Journal of Cutaneous Pathology最新文献_第9页

Commentary on "Amelanotic Melanoma With Features of Keratinocytic Tumor on Reflectance Confocal Microscopy". “反射共聚焦显微镜下具有角质细胞瘤特征的无色素黑色素瘤”评论。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-18 DOI: 10.1111/cup.70195

Ana Danko, Heather M Zimmerman, David Elpern, Ata Moshiri, Douglas Johnson

引用次数: 0

Atypical Lentiginous Melanocytic Proliferations Case Series: Relationship to Type II Dysplastic Nevi and Lentiginous Melanoma. 非典型黄斑性黑色素细胞增生病例系列：与II型发育不良痣和黄斑性黑色素瘤的关系。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-18 DOI: 10.1111/cup.70198

Maged Daruish, Ella De Ryck, Laura Gadeyne, Julie Lemahieu, Siebe Loontiens, Joni Van Der Meulen, Marc Haspeslagh, Boris C Bastian, Saleem Taibjee

引用次数: 0

AI Simplification of Dermatopathology Reports for Patients: Basic Versus Prompt-Engineered Approaches. 人工智能简化患者皮肤病理报告：基本方法与快速工程方法

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-13 DOI: 10.1111/cup.70187

William J Nahm, Arlene M Ruiz de Luzuriaga, Goranit Sakunchotpanit, Dan Nguyen, Krithika Nayudu, Ryan Chen, Arjun Mahajan, Vinod E Nambudiri

{"title":"AI Simplification of Dermatopathology Reports for Patients: Basic Versus Prompt-Engineered Approaches.","authors":"William J Nahm, Arlene M Ruiz de Luzuriaga, Goranit Sakunchotpanit, Dan Nguyen, Krithika Nayudu, Ryan Chen, Arjun Mahajan, Vinod E Nambudiri","doi":"10.1111/cup.70187","DOIUrl":"10.1111/cup.70187","url":null,"abstract":"Background: Patients struggle to comprehend dermatopathology reports. As artificial intelligence (AI) tools become more accessible, patients may use them to interpret reports; however, optimal approaches remain unexplored.Objective: Evaluate whether prompt-engineered AI simplification of dermatopathology reports improves factualness, completeness, and reduces potential harm compared to basic AI usage.Methods: Survey-based study (January-April 2025) of 52 US dermatology and dermatopathology professionals (70.3% response rate). Six fictitious dermatopathology reports were simplified using: (1) Basic ChatGPT-4.0 with simple prompt and (2) Custom \"DermDecoder\" GPT with structured 489-word prompt. Participants rated reports on 3-point Likert scales for factualness, completeness, and potential harm, with free-text responses analyzed thematically.Results: Mean ratings ranged from 1.27 to 1.63 (factualness/completeness) and 1.31-1.83 (harmfulness), indicating \"Agree\" to \"Mostly Agree\" or \"Completely Harmless\" to \"Mostly Harmless.\" DermDecoder performed significantly worse for completeness in psoriasis (t = -2.79, p = 0.007) and harmfulness in molluscum contagiosum (p = 0.049) and melanoma in situ (p = 0.048). Free-text analysis revealed Basic Prompt preserved details but lacked clinical context, while DermDecoder provided generic education disconnected from pathological findings.Limitations: Fictitious reports, small sample, evolving AI capabilities, and absence of patient perspectives.Conclusion: Prompt engineering offered no advantage over basic AI usage in balancing professional accuracy with patient accessibility, necessitating human-in-the-loop oversight for AI-generated explanations.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BRAFV600E-Mutant Non-Langerhans Cell Histiocytosis Clonally Related to Remitted Acute Myeloid Leukemia. brafv600e突变体非朗格汉斯细胞组织细胞增多症与缓解性急性髓性白血病克隆相关

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-11 DOI: 10.1111/cup.70192

Serena Shimshak, Liuyan Jiang, Olayemi Sokumbi

{"title":"BRAFV600E-Mutant Non-Langerhans Cell Histiocytosis Clonally Related to Remitted Acute Myeloid Leukemia.","authors":"Serena Shimshak, Liuyan Jiang, Olayemi Sokumbi","doi":"10.1111/cup.70192","DOIUrl":"https://doi.org/10.1111/cup.70192","url":null,"abstract":"We report a case of a 71-year-old female with acute myeloid leukemia (AML), treated with chemotherapy and hematopoietic stem cell transplant (HSCT), who developed a clonally related non-Langerhans cell histiocytosis (NLCH). She presented with pink papules on the mid-upper cutaneous lip and thighs 3 months following HSCT. Skin biopsies revealed a dermal proliferation of cells with eosinophilic cytoplasm. Immunohistochemistry (IHC) studies demonstrated positivity for CD68, CD163, BRAF, cyclin D1, and Factor XIIIa and negativity for CD1a, S100, MPO, and CD20. Next-generation sequencing (NGS) with a comprehensive myeloid panel revealed corresponding pathogenic mutations to her AML, including BCOR Q176fs*40, IDH1 R132C, and TP53 Y163N, and an additional BRAF V600E mutation. Additional mutations in DNMT3A and KMT2A associated with her AML were not identified. These findings supported the diagnosis of NLCH sharing a clonal origin with the patient's AML. Work up demonstrated isolated cutaneous involvement without AML relapse; therefore, the skin lesions were treated with shave excision, topical tacrolimus 0.1% ointment, and topical clobetasol 0.05% cream without further systemic treatment. The acquired BRAF V600E mutation illustrates the potential for divergent myeloid differentiation and likely explains the emergence of a clonal NLCH after successful AML treatment. Genetic analysis in NLCH can establish clonality with associated hematologic malignancies, uncover actionable mutations, and guide treatment.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lupus Miliaris Disseminatus Faciei and Follicular Mucinosis: A New Pattern of Janus Kinase Inhibitor Acneiform Eruption. 广泛性红斑狼疮和滤泡性黏液病：一种新的Janus激酶抑制剂痤疮样疹。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-06 DOI: 10.1111/cup.70191

Efrain Lee-Diaz, Patrick S Phelan, Sara C Shalin

{"title":"Lupus Miliaris Disseminatus Faciei and Follicular Mucinosis: A New Pattern of Janus Kinase Inhibitor Acneiform Eruption.","authors":"Efrain Lee-Diaz, Patrick S Phelan, Sara C Shalin","doi":"10.1111/cup.70191","DOIUrl":"https://doi.org/10.1111/cup.70191","url":null,"abstract":"We present the case of a 64-year-old patient with a previous history of atopic dermatitis and vitiligo, who presented to the dermatology clinic with persistent \"bumps\" on his face that appeared following treatment with upadacitinib. Examination of the skin revealed multiple skin-colored to erythematous folliculocentric papules located on the temples, lateral canthi, and eyelids. A punch biopsy demonstrated a folliculocentric process; a central follicle exhibited a robust necrotizing granulomatous infiltrate associated with hair follicle destruction. The base of the follicle displayed follicular mucinosis and a lymphocytic infiltrate with an increased CD4:CD8 ratio of 8:1, retention of CD2 and CD5, and diminished CD7 expression. Subsequent PCR analysis showed no evidence of monoclonal T-cell receptor gene rearrangement. Based on the clinical impression, the histopathological features, and ancillary test results, a diagnosis of lupus miliaris disseminatus faciei with follicular mucinosis in the context of Janus kinase (JAK) inhibitor therapy was established. Although acneiform eruptions (\"JAK-ne\") are known side effects of JAK inhibitor therapy, to the authors' knowledge, this novel case report is the first to describe patterns of lupus miliaris disseminatus faciei and follicular mucinosis within the spectrum of inflammatory papular facial eruptions associated with JAK inhibitor therapy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Cutaneous Gamma-Delta T-Cell Lymphoma Complicating Long-Standing Immunosuppressed Dermatomyositis. 原发性皮肤γ - δ t细胞淋巴瘤并发长期免疫抑制性皮肌炎。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-04 DOI: 10.1111/cup.70190

Bennett Christie-Nguyen, Youn H Kim, David F Fiorentino, Danielle Tartar, Ryanne Brown, Robert A Novoa, Kerri E Rieger

{"title":"Primary Cutaneous Gamma-Delta T-Cell Lymphoma Complicating Long-Standing Immunosuppressed Dermatomyositis.","authors":"Bennett Christie-Nguyen, Youn H Kim, David F Fiorentino, Danielle Tartar, Ryanne Brown, Robert A Novoa, Kerri E Rieger","doi":"10.1111/cup.70190","DOIUrl":"https://doi.org/10.1111/cup.70190","url":null,"abstract":"Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a rare cytotoxic lymphoma with key oncogenic drivers in the JAK/STAT pathway. Also primarily involving the subcutaneous adipose tissue, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is more frequently encountered in scenarios of autoimmune disorders. SPTCL shares clinicopathologic overlap with lupus panniculitis. However, the link between autoimmunity and PCGD-TCL is much less established, particularly in the setting of long-standing, immunosuppressed dermatomyositis (DM). We report two cases of PCGD-TCL arising in women with chronic anti-TIF1-γ DM following years of immunosuppressive therapy. Case 1 is a 47-year-old woman with a 19-year history of DM on azathioprine/prednisone who developed rapidly progressive, painful subcutaneous nodules. Incisional biopsy confirmed a TCR-delta+, CD8+ cytotoxic T-cell lymphoproliferative disorder (TCLPD) compatible with PCGD-TCL. She achieved complete remission following pralatrexate and subsequent allogeneic hematopoietic stem cell transplant. Case 2 is a 27-year-old woman with DM on mycophenolate/rituximab who developed subcutaneous nodules with an indolent course and some spontaneous regression. A biopsy revealed a similar panniculitic infiltrate with an atypical TCR-delta+, CD8+ phenotype. Notably, both cases were negative for high-risk JAK/STAT pathway mutations. These cases identify PCGD-TCLPD/TCL as a potential complication of chronic, immunosuppressed DM. The shared, atypical CD8+ immunophenotype and absence of canonical driver mutations suggest a distinct pathogenic mechanism possibly linked to long-term immune modulation. Unlike classic PCGD-TCL, which is characterized by an aggressive course and < 2-year median survival, the clinical courses in these two cases were variable, with one requiring transplant and the other showing indolent behavior and responsiveness to therapy.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lesions Reported as Plaque-Like CD34-Positive Dermal Fibroma Reveal Two Reproducible Clinicopathologic Patterns: Two Cases and Literature Review. 斑块样cd34阳性真皮纤维瘤显示两种可重复的临床病理模式：两例和文献复习。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-04 DOI: 10.1111/cup.70181

Wei Tan, Mingyuan Xu, Yeqiang Liu

{"title":"Lesions Reported as Plaque-Like CD34-Positive Dermal Fibroma Reveal Two Reproducible Clinicopathologic Patterns: Two Cases and Literature Review.","authors":"Wei Tan, Mingyuan Xu, Yeqiang Liu","doi":"10.1111/cup.70181","DOIUrl":"https://doi.org/10.1111/cup.70181","url":null,"abstract":"Plaque-like CD34-positive dermal fibroma (PDF), which historically overlaps with medallion-like dermal dendrocyte hamartoma (MDDH), is a rare benign CD34-positive spindle-cell lesion with highly variable clinicopathologic descriptions. We analyzed two adult-onset cases and reviewed the published literature to determine whether reported PDF/MDDH lesions cluster into reproducible clinicopathologic patterns. Our literature review comprises 25 cases. Comparative analyses revealed marked differences in age at onset, lesion size, anatomic distribution, depth of involvement, papillary dermis sparing, subcutaneous extension, and epidermal response. One pattern was characterized by early-onset, larger plaque-like lesions on the trunk or neck, with deep dermal to subcutaneous spindle-cell proliferation and frequent epidermal atrophy (early-onset deep pattern). The second pattern was characterized by adult-onset, small papules or papuloplaques, predominantly on the extremities, featuring upper reticular dermal spindle-cell proliferation, papillary dermis sparing, elongated rete ridges, and a perpendicular-to-horizontal spindle-cell arrangement (adult-onset superficial pattern). All lesions showed diffuse CD34 positivity. Lesions currently reported under the PDF/MDDH umbrella appear to encompass two reproducible clinicopathologic patterns. Recognizing these patterns may improve diagnostic accuracy and facilitate the distinction of these lesions from dermatofibrosarcoma protuberans and other superficial CD34-positive spindle-cell proliferations.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PDGFD-Rearranged Dermatofibrosarcoma Protuberans With S100 and Pan-TRK Expression. 表达S100和Pan-TRK的pdgfd重排皮肤纤维肉瘤。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-04 DOI: 10.1111/cup.70186

Venezia Podesta, May P Chan, Douglas Rottmann, Kelly L Harms, Paul W Harms

引用次数: 0

A Rare Case of Cutaneous Extramedullary Hematopoiesis in Chronic Myeloid Leukemia 慢性髓性白血病一例罕见的皮肤髓外造血。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-03 Epub Date: 2026-04-10 DOI: 10.1111/cup.70114

Bennett Christie-Nguyen, Hanadi El Achi, Levani Iashvili, Amer Wahed, Brenda Mai, Jacob Armstrong

{"title":"A Rare Case of Cutaneous Extramedullary Hematopoiesis in Chronic Myeloid Leukemia","authors":"Bennett Christie-Nguyen, Hanadi El Achi, Levani Iashvili, Amer Wahed, Brenda Mai, Jacob Armstrong","doi":"10.1111/cup.70114","DOIUrl":"10.1111/cup.70114","url":null,"abstract":"Cutaneous extramedullary hematopoiesis (CEH) is a rare manifestation of extramedullary hematopoiesis (EMH), a process typically associated with fetal development or myeloproliferative neoplasms. EMH most commonly involves the spleen, liver, and lymph nodes, with CEH being exceedingly rare in chronic myeloid leukemia (CML). Here, we present a 34-year-old Hispanic male with multiple bilateral lower extremity lesions, right buttock and leg pain, fatigue, and splenomegaly, who was found to have chronic-phase CML. Punch biopsy of one of the skin lesions demonstrated dermal infiltration by maturing hematopoietic elements, including granulocytes, megakaryocytes, and erythroid precursors, with fluorescence in situ hybridization (FISH) testing confirming a neoplastic extramedullary hematopoietic infiltrate with the presence of BCR::ABL1 fusion. Initial treatment included hydroxyurea and dasatinib; however, after chronic-phase CML was confirmed, therapy was transitioned to imatinib, resulting in resolution of B symptoms, normalization of WBC counts, and reduced leg swelling. This case underscores the importance of distinguishing CEH from aggressive disease states, such as blast-phase CML or myeloid sarcoma, through comprehensive histopathological and immunohistochemical analysis.","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"53 9","pages":"767-771"},"PeriodicalIF":1.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.70114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Manifestation of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Clue to A Gastrointestinal Malignancy 单形上皮性肠t细胞淋巴瘤的皮肤表现：胃肠道恶性肿瘤的线索。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-08-03 Epub Date: 2026-04-21 DOI: 10.1111/cup.70123

Fan Foon Cheo, Aashna Farishta, Briana M. Garcia, Weiyun Z. Ai, Karthik Ganapathi, Laura B. Pincus

{"title":"Cutaneous Manifestation of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Clue to A Gastrointestinal Malignancy","authors":"Fan Foon Cheo, Aashna Farishta, Briana M. Garcia, Weiyun Z. Ai, Karthik Ganapathi, Laura B. Pincus","doi":"10.1111/cup.70123","DOIUrl":"10.1111/cup.70123","url":null,"abstract":"<div>\u0000 \u0000 We present a rare case of cutaneous involvement of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL). A 68-year-old man first presented with multiple purpuric patches which extended from his axilla to his groin. Biopsies demonstrated a dermal-based infiltrate of predominantly medium-sized atypical CD8+/CD56+/TCR-δ-/EBER- T-lymphocytes with slight epidermotropism associated with extravasated red cells. A diagnosis of primary cutaneous cytotoxic T-cell lymphoma was rendered after presumably excluding systemic lymphoma by staging PET/CT scan and bone marrow biopsy. One year later, he developed purpuric patches and ulcerations of the tongue and 3 months after that, jejunal perforation. Both tongue biopsy and small bowel resection revealed a similar infiltrate of epitheliotropic CD8+/CD56+/TCR-δ-/EBER- cytotoxic T-cells. Supportive histopathologic features and the absence of gluten-sensitive enteropathy eventually led to the diagnosis of MEITL in the jejunal resection. In retrospect, his initial cutaneous and oral lesions were a mucocutaneous manifestation of MEITL as well, and systemic involvement was not detected on conventional staging. Cutaneous involvement in MEITL is exceedingly uncommon, and this case underscores the importance of including MEITL in the differential diagnosis of skin biopsies of mostly dermal-based lymphomas with only slight epidermotropism with a CD8+/CD56+/TCRδ-/EBER- phenotype. Early endoscopic evaluation may facilitate diagnosis of occult intestinal disease.\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"53 9","pages":"803-808"},"PeriodicalIF":1.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0