Journal of Cutaneous Pathology最新文献_第6页

Cutaneous Langerhans Cell Sarcoma Harboring BRAF V600E Mutation Followed by Chronic Myelomonocytic Leukemia and EBV-Positive Diffuse Large B-Cell Lymphoma. 含有BRAF V600E突变的皮肤朗格汉斯细胞肉瘤继发慢性髓细胞白血病和ebv阳性弥漫性大b细胞淋巴瘤。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-06 DOI: 10.1111/cup.70208

Seung Hyo Cho, Su Min Lee, Jee-Bum Lee, Sook Jung Yun

引用次数: 0

Aberrant Expression of Multiple T-Cell Markers in Primary Cutaneous Follicle Center Lymphoma: A Rare Case Report. 多种t细胞标记物在原发性皮肤滤泡中心性淋巴瘤中的异常表达：一罕见病例报告。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-06 DOI: 10.1111/cup.70207

V Pfefferle, A Vogelsberg, M Maaß, C M Schürch, S Forchhammer

引用次数: 0

Cutaneous-Only Relapse in T-Cell Prolymphocytic Leukemia With JAK2 Rearrangement 伴有JAK2重排的t细胞前淋巴细胞白血病的皮肤复发。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-03-09 DOI: 10.1111/cup.70076

Francisco Javier Díaz de la Pinta, Iván Prieto-Potín, Rebeca Manso Alonso, Juan Torre Castro, Cristina Serrano del Castillo, Jesús Frutos Díaz-Alejo, Rocío Nieves Salgado, Socorro María Rodríguez Pinilla

引用次数: 0

Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics 直肠浅表性尤文氏肉瘤一例报告及分子诊断的应用。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-05-07 DOI: 10.1111/cup.70128

Jessica L. Muldoon, Laura M. Warmke, Ahmed K. Alomari, Rachel P. Kowal

{"title":"Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics","authors":"Jessica L. Muldoon, Laura M. Warmke, Ahmed K. Alomari, Rachel P. Kowal","doi":"10.1111/cup.70128","DOIUrl":"10.1111/cup.70128","url":null,"abstract":"<p>Ewing sarcoma is an undifferentiated small round cell sarcoma that most commonly presents as a malignant bone tumor in pediatric and young adult patients. The diagnosis is typically confirmed by molecular genetic identification of a fusion protein, most commonly involving members of the FET and ETS gene families. The most frequent translocation is <i>EWSR1</i>::<i>FLI1</i> which occurs in approximately 85% of cases. Rare extraosseous cases of superficial Ewing sarcoma have been described, including one molecularly confirmed tumor involving the rectum. Herein, we report the second molecularly confirmed case of a superficial, rectal primary tumor arising in a 38-year-old male who initially presented with bleeding. Physical exam noted an ulcerated rectal polyp near the dentate line. Excisional biopsy of the lesion revealed a monotonous round cell malignancy involving the submucosal tissue with necrosis and marked mitotic activity. Immunohistochemical studies showed reactivity for CD99 and NKX2.2 with weak, focal expression of synaptophysin. Next-generation sequencing revealed an <i>EWSR1</i>::<i>FLI</i> fusion, confirming the diagnosis of Ewing sarcoma. The fusion variant junction was located in exon 7 for EWSR1 and exon 6 for FLI1. Subsequent imaging revealed no evidence of metastatic disease, and re-excision showed no residual tumor. Primary superficial Ewing sarcoma is extremely rare, and this is only the second molecularly confirmed case of rectal origin.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"53 10","pages":"917-920"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodistributed Hyperpigmentation in a Chronic Kratom User: Histologic and Elemental Characterization 慢性Kratom使用者的光分布色素沉着：组织学和元素特征。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-05-11 DOI: 10.1111/cup.70126

Aubrey Nicole Montebello, Michael R. Lewin-Smith, Liesl Grenier, Stacy L. Strausborger, Michael Royer

{"title":"Photodistributed Hyperpigmentation in a Chronic Kratom User: Histologic and Elemental Characterization","authors":"Aubrey Nicole Montebello, Michael R. Lewin-Smith, Liesl Grenier, Stacy L. Strausborger, Michael Royer","doi":"10.1111/cup.70126","DOIUrl":"10.1111/cup.70126","url":null,"abstract":"<div>\u0000 \u0000 <p>Kratom (<i>Mitragyna speciosa</i>) is a plant-derived supplement increasingly used in the United States for chronic pain and mood elevation due to its opioid-like effects. While systemic side effects have been described, cutaneous manifestations have rarely been reported. We report a case of striking photodistributed dyspigmentation in a chronic kratom user, with a detailed description of the histologic and elemental analysis findings. A 37-year-old Soldier taking kratom for lower back pain presented with asymptomatic blue-gray pigmentation involving his face, neck, and dorsal hands. Biopsy revealed pigment-laden macrophages within the superficial dermis, a mild perivascular and periadnexal lymphohistiocytic infiltrate, and a slightly thickened basement membrane. Special stains confirmed the pigmented particles as melanin-like. Scanning electron microscopy with energy-dispersive X-ray analysis (SEM-EDXA) demonstrated sulfur-containing material, consistent with phaeomelanin and/or a drug metabolite melanin-like complex. This case expands the clinicopathologic understanding of kratom-associated dermatoses and illustrates the utility of SEM-EDXA in identifying exogenous or drug-induced pigmentation.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"53 10","pages":"925-929"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kratom Cutaneous Hyperpigmentation: An Emerging Dermatosis for Dermatopathologists and Dermatologists to Recognize 克拉通皮肤色素沉着：一种新出现的皮肤病皮肤病病理学家和皮肤科医生认识。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-07-12 DOI: 10.1111/cup.70175

Susan Pei, Maxwell A. Fung, Melissa Piliang, Adam I. Rubin

引用次数: 0

Plasmablastic Lymphoma Presenting With Multiple Cutaneous Nodules Mimicking Primary Cutaneous Marginal Zone Lymphoma 浆母细胞淋巴瘤表现为多个皮肤结节，类似原发性皮肤边缘区淋巴瘤。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-05-10 DOI: 10.1111/cup.70137

Bo-Jung Chen, Feng-Jie Lai, Yin-Hsun Feng, Shih-Sung Chuang

{"title":"Plasmablastic Lymphoma Presenting With Multiple Cutaneous Nodules Mimicking Primary Cutaneous Marginal Zone Lymphoma","authors":"Bo-Jung Chen, Feng-Jie Lai, Yin-Hsun Feng, Shih-Sung Chuang","doi":"10.1111/cup.70137","DOIUrl":"10.1111/cup.70137","url":null,"abstract":"<div>\u0000 \u0000 <p>Plasmablastic lymphoma (PBL) is a rare, high-grade large B-cell lymphoma characterized by large atypical cells with plasmablastic or immunoblastic morphology and a terminal B-cell differentiation phenotype. PBL often occurs in patients with immune deficiency or dysregulation, most commonly HIV infection. Cutaneous involvement is rare and occurs most frequently in those with immune deficiency. We report a 73-year-old immunocompetent female presenting with multiple cutaneous lesions and cervical lymphadenopathy. Nasopharyngeal and cutaneous biopsies confirmed EBV-associated PBL with plasmacytic differentiation, mimicking primary cutaneous marginal zone lymphoma (PC-MZL). The patient was treated with multiagent chemotherapy. Her disease progressed and she passed away in 9 months. We reviewed the literature for EBV-associated PBL occurring in the skin and those in immunocompetent patients. A comprehensive systemic evaluation integrating clinical, laboratory, and imaging findings is essential for excluding PC-MZL and plasmablastic multiple myeloma and establishing the correct diagnosis.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"53 10","pages":"930-936"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Presentation of TEN-Like Subacute Cutaneous Lupus Erythematosus Occurring in the Setting of Donepezil Exposure and COVID-19 Infection: A Diagnostic Challenge 罕见的10样亚急性皮肤红斑狼疮发生在多奈哌齐暴露和COVID-19感染的背景下：一个诊断挑战。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-05-11 DOI: 10.1111/cup.70109

Sydney Kenney, Andrea Acosta, Jason Castillo, David Cassarino, Aparche Yang

{"title":"Rare Presentation of TEN-Like Subacute Cutaneous Lupus Erythematosus Occurring in the Setting of Donepezil Exposure and COVID-19 Infection: A Diagnostic Challenge","authors":"Sydney Kenney, Andrea Acosta, Jason Castillo, David Cassarino, Aparche Yang","doi":"10.1111/cup.70109","DOIUrl":"10.1111/cup.70109","url":null,"abstract":"<div>\u0000 \u0000 <p>Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous reaction characterized by rapidly progressive epidermal necrosis within hours to days, extensive skin detachment, and high mortality. Rarely, patients present with TEN-like eruptions that evolve slowly, over days to weeks, and have skin changes mostly confined to photodistributed areas, with possible mucosal involvement. The latter scenario is compatible with TEN-like lupus erythematosus. We report a 65-year-old man without prior lupus history who developed a widespread, photodistributed erythematous patchy eruption within 24 h of initiating donepezil for Parkinsonism-associated aphasia. The erythema rapidly progressed to erosions, bullae, and detachment involving 81% total body surface area (TBSA) and a Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) of 2. Initial differential diagnoses included TEN/Stevens Johnson Syndrome (SJS), bullous pemphigoid, generalized bullous fixed drug eruption, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), and reactive infectious mucocutaneous eruption (RIME). Histopathology revealed interface dermatitis with diffuse basilar apoptosis, focal full-thickness epidermal necrosis and robust dermal mucin deposits. Direct immunofluorescence study was negative. Serologies showed strongly positive anti-Ro/SSA and ANA titers. COVID-19 testing was positive. The constellation of clinical, pathologic and laboratory features supported a diagnosis of TEN-like subcutaneous lupus erythematosus (SCLE), likely triggered by donepezil and complicated by a concurrent COVID-19 infection. To our knowledge, this is a novel case of TEN-like SCLE associated with donepezil initiation.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"53 10","pages":"946-954"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermal-Based Spindle Cell Lipoma: A Case Series of 12 Patients 皮肤为基础的梭形细胞脂肪瘤：12例病例分析。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-05-22 DOI: 10.1111/cup.70146

Luke J. Debenham, Gauri Panse, Christine J. Ko

{"title":"Dermal-Based Spindle Cell Lipoma: A Case Series of 12 Patients","authors":"Luke J. Debenham, Gauri Panse, Christine J. Ko","doi":"10.1111/cup.70146","DOIUrl":"10.1111/cup.70146","url":null,"abstract":"<div>\u0000 \u0000 <p>Spindle cell lipoma (SCL) is a benign adipocytic neoplasm that typically presents as a subcutaneous mass in the “shawl” distribution of older men. This classic prototype is well recognized; however, the clinicopathologic features of dermal variants remain incompletely characterized. This case series includes 12 dermally located SCLs from our archives. Morphologic features were evaluated by consensus, and immunohistochemistry for RB1 and CD117 was performed on available tissue. The cohort included eight men and four women, with a mean age of 55 years. Half of the cases (50%) arose in atypical locations, most commonly the face. Histologically, tumors frequently deviated from the classic morphology: 50% were fat-free or fat-poor, 83% were poorly circumscribed, 33% showed myxoid change, and 16% displayed pseudoangiomatous features. All cases where immunohistochemistry could be performed showed RB1 loss (6 cases) and abundant CD117-positive mast cells (7 cases). Dermal SCL differs from the classic subcutaneous prototype. They are more likely to affect women, occur in atypical sites, be poorly circumscribed, and have fat-free or fat-poor morphologies. These deviations from the prototypical SCL illness script are diagnostically challenging, since they mimic other spindle cell neoplasms, such as neurofibroma, <i>PRRX1</i>-rearranged fibroblastic tumor, and a variety of spindle cell lesions that lack RB1 expression. CD117-positive mast cells may be helpful diagnostically.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"53 10","pages":"955-960"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicentric Asynchronous Endocrine Mucin-Producing Sweat Gland Carcinoma and Mucinous Carcinoma of the Skin 多中心非同步内分泌分泌黏液素的汗腺癌和皮肤黏液癌。

IF 1.2 4区医学

Journal of Cutaneous Pathology Pub Date : 2026-09-01 Epub Date: 2026-04-29 DOI: 10.1111/cup.70122

Ikuko Hirai, Joseph F. Sobanko, Tara C. Mitchell, Jacquelyn Roth, Rosalie Elenitsas, Emily Y. Chu

引用次数: 0