Journal of Burn Care & Research最新文献_第4页

An Analysis of Regional Blocks During Enzymatic Debridement of Burns. 烧伤酶清创过程中局部阻滞的分析。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf084

Zoey Chasen, Justin Suarez, Alexander Kurjatko

{"title":"An Analysis of Regional Blocks During Enzymatic Debridement of Burns.","authors":"Zoey Chasen, Justin Suarez, Alexander Kurjatko","doi":"10.1093/jbcr/iraf084","DOIUrl":"10.1093/jbcr/iraf084","url":null,"abstract":"Anacaulase is a mixture of enzymes used for the breakdown of eschar in patients with deep partial- or full-thickness burns up to 20% of the body's surface area. European consensus guidelines recommend regional anesthesia of an isolated extremity undergoing enzymatic debridement, but no North American consensus has been reached. Our practice has shifted from a multimodal pain strategy to utilize regional blocks prior to the application of anacaulase. The purpose of this study was to determine whether the introduction of regional blocks improved pain control in patients receiving anacaulase therapy. This is a single-center retrospective comparative study evaluating all patients who received anacaulase from July 2016 to July 2024. Continuous data was evaluated via the Wilcoxon rank sum test and categorical data was evaluated via the chi-square test of independence. In the prespecified period, 47 patients received anacaulase and were included for analysis. Of the 47 patients, 24 (51.1%) underwent regional block. There were no significant differences in baseline characteristics except lower baseline opioid requirements in the regional block group. Pain scores during anacaulase application were significantly lower in patients that received regional blocks (4.5 vs 7, P = .003). There was no difference in change in opioid requirements or requirement of adjunct medications except for dexmedetomidine requirements (0% vs 78.3%, P < .001). Our data suggest that regional blocks were associated with lower pain scores in burn patients receiving anacaulase therapy but did not result in a change in opioid requirements from baseline. Regional blocks may be an effective strategy in this population to reduce pain from enzymatic debridement, but prospective studies would be warranted.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1012-1016"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Preexisting Substance Use Disorders on Prolonged Opioid Use and Postoperative Complications After Burns. 既往物质使用障碍对烧伤后阿片类药物长期使用和术后并发症的影响。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf098

Philong Nguyen, Joshua E Lewis, Isabelle J Carroll, Joshua Wang, Mbinui Ghogomu, Blancheneige Beohon, Amina El Ayadi, Steven Wolf, Juquan Song

{"title":"Impact of Preexisting Substance Use Disorders on Prolonged Opioid Use and Postoperative Complications After Burns.","authors":"Philong Nguyen, Joshua E Lewis, Isabelle J Carroll, Joshua Wang, Mbinui Ghogomu, Blancheneige Beohon, Amina El Ayadi, Steven Wolf, Juquan Song","doi":"10.1093/jbcr/iraf098","DOIUrl":"10.1093/jbcr/iraf098","url":null,"abstract":"Previous studies have linked preexisting substance use disorders (SUDs) to adverse postoperative outcomes in burn patients, yet their impact on opioid use remains unclear. This retrospective cohort study compares the effects of various substances on opioid use after burns and aims to analyze the risks and whether they differ among substances. The TriNetX database was queried for burn patients aged 18 years and older with preexisting alcohol, cannabis, or tobacco use disorders, who were placed in their respective cohorts. These patients were matched to a nonsubstance use disorder cohort using propensity score matching based on demographics, mental health, pain syndromes, and burn severity. The measured outcomes assessed were opioid use, wound infection, wound disruption, and postprocedural pain. Risk ratios and 95% confidence intervals were calculated at 3 months and 12 months postburn. After matching, patients with preexisting SUDs had significantly higher risk ratios for prolonged opioid use, wound infections, and wound healing disruptions at both 3 and 12 months compared to matched patient control cohorts. Additionally, all patient cohorts also exhibited increased risk of postprocedural pain. Burn patients with preexisting SUDs face a significantly higher risk of prolonged opioid use and postoperative complications at both 3- and 12-month postburn injury. The alcohol cohort patients were associated with the greatest increase in opioid use and postoperative complications, while the tobacco patient cohort presented with the highest wound disruption rates at 3- and 12-months postburn.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1042-1052"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypermetabolism exacerbation with increased white blood cell counts in patients with severe burns. 严重烧伤患者高代谢加剧伴白细胞计数增高。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf061

Beth A Shields, Alexis D Caponera, Jasmine D Geromiller, Julianne M Koenigsberg, James K Aden, Beatriz George, Leopoldo C Cancio

{"title":"Hypermetabolism exacerbation with increased white blood cell counts in patients with severe burns.","authors":"Beth A Shields, Alexis D Caponera, Jasmine D Geromiller, Julianne M Koenigsberg, James K Aden, Beatriz George, Leopoldo C Cancio","doi":"10.1093/jbcr/iraf061","DOIUrl":"10.1093/jbcr/iraf061","url":null,"abstract":"Severe weight loss after large burns has been previously described when the hypermetabolic response is not met with adequate nutritional provisions. Clinically, we have been able to minimize this weight loss in most patients admitted to our burn center but have identified unexpected weight loss in some. The goal of this analysis was to identify predictors of this weight loss. This retrospective descriptive study included adult patients with at least 20% total body surface area (TBSA) burns admitted between September 2017 and February 2023. There were 63 patients who met the criteria for this study: median of 35% TBSA burn (IQR: 27-51), 44 years old (IQR: 31-55), and 21% women. These patients experienced a median weight loss of 3 kg (IQR: 1-8) over 31 days (IQR: 22-50). Most (78%) patients experienced ≤10% weight loss, whereas 2% sustained >20% weight loss. The final factors significant in the multivariate analysis evaluating weight loss included days from injury to lowest weight, average white blood cells (WBC) × days, and caloric deficit (P < .01). The resulting equation is: weight loss (in kg) = 1.1 + 0.0121 × average WBC in 103/uL × days + 0.0001 × caloric deficit-0.1432 × days from injury to lowest weight (R2 = 0.54). This indicates a further increase in metabolism above the expected hypermetabolic response when there is an elevation in WBC, likely reflecting concurrent sepsis or other processes driving systemic inflammation. Further research should focus on frequent metabolic cart study measurements in patients with elevated WBC counts to further elucidate this relationship.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"970-974"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Retrospective, Noninferiority Study of a Treat-at-Home Strategy Utilizing a Surfactant-based Dressing for Partial-Thickness Burn Wounds. 一项使用表面活性剂为基础的敷料治疗部分厚度烧伤创面的居家治疗策略的回顾性非劣效性研究。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf088

Lorraine A Todor, Matthew Sanders, Elysha Lyle, Denise Knight, Maria Tucci, Jacob Jarreau, Mahmoud Hassouba, David M Hill

{"title":"A Retrospective, Noninferiority Study of a Treat-at-Home Strategy Utilizing a Surfactant-based Dressing for Partial-Thickness Burn Wounds.","authors":"Lorraine A Todor, Matthew Sanders, Elysha Lyle, Denise Knight, Maria Tucci, Jacob Jarreau, Mahmoud Hassouba, David M Hill","doi":"10.1093/jbcr/iraf088","DOIUrl":"10.1093/jbcr/iraf088","url":null,"abstract":"Partial-thickness (PT) burns are the most common depth of burn seen in emergency departments (ED). This study aimed to evaluate the outcomes of patients managed with a treatment-at-home (TAH) strategy using water-soluble surfactant dressing (WSD) compared to any other dressing (non-WSD). This single-center, retrospective study included all patients with thermal burns treated in the burn center-specific ED between May 2019 and May 2023. Patients were excluded if admission was deemed necessary during the initial ED assessment. Additionally, patients were excluded for having first-degree burns, full-thickness burns, electrical burns, being less than 18 years old, pregnant or incarcerated, or not expected to survive. The planned enrollment was designed to fulfill noninferiority and potential superiority of surfactant-based dressing versus any other TAH strategy. Two-thousand seven-hundred forty-seven patients were screened over the 4-year study. After applying exclusion criteria, 1001 patients remained in the study group. There were no differences in demographics and injury mechanism, except the non-WSD group contained more patients that were cocaine positive (P = .009)and had burns to the head/neck (P < .0001). Few in the WSD or non-WSD group required subsequent admission for burn wound excision [5 (1.0%) vs 2 (0.4%)] although the non-WSD had significantly fewer return for follow-up [336 (68.71%) vs 273 (53.32%), P < .001]. This is the largest study to evaluate the use of WSD for immediate treatment of PT burns to avoid admission. WSD was found to be non-inferior to other non-WSD TAH strategies. But no matter the choice of home wound treatment, few required subsequent admission for surgery. Given the success of both groups, a TAH model, when feasible, could allow patients to recover at home and result in cost and resource savings associated with admission.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1031-1035"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Impacting Delayed Return to School Among Children Living with Burn Injury: A Burn Model System Study. 影响烧伤儿童延迟返校的因素：一项烧伤模型系统研究。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf059

Geun-Woo Oh, Gretchen J Carrougher, Xinyao deGrauw, Rachel Field, Stephanie Lillybridge, Caitlin M Orton, Deja Nicholas, Carly Marincasiu, Shelley A Wiechman, Sarah Stoycos, Karen Kowalske, Colleen M Ryan, Barclay T Stewart

{"title":"Factors Impacting Delayed Return to School Among Children Living with Burn Injury: A Burn Model System Study.","authors":"Geun-Woo Oh, Gretchen J Carrougher, Xinyao deGrauw, Rachel Field, Stephanie Lillybridge, Caitlin M Orton, Deja Nicholas, Carly Marincasiu, Shelley A Wiechman, Sarah Stoycos, Karen Kowalske, Colleen M Ryan, Barclay T Stewart","doi":"10.1093/jbcr/iraf059","DOIUrl":"10.1093/jbcr/iraf059","url":null,"abstract":"Return to school is a key indicator of rehabilitation effectiveness for school-age children with burn injuries. Previous studies reported on the timing of return to school but have not delineated how individual and injury characteristics impact RTS due to single-center analyses and limited sample sizes. Our goal is to provide factors to consider when providing guidance and benchmarking days to RTS and allocating rehabilitation resources after burn injury. We analyzed data from a multicenter, longitudinal cohort study of US school-age children between the ages 5 and 17 years who required operation for wound closure and their parents/guardians. Days from index hospital discharge to return to school by self- or parent/guardian-report were recorded via surveys. The associations between days to return to school and age, sex, burn size, body region of injury, inhalation injury, number of operations, and month of discharge were examined using multivariable mixed-effects Poisson regression analyses with robust standard error estimates. Data from 266 participants were analyzed. The median days to return to school after hospital discharge were 43 (IQR 21.5-81 days). Days to return to school after discharge in school-age children with burn injuries were significantly longer among 12-14-year-olds, boys, and children whose fire/flame injury had had ≥5% TBSA, inhalation injury, head/neck injury, more operations, and were discharged during the school year months. Future research should explore children's experiences with barriers in school settings and develop mitigation strategies addressing both clinical and non-clinical aspects of burn aftercare to enhance care for children with burn injuries.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"963-969"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Synthetic Electrospun Fiber Matrix Utilized in Conjunction with Homograft Wound Dressings in the Management of Post Excisional Massive Necrotizing Fasciitis: A Case Report. 修正：人工合成静电纺丝纤维基质与同种移植物伤口敷料联合用于切除后大面积坏死性筋膜炎的治疗：1例报告。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf055

引用次数: 0

What You Wear Underneath Your Gear Matters. 你在你的装备下面穿什么很重要。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf056

Michael J Feldman, Gerald E Pruden, Joshua Petteway, Denise N Statham, Prabhu Senthil-Kumar

{"title":"What You Wear Underneath Your Gear Matters.","authors":"Michael J Feldman, Gerald E Pruden, Joshua Petteway, Denise N Statham, Prabhu Senthil-Kumar","doi":"10.1093/jbcr/iraf056","DOIUrl":"10.1093/jbcr/iraf056","url":null,"abstract":"Protecting firefighters from burn injury risk is a top priority. Having standards ensures the different types of gear adequately meet performance requirements. The National Fire Protection Association (NFPA) standards, NFPA 1971, Standard on Protective Ensembles for Structural Firefighting and Proximity Firefighting, and NFPA 1977, Standard on Protective Clothing and Equipment for Wildland Firefighting and Urban Interface Firefighting, focus on the performance of firefighter protective clothing worn in structural and wildland scenarios respectively, but do not mandate what garments are worn next to the skin. Anecdotal evidence suggests that what firefighters wear under their gear can impact burn injury, but minimal scientific data is available to support these findings. Our study aims to test the effect of different undergarments in realistic flashover events on a test manikin. Manikins were outfitted with sensors to measure the effects of a flashover environment and underwent a review by a verified burn center team to correlate manikin damage to injuries that would occur in a real event. The study focuses on understanding how the increased use of synthetic undergarments affects firefighter safety. This research is vital as firefighters often wear synthetic undergarments without the ability to change quickly during unpredictable incidents, and previous findings may not be applicable to their experiences.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"954-962"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

National Estimates and Outcomes for Supplemental Home Oxygen Therapy Injuries-A Burn Care Quality Platform Analysis. 补充家庭氧疗损伤的国家估计和结果-烧伤护理质量平台分析。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf087

Clifford Sheckter, Eloise Stanton, Karla Klas, Bart Phillips, Rebecca Coffey, Alisa Savetamal, Lucy Wibbenmeyer

{"title":"National Estimates and Outcomes for Supplemental Home Oxygen Therapy Injuries-A Burn Care Quality Platform Analysis.","authors":"Clifford Sheckter, Eloise Stanton, Karla Klas, Bart Phillips, Rebecca Coffey, Alisa Savetamal, Lucy Wibbenmeyer","doi":"10.1093/jbcr/iraf087","DOIUrl":"10.1093/jbcr/iraf087","url":null,"abstract":"The incidence of admissions for burn and inhalation injuries related to home oxygen therapy remains poorly defined in the U.S. We analyzed the American Burn Association's Burn Care Quality Platform (BCQP) database (2013-2022) to generate national estimates of supplemental home oxygen therapy-related injuries and outcomes. Text string extraction identified cases using multiple search permutations related to home oxygen use. Patient demographics, injury characteristics, and inpatient outcomes were described. Logistic regression assessed predictors of oxygen therapy injuries, and Poisson regression estimated adjusted incidence rates. Of 207 364 burn admissions, 79 114 (28%) contained injury descriptions, with 3.0% (2360 cases) attributed to home oxygen therapy. These patients had a median age of 65 years (IQR: 59-71), mean total body surface area (TBSA) of 4.1%, were predominantly male (62.6%) and white (79.0%). Medicare was the most common payer (57.7%). Inhalation injury was present in 11.4%, mean length of stay was 8 days, and inpatient mortality was 6.1%. Smoking was the leading ignition source (63%), followed by cooking/stove (4%), while 22% had no identified cause. The adjusted incidence rate of supplemental home oxygen injuries was 3.6% (95% CI, 2.7%-2.9%; P < 0.001), with a significant annual increase (incidence rate ratio: 1.03; 95% CI, 1.02-1.04). Oxygen therapy-related injuries account for 1088 (95% CI, 1065-1113) burn admissions per year in the U.S. Despite smaller TBSA burns, mortality was twice the national average for burn patients, and for survivors, the odds of discharge home were 15% less likely. Targeted prevention strategies are needed to mitigate this growing public health problem.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1025-1030"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dilution Is Not Always the Solution: A Retrospective Study of Pulmonary Lavage in Inhalation Injury. 稀释并不总是解决办法：吸入性损伤肺灌洗的回顾性研究。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf078

Ashleigh Bull, Colette Galet, Samuel W Jones, Alexander Kurjatko

{"title":"Dilution Is Not Always the Solution: A Retrospective Study of Pulmonary Lavage in Inhalation Injury.","authors":"Ashleigh Bull, Colette Galet, Samuel W Jones, Alexander Kurjatko","doi":"10.1093/jbcr/iraf078","DOIUrl":"10.1093/jbcr/iraf078","url":null,"abstract":"Burned patients with inhalation injury commonly undergo bronchoscopy, at times with pulmonary lavage (PL). We characterized the outcomes of burned patients with inhalation injury who underwent PL at a single burn center in a retrospective cohort study. We included all adult patients admitted between July 1, 2015 to June 30, 2023 who were on the ventilator and diagnosed with inhalation injury. Chemical inhalation, grade 0 inhalation injury, and diagnosis of inhalation injury without bronchoscopy were excluded. Demographics, burn size and anatomic location, and hospital course information were collected. Chi-square and Fisher's exact tests were used to compare categorical variables, and continuous variables were compared using the Mann-Whitney U test. Multivariate analyses were performed to identify variables associated with outcomes. P < .05 was considered significant. One hundred sixteen patients were included; 37 (31.9%) underwent PL. Univariate analysis showed no significant differences in age, total body surface area burned (TBSA) second or third degree TBSA, complication rates, or in-hospital mortality between the no-PL and PL groups. Patients in the PL group had increased ventilator days (6 [2.5-15.5] vs. 2 [1-6], P < .001) and hospital length of stay (LOS) (12 [4-37.5] vs. 5 [2-18], P = .003). Multivariate analysis showed that PL was associated with an increase in ventilator days (OR = 1.84 [1.14-2.98], P = .013), hospital LOS (OR = 1.717 [1.080-2.730], P = .022), and sepsis (OR = 7.216 [1.106-47.080], P = .039). In conclusion, PL was associated with longer ventilator days, longer LOS, and increased risk of sepsis.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"995-1000"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous Skin Cell Suspension in Burn Care: A Systematic Review and Meta-Analysis of Clinical Outcomes. 自体皮肤细胞悬浮液在烧伤治疗中的应用：临床结果的系统回顾和荟萃分析。

IF 1.8 4区医学

Journal of Burn Care & Research Pub Date : 2025-09-19 DOI: 10.1093/jbcr/iraf181

Kian Daneshi, José Antonio Arellano, Sarah Tepe, Hilary Y Liu, Haig A Yenikomshian, Justin Gillenwater, C Scott Hultman, Jenny A Ziembicki, Francesco M Egro

{"title":"Autologous Skin Cell Suspension in Burn Care: A Systematic Review and Meta-Analysis of Clinical Outcomes.","authors":"Kian Daneshi, José Antonio Arellano, Sarah Tepe, Hilary Y Liu, Haig A Yenikomshian, Justin Gillenwater, C Scott Hultman, Jenny A Ziembicki, Francesco M Egro","doi":"10.1093/jbcr/iraf181","DOIUrl":"https://doi.org/10.1093/jbcr/iraf181","url":null,"abstract":"Background: ReCell, an autologous cell harvesting technology also known as Autologous Skin Cell Suspension (ASCS), has shown promise in enhancing skin regeneration for burn patients. Despite its growing use in clinical practice, the current literature displays considerable variability in study design and quality, leading to ongoing uncertainty about its true clinical effectiveness. This systematic review and meta-analysis aim to comprehensively evaluate the clinical efficacy of ASCS in the treatment of burns.Methods: A systematic review was conducted in accordance with PRISMA guidelines, utilizing searches across PubMed, Web of Science, Embase, and Cochrane databases. The review protocol was prospectively registered on PROSPERO (CRD42024606554). The Cochrane Risk of Bias Tool and the ROBINS-I tool were applied to assess bias in randomized controlled trials and observational studies, respectively. The overall methodological quality of included studies was appraised using the GRADE framework.Results: Fourteen studies (n = 3362) fulfilled the inclusion criteria. The pooled mean patient age was 37.6 years, with a male predominance (65.9%). The average %TBSA affected was 14.6% (95% CI: 8.8-20.4), with substantial heterogeneity (I2 = 95.1%). Meta-analysis demonstrated a statistically significant reduction in complication rates with ASCS combined with split-thickness skin grafting (STSG) compared to STSG alone (RR = 0.64, 95% CI: 0.41-1.00, p = 0.048). However, rates of wound infection and graft failure did not differ significantly between groups.Conclusions: ASCS demonstrates potential in reducing complications in burn care. Nevertheless, due to heterogeneous study designs, further high-quality, large-scale randomized trials are warranted to validate its long-term efficacy and broader clinical utility.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0