Journal of Cutaneous Pathology最新文献

{"title":"Demographics of U.S. Dermatopathology Fellowship Applicant Interviewees: A Single Institution Descriptive Analysis","authors":"Peter Chow,&nbsp;Lauren F. Rinehart,&nbsp;Emily H. Smith,&nbsp;Kristin Smith,&nbsp;Gillian Heinecke,&nbsp;M. Yadira Hurley,&nbsp;Nicole Burkemper","doi":"10.1111/cup.14855","DOIUrl":"10.1111/cup.14855","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Matching into a dermatopathology fellowship is increasingly competitive; however, the application process is not standardized, and there is little data to guide a successful match. This study aimed to determine the association of various application variables and a successful match into dermatopathology fellowship.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective anonymized data review of dermatopathology fellowship applicants from a single midwestern institution was conducted. Applicant background and demographics were collected and analyzed with various statistical models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 68 applicant interviewees over a 7-year period were included in the analysis, with 62% of interviewees ultimately matching into dermatopathology fellowship. Most applicants attended an allopathic medical school (90.8%) and were trained in pathology (64.7%). There was no significant correlation in gender, medical school background, residency training background, or research productivity. There was a statistically significant correlation of successful matching with higher mean United States Medical Licensing Examination step 2 scores (<i>p</i> value 0.012), but not for step 1 or 3 scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Results of this study show a minimal difference in dermatopathology application traits, suggesting that intangible factors may hold a greater importance for a successful match. This study provides prospective dermatopathology fellowship applicants with a description of application qualities that help to secure an interview.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 11","pages":"704-709"},"PeriodicalIF":1.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting A New Standard for Histopathologic Reporting of Primary Cutaneous Melanoma: Progress Made by the Melanoma Reporting Task Force of the American Society of Dermatopathology","authors":"Adam I. Rubin,&nbsp;Christopher R. Shea,&nbsp;Beth S. Ruben,&nbsp;May P. Chan","doi":"10.1111/cup.14836","DOIUrl":"10.1111/cup.14836","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 10","pages":"595-596"},"PeriodicalIF":1.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14836","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum Pathology Reporting Elements for Melanoma: A Review of Reporting Guidelines and Proposal for Minimum Reporting Elements for a Quality Pathology Report by the Task Force of the American Society of Dermatopathology","authors":"Klaus J. Busam,&nbsp;Lyn M. Duncan,&nbsp;Pedram Gerami,&nbsp;Lori Lowe,&nbsp;Hina Sheikh,&nbsp;Michael Tetzlaff","doi":"10.1111/cup.14848","DOIUrl":"10.1111/cup.14848","url":null,"abstract":"<p>Guidelines have been proposed for the pathology reporting of melanoma to ensure inclusion of data elements important for patient care. Compliance with guidelines has been made a yardstick for quality performance. However, there is controversy about how comprehensive a report must be, which is why the American Society of Dermatopathology has formed a task force with the goal of defining minimum data elements that should be included in a pathology report of a primary cutaneous melanoma. Importantly, additional information can or at times should be documented if a pathologist believes it is valuable to the clinical care team of a particular patient. The proposed minimum reporting guidelines outlined herein largely reflect core reporting elements by various professional organizations. Data elements must be included if they are needed for pathologic staging. Excisions require a margin status, but detailed margin metrics are not required for most cases. Furthermore, histopathologic subtyping of melanoma in situ is not routinely needed. Whether or not invasive melanoma should be subclassified depends on clinical relevance and whether the available evidence permits a definitive melanoma subclassification. When the minimum data elements are included, a pathology report should be considered compliant with quality reporting guidelines.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 10","pages":"655-660"},"PeriodicalIF":1.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRAME Immunohistochemistry for Differentiating Pigmented Lesions of the Vulva and Perineum","authors":"Kasey J. McCollum,&nbsp;Maria Angelica Selim,&nbsp;Michelle Schneider","doi":"10.1111/cup.14850","DOIUrl":"10.1111/cup.14850","url":null,"abstract":"<div>\u0000 \u0000 <p>Special site pigmented lesions often present a diagnostic challenge for clinicians and for pathologists. Lesions of the genital region present even further challenges due to the sensitivity of the anatomic location and preference to defer physical exam and biopsy. Even after biopsy, the diagnostic challenge persists owing to the frequent presence of atypical features in these sites and the technical difficulties associated with performing complete excisions. Immunohistochemistry plays a crucial role in the classification and categorization of these lesions. PRAME (PReferentially expressed Antigen in MElanoma) is a nuclear receptor and transcriptional regulator that regulates cell differentiation, growth, and apoptosis. Immunohistochemistry for PRAME has proven valuable in assisting pathologists to classify various cutaneous melanocytic proliferations all over the human body. Our study sought to investigate the use of PRAME in determining the biologic nature of pigmented lesions of the genital region. A search of medical records identified 53 cases of genital pigmented lesions for review. Each case received MART1 and PRAME IHC for evaluation and classification by two board certified dermatopathologists. The results found that PRAME was negative (zero nuclear staining) in a total of 32 benign lesions (i.e., melanosis including macules and lentigos as well as nevi). One dysplastic nevus showed focal weak PRAME expression in less than 10% of lesional melanocytes. PRAME was overwhelmingly positive (4+ staining, &gt; 75% of nuclei) in 90% of the malignant lesions (i.e., invasive melanoma and melanoma in situ). Overall, we conclude that PRAME remains a valuable tool in the diagnostic workup of diagnosing pigmented lesions of the genital region.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 10","pages":"644-654"},"PeriodicalIF":1.1,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pembrolizumab-Exacerbated Widespread Pigmented Purpuric Dermatosis in an Elderly Patient, a Potential Diagnostic Pitfall Mimicking Pigmented Purpuric Dermatosis-Like Mycosis Fungoides","authors":"Nicole Chang,&nbsp;Yoni Hirsch,&nbsp;Krisztian Nemeth,&nbsp;Susan Pei","doi":"10.1111/cup.14841","DOIUrl":"10.1111/cup.14841","url":null,"abstract":"<div>\u0000 \u0000 <p>Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic lymphocyte-associated antigen-4 (CTLA-4) have revolutionized cancer treatment but are associated with immune-related adverse events, particularly cutaneous toxicities. We report a rare case of pembrolizumab-exacerbated pigmented purpuric dermatosis (PPD) in a 77-year-old male with a history of metastatic non-small cell lung cancer. His rash, initially confined to the lower extremities, worsened and became widespread to involve the trunk after pembrolizumab initiation. Histopathology showed perivascular lymphocytic infiltrate with extravasated erythrocytes without vasculitis, compatible with PPD; however, due to some lymphocyte atypia and exocytosis, together with the clinically widespread lesions, there was initial concern for PPD-like mycosis fungoides (MF). Subsequent T-cell receptor gene rearrangement studies revealed no monoclonal lymphoid population, and the later resolution of the rash with treatments typical for PPD did not support MF. This represents only the second reported case of ICI-associated PPD and highlights a potential diagnostic pitfall with histopathology and clinical presentation mimicking PPD-like MF. Our case contributes to the expanding spectrum of ICI-related cutaneous reactions and underscores the importance of recognizing inflammatory dermatoses with atypical histopathologic features for dermatologists and dermatopathologists.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 11","pages":"676-680"},"PeriodicalIF":1.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of a Combination of Histopathological and Flow Cytometric Analyses for the Diagnosis of Cutaneous Involvement of GATA3+ Peripheral T-Cell Lymphoma, Not Otherwise Specified","authors":"Norihito Suzuki,&nbsp;Takatoshi Shimauchi,&nbsp;Atsuyoshi Ginoza,&nbsp;Reiko Kageyama,&nbsp;Hideo Hashizume,&nbsp;Taisuke Ito,&nbsp;Koichi Ohshima,&nbsp;Tetsuya Honda","doi":"10.1111/cup.14852","DOIUrl":"https://doi.org/10.1111/cup.14852","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 11","pages":"663-666"},"PeriodicalIF":1.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Dermal Myofibroblastoma Emphasizing the Diagnostic Utility of Immunohistochemical Loss of Rb Expression","authors":"Ayana Crawl-Bey,&nbsp;Ryanne A. Brown,&nbsp;Johanna B. Moore","doi":"10.1111/cup.14842","DOIUrl":"10.1111/cup.14842","url":null,"abstract":"<div>\u0000 \u0000 <p>A 74-year-old female presented with a progressively enlarging and intermittently tender hyperpigmented lesion beneath her left rib cage. Physical examination revealed a firm, telangiectatic linear plaque clinically suspected to represent a hypertrophic scar. A shave biopsy was performed. Histologic sections demonstrated a dermal proliferation of plump spindled cells without cytologic atypia, organized in short fascicles interspersed with hyalinized collagen bundles. Immunohistochemical stains revealed CD34, desmin, and smooth muscle actin expression in the lesional cells. SOX10, S100, and Melan-A were negative. Retinoblastoma 1 (Rb) staining demonstrated loss of nuclear expression in the spindle-shaped cells. The findings support a diagnosis of myofibroblastoma, which rarely occurs in the skin. Myofibroblastoma is an uncommon benign mesenchymal neoplasm composed of fibroblasts and myofibroblasts with recurrent monoallelic loss of the 13q14 region, where <i>RB1</i> resides, with resultant loss of Rb expression. Although the differential diagnosis was vast, this case highlights the utility of Rb immunohistochemistry in the diagnosis of cutaneous myofibroblastoma.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 11","pages":"667-670"},"PeriodicalIF":1.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Melanoma Arising in a BAP1-Inactivated Melanocytic Tumor With NRAS Mutation: A Report of Exceptional Case With Emphasis on Its Genomic Features and Review of the Literature","authors":"Muath Alyahya,&nbsp;Nyi Nyi May-Phyo,&nbsp;Ami Wang,&nbsp;Shamini Selvarajah,&nbsp;Cuihong Wei,&nbsp;Calvin Tseng,&nbsp;Tao Wang,&nbsp;Tara Baetz,&nbsp;Zaid Saeed Kamil","doi":"10.1111/cup.14839","DOIUrl":"10.1111/cup.14839","url":null,"abstract":"<div>\u0000 \u0000 <p>BAP1-inactivated melanocytic tumor is a distinct entity with loss of BAP1 protein and epithelioid morphology. It shares histopathologic features with Spitz nevus and nevoid melanoma, and it can occur sporadically or with germline BAP1 predisposition syndrome. These lesions typically have tumor-infiltrating lymphocytes and infrequent mitoses. They are generally indolent, though melanoma can arise in both germline and sporadic cases. Most show <i>BRAF</i> V600E and <i>BAP1</i> mutations. We describe four tumors in one patient diagnosed with BAP1-tumor predisposition syndrome (BAP1-TPDS): two invasive melanomas arising in BIMT and two BIMTs with uncertain malignant potential. Molecular analysis and fluorescence in situ hybridization (FISH) revealed <i>BAP1</i> and <i>NRAS</i> mutations in melanoma and BAP1-inactivated melanocytic tumor components, with a gain of 6p25 (<i>RREB1</i>) in the melanoma component only. The patient completed pembrolizumab adjuvant therapy with no evidence of metastasis. This is a rare presentation of BIMT with <i>BAP1</i> and <i>NRAS</i> mutations, absence of <i>BRAF</i> V600 mutation, and loss of BAP1 immunoreactivity in all lesional cells. Our case adds to the understanding of the histomorphologic and mutational spectrum in BAP1-inactivated melanocytic tumors.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 10","pages":"627-635"},"PeriodicalIF":1.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic Erythroderma: A Rare, but Important Cause of Mixed Pattern Dermatitis","authors":"Gabriela Fonseca,&nbsp;Hana Ahmed,&nbsp;Lauren Graham,&nbsp;Carly Elston","doi":"10.1111/cup.14851","DOIUrl":"10.1111/cup.14851","url":null,"abstract":"<div>\u0000 \u0000 <p>In dermatopathology, mixed inflammatory patterns, such as mixed spongiotic and interface dermatitis (SID) are not well-characterized and can present a diagnostic challenge. This pattern can be seen in drug eruptions, viral exanthems, and syphilis infection. We present two cases of paraneoplastic erythroderma characterized by a mixed pattern SID. The patients underwent an extensive workup and were found to have positive antinuclear antibodies (ANA) in the absence of symptoms diagnostic of connective tissue disease. Eventually, the patients were both diagnosed with malignancies (systemic marginal zone lymphoma and breast cancer). It is important for dermatopathologists to consider paraneoplastic dermatitis in the differential diagnosis of mixed pattern SID, particularly in the clinical setting of erythroderma, as these findings can be the presenting sign of underlying malignancy. Additionally, if antinuclear antibodies are detected in the absence of classic clinical signs of connective tissue disease, a thorough workup should be conducted to exclude malignancy.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 11","pages":"671-675"},"PeriodicalIF":1.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Spitz Melanocytoma With Activating ZKSCAN1::MET Kinase Fusion","authors":"Tzah Feldman,&nbsp;Hiba Zaaroura,&nbsp;Hanaa Haj Abaya,&nbsp;Yaniv Zohar,&nbsp;Reuven Bergman","doi":"10.1111/cup.14846","DOIUrl":"10.1111/cup.14846","url":null,"abstract":"<div>\u0000 \u0000 <p>Congenital Spitz nevi have been rarely reported, and the diagnoses were usually based on the histopathological and immunohistochemical findings. We describe a case of a congenital Spitz tumor in which the molecular studies demonstrated a <i>ZKSCAN1::MET</i> fusion. No other somatic mutations and/or copy number variations outside of the <i>MET</i> gene were identified. Activating MET kinase rearrangements were previously reported only in a few cases of atypical Spitz tumors and spitzoid melanomas. Specifically, the <i>ZKSCAN1::MET</i> fusion was previously described in a single case of spitzoid melanoma demonstrating an uneventful course. Altogether, the histopathological, immunohistochemical, and molecular studies in our case supported a diagnosis of a congenital Spitz melanocytoma. This underscores the value of molecular analyses in Spitz tumors.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 10","pages":"617-621"},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}