Simrat Kaur, Xinyao DeGrauw, Joseph Grobowski, Carly Marincasiu, Caitlin M Orton, Julie Hodapp, Lewis E Kazis, Maxwell B Johnson, Karen Kowalske, Shelley A Wiechman, Dylan Jason, Jody Sabel, Max Hukil, Robyn Wilkinson, Gretchen J Carrougher, Tam Pham, Barclay T Stewart
{"title":"Mental and Social Health Recovery After Major Burn Injuries: A Burn Model System Study.","authors":"Simrat Kaur, Xinyao DeGrauw, Joseph Grobowski, Carly Marincasiu, Caitlin M Orton, Julie Hodapp, Lewis E Kazis, Maxwell B Johnson, Karen Kowalske, Shelley A Wiechman, Dylan Jason, Jody Sabel, Max Hukil, Robyn Wilkinson, Gretchen J Carrougher, Tam Pham, Barclay T Stewart","doi":"10.1093/jbcr/irag094","DOIUrl":"10.1093/jbcr/irag094","url":null,"abstract":"<p><p>Although survival after major burn injury is increasingly common, persistent psychosocial morbidity often remains prevalent, and the relationship between burn severity and long-term psychosocial recovery is less understood. We aimed to evaluate longitudinal trajectories of mental health and social recovery across large burn-size strata to examine whether injury severity differentially influences internal psychological outcomes vs external social participation. We conducted a retrospective, multicenter longitudinal analysis of adults with ≥ 20% total body surface area burns enrolled in the Burn Model System National Longitudinal Database, using outcome measures available across their respective collection periods. Participants were stratified by total body surface area groups of large (20%-49.9%), very large (50%-69.9%), or massive (≥70%). Outcomes included Patient-Reported Outcomes Measurement Information System domains of Depression, Anxiety, and Ability to Participate in Social Roles; Community Integration Questionnaire-Social Integration; and employment status assessed at 6-, 12-, and 24-month postinjury. Mixed-effects linear regression models adjusted for demographic and clinical covariables. Among 815 participants, depression and anxiety remained elevated relative to population norms, while social participation improved across all burn sizes longitudinally. Survivors with massive burns demonstrated the greatest improvement in mental health over 24 months, with changes reaching clinically meaningful magnitude, and their community integration at 24 months was comparatively preserved, coming closest to preinjury burn levels despite lower perceived social role ability and employment. These findings demonstrate that psychosocial recovery over the first 24 months does not worsen in proportion to injury severity, indicating that injury severity alone should not define prognosis. Rather, survival and rehabilitation after massive burn injury can translate into meaningful psychological adaptation and social integration that benefits from sustained, multidisciplinary follow-up across all burn severities.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1339-1351"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarthak Sinha, Edna Ayerim Mandujano-Tinoco, Eren Kutluberk, Patrick P G Mulder, Nicolás Collao, Keerthana Chockalingam, Alexander Pun, Rkia Dardari, Myriam Verly, Frankie O G Fraulin, A Robertson Harrop, Nicole L Rosin, Vincent Gabriel, Jeff Biernaskie
{"title":"Immature Neutrophil Programs Associate With Burn Mortality and Extend Across Critical Illnesses.","authors":"Sarthak Sinha, Edna Ayerim Mandujano-Tinoco, Eren Kutluberk, Patrick P G Mulder, Nicolás Collao, Keerthana Chockalingam, Alexander Pun, Rkia Dardari, Myriam Verly, Frankie O G Fraulin, A Robertson Harrop, Nicole L Rosin, Vincent Gabriel, Jeff Biernaskie","doi":"10.1093/jbcr/irag067","DOIUrl":"10.1093/jbcr/irag067","url":null,"abstract":"<p><p>Severe burns provoke a systemic \"genomic storm,\" yet cell states associated with divergent outcomes remain unclear. We profiled blood cells by single-cell RNA-Sequencing (73 014 cells) from adult patients with burn injuries within postburn day 17 (n = 4) and healthy donors (n = 5), integrated data with bulk signatures of burn size, inhalation injury, and mortality, and evaluated clinical associations in the American Burn Association National Burn Repository. Burn was associated with emergency hematopoiesis marked by expansion of hematopoietic stem/progenitor-like cells, immature neutrophils, and plasmablast/plasma cell states, alongside depletion of naïve CD4+/CD8+ T cells and dendritic cells. Larger burns (>20% TBSA) showed enrichment of humoral transcriptional programs, including plasmablast/plasma cell activation and suppression of cytotoxic CD8+ T-cell states. In multivariable models, inhalation injury was a stronger predictor of death (adjusted odds ratio [OR] 1.9) than burn size (adjusted OR 1.1) and shared greater overlap with the most perturbed single cells in non-survivors; 55% of co-perturbed cells were neutrophils, implicating granulocyte dysregulation as a common lethal axis. We identified a neutrophil-specific 5-gene panel (OLFM4, RETN, LCN2, ARG1, and BTNL3) that discriminated survivors vs non-survivors after burns (area under the curve [AUC] > 0.9) and generalized to trauma (n = 158; AUC 0.81) and intensive care unit COVID-19 (n = 103; AUC 0.75), providing information orthogonal to conventional biomarkers and severity scores. Cytomorphology corroborated transcriptomic immaturity, with ~2-fold higher band neutrophils and larger neutrophil size in a fatal case. Computational drug-reversal analysis highlighted galectin-1 inhibition as a candidate modulator of mortality-associated neutrophil programs. Together, our findings suggest that immature neutrophils represent a shared immune feature across severe burns and other forms of critical illness.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1445-1459"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Athena Hoppe, Cindy Rutter, Rebekah R Allely, Jeffrey E Carter, Jeffrey W Shupp, M Victoria P Miles
{"title":"The Missing Conversation in Burn Care: Intimacy and Sexuality.","authors":"Athena Hoppe, Cindy Rutter, Rebekah R Allely, Jeffrey E Carter, Jeffrey W Shupp, M Victoria P Miles","doi":"10.1093/jbcr/irag112","DOIUrl":"10.1093/jbcr/irag112","url":null,"abstract":"<p><p>Intimacy and sexuality are essential components of quality of life after burn injury, yet they remain overlooked in burn survivorship care. Evidence demonstrates lasting declines in sexual satisfaction and relational well-being among burn survivors but discussions about these concerns are rarely initiated by providers and standardized approaches remain absent. Surveys of burn care professionals reveal widespread discomfort in addressing sexual health, despite consensus that patients should not be expected to initiate these conversations. In contrast, other specialties, including oncology and cardiology, have recognized sexual health as a core component of survivorship and have implemented structured screening tools, counseling pathways, and multidisciplinary models of care. Burn survivors face distinct challenges that extend beyond physiologic sexual function, including altered body image, visible scarring, psychological recovery, and changes in relational confidence and closeness. These factors underscore the need to expand burn rehabilitation to include both sexual health and broader intimacy concerns. This commentary urges development of provider education and accessible clinical resources to support these conversations throughout the continuum of burn care. By intentionally integrating these elements into care models, the burn community can move beyond survival alone and advocate for recovery that restores connection, identity, and the possibility of fulfilling intimate lives.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1607-1609"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maybelle E Singson, Desiree N Pinto, Katherine F Wallace, Emily Woolhiser, Katelyn Marzo, Tuan D Le, Bonnie C Carney, Lauren T Moffatt, Jamie G Oh, Taryn E Travis, Jeffrey W Shupp, Shawn Tejiram
{"title":"Ultra-Early Mobilization After Split-Thickness Skin Grafting in Burn Patients is not Associated with Graft Loss.","authors":"Maybelle E Singson, Desiree N Pinto, Katherine F Wallace, Emily Woolhiser, Katelyn Marzo, Tuan D Le, Bonnie C Carney, Lauren T Moffatt, Jamie G Oh, Taryn E Travis, Jeffrey W Shupp, Shawn Tejiram","doi":"10.1093/jbcr/irag113","DOIUrl":"10.1093/jbcr/irag113","url":null,"abstract":"<p><p>Timing of mobilization following split-thickness skin grafting (STSG) in burn patients varies amongst burn centers, due to concerns for graft loss with earlier postoperative mobilization. Existing literature supports the feasibility of earlier mobilization after STSG but is limited in scope. This study aimed to explore the association between time to mobilization after STSG and graft loss, hypothesizing that ultra-early mobilization within 24 h of STSG does not increase the risk of graft loss. Adult patients who underwent STSG for treatment of thermal burn injuries at an American Burn Association (ABA)-verified burn center from 2021 to 2024 were included. Each incident of STSG was categorized as ultra-early (£24 h) or late (>24 h) mobilization. Mobilization cohorts were then compared by graft loss using an institutional grading scale, defined as graft loss >50% of the area grafted, requiring prolonged wound care, or requiring re-operation. Mobilization was defined as either passive or active movement. Of the 240 patients included, there were a total of 431 STSG. Of these, 69 patients were critically ill with a total of 193 STSG. Rates of graft loss were similar between groups (9% vs 9.2%; P = .93). Neither ultra-early mobilization (OR, 0.59; 95% CI, 0.20-1.73; P = .33) or ambulation compared to in-bed exercises (OR, 1.41; 95% CI, 0.36-5.50; P = .62) increased the odds of graft loss. The findings suggest that ultra-early mobilization within 24 h after STSG does not increase the risk of graft loss in burn patients, and out-of-bed ambulation does not increase the risk of graft loss compared to in-bed therapy.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1426-1434"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lior Har-Shai, Sapir Gershov, Tomer Lagziel, Noa Manasseh, Alon Keller, Garry Gali Tzarfati, Daniel Hilewitz, Dean Ad-El, Eyal Kalish, Asaf Olshinka
{"title":"Machine Learning-Based Predictive Model for Fever and Adverse Clinical Events in Hospitalized Pediatric Burn Patients.","authors":"Lior Har-Shai, Sapir Gershov, Tomer Lagziel, Noa Manasseh, Alon Keller, Garry Gali Tzarfati, Daniel Hilewitz, Dean Ad-El, Eyal Kalish, Asaf Olshinka","doi":"10.1093/jbcr/irag074","DOIUrl":"10.1093/jbcr/irag074","url":null,"abstract":"<p><p>Systemic inflammation after pediatric burn injury frequently causes fever, complicating early recognition of infectious complications. Improved risk-stratification may help identify patients at risk for adverse clinical events during hospitalization. This study aimed to develop and validate a machine learning (ML)-based model using a Random Forest (RF) algorithm to predict fever and related adverse outcomes in hospitalized pediatric burn patients. We conducted a retrospective analysis of 595 pediatric burn patients admitted to a tertiary center between 2012 and 2022. Extracted data included demographics, burn characteristics, clinical interventions, laboratory values, and outcomes. RF models were trained to predict three key endpoints: fever (>38.5°C), transfer to pediatric intensive care unit (PICU), and need for surgical intervention. To address missing data and class imbalance, we employed multiple imputation techniques and generated synthetic data through bootstrap sampling to improve model robustness. The patient cohort had a mean age of 4.27 (range: 0.2-18.1) years and an average total body surface area of 5.49 (range: 0.3-45.0). The RF models demonstrated high predictive accuracy, with F1-scores of 0.81 ± 0.037 (fever), 0.88 ± 0.091 (PICU transfer), and 0.81 ± 0.027 (surgery). Area Under the Curve values were 0.96, 0.97, and 0.95, respectively. Feature importance analysis identified younger age, lower body weight, female sex, and head and neck burn location as key predictors. These ML-based RF models demonstrate strong potential for early risk-stratification of fever and high-risk trajectories in hospitalized pediatric burn patients, guiding monitoring intensity, diagnostic vigilance, and resource planning. Prospective evaluation is needed to determine whether model-informed workflows improve outcomes.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1467-1473"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mia J Carrarini, Christopher J Fedor, Omar Zein, Hilary Y Liu, José Antonio Arellano, Garth Elias, Alain C Corcos, Jenny A Ziembicki, Mohamed H Yassin, Francesco M Egro
{"title":"Comparative Efficacy of Hypochlorous Acid and Mafenide Acetate in Reducing Infection Rates in Postoperative Burn Patients: A Retrospective Cohort Study.","authors":"Mia J Carrarini, Christopher J Fedor, Omar Zein, Hilary Y Liu, José Antonio Arellano, Garth Elias, Alain C Corcos, Jenny A Ziembicki, Mohamed H Yassin, Francesco M Egro","doi":"10.1093/jbcr/irag080","DOIUrl":"10.1093/jbcr/irag080","url":null,"abstract":"<p><p>Infection is a leading cause of mortality in patients with third-degree burns, contributing to over 75% of burn-related deaths. Despite the widespread use of hypochlorous acid (HOCl) and mafenide acetate (MA) as wet dressings in burn care, direct comparisons of their effectiveness are limited. Thus, this study evaluates the relative efficacy of HOCl and MA in managing infections and improving survival outcomes in postoperative burn patients. This retrospective study included adults with second and third-degree burns who underwent excision and grafting between January 2012 and February 2024 at an American Burn Association-verified burn center. Infection, mortality, length of stay, number of operations, and complications were compared across initial antiseptic treatment using chi-square and Mann-Whitney tests. The study cohort comprised 274 patients, the majority of whom sustained flame burns (63.1%), with an average total body surface area burned of 11.2 ± 13.7%. Within the cohort, 88.7% received MA and 11.3% HOCl. Thirteen patients (41.9%) who received HOCl developed an infection requiring antibiotics, which on average, took 6.85 ± 5.71 days to develop. This was not statistically different from those in the MA group, of which 90 patients (37.0%) developed an infection (P = .5840) which took 6.50 ± 8.47 days to develop (P = .4436). Mortality was also not significantly different between groups. No significant differences were found between HOCl and MA in infection, mortality, or morbidity outcomes. Both treatments are viable antiseptic options for postoperative burn care, and clinicians can be flexible in choosing either treatment based on patient needs, cost, or availability without compromising care quality.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1291-1296"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victoria R Hammond, Sukruthi Yerramreddy, Michael E Egger, Jason W Smith, Matthew C Bozeman
{"title":"Identifying Risk Factors for Readmission amongst Unhoused Burn Patients.","authors":"Victoria R Hammond, Sukruthi Yerramreddy, Michael E Egger, Jason W Smith, Matthew C Bozeman","doi":"10.1093/jbcr/irag108","DOIUrl":"10.1093/jbcr/irag108","url":null,"abstract":"<p><p>Previous studies have used national data to assess readmission risk factors for patients with burn injury. This study sought to identify risk factors for readmission amongst unhoused burn patients. The 2022 Nationwide Readmissions Database, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, was used for this study. Patients with International Classification of Diseases Version 10 codes for burn or corrosive injury between January 1, 2022, to November 30, 2022, were included in analysis. Readmission was defined as a subsequent encounter within 30 days with a diagnosis of burn. 18 607 encounters were identified as index admissions, 1130 (6.1%) were unhoused. 8.6% of unhoused patients (n = 97) were readmitted with a diagnosis of burn injury compared to 5.2% (n = 908) of housed patients (P < .001). Risk factors for readmission for unhoused patients included a third-degree burn (OR 2.4, [1.4-4.2], P < .001), leaving against medical advice (OR 4.1, [2.6-6.6], P < .001), burn of the trunk (OR 1.9, [1.2-3.0], P < .001), burn of the upper extremity (OR 1.9, [1.2-3.0], P < .001), and burn of the lower extremity (OR 1.6, [1.0-2.6], P = .004). Despite higher rates of diagnoses such as schizophrenia, bipolar disorder, alcohol abuse, and/or substance abuse in the unhoused population, these factors did not increase risk for readmission. Unhoused burn patients were at higher risk of readmission than housed patients, even when adjusting for other risk factors for readmission. Severity of injury, location of injury, and leaving against medical advice were associated with readmission amongst unhoused patients. Leaving against medical advice was a potentially modifiable risk factor identified for readmission risk mitigation in this study.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1388-1394"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley E Buchholz, Jeffrey E Carter, Mario A Rivera-Barbosa, Jonathan E Schoen, Victoria P Miles
{"title":"An Oral History Archive Honoring the Legacy of Burn Nurses.","authors":"Ashley E Buchholz, Jeffrey E Carter, Mario A Rivera-Barbosa, Jonathan E Schoen, Victoria P Miles","doi":"10.1093/jbcr/irag078","DOIUrl":"10.1093/jbcr/irag078","url":null,"abstract":"<p><p>History is frequently recorded through statistics; in burn care, this often manifests as mortality rates and graft-take percentages. Yet, the history of burn care is equally a narrative of human resilience and professional evolution. This manuscript presents findings from the Burn Nursing Oral History Archive Project, which sought to preserve the historical identity of the specialty through the voices of its pioneers. By weaving together extensive interview transcripts with foundational historical texts, this project reconstructs the trajectory of burn nursing from the mid-20th century to the present. It identifies key historical inflection points, including pivotal mass casualty events and the formal recognition of burn nursing as a distinct specialty by the American Nurses Association in 2020. Qualitative analysis of interviews with 16 accomplished burn nursing professionals reveals an evolution from bedside clinicians to leaders of interdisciplinary care and champions of prevention. The results are categorized into 3 distinct eras: the foundation period defined by compassion and moral dilemma, the modernization period focused on establishing protocols and survivorship, and the current era of professional validation through national certification. The findings argue that while clinical protocols and technologies have shifted dramatically, the foundational philosophy of humanistic, patient-centered care remains a constant thread. This archive serves as an impactful tool and call to action for future generations, anchoring current practice in the historical advocacy and compassion that define the specialty.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1277-1285"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel M Nygaard, Emily Colonna, Alexander Poole, Lee D Faucher, Rosemary E Paine, Naveen Sangji, Alexandra Lacey, Dhaval Bhavsar, Kristin Colling, Alexis Armour, Irma Fleming, Arek Wiktor, Lucy Wibbenmeyer
{"title":"Synthesis of Protocols for Frostbite Care From the FROST Study Sites.","authors":"Rachel M Nygaard, Emily Colonna, Alexander Poole, Lee D Faucher, Rosemary E Paine, Naveen Sangji, Alexandra Lacey, Dhaval Bhavsar, Kristin Colling, Alexis Armour, Irma Fleming, Arek Wiktor, Lucy Wibbenmeyer","doi":"10.1093/jbcr/irag111","DOIUrl":"10.1093/jbcr/irag111","url":null,"abstract":"<p><p>Frostbite injuries can have lasting sequelae including amputations, intolerance to cold, chronic pain, paresthesia, and inability to return to work. Despite this morbidity, the treatment of frostbite remains understudied. The FRostbite ObServational Trial (FROST) aims to address this gap through a multicenter evaluation of treatment practices and outcomes. As part of FROST, we reviewed institutional frostbite care protocols from 16 participating sites across North America. Practices were categorized as demonstrating uniform agreement (≥90% mentioned the practice), consensus ($ge$75%), or majority if ($ge$50%). Uniform agreement was limited to use of rapid rewarming and thrombolytics, the latter being influenced by site selection criteria for FROST participation. Consensus was achieved in multiple areas (such as urgency of treatment, perfusion assessment, the therapeutic windows for pharmaceutical interventions, and the therapeutic dosing of IV thrombolytics). Protocols varied on grades for thrombolytic treatment initiation, prostacyclin analog use, postthrombolytic anticoagulation treatment and duration, the role of physical or occupational therapy, splinting, and appropriate wound care. This manuscript provides a synthesis of protocols and expert opinions for the acute management of frostbite injury. This synthesized protocol may serve as a tool for centers to develop their own standard protocol to facilitate care for frostbite patients. Additionally, current opportunities for frostbite research and improving care are detailed in the manuscript. Education regarding prevention of injury and the need for emergent treatment is needed for both the public and the medical community.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1405-1425"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joshua Khorsandi, Jason Mirharooni, Justin Kahen, Ezzah Tariq, Michael Harouni, Demitri Franzoni, Joshua MacDavid
{"title":"Artificial Intelligence in Burn and Wound Care: Image Analysis, Prediction, and Clinical Integration.","authors":"Joshua Khorsandi, Jason Mirharooni, Justin Kahen, Ezzah Tariq, Michael Harouni, Demitri Franzoni, Joshua MacDavid","doi":"10.1093/jbcr/irag090","DOIUrl":"10.1093/jbcr/irag090","url":null,"abstract":"<p><p>Burn injuries and chronic wounds impose a substantial and growing global health and economic burden, particularly in low- and middle-income countries and among aging populations with diabetes, vascular disease, and immobility. Conventional wound assessment depends heavily on visual inspection, manual measurements, and clinician experience, leading to variability in burn-depth estimation, wound sizing, and prognostication. Artificial intelligence, especially deep learning-based computer vision, has emerged as a promising approach to provide objective, reproducible, and scalable evaluation of burns and complex wounds. In this narrative review, we synthesize studies published between 2015 and 2025 focused on 3 domains: image-based wound recognition and segmentation, predictive modeling of outcomes such as healing, graft success, infection, and amputation, and integration of artificial intelligence into telemedicine platforms and smart technologies for remote monitoring. Across multiple datasets, convolutional neural networks achieve segmentation Dice coefficients frequently exceeding 0.85 and burn-depth or tissue-type classification sensitivities above 0.90, while multimodal prediction models reach accuracies and areas under the receiver operating characteristic curve of approximately 0.80-0.95. Early clinical pilots demonstrate the feasibility of embedding artificial intelligence tools into smartphone applications, telehealth workflows, and sensor-enabled dressings. Nonetheless, persistent challenges related to algorithmic bias across skin tones, limited dataset diversity, opaque model behavior, workflow integration, and evolving regulatory frameworks must be addressed before artificial intelligence-enabled wound care systems can be safely and equitably deployed at scale.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1331-1338"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}