Journal of Cutaneous Pathology最新文献

{"title":"The association of interleukin-36 staining intensity with histopathologic findings of eosinophil count and spongiosis in patients with psoriasis: A secondary analysis of a retrospective immunohistochemical and chart review pilot study","authors":"William R. Zhang, Tina Bhutani, Joshua M. Schulman, Jeffrey P. North","doi":"10.1111/cup.14711","DOIUrl":"10.1111/cup.14711","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 4","pages":"251-253"},"PeriodicalIF":1.6,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of NONO::TFE3 cutaneous epithelioid and spindle cell tumor with local recurrence after complete excision","authors":"Joseph S. Durgin MD,&nbsp;Emily H. Smith MD,&nbsp;Paul W. Harms MD, PhD,&nbsp;Noah A. Brown MD,&nbsp;May P. Chan MD","doi":"10.1111/cup.14712","DOIUrl":"10.1111/cup.14712","url":null,"abstract":"<p>Mesenchymal tumors may display morphologic and immunohistochemical overlap with melanocytic tumors, presenting a pitfall for misdiagnosis. We report a 62-year-old woman who presented with a recurrent dermal and subcutaneous tumor over the Achilles tendon 15 years following complete excision. Both the primary and the recurrent tumors were characterized by nests and sheets of epithelioid and spindle cells with eosinophilic cytoplasm and uniform ovoid nuclei. The tumor was positive for S100, SOX10, HMB45, cathepsin K, and p63 (weak), while negative for Melan-A, MiTF, smooth muscle actin, and desmin. Gene fusion analysis of the recurrent tumor revealed a <i>NONO::TFE3</i> fusion which has been recently reported in two similar cutaneous cases. Our case highlights the potential of a <i>NONO::TFE3</i> cutaneous epithelioid and spindle cell tumor to recur after a prolonged disease-free interval without evidence of high-grade transformation or distant metastasis. Our findings support its classification as a cutaneous mesenchymal neoplasm of intermediate malignancy.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 12","pages":"954-958"},"PeriodicalIF":1.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NRASQ61R-driven atypical melanocytic tumor with blue nevus-like morphology: A case report","authors":"Tsubasa Hiraki MD, PhD,&nbsp;Hiroki Mori MD, PhD,&nbsp;Junko Misawa MD,&nbsp;Marina Yunoki MD,&nbsp;Keisuke Goto MD","doi":"10.1111/cup.14709","DOIUrl":"10.1111/cup.14709","url":null,"abstract":"<p><i>NRAS</i> Q61 mutations are driver genetic alterations associated with common melanocytic nevi. Herein, we describe a case of <i>NRAS</i>-mutant melanocytic tumor with a blue nevus-like morphology. A 71-year-old Japanese man presented with a 4.6-mm nodule on his back. Histopathological examination revealed a dense distribution of spindle-shaped melanocytes in the upper dermis and a sparse distribution of dendritic melanocytes in the mid-dermis. The vertical periadnexal extension reached the deep dermis at the center of the tumor. A small junctional component, hyperpigmentation, sclerotic stroma, mild nuclear atypia, and a few mitotic figures were observed. Immunohistochemical examination revealed no PRAME expression and preserved p16 expression. Diffuse RASQ61R immunoreactivity was observed in these tumor cells. Nuclear β-catenin expression was not observed. Targeted RNA sequencing revealed two mutations, <i>NRAS</i> c.182A&gt;G (Q61R) and <i>FGFR2</i> c.-157A&gt;G, but no other pathogenic alterations such as <i>BRAF</i>, <i>GNAQ</i>, <i>GNA11</i>, <i>CTNNB1</i>, <i>PRKAR1A</i>, or <i>IDH1</i> mutations or kinase gene fusions. The histopathology fits that of compound-type blue nevus, which is called “Kamino nevus”; however, this tumor was genetically considered to be on the spectrum of conventional acquired melanocytic nevi but not on that of blue nevi. Morphologically, <i>NRAS</i>-driven melanocytic nevi resemble blue nevi without <i>IDH1</i>^R132C coexistence.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 12","pages":"948-953"},"PeriodicalIF":1.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of metastatic osteoblastic osteosarcoma to the scalp","authors":"Efrain Lee-Diaz MD,&nbsp;Brittany L. Dulmage MD,&nbsp;Swati Satturwar MD,&nbsp;Jose A. Plaza MD","doi":"10.1111/cup.14706","DOIUrl":"10.1111/cup.14706","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 1","pages":"1-4"},"PeriodicalIF":1.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of an erythrodermic mycosis fungoides as a biologically indolent anaplastic large T-cell lymphoma initially misdiagnosed as being of donor origin","authors":"Francisco Javier Díaz de la Pinta MD,&nbsp;Rebeca Manso PhD,&nbsp;Juan Torre MD,&nbsp;Luis Requena MD, PhD,&nbsp;Socorro Maria Rodriguez-Pinilla MD, PhD","doi":"10.1111/cup.14710","DOIUrl":"10.1111/cup.14710","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 3","pages":"177-179"},"PeriodicalIF":1.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathologic, genomic, transcriptomic, and functional characteristics of eight melanocytic tumors with BRAF fusions showing stronger MAPK pathway activation compared to BRAF V600E tumors","authors":"Aofei Li MD,&nbsp;Simon J. Warren MD,&nbsp;Brandon A. Umphress MD,&nbsp;Ahmed K. Alomari MD","doi":"10.1111/cup.14704","DOIUrl":"10.1111/cup.14704","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Activating <i>BRAF</i> gene alterations are central to melanocytic tumor pathogenesis. A small, emerging subset of melanocytic tumors driven by <i>BRAF</i> fusions has distinct therapeutic implications and has been described to have Spitzoid morphology patterns. However, such morphological patterns do not encompass all cases, and little is known about the functional molecular events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted a retrospective search through our molecular archives to identify melanocytic tumors with <i>BRAF</i> fusions. We reviewed clinical, histopathological, and genomic features. We further explored transcriptomic and protein-level findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histopathologic patterns varied, with many cases without a distinctive pattern. We identified novel and diverse <i>BRAF</i> gene fusion partners. Differential transcriptomic analysis between low-risk <i>BRAF</i> fusion tumors and reference <i>BRAF V600E</i> tumors showed no differentially expressed genes. However, quantitatively stronger MAPK pathway activation of <i>BRAF</i> fusion tumors over <i>BRAF V600E</i> tumors was demonstrated by statistically significant stronger staining of p-ERK immunohistochemistry. Gene-specific RNA analysis shows comparable <i>BRAF</i> transcript levels between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion and Conclusion</h3>\u0000 \u0000 <p>The quantitatively stronger activation of the MAPK pathway of <i>BRAF</i> fusion tumors, instead of qualitatively different transcriptomes, may account for the morphology difference from conventional <i>BRAF V600E</i> tumors. <i>BRAF</i> fusions likely act through dysregulated protein function rather than RNA upregulation related to the characteristics of the fusion partners.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 11","pages":"899-910"},"PeriodicalIF":1.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14704","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioplasmacellular hyperplasia: Livid exophytic nodule on the anterior hairline","authors":"Tey Hwee Ting Vanessa MBBS, MRCP (UK),&nbsp;Koh Hong Yi MBBS, MRCP (UK), M.Med (Int Med), FAMS (Dermatology),&nbsp;Joel Lim Hua-Liang MBBS, MRCP (UK), M.Med (Int Med), Dip. Dermatopathology (ICDP-UEMS)","doi":"10.1111/cup.14705","DOIUrl":"10.1111/cup.14705","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 12","pages":"919-921"},"PeriodicalIF":1.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exceptional case of imatinib mesylate inducing both psoriasis and lichenoid reaction: A case report","authors":"Kaoutar Belharti,&nbsp;Hasnae Saddouk,&nbsp;Nassiba Zerrouki,&nbsp;Siham Dikhaye,&nbsp;Nada Zizi","doi":"10.1111/cup.14703","DOIUrl":"10.1111/cup.14703","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 2","pages":"78-79"},"PeriodicalIF":1.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of PRAME immunohistochemistry in cutaneous vascular neoplasms reveals frequent expression in primary and post-irradiation cutaneous angiosarcomas","authors":"Andrea Krajisnik MD, MS,&nbsp;Neda Rezaee MD,&nbsp;Eleanor R. Duncan BS,&nbsp;Bonnie L. Balzer MD, PhD,&nbsp;Wonwoo Shon DO","doi":"10.1111/cup.14707","DOIUrl":"10.1111/cup.14707","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Preferentially expressed antigen in melanoma (PRAME) has been extensively studied in cutaneous melanocytic tumors and has proven valuable as a diagnostic adjunct in routine dermatopathology practice. However, its expression in cutaneous vascular neoplasms, particularly angiosarcomas (AS), remains largely unexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To further explore PRAME expression in cutaneous AS, 18 cases of post-irradiation and 13 cases of primary cutaneous AS were evaluated for PRAME. For comparison, sections from 11 deep soft tissue/visceral AS, 10 Kaposi sarcomas, 8 microvenular hemangiomas, 7 infantile hemangiomas, 8 atypical vascular lesions, 6 epithelioid hemangioendotheliomas, 6 pyogenic granulomas, 6 papillary endothelial hyperplasias, 6 epithelioid hemangiomas, 3 capillovenous malformations, 3 hobnail hemangiomas, 2 spindle cell hemangiomas, 2 pseudomyogenic hemangioendotheliomas, and 2 composite hemangioendotheliomas were also retrieved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 22 of 31 (70.9%; 12 post-irradiation and 10 primary) cutaneous AS were positive for PRAME. In contrast, only 1 of 11 (9.1%) deep soft tissue/visceral AS showed diffuse and strong PRAME nuclear staining. All other tumor types were negative for PRAME, except for 5 of 7 (71.4%) infantile hemangiomas, which demonstrated rare (&lt;5%; four cases) and 1+ (5–25%; one case) nuclear staining.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this study, we have demonstrated frequent nuclear PRAME expression in cutaneous AS. PRAME immunohistochemistry may serve as a valuable additional marker in selected clinical settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 11","pages":"893-898"},"PeriodicalIF":1.6,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical clinical presentation of eosinophilic angiocentric fibrosis with cutaneous and upper respiratory tract involvement","authors":"Juan Manuel Liñán-Barroso MD,&nbsp;Nicolás Valérdiz-Menéndez MD,&nbsp;José Salvador García-Morillo MD, PhD,&nbsp;José Bernabeu-Wittel MD, PhD","doi":"10.1111/cup.14701","DOIUrl":"10.1111/cup.14701","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 11","pages":"821-824"},"PeriodicalIF":1.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}