Eccrine Coil Elastosis: A New Dermatopathological Feature Associated With Prediabetes and Diabetes.

IF 1.1 4区 医学 Q3 DERMATOLOGY
Carlos Monteagudo, Miguel Martínez-Rodríguez, Enrique García-Gómez, Silvia Pérez-Debén, Liria Terrádez, Esther Álvarez, José María Martín
{"title":"Eccrine Coil Elastosis: A New Dermatopathological Feature Associated With Prediabetes and Diabetes.","authors":"Carlos Monteagudo, Miguel Martínez-Rodríguez, Enrique García-Gómez, Silvia Pérez-Debén, Liria Terrádez, Esther Álvarez, José María Martín","doi":"10.1111/cup.14864","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The prevalence of diabetes mellitus continues to rise. Cutaneous histological manifestations of diabetes include microangiopathy and atherosclerosis. No morphological alterations of sweat glands have been reported. However, eccrine coil elastosis has been observed in basal cell carcinoma biopsies of a patient with metabolic syndrome, a condition that may provoke elastin glycosylation and degradation.</p><p><strong>Methods: </strong>We conducted a retrospective study analyzing the associations between eccrine coil elastosis and well-established cardiovascular and metabolic risk factors in 245 patients with skin biopsies. The type (stretching, thickening, waving, multilamellation and fragmentation) and extent of eccrine coil elastosis were assessed. In doubtful cases, confirmation was achieved through lysozyme immunostaining.</p><p><strong>Results: </strong>The presence of waving, multilamellation, and/or thickening in at least one eccrine coil was independently associated with diabetes or prediabetes. Associations were also found with cardiovascular complications, age, and actinic damage, but not with hypertension, dyslipidemia, smoking, or overweight.</p><p><strong>Conclusions: </strong>Although eccrine coil elastosis is not restricted to patients with prediabetes and diabetes, it is much more prevalent and appears earlier in patients with these two conditions. Detecting it in skin biopsies obtained for other reasons in patients with an unknown glycemic status may serve as a potential histologic clue warranting further metabolic evaluation.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cutaneous Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/cup.14864","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: The prevalence of diabetes mellitus continues to rise. Cutaneous histological manifestations of diabetes include microangiopathy and atherosclerosis. No morphological alterations of sweat glands have been reported. However, eccrine coil elastosis has been observed in basal cell carcinoma biopsies of a patient with metabolic syndrome, a condition that may provoke elastin glycosylation and degradation.

Methods: We conducted a retrospective study analyzing the associations between eccrine coil elastosis and well-established cardiovascular and metabolic risk factors in 245 patients with skin biopsies. The type (stretching, thickening, waving, multilamellation and fragmentation) and extent of eccrine coil elastosis were assessed. In doubtful cases, confirmation was achieved through lysozyme immunostaining.

Results: The presence of waving, multilamellation, and/or thickening in at least one eccrine coil was independently associated with diabetes or prediabetes. Associations were also found with cardiovascular complications, age, and actinic damage, but not with hypertension, dyslipidemia, smoking, or overweight.

Conclusions: Although eccrine coil elastosis is not restricted to patients with prediabetes and diabetes, it is much more prevalent and appears earlier in patients with these two conditions. Detecting it in skin biopsies obtained for other reasons in patients with an unknown glycemic status may serve as a potential histologic clue warranting further metabolic evaluation.

内分泌线圈弹性增生:与糖尿病前期和糖尿病相关的一种新的皮肤病理特征。
背景:糖尿病的患病率持续上升。糖尿病的皮肤组织学表现包括微血管病变和动脉粥样硬化。未见汗腺形态学改变的报道。然而,在代谢综合征患者的基底细胞癌活检中观察到内分泌线圈弹性增生,这种情况可能引起弹性蛋白糖基化和降解。方法:我们对245例皮肤活检患者进行了回顾性研究,分析了内分泌线圈弹性弹性症与心血管和代谢危险因素之间的关系。评估内分泌线圈弹性弹性的类型(拉伸、增厚、波浪状、多片状和碎裂状)和程度。在有疑问的病例中,通过溶菌酶免疫染色进行确认。结果:至少一个内分泌线圈出现波浪状、多层状和/或增厚与糖尿病或前驱糖尿病独立相关。还发现与心血管并发症、年龄和光化损伤相关,但与高血压、血脂异常、吸烟或超重无关。结论:虽然内分泌线圈弹性弹性症并不局限于糖尿病前期和糖尿病患者,但在这两种疾病的患者中更为普遍,出现时间也更早。在血糖状态未知的患者因其他原因获得的皮肤活检中检测到它可能作为一个潜在的组织学线索,需要进一步的代谢评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信