Journal of Cutaneous Pathology最新文献_第2页

Melanoma Diagnosis in the Mihm Era-And Beyond. 米姆时代及其后的黑色素瘤诊断。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-03 DOI: 10.1111/cup.14742

David E Elder

{"title":"Melanoma Diagnosis in the Mihm Era-And Beyond.","authors":"David E Elder","doi":"10.1111/cup.14742","DOIUrl":"https://doi.org/10.1111/cup.14742","url":null,"abstract":"During the illustrious career of Martin C. Mihm Jr., MD, the diagnosis of melanoma underwent significant changes, to which he made many contributions. In early descriptions, melanomas were fungating tumor masses that were obviously malignant, and highly lethal. In seminal work by Dr. Mihm and his mentor, Wallace H. Clark, Jr., MD, the early phases of development of these neoplasms were recognized and distinguished from the more advanced disease. It was generally believed that the early stage of melanoma, termed radial growth phase (RGP) and characterized by absence of vertical growth phase (VGP) and by favorable microstaging attributes could be recognized, excised, and cured, thus preventing the development of advanced disease. However, strenuous efforts in this direction over several decades have resulted in little or no change in mortality, leading to the recognition that many of these neoplasms, at least, may not be true biological malignancies, and to the conclusion that overdiagnosis commonly occurs in this disease, which is defined as representing diagnosis as melanoma of a neoplasm that would not have had the capacity to cause death or symptoms in the lifetime of the host. Although there may be other subsets of neoplasms in this category, an important category of overdiagnosis in melanomas is concentrated in T1a melanomas that lack VGP. If these neoplasms can be recognized with sensitive and specific criteria, which may already be available, changes in terminology may be appropriate, recognizing that some of them may have low malignant potential, whereas others may have no capacity at all for metastasis and may not warrant the use of the term \"melanoma.\"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquired Epidermodysplasia Verruciformis With HPV5 RNA Expression Using RNA Chromogenic In Situ Hybridization. 利用 RNA 染色原位杂交技术发现伴有 HPV5 RNA 表达的后天性疣状表皮增生症

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-11-03 DOI: 10.1111/cup.14746

Jonathan Lai, Jaroslaw Jedrych

引用次数: 0

Line-Field Confocal Optical Coherence Tomography Imaging of Psoriasis With Histopathology Correlation. 银屑病的线场共焦光学相干断层成像与组织病理学相关性。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-29 DOI: 10.1111/cup.14734

Anna Elisa Verzì, Francesco Lacarrubba, Maria Letizia Musumeci, Rosario Caltabiano, Giuseppe Micali

{"title":"Line-Field Confocal Optical Coherence Tomography Imaging of Psoriasis With Histopathology Correlation.","authors":"Anna Elisa Verzì, Francesco Lacarrubba, Maria Letizia Musumeci, Rosario Caltabiano, Giuseppe Micali","doi":"10.1111/cup.14734","DOIUrl":"https://doi.org/10.1111/cup.14734","url":null,"abstract":"Line-field confocal optical coherence tomography (LC-OCT) is a novel imaging technique for in vivo examination of the skin that has recently been introduced in the dermatologic armamentarium of non-invasive diagnostic tools. Its usefulness in the diagnosis and treatment monitoring of some neoplastic, inflammatory, and infectious skin conditions has been demonstrated. The aim of this study was to evaluate the LC-OCT features of psoriasis in a large number of psoriatic plaques along with their histopathologic correlation. In this retrospective study, the LC-OCT and the corresponding histopathologic images of 100 psoriatic plaques of the trunk, upper and lower arms from 60 patients that underwent both procedures were evaluated and correlated. The following microscopic findings, typical of plaque psoriasis, were observed at both LC-OCT and histopathology: hyperkeratosis, parakeratosis, acanthosis, papillomatosis and vascular changes, Munro microabscesses, and pustules of Kogoj. The LC-OCT findings perfectly matched with histopathology. Our study confirms the usefulness of this new imaging technique in the non-invasive visualization of the common diagnostic clues of psoriasis.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature. 与先天性白细胞介素 17A 受体阻断有关的脓皮病：两例病例的报告和文献综述。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-27 DOI: 10.1111/cup.14740

Cynthia M Magro, Neil Crowson, Taylor Kalomeris, Gerard Nuovo

{"title":"Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature.","authors":"Cynthia M Magro, Neil Crowson, Taylor Kalomeris, Gerard Nuovo","doi":"10.1111/cup.14740","DOIUrl":"https://doi.org/10.1111/cup.14740","url":null,"abstract":"Pyoderma gangrenosum (PG) is a rare necrotizing neutrophilic dermatosis driven by monokines and cytokines elaborated by monocytes and autoreactive T cells, respectively. Th1-mediated autoimmune disorders and myeloproliferative disease are among the potential disease associations. More recently, certain medications were implicated, including TNF-alpha inhibitors, rituximab, and IL-17A inhibitors, such as secukinumab, where the development of PG is held to represent a cutaneous immune adverse effect. We present two patients who developed an autoinflammatory syndrome resembling PG in the setting of drug therapy with agents exhibiting an IL-17A inhibitory effect. The drugs were erunumab in one and secukinumab in the other. One patient received the anti-calcitonin gene-related peptide targeted therapy, erenumab, for migraine prophylaxis. While this drug has not been previously implicated in the development of PG, it can cause IL-17A blockade. The other patient was on secukinumab, a monoclonal antibody that selectively targets IL-17A. We documented a microenvironment enriched in IL-17A, emphasizing that the blockade impacts the functionality of the receptor as opposed to a quantitative reduction in IL-17A production by T cells. Qualitative functional IL-17A blockade could result in a paradoxical increase in IL-23, a pro-inflammatory cytokine that may contribute to the influx of neutrophils pathogenetically implicated in PG.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spitz-Type Proliferative Nodules Arising Within a Large Congenital Melanocytic Nevus Harboring a Novel LMNA-RAF1 Fusion. 先天性黑色素细胞痣中出现的斯皮茨型增殖性结节，携带一种新型 LMNA-RAF1 融合体。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-26 DOI: 10.1111/cup.14741

Gautham Vellaichamy, Janet Poulik, Nallasivam Palanisamy, Olena Kis, Xiaolan Fang, Khaleel I Al-Obaidy, Tor A Shwayder, Ben J Friedman

引用次数: 0

Immunohistochemical Expression of Immune Regulatory Proteins in Interface Dermatoses. 界面皮肤病中免疫调节蛋白的免疫组化表达。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-25 DOI: 10.1111/cup.14736

Sarah Grace McAlpine, Donna Culton, Michael Duplisea, Zhi Liu, Si On Lim, Paul Googe

{"title":"Immunohistochemical Expression of Immune Regulatory Proteins in Interface Dermatoses.","authors":"Sarah Grace McAlpine, Donna Culton, Michael Duplisea, Zhi Liu, Si On Lim, Paul Googe","doi":"10.1111/cup.14736","DOIUrl":"https://doi.org/10.1111/cup.14736","url":null,"abstract":"Cutaneous immune-related adverse events (irAEs) of immunotherapies, such as anti-programmed cell death protein-1 (PD-1), suggest that immune checkpoint factors may contribute to the pathobiology of lichenoid interface dermatitis in immunotherapy-naïve patients. Our study aimed to describe innate and adaptive immune markers via immunohistochemical (IHC) staining of lichenoid interface dermatoses. We studied the staining patterns of PD-L1, STING, IL-36 gamma, CD8, PD-1, and LAG-3 in five interface dermatoses: oral lichen planus (LP) (n = 10), cutaneous LP (n = 10), chronic cutaneous lupus erythematosus (CLE) (n = 11), erythema multiforme (EM) (n = 11), and toxic epidermal necrolysis (TEN) (n = 13), by immunohistochemistry (IHC) analysis. Expression was evaluated semi-quantitively according to the percentage of keratinocytes and dermal lymphocytes stained compared to keratinocytes and resident pericapillary lymphocytes in normal human skin. All interface dermatoses evaluated showed increased expression of PD-L1 on keratinocytes and LAG-3 in lymphocytes. STING was increased on the keratinocytes of most specimens. Expression of IL-36 gamma, in basal layer keratinocytes was more extensive in oral LP and cutaneous LP and varied in CLE, EM, and TEN. Lymphocytic infiltration expressing PD-1 was elevated in oral LP, cutaneous LP, and CLE. Current thinking is that interface dermatitis is the result of a cell-mediated immune reaction involving cytotoxic CD8+ T-cell-mediated apoptosis of keratinocytes. The findings of this study suggest that in addition to cell-mediated immunity, innate immune factors may contribute to pathobiology.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thymoma-Associated Multiorgan Autoimmunity (TAMA) Presenting as a Graft Versus Host Disease-Like Erythroderma. 胸腺瘤相关多器官自身免疫（TAMA）表现为移植物抗宿主疾病样红斑。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-23 DOI: 10.1111/cup.14743

Noah Hewitt, Brooke Bertus, William Farmer, Katrin Kiavash, Colleen Beatty, Roxann Powers

引用次数: 0

Compound Follicles in Folliculitis Decalvans Do Not Contain Vellus and Retained Telogen Follicles-A Pilot Histopathologic Series on Polytrichia. 蜕皮性毛囊炎中的复合毛囊不包含绒毛和残留的脱发毛囊--关于多毛孢子菌的试验性组织病理学系列研究。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-22 DOI: 10.1111/cup.14735

Juwon Lee, Mariya Miteva

{"title":"Compound Follicles in Folliculitis Decalvans Do Not Contain Vellus and Retained Telogen Follicles-A Pilot Histopathologic Series on Polytrichia.","authors":"Juwon Lee, Mariya Miteva","doi":"10.1111/cup.14735","DOIUrl":"https://doi.org/10.1111/cup.14735","url":null,"abstract":"Background: Polytrichia is a common clinical and trichoscopic feature in folliculitis decalvans (FD) that morphologically corresponds to compound follicular structures (CFS) of six or more follicles sharing a single infundibulum, surrounded by fibrosis.Objectives: To characterize the type of follicles in the CFS in scalp biopsy specimens from FD.Methods: We retrospectively reviewed 10 scalp biopsy specimens obtained by using the trichoscopy-guided approach from the affected scalp of patients diagnosed with early-stage FD between 2018 and 2023. We assessed the number and type of follicles within the CFS on horizontal sections.Results: The total number of assessed follicles was 205, out of which 159 were part of CFS. Of those, 156 were terminal follicles (146 anagen and ten telogen), three intermediate, and zero vellus follicles. Other common findings included dense mixed cell infiltrate consisting of histiocytes, plasma cells, lymphocytes, neutrophils, and eosinophils; psoriasiform hyperplasia; and fragmented hair shafts.Conclusions: We show that CFS in FD are composed largely of terminal anagen follicles. This may help with further understanding of the disease.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pacinioma of Lumbosacral Skin in Closed Spinal Dysraphism. 闭合性脊椎发育不良的腰骶部皮肤acinioma。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-20 DOI: 10.1111/cup.14733

Bryan Johnston, Katelynn Campbell

{"title":"Pacinioma of Lumbosacral Skin in Closed Spinal Dysraphism.","authors":"Bryan Johnston, Katelynn Campbell","doi":"10.1111/cup.14733","DOIUrl":"https://doi.org/10.1111/cup.14733","url":null,"abstract":"Closed spinal dysraphism (CSD) is a congenital condition caused by a failure in secondary neurulation during embryogenesis. CSD is associated with characteristic cutaneous stigmata often identified clinically. Rarely, such stigmata have been reported to occur with complex congenital intraspinal lipomas containing Pacinian corpuscle hyperplasia. Herein, we present our case of an asymptomatic 8-month-old female who presented with a midline lumbosacral acrochordon-like lesion. MRI revealed a midline lipomatous lesion at S2-S3 with a fibrovascular stalk likely continuous with the acrochordon. Given the absence of neurological symptoms concerning tethered cord syndrome (TCS), only the skin lesion was removed for cosmesis. Subsequent histopathological examination revealed numerous Pacinian corpuscles in a background of dermal collagen and subcutaneous adipose tissue. No features suggested a co-existent peripheral nerve sheath lesion (such as a neurofibroma). Given the spinal cord abnormalities, and the histologic features of a pure proliferation of Pacinian corpuscles, a diagnosis of the so-called \"Pacinioma\" was made. To the best of our knowledge, only four other cases of complex intraspinal lipomatous lesions containing Pacinioma in the setting of CSD with a tethered cord have been previously reported. This case highlights the complexity of the cutaneous stigmata of CSD.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisystem ALK-Positive Histiocytosis With DCTN1::ALK Fusion in an Adult, Responsive to Alectinib: Case Report and Literature Review. 成人多系统 ALK 阳性组织细胞增生症伴 DCTN1::ALK 融合，对 Alectinib 有反应：病例报告和文献综述。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2024-10-15 DOI: 10.1111/cup.14732

Gregory S Phillips, Maxwell Knapp, Keith C Olsen, William Martin, Brandon Hayes-Lattin, Jina Chung

{"title":"Multisystem ALK-Positive Histiocytosis With DCTN1::ALK Fusion in an Adult, Responsive to Alectinib: Case Report and Literature Review.","authors":"Gregory S Phillips, Maxwell Knapp, Keith C Olsen, William Martin, Brandon Hayes-Lattin, Jina Chung","doi":"10.1111/cup.14732","DOIUrl":"https://doi.org/10.1111/cup.14732","url":null,"abstract":"Anaplastic lymphoma kinase (ALK)-positive histiocytosis has emerged as a clinically relevant diagnosis featuring a wide span of clinical presentations, which are unified by the presence of ALK-positive histiocytes on histopathology and molecular drivers involving the ALK kinase gene. This report presents an adult case of multisystem ALK-positive histiocytosis with xanthogranuloma-like features on histopathology that was responsive to ALK inhibition, and includes a review of ALK-positive histiocytoses with cutaneous involvement reported in the literature. A 56-year-old male developed a widespread eruption of red-brown papules on the face, trunk, and upper extremities. Histopathological evaluation revealed a well-circumscribed, nodular dermal infiltrate of epithelioid histiocytes with Touton giant cells, rare bizarre multinucleated cells, and focal emperipolesis. The lesional cells were positive for CD68 and ALK1 immunohistochemical stains, and negative for CD1a. Next-generation sequencing identified a DCTN1::ALK fusion. On imaging, he was found to have bone, lung, soft tissue, and salivary gland involvement. ALK inhibition was initiated with alectinib, resulting in rapid improvement of cutaneous lesions and eventual complete resolution of abnormal imaging findings, which was sustained at 24 months of follow-up. This case adds to the spectrum of ALK-positive histiocytoses and further demonstrates the positive response with targeted therapy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0