{"title":"地衣样糠疹和蕈样真菌病的重叠临床病理表现。","authors":"Olivia Pierog, Mariah Estill, Jaroslaw Jedrych, Sima Rozati, Rachel Marchalik","doi":"10.1111/cup.14856","DOIUrl":null,"url":null,"abstract":"<p><p>Pityriasis lichenoides (PL) has traditionally been considered a benign cutaneous disorder with a diverse clinical presentation. This comprehensive literature review challenges that notion by exploring its histopathologic, immunopathologic, and molecular overlap with mycosis fungoides (MF). Through examination of lymphocyte populations, T-lymphocyte clonality, and aberrant immunohistochemical phenotypes, our findings indicate that a subset of PL cases, particularly those exhibiting a loss of pan-T-cell markers (CD2, CD5, CD7), or T-cell clonality, may have a closer association with MF. These findings highlight the need for heightened clinical awareness and surveillance in select PL cases, as early identification of MF may improve patient outcomes.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Overlapping Clinicopathological Presentations of Pityriasis Lichenoides and Mycosis Fungoides.\",\"authors\":\"Olivia Pierog, Mariah Estill, Jaroslaw Jedrych, Sima Rozati, Rachel Marchalik\",\"doi\":\"10.1111/cup.14856\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pityriasis lichenoides (PL) has traditionally been considered a benign cutaneous disorder with a diverse clinical presentation. This comprehensive literature review challenges that notion by exploring its histopathologic, immunopathologic, and molecular overlap with mycosis fungoides (MF). Through examination of lymphocyte populations, T-lymphocyte clonality, and aberrant immunohistochemical phenotypes, our findings indicate that a subset of PL cases, particularly those exhibiting a loss of pan-T-cell markers (CD2, CD5, CD7), or T-cell clonality, may have a closer association with MF. These findings highlight the need for heightened clinical awareness and surveillance in select PL cases, as early identification of MF may improve patient outcomes.</p>\",\"PeriodicalId\":15407,\"journal\":{\"name\":\"Journal of Cutaneous Pathology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cutaneous Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/cup.14856\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cutaneous Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/cup.14856","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
The Overlapping Clinicopathological Presentations of Pityriasis Lichenoides and Mycosis Fungoides.
Pityriasis lichenoides (PL) has traditionally been considered a benign cutaneous disorder with a diverse clinical presentation. This comprehensive literature review challenges that notion by exploring its histopathologic, immunopathologic, and molecular overlap with mycosis fungoides (MF). Through examination of lymphocyte populations, T-lymphocyte clonality, and aberrant immunohistochemical phenotypes, our findings indicate that a subset of PL cases, particularly those exhibiting a loss of pan-T-cell markers (CD2, CD5, CD7), or T-cell clonality, may have a closer association with MF. These findings highlight the need for heightened clinical awareness and surveillance in select PL cases, as early identification of MF may improve patient outcomes.
期刊介绍:
Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.