地衣样糠疹和蕈样真菌病的重叠临床病理表现。

IF 1.1 4区 医学 Q3 DERMATOLOGY
Olivia Pierog, Mariah Estill, Jaroslaw Jedrych, Sima Rozati, Rachel Marchalik
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引用次数: 0

摘要

地衣样糠疹(PL)传统上被认为是一种具有多种临床表现的良性皮肤病。这篇全面的文献综述通过探索其组织病理学、免疫病理学和与蕈样真菌病(MF)的分子重叠来挑战这一概念。通过对淋巴细胞群、t淋巴细胞克隆性和异常免疫组织化学表型的检查,我们的研究结果表明,一部分PL病例,特别是那些表现出泛t细胞标记物(CD2、CD5、CD7)缺失或t细胞克隆的病例,可能与MF有更密切的联系。这些发现强调了在特定的PL病例中需要提高临床意识和监测,因为早期识别MF可能会改善患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Overlapping Clinicopathological Presentations of Pityriasis Lichenoides and Mycosis Fungoides.

Pityriasis lichenoides (PL) has traditionally been considered a benign cutaneous disorder with a diverse clinical presentation. This comprehensive literature review challenges that notion by exploring its histopathologic, immunopathologic, and molecular overlap with mycosis fungoides (MF). Through examination of lymphocyte populations, T-lymphocyte clonality, and aberrant immunohistochemical phenotypes, our findings indicate that a subset of PL cases, particularly those exhibiting a loss of pan-T-cell markers (CD2, CD5, CD7), or T-cell clonality, may have a closer association with MF. These findings highlight the need for heightened clinical awareness and surveillance in select PL cases, as early identification of MF may improve patient outcomes.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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