Journal of Cutaneous Pathology最新文献_第4页

The National Resident Match Program Arrives in Dermatopathology: 15 Years of Resilient Advocacy by the American Society of Dermatopathology's Fellowship Training Program Directors' Committee 全国居民匹配计划到达皮肤病理学：15年弹性倡导由美国皮肤病理学协会的奖学金培训项目主任委员会。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-28 DOI: 10.1111/cup.70167

Jane L. Messina, Maxwell A. Fung, Ata S. Moshiri, Adam I. Rubin, Melissa Piliang, Nicole Burkemper

引用次数: 0

Histopathologic Characterization of Untreated and Treated Psoriasis: A Cross-Sectional Study. 未经治疗和治疗的牛皮癣的组织病理学特征：一项横断面研究。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-30 DOI: 10.1111/cup.70225

Terese Monette O Aquino, Mary Grace Anne A Calvarido, Claudine Joy M Ramos, Maria Jasmin J Jamora, Johannes S Kern

{"title":"Histopathologic Characterization of Untreated and Treated Psoriasis: A Cross-Sectional Study.","authors":"Terese Monette O Aquino, Mary Grace Anne A Calvarido, Claudine Joy M Ramos, Maria Jasmin J Jamora, Johannes S Kern","doi":"10.1111/cup.70225","DOIUrl":"https://doi.org/10.1111/cup.70225","url":null,"abstract":"Background: The histopathological presentation of psoriasis may vary depending on the timing of the biopsy, prior treatments utilized, and the presence of secondary skin changes. Consequently, dermatopathologists play a pivotal role in ensuring an accurate diagnosis, particularly when the psoriatic histopathology deviates from the classic features. This study aims to compare the prevalence of classic and non-classic histopathologic features of psoriasis between untreated and treated psoriasis.Methods: This is a review of 109 biopsies of psoriasis from 2015 to 2021 obtained from a single institution. The cases were reviewed by two independent dermatopathologists who were blinded to the assigned groups (untreated, n = 62, and treated, n = 47). A 20-item histopathologic grading criterion, comprising both classic and non-classic features of psoriasis, was used for assessment.Results: The prevalence of both classic (p = 0.274; CI: -0.169, 0.593) and non-classic (p = 0.456; CI: -0.526, 0.236) histopathologic features of psoriasis did not differ between untreated (classic = 78%, non-classic = 27%) and treated (classic = 76%, non-classic = 29%) groups. A comparison of each histopathologic feature did not vary between groups (p > 0.05).Conclusions: Psoriasis is a dynamic condition under the microscope. Classic histopathologic features of psoriasis seem to persist despite treatment. Non-classic features may also occur regardless of the treatment status. Hence, the presence of these features should not preclude the tissue diagnosis of psoriasis.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Characterization of Sclerosing Nevi With Pseudomelanomatous Features. 假性黑色素瘤特征的硬化痣的分子特征。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-30 DOI: 10.1111/cup.70226

Zachary Corey, Mckinzie Johnson, John Fowler, Joshua Wisell, Dara L Aisner, Amy Guimaraes-Young, Shyam S Raghavan

{"title":"Molecular Characterization of Sclerosing Nevi With Pseudomelanomatous Features.","authors":"Zachary Corey, Mckinzie Johnson, John Fowler, Joshua Wisell, Dara L Aisner, Amy Guimaraes-Young, Shyam S Raghavan","doi":"10.1111/cup.70226","DOIUrl":"https://doi.org/10.1111/cup.70226","url":null,"abstract":"Introduction: Sclerosing nevi with pseudomelanomatous features (SNPF) are rare melanocytic lesions characterized by a distinctive trizonal architecture, created by lateral shouldering of the junctional component and nests of melanocytes within the dermis that can histologically mimic melanoma, posing a diagnostic dilemma. Although prior clinicopathologic studies suggest benign behavior, their molecular features have not been characterized.Methods: We retrospectively identified nine SNPFs (2004-2024) and performed detailed histopathologic and immunohistochemical evaluation. Targeted next-generation sequencing (NGS) with a 498-gene hybrid capture-based panel was performed on microdissected, melanocyte-enriched tissue, with macrodissection used as salvage in low nucleic acid yield cases that initially failed. SNPF results were compared to a comparator group of BRAF-mutated melanomas tested on the same assay.Results: Patients ranged from 25 to 65 years (median: 41), with lesions most commonly on the trunk. All cases demonstrated classic trizonal morphology with epidermal flattening, superficial dermal fibroplasia, and deeper dermal nevus nests. Immunohistochemistry showed uniform PRAME negativity and retained mosaic p16 expression. Molecular testing was successful in eight of the nine cases, all of which harbored a BRAF V600E mutation (VAF: 1.3%-27%). No additional pathogenic mutations or copy number alterations were identified. Comparator BRAF-mutated melanomas had additional, detectable co-occurring pathogenic mutations and/or copy number variations in 19 of the 20 cases.Conclusions: SNPFs consistently demonstrate a molecular profile indistinguishable from conventional benign nevi and lack genomic features of melanoma. These findings provide molecular support for the benign nature of SNPF.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated Xanthogranuloma Harboring a GAB2::BRAF Fusion and MITF Pathogenic Variant Successfully Treated With Cobimetinib: A Rare Case Report. Cobimetinib成功治疗含有GAB2::BRAF融合和MITF致病变异的弥散性黄色肉芽肿：一例罕见病例报告。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-30 DOI: 10.1111/cup.70229

Pauline C Xu, Allison M Cushman-Vokoun, Christopher R D'Angelo, Dinesh Pradhan

引用次数: 0

Inconsistent Staining for Ber-EP4 in Clear Cell Basal Cell Carcinoma: A Potential Diagnostic Pitfall. 透明细胞基底细胞癌中Ber-EP4染色不一致：一个潜在的诊断缺陷。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-29 DOI: 10.1111/cup.70222

Marina Kristy Ibraheim, Jeffrey North

引用次数: 0

Bullous Eruption Associated With Loncastuximab Tesirine in a Patient With Diffuse Large B-Cell Lymphoma. 弥漫性大b细胞淋巴瘤患者与Loncastuximab Tesirine相关的大疱性爆发。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-28 DOI: 10.1111/cup.70220

Daniella Jaguan, Cuong Nguyen, Jennifer N Choi

{"title":"Bullous Eruption Associated With Loncastuximab Tesirine in a Patient With Diffuse Large B-Cell Lymphoma.","authors":"Daniella Jaguan, Cuong Nguyen, Jennifer N Choi","doi":"10.1111/cup.70220","DOIUrl":"https://doi.org/10.1111/cup.70220","url":null,"abstract":"Loncastuximab tesirine (LT) is an antibody-drug conjugate (ADC), a novel class of therapeutics that combines a target-specific monoclonal antibody with a cytotoxic agent via a chemical linker. LT has been approved in the United States as therapy for relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Given the novelty of this drug, cutaneous adverse effects remain poorly characterized. In this case report, we present a 35-year-old male with relapsing and refractory DLBCL who developed a bullous eruption after his third cycle of LT. Physical exam revealed scattered erosions and erythema of the neck and extremities, along with multiple bullae and erosions on the hands and dorsal feet, and vesicles on the shin. Histopathological exam revealed basovacuolar alteration with epidermal dysmaturation and a re-epithelializing blister, features suggestive of toxic erythema of chemotherapy (TEC). Direct immunofluorescence was negative for immune complex deposition. To date, there are only three cases of LT-associated bullous eruptions in the literature, all demonstrating subepidermal blistering with granular IgA deposition along the basement membrane. This case lacks immunoglobulin deposition and instead exhibits TEC-like cytotoxic interface dermatitis. This case expands the clinicopathologic spectrum of LT-associated cutaneous toxicity and highlights a distinct non-immune mediated, TEC-like vesiculobullous presentation.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail Unit Involvement in a Porokeratosis-Spectrum Lesion Exhibiting Porokeratotic Adnexal Ostial Nevus-Like Features: Expanding the Clinical Spectrum. 甲单位累及的多孔角化光谱病变表现为附件口痣样特征：扩大临床谱。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-28 DOI: 10.1111/cup.70206

Jeremy Ellis, Kripa Ahuja, Molly Hinshaw

{"title":"Nail Unit Involvement in a Porokeratosis-Spectrum Lesion Exhibiting Porokeratotic Adnexal Ostial Nevus-Like Features: Expanding the Clinical Spectrum.","authors":"Jeremy Ellis, Kripa Ahuja, Molly Hinshaw","doi":"10.1111/cup.70206","DOIUrl":"https://doi.org/10.1111/cup.70206","url":null,"abstract":"Porokeratotic Adnexal Ostial Nevus (PAON) is an uncommon disorder characterized by abnormal keratinization affecting eccrine and follicular adnexa. Initially described separately as porokeratotic eccrine ostial and dermal duct nevus and porokeratotic eccrine and hair follicle nevus, the term PAON was introduced in 2009 to encompass these conditions. PAON presents with diverse clinical manifestations, ranging from asymptomatic keratotic papules and plaques to verrucous lesions. Typically appearing at birth, PAON can rarely manifest in adulthood. We report a case of a porokeratosis-spectrum lesion with features overlapping with PAON in a male patient in his 30s presenting with longitudinal splitting of the left thumbnail associated with an erythematous linear lesion extending from the nail matrix, alongside a scaly plaque on the proximal nail fold and dorsal thumb. This case highlights the importance of considering porokeratosis-spectrum disorders, including lesions with PAON-like features, in the differential diagnosis of monodactylous erythronychia and onychodystrophy, particularly due to its potential for subtle cutaneous involvement as was present in this case. This instance represents a rare presentation of a porokeratosis-spectrum lesion involving the nail unit epithelium and contributes to the expanding clinical spectrum of porokeratosis with PAON-like features.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous IgG4-Related Disease Accompanied by Granulomatous Vasculitis: A Case Report. 皮肤igg4相关疾病伴肉芽肿性血管炎1例

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-24 DOI: 10.1111/cup.70217

Tomoki Sakiyama, Toshiya Miyake, Satoshi Nakamizo, Takuto Fukutome, Masakazu Fujimoto, Hironori Haga, Kenji Kabashima

{"title":"Cutaneous IgG4-Related Disease Accompanied by Granulomatous Vasculitis: A Case Report.","authors":"Tomoki Sakiyama, Toshiya Miyake, Satoshi Nakamizo, Takuto Fukutome, Masakazu Fujimoto, Hironori Haga, Kenji Kabashima","doi":"10.1111/cup.70217","DOIUrl":"https://doi.org/10.1111/cup.70217","url":null,"abstract":"IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder characterized by dense infiltration of IgG4-positive plasma cells, fibrosis, and elevated serum IgG4 levels. Although various cutaneous manifestations of IgG4-RD have been described, and vasculitic changes have occasionally been reported, granulomatous vasculitis is not considered a typical histopathological feature of cutaneous IgG4-RD. We report a 93-year-old woman with a history of IgG4-RD who presented with long-standing subcutaneous nodules on both knees. Histopathological examination revealed dense lymphoplasmacytic infiltration with marked fibrosis, obliterative phlebitis, and granulomatous vasculitis characterized by vascular destruction with multinucleated giant cells. Immunohistochemistry demonstrated a marked increase in IgG4-positive plasma cells with a high IgG4/IgG-positive plasma cell ratio. Comprehensive clinical, serological, and histopathological evaluation excluded other causes of granulomatous vasculitis, including eosinophilic granulomatosis with polyangiitis, granulomatosis with polyangiitis, and sarcoid vasculitis. The lesions responded favorably to systemic corticosteroid therapy. To our knowledge, granulomatous vasculitis has not been recognized as a typical histopathological feature of cutaneous IgG4-RD. This case suggests that granulomatous vasculitis may rarely occur in cutaneous lesions of IgG4-RD, but additional cases are needed to confirm this association.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma-Delta Phenotypic Evolution in Mycosis Fungoides With CD30-Positive Cutaneous Progression. 伴有cd30阳性皮肤进展的蕈样真菌病的γ - δ表型进化。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-23 DOI: 10.1111/cup.70221

Sahil Chaudhary, Folashade Adekunle, Nathan Roberts, Thomas Cropley, Enrica Marchi, Jinbo Fan, Ifeyinwa E Obiorah

{"title":"Gamma-Delta Phenotypic Evolution in Mycosis Fungoides With CD30-Positive Cutaneous Progression.","authors":"Sahil Chaudhary, Folashade Adekunle, Nathan Roberts, Thomas Cropley, Enrica Marchi, Jinbo Fan, Ifeyinwa E Obiorah","doi":"10.1111/cup.70221","DOIUrl":"https://doi.org/10.1111/cup.70221","url":null,"abstract":"CD30-positive large-cell proliferations arising in patients with mycosis fungoides can be diagnostically challenging, particularly when they show variable T-cell receptor expression or gamma/delta (γδ) phenotype. We present two cases of mycosis fungoides (MF) with CD30-positive large cell transformation (LCT)/progression exhibiting γδ T-cell phenotypic evolution. Case 1, a 50-year-old woman, initially presented with hyperpigmented patches and papulonodular lesions showing epidermotropic small-cell MF alongside dermal CD30-positive large cells with a γδ phenotype. Over ten years, she developed recurrent cutaneous and eventually nodal disease with phenotypic shifts between γδ and αβ expression, while molecular studies confirmed a single clonal process across all biopsies. Potentially pathogenic variants in FAS and CD70 were identified. Case 2, a 72-year-old man with longstanding MF, developed CD30-positive LCT initially with an αβ phenotype that subsequently acquired γδ expression and DUSP22 rearrangement. Oncoscan microarray revealed shared copy-number alterations including CDKN2A/B loss across temporally distinct biopsies, and sequencing identified KMT2C and TET1 variants. Both cases illustrate that MF can exhibit dynamic T-cell receptor phenotypic evolution, posing significant diagnostic challenges with lymphomatoid papulosis and primary cutaneous γδ T-cell lymphoma. Clonal identity confirmation through molecular studies is essential for accurate classification.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Histopathologic Analysis of Pigmentation and Melanophage Distribution in Dermal Postinflammatory Hyperpigmentation. 皮肤炎症后色素沉着及噬黑细胞分布的定量组织病理学分析。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-22 DOI: 10.1111/cup.70216

Hye Jin Chung, Danielle R Rinck, Li-Chi Chen, Steven R Tahan

{"title":"Quantitative Histopathologic Analysis of Pigmentation and Melanophage Distribution in Dermal Postinflammatory Hyperpigmentation.","authors":"Hye Jin Chung, Danielle R Rinck, Li-Chi Chen, Steven R Tahan","doi":"10.1111/cup.70216","DOIUrl":"https://doi.org/10.1111/cup.70216","url":null,"abstract":"Background: Dermal postinflammatory hyperpigmentation (PIH) is frequently refractory to treatment, and therapeutic response is thought to depend on the depth and distribution of dermal pigment. Key quantitative histopathologic features, however, remain poorly defined.Methods: Ninety-five biopsy-proven cases of dermal PIH were analyzed. Fontana-Masson-stained sections underwent image analysis to quantify epidermal and dermal pigmentation intensity, melanophage density, cross-sectional area, and depth. Associations with inflammatory etiology, Fitzpatrick skin type (FST), and sun-exposure status of the biopsy site were assessed.Results: Epidermal pigmentation intensity was significantly increased in spongiotic dermatitis, higher FST, and sun-exposed sites. Dermal pigmentation intensity was associated with sun exposure. Melanophage density increased with higher FST but was lower in spongiotic dermatitis compared with lichenoid and vacuolar interface dermatitis. In contrast, melanophage cross-sectional area and depth showed no significant associations with etiology, FST, or anatomic site. Median melanophage depth was 295.0 μm (IQR, 220.0-407.0 μm) from stratum corneum and 163.0 μm (IQR, 111.2-235.5 μm) from basement membrane, with consistent measurements across subgroups.Conclusion: Despite variability in epidermal pigmentation and melanophage density, melanophage depth is uniform across dermal PIH. These findings refine the conventional epidermal-dermal PIH classification and support a quantitative, anatomy-based framework to inform depth-targeted treatment strategies.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0