Journal of Cutaneous Pathology最新文献_第6页

Merkel Cell Carcinosarcoma: Wnt Pathway Activation Associated With Sarcomatoid Transformation 默克尔细胞癌肉瘤：Wnt通路激活与肉瘤样转化相关。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-05-28 DOI: 10.1111/cup.14825

Satsuki Kishikawa, Seiji Tsuruta, Eiji Nakano, Dai Ogata, Kenjiro Namikawa, Naoya Yamazaki, Yasushi Yatabe, Taisuke Mori

引用次数: 0

BCL-6-Positive Cutaneous Mantle Zone Hyperplasia: A Novel Subtype of B-Cell Cutaneous Lymphoid Hyperplasia bcl -6阳性皮套带增生：b细胞皮淋巴样增生的一种新亚型。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-05-05 DOI: 10.1111/cup.14820

Atsushi Naito, Hiroyuki Irie, Masakazu Fujimoto, Satoshi Nakamizo, Naotomo Kambe, Hironori Haga, Kenji Kabashima

{"title":"BCL-6-Positive Cutaneous Mantle Zone Hyperplasia: A Novel Subtype of B-Cell Cutaneous Lymphoid Hyperplasia","authors":"Atsushi Naito, Hiroyuki Irie, Masakazu Fujimoto, Satoshi Nakamizo, Naotomo Kambe, Hironori Haga, Kenji Kabashima","doi":"10.1111/cup.14820","DOIUrl":"10.1111/cup.14820","url":null,"abstract":"<div>\u0000 \u0000 <p>Cutaneous lymphoid hyperplasia (CLH) is a benign lymphoid proliferation that may share features of skin lymphoma. Although reactive germinal centers (GCs) are common in B-cell CLH, cases with mantle zone hyperplasia (MZH), a rare phenomenon reported in reactive lymphadenopathy, have never been documented. We report a case of CLH with MZH showing weak BCL-6 expression, complicating its distinction from cutaneous B-cell lymphoma (CBCL). A 57-year-old man presented with erythematous nodules on the face. Biopsy showed diffuse B-cell infiltrates with lymph follicles. BCL-6 was weakly positive in lymphocytes outside the GCs, raising concerns about CBCLs, such as primary cutaneous follicle center lymphoma (PCFCL). However, the infiltrate outside the GCs expressed IgD and TCL1 and was confirmed to be an expanded mantle zone. The absence of cyclin-D1 expression ruled out mantle cell lymphoma. Although Southern blotting showed weak clonal bands, polymerase chain reaction-based clonality analysis and ultrasensitive RNA in situ hybridization for kappa and lambda chains did not detect clonal B-cell proliferation, leading to the diagnosis of CLH. Herein, we report BCL-6-positive cutaneous MZH as a novel subtype of CLH, highlighting the limitations of BCL-6 positivity in extrafollicular B-cells as an indicator for CBCLs, as it can be observed outside the GCs.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"482-486"},"PeriodicalIF":1.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Trichophyton rubrum Mimicking Blastomycosis in an Immunocompromised Patient 免疫功能低下患者侵袭性红毛菌模拟芽孢菌病。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-05-05 DOI: 10.1111/cup.14817

Ezdean Alkurdi, Omar Alani, Dany Alkurdi, Elizabeth Page, Artur Zembowicz, Adriano Piris, Zachary Schwager

引用次数: 0

Unilateral Pachydermodactyly in a Young Female: A Rare Diagnosis Requiring Novel Clinicopathological Correlation 年轻女性单侧厚皮畸形：罕见的诊断需要新的临床病理相关性。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-04-26 DOI: 10.1111/cup.14818

Nicole K. Hooten, Patrick S. Phelan, Sara C. Shalin, Megan S. Evans

{"title":"Unilateral Pachydermodactyly in a Young Female: A Rare Diagnosis Requiring Novel Clinicopathological Correlation","authors":"Nicole K. Hooten, Patrick S. Phelan, Sara C. Shalin, Megan S. Evans","doi":"10.1111/cup.14818","DOIUrl":"10.1111/cup.14818","url":null,"abstract":"<div>\u0000 \u0000 <p>Pachydermodactyly (PDD) is a rare, non-inflammatory fibromatosis characterized by thickening of the proximal interphalangeal joints, typically presenting bilaterally in adolescent males. We report a case of unilateral pachydermodactyly transgrediens in a 14-year-old female with a one-year history of painless, doughy thickening and hyperpigmentation on the left proximal interphalangeal joints. Comprehensive labwork and imaging studies revealed no evidence of inflammatory joint disease, leading to further investigation by biopsy to confirm the suspected diagnosis of unilateral pachydermodactyly and to exclude other diagnostic possibilities. Histopathologic examination revealed findings consistent with PDD: epidermal hyperkeratosis, acanthosis, and disorganized dermal collagen bundles without significant inflammation or sclerosis. This case emphasizes the importance of recognizing the typical clinical, histopathologic, and radiographic features of pachydermodactyly, particularly highlighting the absence of specific histopathological features such as inflammation, significant mucin deposition, increased cellularity, fibrosis, or sclerosis. Increased awareness of the varying presentations of PDD may aid in timely diagnosis and help avoid unnecessary evaluation and treatment of more serious conditions that mimic PDD. Our case highlights the importance of clinicopathological correlation in diagnosis PDD, especially in atypical presentations, and aims to increase awareness of this entity among dermatopathologists.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"453-458"},"PeriodicalIF":1.6,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrofolliculoma/Trichodiscoma With Focal Follicular Germinative Cell Differentiation 纤维滤泡瘤/毛线虫伴局灶性滤泡萌发细胞分化。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-04-25 DOI: 10.1111/cup.14819

Kotomi Arioka, Taro Sugawara, Kenta Sasaki, Marimi Funahashi, Kaori Koga, Shintaro Sugita

{"title":"Fibrofolliculoma/Trichodiscoma With Focal Follicular Germinative Cell Differentiation","authors":"Kotomi Arioka, Taro Sugawara, Kenta Sasaki, Marimi Funahashi, Kaori Koga, Shintaro Sugita","doi":"10.1111/cup.14819","DOIUrl":"10.1111/cup.14819","url":null,"abstract":"<div>\u0000 \u0000 <p>Fibrofolliculoma (FF) and trichodiscoma (TD) are benign adnexal tumors that arise from hair follicles or their surrounding structures. They seldom show a histology of hair germ. In this report, we present an interesting case of FF/TD with focal follicular germinative cell differentiation. A 56-year-old female presented with a solitary 8 mm nodule that was located behind the left ear. Histologically, a nodular tumor protruded from the skin surface and presented some follicular infundibulum-like structures that showed cystic expansion continuous with the epidermis. Thin epithelial cords consisted of 2 to 3 layers of cuboidal to columnar cells, and they radially expanded from a center of the follicle-like structure. The epithelial cords showed an anastomosed to fenestrated pattern with many various-sized sebaceous lobules. In some areas, peripheral portions of the epithelial cords continued to the follicular germs that were composed of basaloid cells with peripheral palisading. On immunohistochemistry, basaloid cells of the nest of follicular germinative cells only showed a strong expression of PHLDA1 and BerEP4. Based on these findings, we diagnosed this tumor as FF/TD with focal follicular germinative cell differentiation. It provides valuable insights into the origin and disease concept of these tumors.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"478-481"},"PeriodicalIF":1.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contact Dermatitis of the Scalp Also Demonstrates Sebaceous Gland Atrophy 头皮接触性皮炎也表现为皮脂腺萎缩。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-04-23 DOI: 10.1111/cup.14814

Jonathan J. Lee, Divya Angra, Leonard C. Sperling

引用次数: 0

Histopathologic Features in Urticaria and Urticarial Variants: Plasma Cells Should Be Rare 荨麻疹和荨麻疹变体的组织病理学特征：浆细胞应该是罕见的。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-04-22 DOI: 10.1111/cup.14815

Sena Zengin, Lauren C. Morehead, Sara C. Shalin

{"title":"Histopathologic Features in Urticaria and Urticarial Variants: Plasma Cells Should Be Rare","authors":"Sena Zengin, Lauren C. Morehead, Sara C. Shalin","doi":"10.1111/cup.14815","DOIUrl":"10.1111/cup.14815","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Urticaria is a common cutaneous reaction pattern characterized by clinically transient edematous papules and wheals. Microscopically, intensity and predominant inflammatory cell type can vary, including lymphocytes, eosinophils, neutrophils, and mast cells. Plasma cells are rarely described within the infiltrate of urticaria, but systematic study to evaluate the frequency of this finding is lacking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The institutional dermatopathology archive was searched for 2018–2023 to identify cases diagnosed as urticaria and urticarial variants; 58 consecutive cases were included. Study authors, including one board-certified dermatopathologist, evaluated H&E slides for variation in inflammatory cells present, inflammation density/distribution, and predominant cell types.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-eight cases (female: 39, male: 19) were reviewed. Eleven cases (19%) showed rare, scattered plasma cells (0.02–0.09/mm<sup>2</sup>). Other inflammatory cell types predominated and, like other studies, fell into lymphocytic and neutrophilic predominant categories. Inflammation density predominantly ranged from sparse to moderate, with only two cases having brisk inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights that rare plasma cells may be present in urticaria biopsies but should not be abundant or clustered.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"497-505"},"PeriodicalIF":1.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Griscelli Syndrome Type 2 Secondary to a Novel RAB27A Variant Presenting With Dermatitis Griscelli综合征2型继发于一种新的RAB27A变异，表现为皮炎。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-04-22 DOI: 10.1111/cup.14812

Dharmagat Bhattarai, Aaqib Zaffar Banday, Smita Joshi, Ram Chandra Adhikari, Iftikhar Ali, Mohsin Rashid, Altaf Hussain Kambay

引用次数: 0

Nail Unit Amyloidoma With Prominent Onycholemmal Cysts Masquerading as Malignancy 甲单位淀粉样瘤伴突出的甲乳头囊肿伪装成恶性肿瘤

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-04-21 DOI: 10.1111/cup.14816

Blaire A. Anderson, Corinne Rauck, Meaghan C. Dougher, Adam I. Rubin

引用次数: 0

Rare Concomitant Langerhans Cell Histiocytosis in a Patient With Folliculotropic Mycosis Fungoides 嗜滤泡性蕈样真菌病罕见合并朗格汉斯细胞组织细胞增多症。

IF 1.6 4区医学

Journal of Cutaneous Pathology Pub Date : 2025-04-19 DOI: 10.1111/cup.14811

Cristo A. Carrasco Mendoza, Isabel Arana, David S. Cassarino

{"title":"Rare Concomitant Langerhans Cell Histiocytosis in a Patient With Folliculotropic Mycosis Fungoides","authors":"Cristo A. Carrasco Mendoza, Isabel Arana, David S. Cassarino","doi":"10.1111/cup.14811","DOIUrl":"10.1111/cup.14811","url":null,"abstract":"<div>\u0000 \u0000 <p>The relationship between lymphomas such as mycosis fungoides and Langerhans cell histiocytosis (LCH) is exceedingly rare. Cases reported in the literature describe lymphomas preceding a diagnosis of LCH, as well as LCH followed by a diagnosis of lymphoma. Here, we present a 76-year-old patient with a years-long history of recalcitrant folliculotropic mycosis fungoides (FMF) who presented to the outpatient dermatology clinic with newly developed painful and itchy cutaneous nodules. Subsequent flow cytometry showed no evidence of Sezary syndrome. NM PET/CT FDG showed no systemic involvement but revealed areas of intense FDG uptake in multiple sites. Biopsy from one of these sites revealed dense, nodular atypical lymphohistiocytic infiltrate and several large intrafollicular Langerhans cell collections, consistent with LCH. Immunohistochemical staining was strongly and diffusely positive for S100, Langerin, and CD1a, confirming the diagnosis of LCH. This is a very rare and unusual case of a patient with FMF who subsequently developed LCH. We emphasize the importance of distinguishing mycosis fungoides from LCH using histopathological, immunohistochemical, and clinical findings. Additionally, we encourage the differentiation between reactive Langerhans cell hyperplasia and neoplastic, malignant LCH and to consider repeat biopsies as appropriate.</p>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"52 7","pages":"474-477"},"PeriodicalIF":1.6,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0