原发性伴有转移的皮肤smarca4缺陷肿瘤。

IF 1.1 4区医学 Q3 DERMATOLOGY

Journal of Cutaneous Pathology Pub Date : 2025-06-04 DOI:10.1111/cup.14828

Supriya Pradhan, Martha Lehman, Abdul Mohd Tahir, Michael Su, Steven Kossard, Renukadas Sakalkale

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引用次数: 0

摘要

缺乏SMARCA-4的皮肤肿瘤极为罕见。这些都是侵袭性肿瘤，应该在一开始就从其高度形态学和常规肿瘤标志物的缺失或极度缺乏中识别出来，而且应该进行SMARCA-4的完全缺失。我们提出这样一个病例广泛转移，值得注意的是相对相当小的原发皮肤病变。必须对病例进行全面评估，以排除全身性疾病，包括胸内脏疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Primary Cutaneous SMARCA4-Deficient Tumor With Metastases

SMARCA-4 deficient cutaneous tumor is extremely uncommon. These are aggressive tumors to begin with, and should be recognised at the outset from their extremely high-grade morphology and absence or extreme paucity of not only usual carcinoma markers but also complete absence of SMARCA-4, which should be performed. We present such a case with extensive metastases, notable for relatively quite small size of primary skin lesion. The case must be evaluated in full to rule out systemic including thoraco-visceral disease.

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来源期刊

Journal of Cutaneous Pathology 医学-病理学

CiteScore

3.20

自引率

5.90%

发文量

174

审稿时长

3-8 weeks

期刊介绍： Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.