Journal of Burn Care & Research最新文献

{"title":"Cross-Sectional Study on the Management of Nonoperative Burns at American Burn Association-Verified Burn Centers.","authors":"Hilary Y Liu, Mario Alessandri Bonetti, Siddhi Shockey, Garth A Elias, Alain C Corcos, Jenny A Ziembicki, Francesco M Egro","doi":"10.1093/jbcr/iraf102","DOIUrl":"10.1093/jbcr/iraf102","url":null,"abstract":"<p><p>Nonfatal burn injuries are a leading cause of morbidity. However, among a variety of burn treatment options, there is no standard of care for the nonoperative management of burns that do not require excision and skin grafting. This study aims to identify the most frequently used agents for nonoperative burns in the United States. A survey related to nonoperative burns management was sent to 64 directors of American Burn Association (ABA)-verified burn centers. A total of 51.6% (n = 33) directors of ABA-verified burn centers responded to the survey, reporting their most used agents for nonoperative superficial, superficial partial-thickness, deep partial-thickness, and full-thickness burns. Preferences varied by burn depth. For superficial burns, the top choice agents identified were Aquaphor (n = 20; 60.6%), Eucerin (n = 16; 48.5%), and antimicrobial ointments such as bacitracin, neomycin, or polymyxin (n = 8; 24.2%). For superficial partial-thickness burns, antimicrobial ointments (n = 27; 81.8%) and Mepilex Ag (n = 19; 57.6%) were the preferred agents. The preferred agents for deep partial-thickness burns were antimicrobial ointments (n = 18; 54.5%), Mepilex Ag (n = 15; 45.5%), and chemical debridement agents such as Santyl, Xenaderm, or Granulex (n = 13; 39.4%). The preferred agents for full-thickness burns were silver sulfadiazine cream 1% (n = 15; 45.5%), chemical debridement agents (n = 8; 24.2%), and antimicrobial ointments (n = 6; 18.2%).</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1128-1132"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Fungal Infection Increases Mortality Risk After Burn Injury.","authors":"Allison B Frederick, Savannah H Skidmore, Aaron P Lesher, Steven A Kahn, Rohit Mittal","doi":"10.1093/jbcr/iraf047","DOIUrl":"10.1093/jbcr/iraf047","url":null,"abstract":"<p><p>While invasive fungal infections (IFIs) can be deadly for any hospitalized patient, a high-risk subset are those with burn injuries due to their immunocompromised state, and an increasing number of non-Candida infections have been on the rise. This novel study captures data from across the United States using a multi-institutional dataset derived from electronic health record data and is the largest study to date evaluating mortality associated with fungal infections in burn injury. Inclusion criteria identified all patients with burn injury from 2002 to 2024; IFI was defined as a diagnosis of fungal mycosis with systemic antifungal treatment which was compared to a control cohort of burn patients without mycoses or antifungal treatment. The cohorts were then propensity-matched for gender, age, and percent total body surface area (%TBSA). The unmatched fungal infection cohort contained 3325 patients while the control cohort contained 50 5421. After propensity matching, the 1-year mortality rate for all burn patients with fungal infection was 18.5% compared to 1.9% in controls (risk ratio: 9.8, 95% confidence interval, 7.2-13.2; P < .0001). Additionally, when stratified by %TBSA there was a stepwise increase in mortality: 21.6% for <10% TBSA (P < .0001), 29.0% for 10%-49% TBSA (P < .0001), and 33.1% for >50% TBSA (P = .2). The 3 most common and deadly infections among all burn patients were Aspergillus, invasive Candida, and unspecified mycoses. In all burns, fungal infection was associated with a nearly 10-fold increase in mortality. An incremental increase is noted when stratified by %TBSA and even <10% TBSA burns have an over 20% risk of mortality.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"940-946"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Prealbumin Ratio as a Potential Predictive Marker for Severe Burn Patients' Prognosis.","authors":"Ozan Baris Namdaroglu, Hilmi Yazıcı, Ahmet Cem Esmer, Mehmet Alperen Ugur, Ahmet Erim Erdogan, Ahmet Mucteba Ozturk, Ahmet Deniz Ucar, Mehmet Yildirim","doi":"10.1093/jbcr/iraf096","DOIUrl":"10.1093/jbcr/iraf096","url":null,"abstract":"<p><strong>Objective: </strong>Severe burn injuries are associated with high morbidity and mortality, necessitating reliable prognostic markers for effective patient management. The Neutrophil-to-Prealbumin Ratio (NPR), which combines inflammatory and nutritional status, has emerged as a potential prognostic tool. This study aimed to evaluate the prognostic value of NPR in predicting mortality among severe burn patients.</p><p><strong>Design: </strong>Patients were categorized into survivor and nonsurvivor groups.</p><p><strong>Setting: </strong>The study was conducted retrospectively.</p><p><strong>Participants: </strong>Severe burn patients admitted to the Burn Treatment Center between January 2020 and December 2023 were analyzed.</p><p><strong>Main outcomes: </strong>Inflammatory markers, including NPR, Neutrophil-to-Lymphocyte Ratio, Systemic Inflammatory Response Index, and Platelet-to-Lymphocyte Ratio, were evaluated for their association with mortality using Receiver Operating Characteristic curve analysis and multivariate logistic regression.</p><p><strong>Results: </strong>A total of 357 patients were included in the study. Of the 357 patients, 101 (28.3%) were nonsurvivors. The nonsurvivor group had significantly higher TBSA, full-thickness burns, inhalation injuries, and blood transfusion requirements (P < .001). Receiver Operating Characteristic curve analysis demonstrated that NPR had the highest area under the curve (0.760). A cut-off value of 0.75 for NPR was associated with a significant increase in mortality risk. Multivariate logistic-regression analysis identified NPR as an independent predictor of mortality alongside TBSA, full-thickness burns, and inhalation injuries.</p><p><strong>Conclusions and relevance: </strong>Neutrophil-to-Prealbumin Ratio is a promising prognostic marker for mortality in severe burn patients, outperforming traditional inflammatory markers. Its integration of inflammatory and nutritional status provides a comprehensive assessment of patient risk. Further prospective studies are needed to validate these findings and explore the broader applications of NPR in burn care and other critical settings.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1113-1118"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-223-3p Expression in Deep Second-Degree Burn and its Role in the Wound Healing Process.","authors":"Rong Zhao, Yi Deng, Yan Han, Menghe Wang, Yiyun Huang","doi":"10.1093/jbcr/iraf083","DOIUrl":"10.1093/jbcr/iraf083","url":null,"abstract":"<p><p>Deep second-degree burns represent a prevalent form of trauma encountered in clinical settings. The intricacies of the wound healing process are profoundly linked to the prognosis of affected patients. This study aims to explore the expression of miR-223-3p in deep second-degree burns and its role in wound healing. A total of 95 patients with deep second-degree burn were enrolled in this study and 50 healthy individuals were included in this study. Real-time quantitative PCR was employed to assess the expression levels of miR-223-3p. The TargetScan database was utilized to predict the target genes of miR-223-3p, and the luciferase reporter gene assay was employed to validate the predicted results. Pearson correlation analysis was conducted to examine the connection. The results indicate that the level of miR-223-3p was markedly increased in patients with deep second-degree burns and markedly decreased on the 28th day of wound healing. FOXO1 was the target gene of miR-223-3p. The level of miR-223-3p at the time of burn and after recovery is significantly negatively related to the expression of FOXO1 in patients with deep second-degree burn. Overexpression of miR-223-3p significantly inhibits the viability of HUVECs, while FOXO1 can partially reverse this inhibitory effect. In conclusion, the level of miR-223-3p is associated with the progression of deep second-degree burns, and it may participate in the wound healing process of burn injuries by targeting FOXO1.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1099-1104"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Racial and Gender Differences in Outcomes Among Older Burn Patients.","authors":"Joshua E Lewis, Shawn E Lim, Manav M Patel, Gengi Kleto, Bethel D Desta, Juquan Song","doi":"10.1093/jbcr/iraf091","DOIUrl":"10.1093/jbcr/iraf091","url":null,"abstract":"<p><p>This study aims to evaluate outcomes, including mortality rates, among older adult burn patients, with a focus on differences across race and gender. We hypothesize that African American patients and females would exhibit higher risks of mortality over a ten-year period. Using data from the TriNetX US Collaborative Network, we analyzed older adult patients (≥65 years) diagnosed with burn injuries (T31.0 - T31.9) from May 6, 2014, to May 6, 2024. To assess changes over time, patients were divided into two five-year intervals (2014-2019 and 2019-2024). Cohorts were stratified by race and gender, with propensity score matching applied to ensure comparability. Statistical significance was set at p<0.05. Among older patients diagnosed with burns, 56.15% were male, and 14.78% were African American. The overall mortality rate was 9.2%, with a reduction to 4.2% from 2019-2024. However, analysis by race revealed that while mortality rates declined overall, African American patients experienced a significant increase in mortality in the latter time period, with a 2.404 times higher mortality risk compared to white patients (20.2% vs. 8.4%, RR 95% CI 1.864-3.003, p=0.0002). Gender analysis showed that females had a 1.312 times higher mortality risk compared to males (10.1% vs. 7.7%, RR 95% CI 1.172-1.86, p<0.0001). These findings highlight the persistent racial and gender disparities in outcomes among older adult burn patients, despite an overall decline in mortality rates. Targeted interventions are needed to address these disparities and improve care management for vulnerable populations.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"e1"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction of: Racial and Gender Differences in Outcomes Among Older Burn Patients.","authors":"","doi":"10.1093/jbcr/iraf164","DOIUrl":"https://doi.org/10.1093/jbcr/iraf164","url":null,"abstract":"","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":"46 5","pages":"e1"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Chemical Burns: Water Irrigation First Aid Improves Short-term Outcomes.","authors":"Hayley Chai, Lisa Martin, Rachel Kornhaber, Leila Cuttle, Mark Fear, Fiona Wood","doi":"10.1093/jbcr/iraf079","DOIUrl":"10.1093/jbcr/iraf079","url":null,"abstract":"<p><p>First aid recommendations for chemical burns include copious water irrigation for 30 minutes to 2 h after removal of the substance from skin. The aim of this retrospective analysis was to assess the efficacy of water irrigation on short-term outcomes for chemical burn injuries. Data from the Australian and New Zealand Burn registry (2009-2020) were analyzed to categorize the application of running water for first aid for presence, timing of application postinjury, and duration. The timing of first aid application was classified into whether the application was pre-hospital or in-hospital. Multivariate regression analyses then evaluated how water irrigation affected hospital stay, Intensive Care Unit admission, and the necessity for acute surgery for wound closure. Among 1549 chemical burn patients, for those who received in-hospital first aid their stay was reduced by about 18% compared to those who did not. Patients receiving pre-hospital or in-hospital first aid had 37% and 31% lower odds, respectively, of needing acute care surgery for wound closure compared to those who did not. There was no evidence that first aid provision influenced the need for intensive care admission. Water irrigation is associated with shorter hospital stays and reduced acute care surgery for wound closure following chemical burns without impacting intensive care admission rates.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1085-1090"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The State of Michigan Burn Mass Casualty Incident Surge Plan: Leveraging Trauma Centers as Burn Surge Facilities.","authors":"Jacob M Dougherty, Aren E Kurth, Sarah Parviz, Madison Kozlowski, Don Edwards, Stewart C Wang, Naveen F Sangji","doi":"10.1093/jbcr/iraf077","DOIUrl":"10.1093/jbcr/iraf077","url":null,"abstract":"<p><p>The Michigan burn mass casualty incident (BMCI) surge plan provides the framework and guidelines for responding to a BMCI within the state of Michigan. It relies on collaborative efforts across the state, utilizing American College of Surgeons Committee on Trauma verified Level I and Level II trauma centers as Burn Surge Facilities in the event of a BMCI, ensuring the best use of resources across the state. Preparation for mass casualty incidents (MCIs) with standardized frameworks as illustrated in the Michigan BMCI Surge Plan, as well as through trainings and simulated disaster planning, help ensure effective disaster preparation.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"935-939"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual Function, Body Image, and Quality of Life After Genital Burns: A Burn Model System Database Study.","authors":"Dania Johnson, Andrew Humbert, Kimberly Roaten, Shelley Wiechman, Jeffrey C Schneider, Haig A Yenikomshian","doi":"10.1093/jbcr/iraf070","DOIUrl":"10.1093/jbcr/iraf070","url":null,"abstract":"<p><p>Burn injuries impact both functional and psychosocial quality of life. Genital burns may uniquely affect anatomy, sensation, and self-perception, yet research remains limited. This study explores the impact of genital burns on body image, sexual satisfaction, and health-related quality of life. This retrospective analysis included adults (≥18 years) from 2016 to 2024 in a multicenter longitudinal patient-reported outcome database. Linear mixed-effect models evaluated the impact of genital burns on Patient-Reported Outcome Measurement Information System (PROMIS-29) outcomes (anxiety, depression, fatigue, pain, function, sleep, and sexual satisfaction) and Burn Specific Health Scale (BSHS) body image at 6, 12, and 24 months, adjusting for demographics, total burn size, and time. Interaction terms assessed differences in recovery trajectories. Of 4594 participants, 649 had genital burns and 3945 did not. After adjustment, no significant differences were observed in baseline PROMIS-29 or BSHS outcomes. Longitudinal analyses revealed significant differences in recovery trajectories for depression, sleep disturbance, and body image. At 24 months, participants with genital burns had increased depression scores (+1.22) compared to a reduction (-0.60) in those without (P = 0.036). Sleep disturbance improvements at 12 months were smaller for those with genital burns (0.9 vs. 1.88-point reduction, P = 0.042). Body image scores declined for participants with genital burns, while improving for those without, with significant differences at 12 months (P = 0.026) and 24 months (P = 0.001). No significant differences were observed for anxiety, fatigue, pain interference, physical function, or sexual satisfaction. Genital burns significantly impact recovery, particularly depression, sleep, and body image.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"987-994"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout in Burn Surgeons: A Survey of Burn Surgeon Wellness.","authors":"Anastasiya Ivanko, M Victoria Miles, Jonathan E Schoen, Herb A Phelan, Nathan H Brown, Kathleen Romanowski, Steven Kahn, Alisa Savetamal, Arpana Jain, Anju Bakhshi Saraswat, James Hill Holmes, Richard J Kagan, Jeffrey E Carter","doi":"10.1093/jbcr/iraf089","DOIUrl":"10.1093/jbcr/iraf089","url":null,"abstract":"<p><p>The U.S. faces a surgeon shortage, threatening a decline in burn care specialists as surgeons shift to other fields. With only 0.3% of the workforce in burn surgery, attrition could severely impact burn care availability. Addressing recruitment and retention challenges requires identifying stressors and workload factors contributing to the strain of operative burn care. In May 2024, a de-identified survey was conducted with Institutional Review Board approval to assess burn surgeons' self-reported well-being. A diverse surgeon panel reviewed the survey, and the American Burn Association distributed it via email and Survey Monkey. Statistical analysis included Chi-square and t-tests. Seventy-seven burn surgeons (62% male) participated, representing a 20% response rate. Most took burn call (95%) and worked in an academic setting (80%). While 73% were satisfied with their careers and 91% valued the complexities of burn care, 54% lacked time for personal activities, and 62% felt maternity/paternity leave was insufficient. Forty percent experienced burnout, and 26% considered leaving the field. Over half (54%) felt they lacked time to recover after demanding cases, and 65% believed burn surgery negatively impacted their health. Using a Likert scale (10 = high performance), they rated their ability to meet job demands at 7 (±1), with a projected decline to 4.2 (±0.5) in two years. Despite overall career satisfaction, burn surgeons face challenges that threaten their health and the quality and sustainability of burn care. Our findings highlight the need for interventions to mitigate burnout and enhance well-being, ensuring the long-term viability of burn surgery and patient care.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1036-1041"},"PeriodicalIF":1.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}