Journal of Cutaneous Pathology最新文献

{"title":"A rare case of metastatic osteoblastic osteosarcoma to the scalp.","authors":"Efrain Lee-Diaz, Brittany L Dulmage, Swati Satturwar, Jose A Plaza","doi":"10.1111/cup.14706","DOIUrl":"https://doi.org/10.1111/cup.14706","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NRASQ61R-driven atypical melanocytic tumor with blue nevus-like morphology: A case report","authors":"Tsubasa Hiraki MD, PhD,&nbsp;Hiroki Mori MD, PhD,&nbsp;Junko Misawa MD,&nbsp;Marina Yunoki MD,&nbsp;Keisuke Goto MD","doi":"10.1111/cup.14709","DOIUrl":"10.1111/cup.14709","url":null,"abstract":"<p><i>NRAS</i> Q61 mutations are driver genetic alterations associated with common melanocytic nevi. Herein, we describe a case of <i>NRAS</i>-mutant melanocytic tumor with a blue nevus-like morphology. A 71-year-old Japanese man presented with a 4.6-mm nodule on his back. Histopathological examination revealed a dense distribution of spindle-shaped melanocytes in the upper dermis and a sparse distribution of dendritic melanocytes in the mid-dermis. The vertical periadnexal extension reached the deep dermis at the center of the tumor. A small junctional component, hyperpigmentation, sclerotic stroma, mild nuclear atypia, and a few mitotic figures were observed. Immunohistochemical examination revealed no PRAME expression and preserved p16 expression. Diffuse RASQ61R immunoreactivity was observed in these tumor cells. Nuclear β-catenin expression was not observed. Targeted RNA sequencing revealed two mutations, <i>NRAS</i> c.182A&gt;G (Q61R) and <i>FGFR2</i> c.-157A&gt;G, but no other pathogenic alterations such as <i>BRAF</i>, <i>GNAQ</i>, <i>GNA11</i>, <i>CTNNB1</i>, <i>PRKAR1A</i>, or <i>IDH1</i> mutations or kinase gene fusions. The histopathology fits that of compound-type blue nevus, which is called “Kamino nevus”; however, this tumor was genetically considered to be on the spectrum of conventional acquired melanocytic nevi but not on that of blue nevi. Morphologically, <i>NRAS</i>-driven melanocytic nevi resemble blue nevi without <i>IDH1</i>^R132C coexistence.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 12","pages":"948-953"},"PeriodicalIF":1.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of an erythrodermic mycosis fungoides as a biologically indolent anaplastic large T-cell lymphoma initially misdiagnosed as being of donor origin.","authors":"Francisco Javier Díaz de la Pinta, Rebeca Manso, Juan Torre, Luis Requena, Socorro Maria Rodriguez-Pinilla","doi":"10.1111/cup.14710","DOIUrl":"https://doi.org/10.1111/cup.14710","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathologic, genomic, transcriptomic, and functional characteristics of eight melanocytic tumors with BRAF fusions showing stronger MAPK pathway activation compared to BRAF V600E tumors","authors":"Aofei Li MD,&nbsp;Simon J. Warren MD,&nbsp;Brandon A. Umphress MD,&nbsp;Ahmed K. Alomari MD","doi":"10.1111/cup.14704","DOIUrl":"10.1111/cup.14704","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Activating <i>BRAF</i> gene alterations are central to melanocytic tumor pathogenesis. A small, emerging subset of melanocytic tumors driven by <i>BRAF</i> fusions has distinct therapeutic implications and has been described to have Spitzoid morphology patterns. However, such morphological patterns do not encompass all cases, and little is known about the functional molecular events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted a retrospective search through our molecular archives to identify melanocytic tumors with <i>BRAF</i> fusions. We reviewed clinical, histopathological, and genomic features. We further explored transcriptomic and protein-level findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histopathologic patterns varied, with many cases without a distinctive pattern. We identified novel and diverse <i>BRAF</i> gene fusion partners. Differential transcriptomic analysis between low-risk <i>BRAF</i> fusion tumors and reference <i>BRAF V600E</i> tumors showed no differentially expressed genes. However, quantitatively stronger MAPK pathway activation of <i>BRAF</i> fusion tumors over <i>BRAF V600E</i> tumors was demonstrated by statistically significant stronger staining of p-ERK immunohistochemistry. Gene-specific RNA analysis shows comparable <i>BRAF</i> transcript levels between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion and Conclusion</h3>\u0000 \u0000 <p>The quantitatively stronger activation of the MAPK pathway of <i>BRAF</i> fusion tumors, instead of qualitatively different transcriptomes, may account for the morphology difference from conventional <i>BRAF V600E</i> tumors. <i>BRAF</i> fusions likely act through dysregulated protein function rather than RNA upregulation related to the characteristics of the fusion partners.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 11","pages":"899-910"},"PeriodicalIF":1.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14704","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioplasmacellular hyperplasia: Livid exophytic nodule on the anterior hairline","authors":"Tey Hwee Ting Vanessa MBBS, MRCP (UK),&nbsp;Koh Hong Yi MBBS, MRCP (UK), M.Med (Int Med), FAMS (Dermatology),&nbsp;Joel Lim Hua-Liang MBBS, MRCP (UK), M.Med (Int Med), Dip. Dermatopathology (ICDP-UEMS)","doi":"10.1111/cup.14705","DOIUrl":"10.1111/cup.14705","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 12","pages":"919-921"},"PeriodicalIF":1.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exceptional case of imatinib mesylate inducing both psoriasis and lichenoid reaction: A case report.","authors":"Kaoutar Belharti, Hasnae Saddouk, Nassiba Zerrouki, Siham Dikhaye, Nada Zizi","doi":"10.1111/cup.14703","DOIUrl":"https://doi.org/10.1111/cup.14703","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of PRAME immunohistochemistry in cutaneous vascular neoplasms reveals frequent expression in primary and post-irradiation cutaneous angiosarcomas","authors":"Andrea Krajisnik MD, MS,&nbsp;Neda Rezaee MD,&nbsp;Eleanor R. Duncan BS,&nbsp;Bonnie L. Balzer MD, PhD,&nbsp;Wonwoo Shon DO","doi":"10.1111/cup.14707","DOIUrl":"10.1111/cup.14707","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Preferentially expressed antigen in melanoma (PRAME) has been extensively studied in cutaneous melanocytic tumors and has proven valuable as a diagnostic adjunct in routine dermatopathology practice. However, its expression in cutaneous vascular neoplasms, particularly angiosarcomas (AS), remains largely unexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To further explore PRAME expression in cutaneous AS, 18 cases of post-irradiation and 13 cases of primary cutaneous AS were evaluated for PRAME. For comparison, sections from 11 deep soft tissue/visceral AS, 10 Kaposi sarcomas, 8 microvenular hemangiomas, 7 infantile hemangiomas, 8 atypical vascular lesions, 6 epithelioid hemangioendotheliomas, 6 pyogenic granulomas, 6 papillary endothelial hyperplasias, 6 epithelioid hemangiomas, 3 capillovenous malformations, 3 hobnail hemangiomas, 2 spindle cell hemangiomas, 2 pseudomyogenic hemangioendotheliomas, and 2 composite hemangioendotheliomas were also retrieved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 22 of 31 (70.9%; 12 post-irradiation and 10 primary) cutaneous AS were positive for PRAME. In contrast, only 1 of 11 (9.1%) deep soft tissue/visceral AS showed diffuse and strong PRAME nuclear staining. All other tumor types were negative for PRAME, except for 5 of 7 (71.4%) infantile hemangiomas, which demonstrated rare (&lt;5%; four cases) and 1+ (5–25%; one case) nuclear staining.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this study, we have demonstrated frequent nuclear PRAME expression in cutaneous AS. PRAME immunohistochemistry may serve as a valuable additional marker in selected clinical settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 11","pages":"893-898"},"PeriodicalIF":1.6,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical clinical presentation of eosinophilic angiocentric fibrosis with cutaneous and upper respiratory tract involvement","authors":"Juan Manuel Liñán-Barroso MD,&nbsp;Nicolás Valérdiz-Menéndez MD,&nbsp;José Salvador García-Morillo MD, PhD,&nbsp;José Bernabeu-Wittel MD, PhD","doi":"10.1111/cup.14701","DOIUrl":"10.1111/cup.14701","url":null,"abstract":"","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 11","pages":"821-824"},"PeriodicalIF":1.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulomatous secondary syphilis: When to maintain a high index of suspicion?","authors":"Monia Di Prete,&nbsp;Alessandra Latini,&nbsp;Viviana Lora,&nbsp;Fulvia Pimpinelli,&nbsp;Carlo Cota","doi":"10.1111/cup.14702","DOIUrl":"10.1111/cup.14702","url":null,"abstract":"&lt;p&gt;We recently read with great interest, the publication entitled “Granulomatous secondary syphilis: Another diagnostic pitfall for dermatopathologist” concerning a case of secondary syphilis with granulomatous inflammation on histopathology, which was immunohistochemically negative for &lt;i&gt;Treponema pallidum&lt;/i&gt;.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Jin et al. underlined that granulomatous infiltration is uncommon in cases of secondary syphilis cutaneous lesions. In these cases, detecting the spirochetes may be difficult, as the number of microorganisms decreases in established, non-treated infections. Although the &lt;i&gt;T. pallidum&lt;/i&gt; immunohistochemistry is highly sensitive and can detect even a small number of pathogens, the case described in the paper failed to stain. It was possible to establish the correct diagnosis by matching serological results.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Recently, a 48-year-old Caucasian woman visited our unit with a diffuse rash, which was present for 3 months without any other symptoms. The eruption consisted of widespread erythematous papules and nodules on the trunk and extremities without the involvement of the mucous membranes, palms, and soles (Figure 1A,B). She was referred to us by an external dermatologist with the suspected diagnosis of cutaneous lymphoma. The histopathological examination of a punch-biopsy specimen, a lesion on the left flank, revealed a granulomatous inflammatory infiltration in the dermis, with perivascular distribution (Figure 1C). At higher magnification, the epithelioid granulomas were surrounded by small lymphocytes and numerous plasma cells (Figure 1D). Immunohistochemistry for &lt;i&gt;T. pallidum&lt;/i&gt; failed to reveal organisms. Despite the negativity of the stain, the histopathology was highly suspicious of secondary granulomatous syphilis; therefore, we suggested performing serological investigations to confirm the diagnosis of syphilis; both the Venereal Disease Research Laboratory and the &lt;i&gt;T. pallidum&lt;/i&gt; hemagglutination assay (TPHA) were negative. The patient returned to us 3 weeks later due to the development of new lesions on the oral mucosa and a single lesion on the sole of the right foot. We decided to directly test for &lt;i&gt;T. pallidum&lt;/i&gt; from an exudative lesion on the trunk using a real-time polymerase chain reaction (PCR) assay, which finally resulted in a positive detection. We repeated the serology in the Microbiology Laboratory of our Hospital on the same day of the cutaneous swab, and at this time, it resulted positive in syphilis, with a rapid plasma reagin (RPR) titer of 1:64 and a TPHA titer of 1:2560 and negative for HIV.&lt;/p&gt;&lt;p&gt;The patient received two intramuscular injections of 1 200 000 units of diaminocillin, preceded by 4 mg of betamethasone, resulting in complete remission of the disease.&lt;/p&gt;&lt;p&gt;Syphilis still represents a diagnostic pitfall for dermatologists and dermatopathologists, as it may manifest with a variety of clinical and histopathological features. From a cl","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 11","pages":"866-867"},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread purplish-red plaques with plasma cell infiltrate: A rare type of lichen planus","authors":"Szeman Cheung MD,&nbsp;Jie Zheng MD, PhD,&nbsp;Xiaoqing Zhao MD","doi":"10.1111/cup.14699","DOIUrl":"10.1111/cup.14699","url":null,"abstract":"<p>Diseases in which cutaneous plasma cell infiltrates predominate are rare and usually of unknown etiology, including those that transition from benign to malignant, such as cutaneous plasmacytosis, multicentric Castleman disease, and extramedullary plasmacytoma. These diseases may present as purplish, reddish-brown cutaneous plaques or nodules. Here, we report an exceptional case of lichen planus (LP) in which the patient had classic histopathological features, but the infiltrating inflammatory cells were plasma cells with restricted light chain expression. The patient presented with severe rashes, including purplish-red plaques and nodules, erythema, and erosions in the palmoplantar area, verrucous hyperplasia of the oral mucosa, and anonychia of the toes. These findings suggest a possible role of plasma cells with restricted light chain expression in the LP. Clinicians should closely follow patients for changes in their rash, perform repeat biopsies if necessary, and regularly conduct multisystemic evaluations.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":"51 12","pages":"938-941"},"PeriodicalIF":1.6,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}