Journal of Cutaneous Pathology最新文献

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Griscelli Syndrome Type 2 Secondary to a Novel RAB27A Variant Presenting With Dermatitis Griscelli综合征2型继发于一种新的RAB27A变异,表现为皮炎。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-22 DOI: 10.1111/cup.14812
Dharmagat Bhattarai, Aaqib Zaffar Banday, Smita Joshi, Ram Chandra Adhikari, Iftikhar Ali, Mohsin Rashid, Altaf Hussain Kambay
{"title":"Griscelli Syndrome Type 2 Secondary to a Novel RAB27A Variant Presenting With Dermatitis","authors":"Dharmagat Bhattarai, Aaqib Zaffar Banday, Smita Joshi, Ram Chandra Adhikari, Iftikhar Ali, Mohsin Rashid, Altaf Hussain Kambay","doi":"10.1111/cup.14812","DOIUrl":"10.1111/cup.14812","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"459-461"},"PeriodicalIF":1.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nail Unit Amyloidoma With Prominent Onycholemmal Cysts Masquerading as Malignancy 甲单位淀粉样瘤伴突出的甲乳头囊肿伪装成恶性肿瘤
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-21 DOI: 10.1111/cup.14816
Blaire A. Anderson, Corinne Rauck, Meaghan C. Dougher, Adam I. Rubin
{"title":"Nail Unit Amyloidoma With Prominent Onycholemmal Cysts Masquerading as Malignancy","authors":"Blaire A. Anderson, Corinne Rauck, Meaghan C. Dougher, Adam I. Rubin","doi":"10.1111/cup.14816","DOIUrl":"https://doi.org/10.1111/cup.14816","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 6","pages":"393-398"},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Concomitant Langerhans Cell Histiocytosis in a Patient With Folliculotropic Mycosis Fungoides 嗜滤泡性蕈样真菌病罕见合并朗格汉斯细胞组织细胞增多症。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-19 DOI: 10.1111/cup.14811
Cristo A. Carrasco Mendoza, Isabel Arana, David S. Cassarino
{"title":"Rare Concomitant Langerhans Cell Histiocytosis in a Patient With Folliculotropic Mycosis Fungoides","authors":"Cristo A. Carrasco Mendoza,&nbsp;Isabel Arana,&nbsp;David S. Cassarino","doi":"10.1111/cup.14811","DOIUrl":"10.1111/cup.14811","url":null,"abstract":"<div>\u0000 \u0000 <p>The relationship between lymphomas such as mycosis fungoides and Langerhans cell histiocytosis (LCH) is exceedingly rare. Cases reported in the literature describe lymphomas preceding a diagnosis of LCH, as well as LCH followed by a diagnosis of lymphoma. Here, we present a 76-year-old patient with a years-long history of recalcitrant folliculotropic mycosis fungoides (FMF) who presented to the outpatient dermatology clinic with newly developed painful and itchy cutaneous nodules. Subsequent flow cytometry showed no evidence of Sezary syndrome. NM PET/CT FDG showed no systemic involvement but revealed areas of intense FDG uptake in multiple sites. Biopsy from one of these sites revealed dense, nodular atypical lymphohistiocytic infiltrate and several large intrafollicular Langerhans cell collections, consistent with LCH. Immunohistochemical staining was strongly and diffusely positive for S100, Langerin, and CD1a, confirming the diagnosis of LCH. This is a very rare and unusual case of a patient with FMF who subsequently developed LCH. We emphasize the importance of distinguishing mycosis fungoides from LCH using histopathological, immunohistochemical, and clinical findings. Additionally, we encourage the differentiation between reactive Langerhans cell hyperplasia and neoplastic, malignant LCH and to consider repeat biopsies as appropriate.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"474-477"},"PeriodicalIF":1.6,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatally Metastatic Diagnostic Pitfall: Pseudolymphomatous Epithelioid Cutaneous Angiosarcoma Arising From an Ulcerative Scalp Injury 致命转移性诊断缺陷:由溃疡性头皮损伤引起的假淋巴瘤上皮样皮肤血管肉瘤。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-10 DOI: 10.1111/cup.14813
Michelle Y. Zhu, Mahyar Khazaeli
{"title":"Fatally Metastatic Diagnostic Pitfall: Pseudolymphomatous Epithelioid Cutaneous Angiosarcoma Arising From an Ulcerative Scalp Injury","authors":"Michelle Y. Zhu,&nbsp;Mahyar Khazaeli","doi":"10.1111/cup.14813","DOIUrl":"10.1111/cup.14813","url":null,"abstract":"<div>\u0000 \u0000 <p>Rare morphological variants of cutaneous angiosarcoma (AS) can be diagnostically challenging. Angiosarcoma located on the head and scalp of the elderly has been associated with especially poor prognosis. We report a difficult diagnostic pitfall of pseudolymphomatous AS variant with overlapping features of epithelioid variant and aberrant immunohistochemistry staining, arising on an ulcerative scalp lesion in a 79-year old woman. Initial histopathological exam showed extensive cutaneous necrosis with prominent dermal inflammation within which, scattered large cells were CD31 positive and CD34 negative. After cutaneous lymphoma was ruled out, these large cells within the inflammatory infiltrate were determined to be dermal histiocytes and initial biopsy was diagnosed as benign. Subsequent re-biopsy showed similar features and was also called benign. Post-mortem re-review found the large cells were positive for ERG and formed solid clusters and papillae in some areas. A diagnosis of pseudolymphomatous epithelioid AS was rendered. Autopsy demonstrated lung nodules to be metastatic AS, consistent with findings from scalp primary. Our case draws attention to multiple features that can confound angiosarcoma diagnosis, and we discuss the appropriate endothelial IHC panel to rule out angiosarcoma in this clinical context.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"469-473"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Cutaneous Anaplastic Large Cell Lymphoma With TCR-γδ Expression: A Case Series of Eleven Patients of a Rare Immunophenotypic Variant 原发性皮肤间变性大细胞淋巴瘤伴TCR-γδ表达:11例罕见免疫表型变异患者
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-09 DOI: 10.1111/cup.14809
Anna Sarah Erem, Werner Kempf, Christina Mitteldorf, Melissa Pulitzer, Carlos A Torres-Cabala, Stefano Pileri, Socorro Maria Rodriguez Pinilla, Andrew L. Feldman, Alejandro A. Gru
{"title":"Primary Cutaneous Anaplastic Large Cell Lymphoma With TCR-γδ Expression: A Case Series of Eleven Patients of a Rare Immunophenotypic Variant","authors":"Anna Sarah Erem,&nbsp;Werner Kempf,&nbsp;Christina Mitteldorf,&nbsp;Melissa Pulitzer,&nbsp;Carlos A Torres-Cabala,&nbsp;Stefano Pileri,&nbsp;Socorro Maria Rodriguez Pinilla,&nbsp;Andrew L. Feldman,&nbsp;Alejandro A. Gru","doi":"10.1111/cup.14809","DOIUrl":"10.1111/cup.14809","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Primary cutaneous anaplastic large cell lymphoma (pcALCL) and lymphomatoid papulosis (LyP) are indolent CD30-positive lymphoproliferative disorders that rarely express TCR-γδ. However, primary cutaneous gamma-delta T-cell lymphoma (pcGDTCL), characterized by TCR-γδ expression on neoplastic cells, is a rare, aggressive cutaneous T-cell lymphoma with a poor prognosis. Accurate differentiation is essential due to distinct clinical behavior and treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We identified 11 TCR-γδ-positive pcALCL cases from internal and consultation files, verified by two cutaneous lymphoma experts, with clinicopathologic data recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age was 68 years (range 38–95). Most cases presented as a single dermal lesion on the upper extremities. All were ALK-negative, CD30-positive (&gt; 90% tumor cells), TCR-βF1-negative, and diffusely TCR-γδ-positive. CD4−/CD8− (54.5%) and CD4+/CD8− (45.5%) immunophenotypes were observed. CD2 (63.6%) and CD3 (54.5%) were the most common T-cell antigens. Ulceration, inflammation (both 45.5%), and necrosis (36.4%) were frequent. Angiotropism, angiocentricity, and myxoid stroma appeared in one case; epidermotropism in two. Four of ten tested were <i>DUSP22</i>-rearranged, and TP63 was negative in all eight tested.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Most ALK-negative TCR-γδ-positive pcALCL were CD4−/CD8−, followed by CD4+/CD8−. <i>DUSP22</i> rearrangement occurred in 40% of cases, similar to reports in typical pcALCL. Its prognosis and the role of <i>DUSP22</i> are yet to be clarified.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"487-496"},"PeriodicalIF":1.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathologic Evaluation of Density and Depth of the Lymphoid Infiltrate in Clinically Defined Patches and Plaques in Early Stage Mycosis Fungoides 早期蕈样真菌病临床定义斑块和斑块中淋巴浸润密度和深度的组织病理学评估。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-08 DOI: 10.1111/cup.14810
Juliette M. Kersten, Rosanne Ottevanger, Thom Doeleman, Pieter A. Valkema, Anne M. R. Schrader, Patty M. Jansen, Maarten H. Vermeer, Rein Willemze
{"title":"Histopathologic Evaluation of Density and Depth of the Lymphoid Infiltrate in Clinically Defined Patches and Plaques in Early Stage Mycosis Fungoides","authors":"Juliette M. Kersten,&nbsp;Rosanne Ottevanger,&nbsp;Thom Doeleman,&nbsp;Pieter A. Valkema,&nbsp;Anne M. R. Schrader,&nbsp;Patty M. Jansen,&nbsp;Maarten H. Vermeer,&nbsp;Rein Willemze","doi":"10.1111/cup.14810","DOIUrl":"10.1111/cup.14810","url":null,"abstract":"&lt;p&gt;Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL) [&lt;span&gt;1&lt;/span&gt;]. In most patients, MF runs an indolent clinical course for years to decades, but in approximately 25% of patients, progression to advanced-stage MF is observed [&lt;span&gt;2, 3&lt;/span&gt;]. The prognosis of MF depends on the type and extent of skin lesions and the presence of extracutaneous disease. Early-stage MF is characterized by the presence of patches and/or plaques covering less than 10% (stage IA) or 10% or more of the body surface area (stage IB). Several studies reported that patients presenting with both patches and plaques have a higher risk of progression to advanced-stage MF and a worse survival than patients presenting with only patches [&lt;span&gt;3-5&lt;/span&gt;]. Therefore, the distinction between patches and plaques is clinically relevant, but it can be difficult due to a lack of standardized and reproducible criteria [&lt;span&gt;6&lt;/span&gt;]. In the current classification system, differentiation between patches and plaques is based exclusively on clinical examination. Patches are defined as skin lesions without significant elevation or induration, while plaques are defined as skin lesions with elevation or induration [&lt;span&gt;7&lt;/span&gt;]. However, this definition is subjective and prone to considerable inter-observer variability [&lt;span&gt;6&lt;/span&gt;]. Previous studies on folliculotropic MF (FMF) found that a clinicopathologic approach, combining clinical and histopathological criteria, can facilitate the distinction between early and advanced plaque-stage disease [&lt;span&gt;8, 9&lt;/span&gt;]. At recent meetings, the question was raised whether histopathologic criteria, in particular the extent and depth of the infiltrates, could also facilitate the distinction between patches and plaques in classical MF. The infiltrates in plaques in classical MF are indeed generally denser and deeper than in patches [&lt;span&gt;6, 10&lt;/span&gt;]. However, studies investigating whether these differences may contribute to a more reliable distinction between patches and plaques have not been published thus far. In the present study, we investigated the extent and depth of the infiltrate in patches and plaques in classic MF to find out if these histopathological criteria can serve as an adjunct to differentiate between these two types of lesions.&lt;/p&gt;&lt;p&gt;Using a database of scanned HE stained sections obtained from pretreatment biopsies of patients with early-stage classical MF, 100 cases with variable extent and depth of the infiltrates were selected without knowledge of the clinical data. Corresponding clinical records and clinical images of the biopsied lesions were evaluated and, blinded to the histopathologic characteristics, scored as either patch or plaque by three individual dermatologists using ISCL/EORTC criteria described previously [&lt;span&gt;7&lt;/span&gt;]. In case of discrepancy (&lt; 5% of lesions) cases were discussed together and consensus was reached. In the total group of 100 cases with ear","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 6","pages":"406-409"},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypopigmented Junctional BAP1-Inactivated Melanocytoma: A Paradigm Shift 低色素沉着的连接bap1失活黑色素细胞瘤:一种范式转变。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-06 DOI: 10.1111/cup.14808
Ali Gunesch, Iwei Yeh, Timothy McCalmont, Elizabeth Berry, Gretchen Vanderbeek, Kevin P. White
{"title":"Hypopigmented Junctional BAP1-Inactivated Melanocytoma: A Paradigm Shift","authors":"Ali Gunesch,&nbsp;Iwei Yeh,&nbsp;Timothy McCalmont,&nbsp;Elizabeth Berry,&nbsp;Gretchen Vanderbeek,&nbsp;Kevin P. White","doi":"10.1111/cup.14808","DOIUrl":"10.1111/cup.14808","url":null,"abstract":"<div>\u0000 \u0000 <p>Since their original description by Wiesner et al., the spectrum of clinical, histopathologic, and molecular findings of BAP1 (BRCA1-associated protein 1)-inactivated melanocytomas has been more fully characterized. Herein, we report an exceptional presentation of multiple junctional melanocytic BAP1-inactivated melanocytomas with a clinically hypopigmented appearance in a patient. Targeted DNA sequencing demonstrated the same <i>BAP1</i> frameshift mutation (<i>BAP1</i> p.R59f) in three different lesions. One of the specimens also displayed two truncating mutations in <i>NF1</i> (<i>NF1 p.Q129*</i> and <i>NF1 p.Q1801*</i>) at 8%–9% mutant allele frequency. To our knowledge, BIM confined entirely to the epidermis, and multiple BIMs presenting in hypopigmented fashion have not been widely reported previously.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 6","pages":"428-431"},"PeriodicalIF":1.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic Features of Penile Ulceration in Malignant Atrophic Papulosis: A Case Report and Review of the Literature 恶性萎缩性丘疹病阴茎溃疡的临床病理特征:1例报告及文献复习。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-04 DOI: 10.1111/cup.14805
Matthew H. Lanehart, Brooke Bertus, Patrick J. Bacaj, Michael S. Kolodney, Colleen J. Beatty
{"title":"Clinicopathologic Features of Penile Ulceration in Malignant Atrophic Papulosis: A Case Report and Review of the Literature","authors":"Matthew H. Lanehart,&nbsp;Brooke Bertus,&nbsp;Patrick J. Bacaj,&nbsp;Michael S. Kolodney,&nbsp;Colleen J. Beatty","doi":"10.1111/cup.14805","DOIUrl":"10.1111/cup.14805","url":null,"abstract":"<div>\u0000 \u0000 <p>Degos disease, or malignant atrophic papulosis (MAP), is a rare vasculopathic disorder that commonly involves the skin, gastrointestinal tract, and central nervous system. Diagnosis is made through recognition of characteristic histopathologic features of cutaneous lesions. Here, we report a 58-year-old male who initially presented with a penile eschar exhibiting vascular dilation, hyalinization of superficial dermal vessels, and hemosiderin deposition. Later, he developed scattered erythematous papules with central porcelain-white scarring; biopsies of these lesions exhibited features histopathologically consistent with MAP, including wedge-shaped necrosis extending from the epidermis into the deep dermis, dermal mucinosis, and vascular occlusion. Our patient subsequently developed multiple bowel perforations and ultimately succumbed to the disease. Recognition of various distinctive histopathologic features, including the diverse findings associated with penile ulceration, is important for prompt diagnosis and early initiation of treatment. As such, we review the clinicopathologic features reported in penile ulcerations among patients with MAP.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 6","pages":"423-427"},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shifts in Cutaneous Melanocytic Tumor Diagnostic Terminology: Melanocytoma, MPATH-Dx V2.0 and the WHO Skin5. 皮肤黑色素细胞肿瘤诊断术语的转变:黑色素细胞瘤》、《MPATH-Dx V2.0》和《世界卫生组织皮肤5》。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-04-04 DOI: 10.1111/cup.14788
Lyn M Duncan, David E Elder, Michael W Piepkorn, Stevan R Knezevich, Willeke A M Blokx, Marcus Bosenberg, Klaus J Busam, Richard Carr, Martin G Cook, Pedram Gerami, Jennifer Ko, Gilles Landman, Alexander J Lazar, Lori Lowe, Daniela Mihic-Probst, Birgitta Schmidt, Christopher R Shea, Richard A Scolyer, Xiaowei Xu, Joann G Elmore, Raymond L Barnhill
{"title":"Shifts in Cutaneous Melanocytic Tumor Diagnostic Terminology: Melanocytoma, MPATH-Dx V2.0 and the WHO Skin5.","authors":"Lyn M Duncan, David E Elder, Michael W Piepkorn, Stevan R Knezevich, Willeke A M Blokx, Marcus Bosenberg, Klaus J Busam, Richard Carr, Martin G Cook, Pedram Gerami, Jennifer Ko, Gilles Landman, Alexander J Lazar, Lori Lowe, Daniela Mihic-Probst, Birgitta Schmidt, Christopher R Shea, Richard A Scolyer, Xiaowei Xu, Joann G Elmore, Raymond L Barnhill","doi":"10.1111/cup.14788","DOIUrl":"https://doi.org/10.1111/cup.14788","url":null,"abstract":"<p><p>In this Special Issue of the Journal of Cutaneous Pathology in memory of Dr. Martin C. Mihm, Jr, we highlight his many contributions over more than 50 years to the catalog of specific melanocytic tumor terminology. Dr. Mihm was an active participant in the International Melanoma Pathology Study Group (IMPSG). Discussions led to proposed recommendations for changes in the terminology of melanocytic tumors and their standardized diagnostic reporting. Histopathological reports of melanocytic tumors provide critical information that guides patient counseling and therapy. Importantly the pathology report must relay whether the melanocytic tumor is benign, intermediate, or malignant, and when appropriate, indicate diagnostic and/or prognostic uncertainty. Recent shifts in diagnostic terminology include the recommended use of the term \"melanocytoma\" to describe a morphologically and genetically defined subset of intermediate risk melanocytic tumors with higher (although still very low) risk of progression compared with benign nevi. Melanocytomas are distinguished from melanocytic tumors of uncertain malignant potential (MELTUMP) which are histopathologically indeterminate or uncertain tumors. In the setting of a broad lexicon for the reporting of melanocytic tumors, an assessment tool has been developed to map existing diverse terminologies into distinct hierarchical classes. The Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) V2.0 provides a four-tiered classification scheme that is tiered by risk of tumor progression and recommended treatment. The purpose of this review is to report these shifts in diagnostic terminology, discussed and reviewed at the annual workshop of the IMPSG, in Edinburg, Scotland, in November 2022. This discussion included the use of the term melanocytoma, and the use of the MPATH-Dx V2.0 classification and terminology for melanocytic tumors. Dr. Mihm was diligent in his attention to specific terminology, in his memory we aim to recommend terminology that improves communication in the care of those diagnosed with melanocytic tumors.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathologic Features in Vancomycin-Associated Drug-Induced Hypersensitivity Syndrome 万古霉素相关药物致过敏综合征的组织病理学特征。
IF 1.6 4区 医学
Journal of Cutaneous Pathology Pub Date : 2025-03-25 DOI: 10.1111/cup.14804
Hannah B. Haberecht, Rachel L. Ziebart, Olivia C. Iverson, Austin Todd, Mark D. Davis, David A. Wetter, Julio C. Sartori-Valinotti, Hafsa M. Cantwell, Marian T. McEvoy, Nessa Aghazadeh Mohandesi, Afsaneh Alavi, Emma F. Johnson
{"title":"Histopathologic Features in Vancomycin-Associated Drug-Induced Hypersensitivity Syndrome","authors":"Hannah B. Haberecht,&nbsp;Rachel L. Ziebart,&nbsp;Olivia C. Iverson,&nbsp;Austin Todd,&nbsp;Mark D. Davis,&nbsp;David A. Wetter,&nbsp;Julio C. Sartori-Valinotti,&nbsp;Hafsa M. Cantwell,&nbsp;Marian T. McEvoy,&nbsp;Nessa Aghazadeh Mohandesi,&nbsp;Afsaneh Alavi,&nbsp;Emma F. Johnson","doi":"10.1111/cup.14804","DOIUrl":"10.1111/cup.14804","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Drug-induced hypersensitivity syndrome (DiHS), or drug reaction with eosinophilia and systemic symptoms (DRESS), is a delayed and severe immune response to certain medications. We investigated vancomycin-induced DiHS/DRESS, notable for frequent and severe organ involvement, to describe its specific histopathology and the correlations between histopathologic and clinical findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective review was conducted to identify patients between 2006 and 2022 who received vancomycin, had archived skin biopsy specimens, and were scored as having probable or definite DiHS/DRESS. Clinical features were retrospectively collected, and biopsy specimens were reviewed by a board-certified dermatopathologist. A subset of histopathologic and clinical features was analyzed for statistical correlation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-three patients met the inclusion criteria. Most biopsy specimens (87%) showed an eczematous reaction pattern; 17 (74%) showed a secondary reaction pattern. Spongiosis (87%) and neutrophilic infiltration (91%) were common epidermal characteristics. The dermal inflammatory infiltrate was frequently superficial (87%) and consistently included plasma cells (96%). Eosinophils were present in the dermis in 70% of cases. Parakeratosis negatively correlated with liver involvement and positively correlated with desquamative rash. Epidermal lymphocytes were negatively correlated with the RegiSCAR score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Vancomycin-associated DiHS/DRESS histopathology was characterized by a frequent eczematous reaction pattern, multiple coexisting reaction patterns, and epidermal neutrophilic infiltration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 6","pages":"442-451"},"PeriodicalIF":1.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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