Neutrophil Prealbumin Ratio as a Potential Predictive Marker for Severe Burn Patients' Prognosis.

Severe burn injuries are associated with high morbidity and mortality, necessitating reliable prognostic markers for effective patient management. The Neutrophil-to-Prealbumin Ratio (NPR), which combines inflammatory and nutritional status, has emerged as a potential prognostic tool. This study aimed to evaluate the prognostic value of NPR in predicting mortality among severe burn patients. Severe burn patients admitted to the Burn Treatment Center between January 2020 and December 2023 were retrospectively analyzed. Patients were categorized into survivor and non-survivor groups. Inflammatory markers, including NPR, Neutrophil-to-Lymphocyte Ratio (NLR), Systemic Inflammatory Response Index (SIRI), and Platelet-to-Lymphocyte Ratio (PLR), were evaluated for their association with mortality using Receiver Operating Characteristic (ROC) curve analysis and multivariate logistic regression. A total number of 357 patients were included in the study. Of the 357 patients, 101 (28.3%) were non-survivors. The non-survivor group had significantly higher TBSA, full-thickness burns, inhalation injuries, and blood transfusion requirements (p<0.001). ROC curve analysis demonstrated that NPR had the highest area under the curve (AUC=0.760). A cut-off value of 0.75 for NPR was associated with a significant increase in mortality risk. Multivariate logistic-regression identified NPR as an independent predictor of mortality alongside TBSA, full-thickness burns, and inhalation injuries. NPR is a promising prognostic marker for mortality in severe burn patients, outperforming traditional inflammatory markers. Its integration of inflammatory and nutritional status provides a comprehensive assessment of patient risk. Further prospective studies are needed to validate these findings and explore the broader applications of NPR in burn care and other critical settings.