Journal of Cutaneous Pathology最新文献_第2页

Eccrine Coil Elastosis: A New Dermatopathological Feature Associated With Prediabetes and Diabetes. 内分泌线圈弹性增生：与糖尿病前期和糖尿病相关的一种新的皮肤病理特征。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-01 DOI: 10.1111/cup.14864

Carlos Monteagudo, Miguel Martínez-Rodríguez, Enrique García-Gómez, Silvia Pérez-Debén, Liria Terrádez, Esther Álvarez, José María Martín

{"title":"Eccrine Coil Elastosis: A New Dermatopathological Feature Associated With Prediabetes and Diabetes.","authors":"Carlos Monteagudo, Miguel Martínez-Rodríguez, Enrique García-Gómez, Silvia Pérez-Debén, Liria Terrádez, Esther Álvarez, José María Martín","doi":"10.1111/cup.14864","DOIUrl":"https://doi.org/10.1111/cup.14864","url":null,"abstract":"Background: The prevalence of diabetes mellitus continues to rise. Cutaneous histological manifestations of diabetes include microangiopathy and atherosclerosis. No morphological alterations of sweat glands have been reported. However, eccrine coil elastosis has been observed in basal cell carcinoma biopsies of a patient with metabolic syndrome, a condition that may provoke elastin glycosylation and degradation.Methods: We conducted a retrospective study analyzing the associations between eccrine coil elastosis and well-established cardiovascular and metabolic risk factors in 245 patients with skin biopsies. The type (stretching, thickening, waving, multilamellation and fragmentation) and extent of eccrine coil elastosis were assessed. In doubtful cases, confirmation was achieved through lysozyme immunostaining.Results: The presence of waving, multilamellation, and/or thickening in at least one eccrine coil was independently associated with diabetes or prediabetes. Associations were also found with cardiovascular complications, age, and actinic damage, but not with hypertension, dyslipidemia, smoking, or overweight.Conclusions: Although eccrine coil elastosis is not restricted to patients with prediabetes and diabetes, it is much more prevalent and appears earlier in patients with these two conditions. Detecting it in skin biopsies obtained for other reasons in patients with an unknown glycemic status may serve as a potential histologic clue warranting further metabolic evaluation.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatofibrosarcoma Protuberans With a Novel FBN1::PDGFD Fusion: Expanding the Molecular Spectrum. 与新型FBN1::PDGFD融合的皮肤纤维肉瘤隆突：扩大分子谱。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-09-01 DOI: 10.1111/cup.14868

Ken-Ichi Yoshida, Yoji Kukita, Satoshi Takenaka, Toshinari Yagi, Keiichiro Honma, Shigeki Kakunaga

引用次数: 0

Histopathologic and Immunophenotypic Properties of Primary Cutaneous Large Cell Neuroendocrine Carcinomas. 原发性皮肤大细胞神经内分泌癌的组织病理学和免疫表型特征。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-08-31 DOI: 10.1111/cup.14853

Myles R McCrary, Riechelle Garcia, Janice Jiang, Michael B Morgan

{"title":"Histopathologic and Immunophenotypic Properties of Primary Cutaneous Large Cell Neuroendocrine Carcinomas.","authors":"Myles R McCrary, Riechelle Garcia, Janice Jiang, Michael B Morgan","doi":"10.1111/cup.14853","DOIUrl":"https://doi.org/10.1111/cup.14853","url":null,"abstract":"Cutaneous large cell neuroendocrine carcinoma (LCNEC) is a rare and poorly understood malignancy. Here we describe the clinicopathological characteristics of six cutaneous LCNEC case. A retrospective chart and slide review of PCLCNEC cases at a large commercial dermatopathology practice from January 2017 to May 2025 was performed. Patient characteristics, histopathologic features, and immunohistochemical profiles, including Merkel cell polyoma virus large T antigen/MCPyV antigenicity, were summarized. Demographically, PCLCNEC occurred in elderly white patients, presenting as a rapidly progressing nodule in sun-exposed skin. Histologically, the tumors were characterized by predominantly infiltrative growth patterns with varying levels of neuroendocrine architectural and cytologic features, including rosette and trabeculae formation, organoid nesting, and peripheral palisading. All were positive for CK7 and neuroendocrine markers and negative for MCPyV, CK20, and TTF1 expression by immunohistochemistry. Metastasis was identified in one patient, while the remaining five patients had no evidence of disease following wide local excision with a median follow-up period of 25 months. This series contributes valuable insights into the characterization and diagnosis of primary cutaneous LCNEC. In conjunction with previously reported data, we suggest that the morphology and immunophenotype support further inquiry into its potential distinction as a unique cutaneous entity.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRTC1::MAML2-Positive Hidradenoma With Sebaceous Differentiation. CRTC1:: maml2阳性皮脂腺瘤。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-08-29 DOI: 10.1111/cup.14862

Megumi Aoki, Keisuke Goto, Kazuyasu Fujii, Mitsuharu Nomoto, Masamichi Goto, Manami Kajiwara, Toshitaka Nagao, Shigeto Matsushita

{"title":"CRTC1::MAML2-Positive Hidradenoma With Sebaceous Differentiation.","authors":"Megumi Aoki, Keisuke Goto, Kazuyasu Fujii, Mitsuharu Nomoto, Masamichi Goto, Manami Kajiwara, Toshitaka Nagao, Shigeto Matsushita","doi":"10.1111/cup.14862","DOIUrl":"https://doi.org/10.1111/cup.14862","url":null,"abstract":"Hidradenoma can exhibit several cell types, including clear cells, polyhedral eosinophilic cells, squamoid cells, mucinous cells, oxyphilic (oncocytic) cells, and transitional (intermediate) cells. However, sebocytes have not yet been described in hidradenoma. Here, we present a case of CRTC1::MAML2-positive hidradenoma with sebaceous differentiation. In addition, this tumor had two cell-type layers that were morphologically similar to apocrine glandular cells and myoepithelial cells throughout the lesion. A 66-year-old male presented with a 20 mm nodule on his upper lip with a 3-year history. Histopathological examination revealed a multinodular tumor adherent to the overlying epidermis. No surrounding salivary glands were seen. The tumor consisted of eosinophilic ductoglandular cells surrounded by basaloid cells at the outer periphery. Numerous sebocytes were scattered throughout the tumor. Severe nuclear atypia or mitotic figures were not observed. Immunohistochemical examination showed no expression of α-smooth muscle actin, calponin, and S100 protein in the tumor cells. Adipophilin highlighted scattered sebocytic tumor cells. Immunoexpression of MLH1, PMS2, MSH2, and MSH6 was preserved. MAML2 break-apart fluorescence in situ hybridization revealed frequent split signals. Sanger sequencing revealed a CRTC1(e1)::MAML2(e2) fusion. Based on this report, hidradenoma should be included in the differential diagnosis of cutaneous adnexal tumors with sebaceous differentiation other than sebaceous adnexal tumors. In addition, sebocytes should be added to the list of tumor cell types in hidradenoma.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reaction to Cutaneous Filler Elleva Poly-l-Lactic Acid: Report of Two Cases. 皮肤填充物Elleva聚l-乳酸反应2例报告。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-08-27 DOI: 10.1111/cup.14857

Pedro Carneiro Marinho, Maria Belen Mendoza Macias, Joaquim Mesquita Filho, Luciana França, Maria Auxiliadora Jeunon Sousa, Thiago Jeunon de Sousa Vargas

引用次数: 0

Diagnostic Utility of PRAME in Rare Melanoma Mimics: A Comparative Analysis Including GNET, MMNST, Epithelioid MPNST, and MITF-Rearranged Melanocytic Tumors. PRAME在罕见黑色素瘤模拟物中的诊断应用：包括GNET、MMNST、上皮样MPNST和mitf重排黑色素细胞肿瘤的比较分析。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-08-17 DOI: 10.1111/cup.14849

Ahmed Shah, Jeremiah F Molligan, Carina A Dehner, Jorge Torres-Mora

{"title":"Diagnostic Utility of PRAME in Rare Melanoma Mimics: A Comparative Analysis Including GNET, MMNST, Epithelioid MPNST, and MITF-Rearranged Melanocytic Tumors.","authors":"Ahmed Shah, Jeremiah F Molligan, Carina A Dehner, Jorge Torres-Mora","doi":"10.1111/cup.14849","DOIUrl":"https://doi.org/10.1111/cup.14849","url":null,"abstract":"Background: Differentiating metastatic melanoma from histologic mimics such as malignant gastrointestinal neuroectodermal tumor (GNET), malignant melanotic nerve sheath tumor (MMNST), and epithelioid malignant peripheral nerve sheath tumor (EMPNST) poses significant diagnostic challenges due to overlapping morphology and immunophenotypes. PRAME is a novel immunohistochemical marker increasingly used to distinguish melanoma from its mimics, but remains underexplored in these rare tumor types.Methods: PRAME immunohistochemistry was performed on four GNETs, seven MMNSTs, 10 EMPNSTs, 16 metastatic melanomas (including eight undifferentiated melanomas), and two MITF-rearranged melanocytic tumors. PRAME expression was scored from 0 to 4+ based on the percentage of tumor nuclei showing moderate to strong staining.Results: All GNETs, MMNSTs, and MITF-rearranged tumors were PRAME-negative. EMPNSTs showed variable expression: six were negative (0-1), one equivocal (2+), and three positive (3-4+). Fifteen of 16 melanomas were PRAME-positive. PRAME scores differed significantly among tumor types (p = 1.99 × 10-5). PRAME demonstrated high sensitivity and specificity for distinguishing metastatic melanoma from primary mimickers including GNET and MMNST, but low specificity in EMPNST (71.4%).Conclusions: PRAME reliably distinguishes metastatic melanoma from GNET and MMNST, supporting its use in this differential. However, its reduced specificity in EMPNST limits its standalone diagnostic value in this context, emphasizing the need for a multimodal approach.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Acanthamoebiasis: Two Cases Highlighting Diverse Histopathologic Findings. 皮肤棘阿米巴病：两例不同的组织病理表现。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-08-17 DOI: 10.1111/cup.14854

Nadia Siddiqui, Bicong Wu, Lindsay Gunnell, Evan George, Oliver Chang

{"title":"Cutaneous Acanthamoebiasis: Two Cases Highlighting Diverse Histopathologic Findings.","authors":"Nadia Siddiqui, Bicong Wu, Lindsay Gunnell, Evan George, Oliver Chang","doi":"10.1111/cup.14854","DOIUrl":"https://doi.org/10.1111/cup.14854","url":null,"abstract":"Acanthamoeba is a free-living ameba, known to most commonly cause amebic keratitis in contact lens users and granulomatous amebic encephalitis in immunocompromised patients. Cutaneous Acanthamoebiasis as a single-organ manifestation is less common. We report two cases seen in our department. Case one is a 23-year-old hospitalized patient with systemic lupus erythematosus and pancytopenia who acutely developed nodules on the extremities. Biopsy showed lymphohistiocytic inflammation and focal coagulative necrosis in the subcutaneous fat. Acanthamoeba trophozoites and cysts were apparent in H&E-stained sections and highlighted by PAS and GMS stains. PCR studies were positive for Acanthamoeba species. Case two is an 81-year-old with diffuse large B-cell lymphoma on idelalisib, who presented with a three-week history of ulcerating nodules on the extremities. Biopsy from the left arm exhibited a mixed deep dermal infiltrate with neutrophils and histiocytes while biopsy from the right arm exhibited granulomatous inflammation. Acanthamoeba trophozoites and cysts were apparent in H&E and PAS-stained sections, confirmed to be Acanthamoeba by PCR. Cutaneous Acanthamoebiasis should be considered in biopsies of cutaneous nodules from immunocompromised patients. The histopathologic inflammatory changes are variable and non-specific, while the organisms are easily overlooked due to their resemblance to histiocytes. Familiarity with these features is essential for accurate, timely diagnosis.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demographics of U.S. Dermatopathology Fellowship Applicant Interviewees: A Single Institution Descriptive Analysis. 美国皮肤病理学奖学金申请人受访者的人口统计数据：单一机构描述性分析。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-08-05 DOI: 10.1111/cup.14855

Peter Chow, Lauren F Rinehart, Emily H Smith, Kristin Smith, Gillian Heinecke, M Yadira Hurley, Nicole Burkemper

{"title":"Demographics of U.S. Dermatopathology Fellowship Applicant Interviewees: A Single Institution Descriptive Analysis.","authors":"Peter Chow, Lauren F Rinehart, Emily H Smith, Kristin Smith, Gillian Heinecke, M Yadira Hurley, Nicole Burkemper","doi":"10.1111/cup.14855","DOIUrl":"https://doi.org/10.1111/cup.14855","url":null,"abstract":"Introduction: Matching into a dermatopathology fellowship is increasingly competitive; however, the application process is not standardized, and there is little data to guide a successful match. This study aimed to determine the association of various application variables and a successful match into dermatopathology fellowship.Methods: A retrospective anonymized data review of dermatopathology fellowship applicants from a single midwestern institution was conducted. Applicant background and demographics were collected and analyzed with various statistical models.Results: A total of 68 applicant interviewees over a 7-year period were included in the analysis, with 62% of interviewees ultimately matching into dermatopathology fellowship. Most applicants attended an allopathic medical school (90.8%) and were trained in pathology (64.7%). There was no significant correlation in gender, medical school background, residency training background, or research productivity. There was a statistically significant correlation of successful matching with higher mean United States Medical Licensing Examination step 2 scores (p value 0.012), but not for step 1 or 3 scores.Conclusions: Results of this study show a minimal difference in dermatopathology application traits, suggesting that intangible factors may hold a greater importance for a successful match. This study provides prospective dermatopathology fellowship applicants with a description of application qualities that help to secure an interview.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Setting A New Standard for Histopathologic Reporting of Primary Cutaneous Melanoma: Progress Made by the Melanoma Reporting Task Force of the American Society of Dermatopathology 为原发性皮肤黑色素瘤的组织病理学报告制定新标准：美国皮肤病理学会黑色素瘤报告工作组取得的进展。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-08-04 DOI: 10.1111/cup.14836

Adam I. Rubin, Christopher R. Shea, Beth S. Ruben, May P. Chan

引用次数: 0

Minimum Pathology Reporting Elements for Melanoma: A Review of Reporting Guidelines and Proposal for Minimum Reporting Elements for a Quality Pathology Report by the Task Force of the American Society of Dermatopathology 黑色素瘤的最低病理报告要素：美国皮肤病理学会工作组对报告指南和高质量病理报告最低报告要素的建议的回顾。

IF 1.1 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-07-31 DOI: 10.1111/cup.14848

Klaus J. Busam, Lyn M. Duncan, Pedram Gerami, Lori Lowe, Hina Sheikh, Michael Tetzlaff

{"title":"Minimum Pathology Reporting Elements for Melanoma: A Review of Reporting Guidelines and Proposal for Minimum Reporting Elements for a Quality Pathology Report by the Task Force of the American Society of Dermatopathology","authors":"Klaus J. Busam, Lyn M. Duncan, Pedram Gerami, Lori Lowe, Hina Sheikh, Michael Tetzlaff","doi":"10.1111/cup.14848","DOIUrl":"10.1111/cup.14848","url":null,"abstract":"Guidelines have been proposed for the pathology reporting of melanoma to ensure inclusion of data elements important for patient care. Compliance with guidelines has been made a yardstick for quality performance. However, there is controversy about how comprehensive a report must be, which is why the American Society of Dermatopathology has formed a task force with the goal of defining minimum data elements that should be included in a pathology report of a primary cutaneous melanoma. Importantly, additional information can or at times should be documented if a pathologist believes it is valuable to the clinical care team of a particular patient. The proposed minimum reporting guidelines outlined herein largely reflect core reporting elements by various professional organizations. Data elements must be included if they are needed for pathologic staging. Excisions require a margin status, but detailed margin metrics are not required for most cases. Furthermore, histopathologic subtyping of melanoma in situ is not routinely needed. Whether or not invasive melanoma should be subclassified depends on clinical relevance and whether the available evidence permits a definitive melanoma subclassification. When the minimum data elements are included, a pathology report should be considered compliant with quality reporting guidelines.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 10","pages":"655-660"},"PeriodicalIF":1.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0