Journal of Cutaneous Pathology最新文献_第2页

Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms-An Analysis of 70 Cases. 靶向测序在 Spitz 黑素细胞肿瘤常规诊断中的作用--对 70 例病例的分析。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-07 DOI: 10.1111/cup.14750

Daja Šekoranja, Andrej Zupan, Alenka Matjašič, Emanuela Boštjančič, Eduardo Calonje, Jože Pižem

{"title":"Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms-An Analysis of 70 Cases.","authors":"Daja Šekoranja, Andrej Zupan, Alenka Matjašič, Emanuela Boštjančič, Eduardo Calonje, Jože Pižem","doi":"10.1111/cup.14750","DOIUrl":"10.1111/cup.14750","url":null,"abstract":"Background: There is growing evidence that the Spitz group of melanocytic neoplasms should be restricted to those harboring kinase receptor fusions and HRAS mutations/11p15 amplification. The presence of genomic alterations characteristic of conventional melanomas (BRAF and NRAS mutations) precludes a diagnosis of a Spitz neoplasm. It is often challenging to distinguish Spitz neoplasms from conventional melanomas with spitzoid morphology on histopathological grounds alone.Methods: We report a series of 70 consecutive melanocytic tumors in which targeted sequencing was indicated to distinguish Spitz from spitzoid neoplasms and to classify Spitz neoplasms along the biological spectrum.Results: Final diagnoses incorporating molecular results included 12 conventional melanomas (nine of which with NRAS mutations), five Spitz melanomas, 35 atypical Spitz tumors, eight Spitz nevi, three melanocytic tumors with a MAP2K1 mutation, and seven desmoplastic Spitz nevi/tumors. There were significant discrepancies between initial diagnoses and final diagnoses after incorporating molecular results in 24 (34%) cases, including nine conventional melanomas favored to be Spitz neoplasms and nine Spitz neoplasms favored to be conventional melanomas.Conclusions: It is often not possible to reliably distinguish Spitz neoplasms from spitzoid melanocytic tumors without identifying their driver genomic alterations. Applying next-generation sequencing in diagnostically problematic tumors improves diagnostic accuracy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"141-153"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequent Occurrence of High-Risk Basal Cell Carcinoma in Xeroderma Pigmentosum: A Histopathological Insight From an Indian Cohort. 色素性皮肤病中高风险基底细胞癌的频繁发生：来自印度队列的组织病理学启示

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-11 DOI: 10.1111/cup.14753

Shafaque Imran, Shivangi Dagar, Rhea Ahuja, Devesh Kumar Jag Swaroop, Somesh Gupta, Sudheer Arava, Kaushal K Verma, Neetu Bhari

{"title":"Frequent Occurrence of High-Risk Basal Cell Carcinoma in Xeroderma Pigmentosum: A Histopathological Insight From an Indian Cohort.","authors":"Shafaque Imran, Shivangi Dagar, Rhea Ahuja, Devesh Kumar Jag Swaroop, Somesh Gupta, Sudheer Arava, Kaushal K Verma, Neetu Bhari","doi":"10.1111/cup.14753","DOIUrl":"10.1111/cup.14753","url":null,"abstract":"Background: Xeroderma pigmentosum (XP) is a genodermatosis, characterized both by premature aging and significantly increased risk of non-melanoma and melanoma skin cancers at an early age. However, limited literature is available on the common histopathological subtypes of basal cell carcinoma (BCC) in these patients.Methods: In this ambispective case series, we recruited patients of XP who had either a currently present skin tumor or previously excised one, provided their histopathological sections were available. Cytogenetic analysis was performed in all the patients. The histopathological findings were recorded by two trained dermatopathologists.Results: Of 22 recruited patients with XP, 12 patients had 41 BCCs, and 23 (56.09%) of them showed a high-risk histopathological subtype. Basosquamous carcinoma (10, 24.39%) was the most frequent high-risk tumor followed by infiltrative variant (7, 17.07%). Mixed-histopathological subtypes were noted in six (14.63%) cases, and all of them had a high-risk component. The low-risk subtypes included nodular (n = 17, 41.46%) and superficial BCC (1, 2.43%). Though a deep dermal involvement was seen in 27 (65.85%) lesions, none showed a perineural invasion or necrosis. Three (7.31%) lesions showed ulceration, while 10 (24.39%) showed presence of pigmentation.Conclusions: A frequent occurrence of high-risk basal cell carcinoma was noted in patients with XP-mandating creation of appropriate treatment and follow-up strategies in these patients.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"154-161"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Facial Nodule: A Presenting Sign of Metastatic Pulmonary Enteric Adenocarcinoma. 皮肤面部结节：转移性肺肠腺癌的表现征兆

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-26 DOI: 10.1111/cup.14759

Sarah K Zemlok, Neelesh Jain, Brett Sloan, Campbell L Stewart

引用次数: 0

Perineuriomatous Melanocytic Nevi: A Case Series of Four Cases. 毛周黑素细胞痣：四例病例系列

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-07 DOI: 10.1111/cup.14749

Aya Almashad, Miki Lindsey, Nicholas Zoumberos, Sara C Shalin

{"title":"Perineuriomatous Melanocytic Nevi: A Case Series of Four Cases.","authors":"Aya Almashad, Miki Lindsey, Nicholas Zoumberos, Sara C Shalin","doi":"10.1111/cup.14749","DOIUrl":"10.1111/cup.14749","url":null,"abstract":"Background: Melanocytic tumors with perineuriomatous differentiation may pose diagnostic challenges. This study explores characteristics of perineuriomatous melanocytic nevi, an entity merging features of perineurioma and melanocytic nevi. The aim is to elucidate histopathological features of perineuriomatous nevi to allow dermatopathologists to recognize them and differentiate them from other spindle cell lesions.Method: This study reviews four cases (2020-2023) of melanocytic nevi with perineuriomatous components.Results: All cases comprised adults (median age: 64.50, mean age: 60.25), with a female predominance, and exhibited clinical features characterized by irregular brown macules or papules on the trunk and extremities. Histopathologically, all lesions were compound, and biphasic patterns were evident, encompassing superficial nevoid and deeper spindled populations arranged in whorled fascicles and embedded in a sclerotic or myxoid stroma. Immunohistochemistry revealed expression of at least one perineuriomatous marker in deeper cells. Cases were assessed and compared with previously published cases for comprehensive insights. Three of our four cases demonstrated the presence of a junctional component that was smaller than the dermal component. We suggest that this unusual feature, which we term the \"reverse shoulder\", may allow dermatopathologists to help consider perineurial differentiation in the appropriate setting.Conclusion: Perineuriomatous nevi can pose diagnostic challenges. This study contributes to the growing body of literature on perineuriomatous nevi, emphasizing their unique features and the importance of accurate diagnosis to avoid unnecessary interventions.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":"132-140"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence and Propensities of Cutaneous Immunofluorescence in ANCA-Associated Vasculitis. 皮肤免疫荧光在anca相关性血管炎中的存在和倾向。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-01-16 DOI: 10.1111/cup.14787

Julian Stashower, Ugochukwu Kingsley Odega, Nakisa Sadeghi, Briana Heinly, Karlyn Pollack, Vimal K Derebail, Matthew Helm, Sarah Gradecki, Galen Foulke, R Hal Flowers

引用次数: 0

Nicotinic Acetylcholine Receptor Expression in Merkel Cell Carcinoma Is Associated With Clinical and Histopathologic Parameters. 烟碱乙酰胆碱受体在默克尔细胞癌中的表达与临床和组织病理学参数相关。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-01-15 DOI: 10.1111/cup.14773

Christopher R Cunningham, Yiannis P Dimopoulos, Ian M García-Quiñones, Denái R Milton, Manuel Delgado-Vélez, Woo Cheal Cho, Victor G Prieto, José A Lasalde-Dominicci, Leomar Y Ballester, Phyu P Aung

{"title":"Nicotinic Acetylcholine Receptor Expression in Merkel Cell Carcinoma Is Associated With Clinical and Histopathologic Parameters.","authors":"Christopher R Cunningham, Yiannis P Dimopoulos, Ian M García-Quiñones, Denái R Milton, Manuel Delgado-Vélez, Woo Cheal Cho, Victor G Prieto, José A Lasalde-Dominicci, Leomar Y Ballester, Phyu P Aung","doi":"10.1111/cup.14773","DOIUrl":"https://doi.org/10.1111/cup.14773","url":null,"abstract":"Background: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy with neuroendocrine differentiation. Several molecular pathways have been implicated in MCC development and multiple cell-of-origin candidates have been proposed, including neural crest cells, which express acetylcholine receptors (AChRs). The role of nicotinic acetylcholine receptors (nAChRs) in MCC has not been explored. In this study, we investigated if MCC expresses nAChRs and if nAChR expression correlates with patient characteristics.Methods: The study included 71 MCC cases diagnosed with sufficient tissue available to perform immunohistochemical analysis. The median follow-up was 29.8 months (range, 2.7-234.1). We performed immunohistochemistry using antibodies against the α3, α5, and α7nAChR subunits.Results: Our results show that the majority of MCC cases expressed α3, α5, and α7-nAChR subunits. Of the 71 cases, 59 (83%) expressed α3-nAChR, 71 (100%) expressed α5-nAChR, and 63 (88%) expressed α7-nAChR. Location of immunoreactivity differed between cases and included cytoplasmic only and nuclear/peri-nuclear, with variation in the intensity of staining. There were significant correlations between the intensity or location of immunoreactivity and clinical and histopathologic parameters.Conclusions: These findings seem to support that MCC displays the features of neural crest cells, and suggest the potential for nAChR-targeted therapy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blue Nevus-Like Metastatic Melanoma in a Patient With Primary Lentigo Maligna Melanoma. 原发性黄斑性恶性黑色素瘤患者的蓝色痣样转移性黑色素瘤。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-01-08 DOI: 10.1111/cup.14765

Kristen Fernandez, Mitul B Modi, Jodi J Speiser

{"title":"Blue Nevus-Like Metastatic Melanoma in a Patient With Primary Lentigo Maligna Melanoma.","authors":"Kristen Fernandez, Mitul B Modi, Jodi J Speiser","doi":"10.1111/cup.14765","DOIUrl":"https://doi.org/10.1111/cup.14765","url":null,"abstract":"Metastatic melanoma with unusual histopathology can be diagnostically challenging. One exceptionally rare cutaneous manifestation of metastases is blue-nevus-like metastatic melanoma (BNLMM). A 74-year-old male presented with a blue-gray lesion on his left helix in the same anatomical region of a previously resected lentigo maligna. Histopathological sections demonstrated an atypical biphasic proliferation of dendritic melanocytes with pigment incontinence and epidermal sparing, measuring > 0.05 mm in diameter. Although the majority of the cell population exhibited cytologic features consistent with a blue nevus, there was a subset of dendritic cells with irregular epithelioid contours and rare, typical dermal mitotic figures. Sections showed an increased Mart-1/Ki67 rate. Perineural and angiotropic involvement by the atypical melanocytes was identified. Immunohistochemical (IHC) stains for SOX-10, HMB45, and PRAME highlighted melanocytic proliferation. BAP-1 IHC was retained, and p16 IHC showed complete loss. No previous procedure site changes were present, indicating that the dendritic cell proliferation was separated from the primary invasive melanoma by normal dermis. The histopathological and immunohistochemical findings led to a diagnosis of microsatellite BNLMM. We report this case to highlight the importance of this rare entity and to avoid misdiagnosis of BNLMM, which would significantly impact patient prognosis, treatment, follow-up, and outcomes.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White Depressed Areas and Tumor Infiltrating Lymphocytes: The Cancer Cure That Lies Within? 白色凹陷区与肿瘤浸润淋巴细胞：癌症的治疗方法？

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-01-07 DOI: 10.1111/cup.14768

George F Murphy

引用次数: 0

Martin C. Mihm, Jr. and Dermatopathology Education at Harvard Medical School. Martin C. Mihm, Jr.和哈佛医学院的皮肤病理学教育。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-01-07 DOI: 10.1111/cup.14747

Lyn M Duncan, Steven R Tahan, Mai P Hoang, George F Murphy

引用次数: 0

Aging Skin: A Dermatitis To Which All Flesh Is Heir? 皮肤老化：一种所有肉体都继承的皮炎？

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-01-07 DOI: 10.1111/cup.14756

George F Murphy

{"title":"Aging Skin: A Dermatitis To Which All Flesh Is Heir?","authors":"George F Murphy","doi":"10.1111/cup.14756","DOIUrl":"https://doi.org/10.1111/cup.14756","url":null,"abstract":"The human body is composed mostly of water fortified by a variety of proteins, fats, carbohydrates, vitamins, minerals, and other nutrients, all organized into an elegant structurally complex and functionally efficient machine in which our consciousness resides. This heterogeneous assemblage of essential ingredients is enclosed in a container known as the integument, or simply, the skin. The container is as important as its contents; when itself devoid of structural and functional integrity, it will both leak as well as become infused with potentially harmful external agents. As we age, skin loses its integrity, and over time it is not unreasonable to conceive of the skin as becoming progressively \"leaky.\" With this deterioration, skin becomes dry, scaly, accessible to microbes, pruritic, and inflamed, the latter setting up the potentially vicious cycle known as \"inflammaging.\" One major example of the effects of chronological aging on the barrier function of skin involves depletion of filaggrin, a 37-kD histidine-rich protein which originates within keratohyaline granules of the epidermis. Some of the consequences of age-related filaggrin depletion may be inferred by experiments of nature known as ichthyosis vulgaris and atopic dermatitis (AD), the latter with atopy being the most common inflammatory disease worldwide. In AD, loss of function mutations in the FLG gene encoding for the filaggrin precursor, profilaggrin, are associated with skin that, as with aging, is also dry, scaly, accessible to microbes, pruritic and inflamed. In this mini-review, AD will be compared and contrasted with aging in terms of the consequences of deficient filaggrin barrier function. The goal is to enhance recognition that one of the most clinically symptomatic and visible signs of aging is a subtle yet ubiquitous form of \"dermatitis\" due to \"leaky\" skin, one that may be addressed therapeutically with smart combinatorial strategies that restore the molecular basis for skin barrier dysfunction.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0