Journal of Burn Care & Research最新文献_第10页

Ethical Challenges of Bioprinted and Lab-Grown Skin Substitutes in Burn Care. 生物打印和实验室培养皮肤替代品在烧伤护理中的伦理挑战。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-22 DOI: 10.1093/jbcr/irag125

Joshua Khorsandi, Brian Mansoury, Abu-Bakr Ahmed, Liahm Blank, Michael Harouni, Demitri Franzoni, Joshua MacDavid

{"title":"Ethical Challenges of Bioprinted and Lab-Grown Skin Substitutes in Burn Care.","authors":"Joshua Khorsandi, Brian Mansoury, Abu-Bakr Ahmed, Liahm Blank, Michael Harouni, Demitri Franzoni, Joshua MacDavid","doi":"10.1093/jbcr/irag125","DOIUrl":"https://doi.org/10.1093/jbcr/irag125","url":null,"abstract":"Severe burns continue to impose significant global morbidity and mortality, particularly where surgical and critical-care resources are limited. As survival has improved, attention has shifted toward optimizing reconstruction. Bioprinted and lab-grown skin substitutes-building on advances in tissue engineering, cellular scaffolds, and 3D bioprinting-offer new possibilities for coverage, yet raise ethical, legal, and distributive challenges that remain underexamined in burn care. A narrative review was conducted using PubMed, Embase, Web of Science, and Google Scholar (2010-2025), supplemented by foundational legal and bioethics literature. Sources were selected for conceptual and policy relevance to ownership, consent, commercialization, intellectual property, and equity in regenerative skin technologies. Fifty publications spanning burn surgery, biobanking, organoid governance, IP law, and global health were synthesized inductively. Five major ethical domains emerged: (1) ambiguous ownership and ontological status of hybrid bioprinted tissues; (2) inadequacy of consent processes to address commercialization and downstream uses of patient-derived cells; (3) complex intellectual property environments that may restrict access and clinical innovation; (4) distributive injustice driven by high costs and global resource disparities; and (5) a near absence of empirical ethics research involving burn patients or care teams. Bioprinted and lab-grown skin substitutes could transform burn reconstruction, but current ethical and regulatory frameworks lag behind. Addressing ownership, consent, commercialization, and equity-supported by robust empirical engagement with patients-is essential for responsible integration of these technologies into burn care.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anesthetic Practices for Laser Therapy in Pediatric Patients with Hypertrophic Burn Scars: A Retrospective Multicenter Cohort Study. 儿童增生性烧伤疤痕患者激光治疗的麻醉实践：一项回顾性多中心队列研究。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-22 DOI: 10.1093/jbcr/irag122

Nicole C McCoy, Noah Ashley, Amanda T Tran, Patricia Fuentes, Audra Clark, Rohit Mittal, Bethany J Wolf, Matthew Stumme, Aditee Ambardekar

{"title":"Anesthetic Practices for Laser Therapy in Pediatric Patients with Hypertrophic Burn Scars: A Retrospective Multicenter Cohort Study.","authors":"Nicole C McCoy, Noah Ashley, Amanda T Tran, Patricia Fuentes, Audra Clark, Rohit Mittal, Bethany J Wolf, Matthew Stumme, Aditee Ambardekar","doi":"10.1093/jbcr/irag122","DOIUrl":"https://doi.org/10.1093/jbcr/irag122","url":null,"abstract":"Burn injuries are a leading cause of death and disability worldwide, disproportionally impacting pediatric patients. Many affected children will develop hypertrophic scarring, limiting activity, restricting range of motion, and negatively impacting psychosocial development. Although laser therapy is a routine treatment for hypertrophic burn scars in children, there is no consensus on the best anesthetic technique. In this multicenter retrospective cohort study, we aimed to identify effective anesthetic strategies that correlated with outcomes for pediatric laser scar therapy. We characterized perioperative anesthetic approaches for pediatric patients with burn scars who were undergoing laser therapy at 2 academic centers from 2020 - 2023. Among 239 encounters for 98 patients, intraoperative/ postoperative opioids were given in 53% of encounters. Preoperative opioid use was associated with 86% lower odds of intraoperative/postoperative opioid administration (OR, 0.14; 95% CI, 0.06-0.34; P < .001). A 2-fold increase in total body surface area treated was associated with a 32% increase in the odds of opioid use (OR, 1.32; 95% CI, 1.11-1.58; P = 0.002) and 23% greater odds of pain (OR, 1.23; 95% CI, 1.05-1.43; P = 0.009) when controlling for other variables. Laser type was associated with a 2-fold higher odds of pain (OR, 2.11; 95% CI, 1.07-4.14; P = 0.030), and the incidence of emergence delirium was low (2.5% of the cohort). Differences in laser type and anesthetic management also varied across institutions, which impacted pain and recovery. These findings uncovered key patient and procedure factors that can inform standardized anesthetic guidelines for pediatric laser scar therapy.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residential Air Pollution, Inhalation Injury, and Burn Recovery: A Burn Model System Study. 住宅空气污染、吸入性损伤与烧伤恢复：一项烧伤模型系统研究。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-20 DOI: 10.1093/jbcr/irag120

Maya Matheny, Erin Ross, Trevor A Pickering, Colleen M Ryan, Caitlin M Orton, Connie Valencia, Haig A Yenikomshian

{"title":"Residential Air Pollution, Inhalation Injury, and Burn Recovery: A Burn Model System Study.","authors":"Maya Matheny, Erin Ross, Trevor A Pickering, Colleen M Ryan, Caitlin M Orton, Connie Valencia, Haig A Yenikomshian","doi":"10.1093/jbcr/irag120","DOIUrl":"https://doi.org/10.1093/jbcr/irag120","url":null,"abstract":"Chronic air pollution, specifically particulate matter 2.5 (PM2.5), increases the risk and severity of acute respiratory distress syndrome, and is most concentrated in lower-income areas. Burn survivors from these communities may be especially vulnerable to respiratory complications of burn injury and inhalation injuries. In this retrospective national longitudinal cohort study of adult burn survivors (2015 and 2021), the association of 3-year pre-burn PM2.5 exposure, estimated from home census tract code from the CDC, and clinical outcomes extracted from the Burn Model System (mortality, ventilator days, tracheostomy, hospital length of stay (LOS), and patient-reported outcomes from PROMIS Global Health and employment status at 6 and 12 months) were assessed via mixed-effects regression models adjusting for age, sex, race/ethnicity, total body surface area (TBSA), and inhalation injury. Among 582 adult burn survivors (mean age of 46.2 years), unadjusted models found that higher PM2.5 exposure was associated with longer LOS, worse PROMIS Global Health scores (pooled 6- and 12-months), and a decreased likelihood of employment at follow-up (pooled 6- and 12-months). These associations were attenuated after adjustment; though PM2.5 exposure was associated with inhalation injury, which was strongly associated with prolonged ventilation, tracheostomy, lower Global Health scores, and lower employment at follow-up. Higher PM2.5 exposure was associated with a greater likelihood of inhalation injury, which was associated with poorer outcomes, suggesting that residential PM2.5 exposure, or factors that co-vary with it, may identify patients at greater risk for inhalation injury and poorer recovery after burn injury.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconstruction of the Burned Nose Using an Expanded Skin-Grafted Forehead Flap, Delayed Turnover Flaps, and Indocyanine Green Perfusion Assessment. 应用扩展皮瓣、延迟翻转皮瓣及吲哚菁绿灌注评估重建烧伤鼻。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-11 DOI: 10.1093/jbcr/irag119

Syena Moltaji, Alan D Rogers, Jeffrey Fialkov

{"title":"Reconstruction of the Burned Nose Using an Expanded Skin-Grafted Forehead Flap, Delayed Turnover Flaps, and Indocyanine Green Perfusion Assessment.","authors":"Syena Moltaji, Alan D Rogers, Jeffrey Fialkov","doi":"10.1093/jbcr/irag119","DOIUrl":"https://doi.org/10.1093/jbcr/irag119","url":null,"abstract":"Reconstruction of the burned nose is challenging because defects may involve external skin, internal lining, and structural support within scarred or previously grafted tissues. We report the case of a 35-year-old man who sustained an approximately 20% total body surface area flame burn involving the face, neck, chest, and upper extremities, requiring acute excision and split-thickness skin grafting. He later developed a severe postburn nasal deformity with loss of the lower third of the nose, airway compromise, and deficiency of lining, support, and external soft tissue. Both the forehead and nasal dorsum had previously been resurfaced with split-thickness skin grafts, limiting standard reconstructive options. A staged reconstruction was performed using tissue expansion of the grafted forehead, delayed bipedicled turnover flaps from grafted dorsal nasal skin for internal lining, costal cartilage grafting for structural support, and a paramedian forehead flap for external coverage. Intraoperative indocyanine green fluorescence angiography was used to assess perfusion and guide operative decision-making. The reconstruction restored nasal contour and airway patency without flap loss, infection, or major complication, and avoided microsurgical free tissue transfer. At long-term follow-up extending to 10 years from the initial injury, the reconstruction remained stable. This case demonstrates that previously grafted tissue can be recruited for complex nasal reconstruction when augmented by tissue expansion, staged delay, and intraoperative perfusion assessment.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reviewing the Safety of Providing Out of Operating Room Anesthesia for Acute Burns in Pediatric Patients. 儿科急性烧伤患者提供手术外麻醉的安全性综述。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-08 DOI: 10.1093/jbcr/irag118

Sabrina Yang, Sara Faour, Farrukh Munshey, Tobias Everett, Charis Kelly, Eduardo Gus, Joel Fish

{"title":"Reviewing the Safety of Providing Out of Operating Room Anesthesia for Acute Burns in Pediatric Patients.","authors":"Sabrina Yang, Sara Faour, Farrukh Munshey, Tobias Everett, Charis Kelly, Eduardo Gus, Joel Fish","doi":"10.1093/jbcr/irag118","DOIUrl":"https://doi.org/10.1093/jbcr/irag118","url":null,"abstract":"Pain management is a cornerstone of acute pediatric burn care, and burn wound care frequently requires sedation or anesthesia to optimize patient comfort and procedural success. Anesthesia delivered outside of the operating room (OR) has been shown to be a safe and effective alternative to OR-based care; however, eligibility has traditionally been restricted to older and larger children. Following a quality care audit in 2022, eligibility for anesthesiologist-administered out-of-OR anesthesia at our tertiary pediatric burn center was expanded to include children aged 8-12 months and/or weighing 8-10 kg. The objective of this study was to compare key quality and safety indicators between patients meeting expanded eligibility criteria and those meeting historical criteria (>10 kg and/or 12-24 months) undergoing burn dressing changes in a general anesthesia-ready satellite anesthesia room. This single-center retrospective study included patients treated between January 2022 and January 2024. Outcomes included procedure duration, anesthetic technique, airway management, anesthesia-related complications, and post-procedure disposition. A total of 211 patients undergoing 296 procedures were included. Burn characteristics were similar between groups, with scald injuries and partial-thickness burns predominating. No episodes of oxygen desaturation, hemodynamic instability, airway obstruction, or difficult mask ventilation were observed. One episode of laryngospasm occurred in the expanded group and resolved with conservative airway management. Procedure duration was shorter, while time to discharge was slightly longer, in the expanded group. These findings suggest that expanding eligibility criteria for out-of-OR anesthesia in pediatric burn patients is safe and feasible and does not compromise procedural efficiency or outcomes.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Patient's Irreconcilable Voices: Considering Another Type of "Refusal" in Burn Care. 病人不可调和的声音：考虑烧伤护理中的另一种“拒绝”。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-06 DOI: 10.1093/jbcr/irag038

Anna D Goff, Barrie J Huberman

引用次数: 0

Responses to the Letter to the Editor: Evaluating ChatGPT's Utility in Addressing Socioeconomic Disparities in Burn Patients: A Comparative Study With Google. 致编辑的回复：评估ChatGPT在解决烧伤患者社会经济差异方面的效用：与b谷歌的比较研究。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-06 DOI: 10.1093/jbcr/irag054

Blancheneige Beohon, Amina El Ayadi, Steven Wolf, Juquan Song

引用次数: 0

Epidemiology of Burns in Eastern Slovakia (2014-2024). 斯洛伐克东部烧伤流行病学（2014-2024）。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-06 DOI: 10.1093/jbcr/irag044

Tomas Demcak, Michala Gazdova, Peter Lengyel, Ludwik K Branski, Jakub Gazda

{"title":"Epidemiology of Burns in Eastern Slovakia (2014-2024).","authors":"Tomas Demcak, Michala Gazdova, Peter Lengyel, Ludwik K Branski, Jakub Gazda","doi":"10.1093/jbcr/irag044","DOIUrl":"10.1093/jbcr/irag044","url":null,"abstract":"Burn injuries remain a major global health issue, and despite multidisciplinary advances, mortality among patients with major burns remains substantial. Preventive measures have reduced incidence worldwide; however, demographic and societal changes over recent decades warrant reassessment. We therefore analyzed recent trends in burn incidence requiring tertiary-care hospitalization between 2014 and 2024. A retrospective observational study was conducted including all patients with acute burn injuries admitted to the sole tertiary burn center serving Eastern Slovakia between 2014 and 2024. Annual incidence rates per 100 000 inhabitants were calculated using census-based regional population data and stratified by age and sex. A total of 2346 patients were hospitalized (62% male; median age 25 years; IQR 2-55). Scalds predominated (55%), followed by flame burns (25%). Median burn size was 9% TBSA; inhalation injury occurred in 4.1%, and 3.9% were work-related. The median annual incidence was 12.95 per 100 000 (IQR 11.78-13.85), increasing from 9.41 in 2014 to 15.42 in 2024 (incidence rate ratio 1.64; 95% CI, 1.34-2.01). Male annual incidence remained higher than female (median 16.3 vs 9.4 per 100 000). Infants (0-1 year) comprised 22% of admissions, with the highest annual incidence among all age groups (median 119 per 100 000). The incidence of burn injuries requiring tertiary-care admission in Eastern Slovakia increased over the past decade, particularly among males and infants. These findings highlight the need for targeted preventive strategies focusing on domestic scald injuries and early childhood safety.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1126-1130"},"PeriodicalIF":1.9,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Toward Consensus-Based Referral Criteria for Palliative Care in Burn Injury. 致编辑的信：朝着基于共识的转诊标准的缓和治疗烧伤。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-06 DOI: 10.1093/jbcr/irag058

Anjay Khandelwal, Sarah Friebert, Daniel H Grossoehme, Richard Lou

引用次数: 0

A Statewide Multisource Analysis of Supplemental Oxygen-Related Fires and Burn Injuries. 补充氧相关火灾和烧伤的全州多源分析。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-07-06 DOI: 10.1093/jbcr/irag055

Karla S Klas, Dayan Zorkot, Michael White, Alita Pitogo

{"title":"A Statewide Multisource Analysis of Supplemental Oxygen-Related Fires and Burn Injuries.","authors":"Karla S Klas, Dayan Zorkot, Michael White, Alita Pitogo","doi":"10.1093/jbcr/irag055","DOIUrl":"10.1093/jbcr/irag055","url":null,"abstract":"Despite the increasing prevalence of home oxygen therapy, its associated injury risks remain underrecognized. This study analyzed the statewide incidence of oxygen therapy-related fires, burns, and deaths to identify systemic barriers for data capture, outline improved surveillance pathways, and inform prevention strategies. Retrospective, multisource analysis of statewide data (2020-2023) from death certificates, hospital admissions, registries, and fire incident reports. Liaisons performed free-text field searches. Data reported in de-identified aggregate counts and analyzed descriptively for comparison. Reporting was highly inconsistent across all data systems, without specific International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) injury codes (top used: flammable material, uncontrolled fire). State National Fire Incident Reporting System data revealed a total of only 2 oxygen therapy fire deaths (mean 3.5 fires/year). In sharp contrast, death certificates and fire inspectors reported a mean 9.8-10.3 deaths/year with 97% linked to smoking, confirming home oxygen therapy deaths are underreported by a factor of 20 in state fire incident data. Four hospitals reported a mean of 17.9/year (range 13-31) oxygen therapy admissions each, with combined 4-year total of 285 (range 51-124). This represents 33% of all home oxygen therapy patients compared to published national burn center data. Home oxygen burns and deaths are underreported in state and national datasets. Most incidents are preventable, with smoking as primary ignition source. Lack of dedicated injury codes, gaps in trauma/emergency medical services variable data, and data suppression thresholds prevent reporting of low-frequency events. Establishing specific ICD-10-CM codes and cohesive prevention strategies are necessary to reduce this injury burden.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1170-1176"},"PeriodicalIF":1.9,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0