy progressed and died more frequently than those with reduced MMR-e (75% vs. 33.3%).Conclusion: More studies are needed to further define the role of MSI in melanoma prognosis and response to immunotherapy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"162-171"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0