Journal of Burn Care & Research最新文献_第2页

Evaluating Patient Perceptions of their Upper Extremity Function and Rehabilitation Outcomes After Acute Burn Injury. 评估急性烧伤后患者对其上肢功能和康复结果的认知。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-09 DOI: 10.1093/jbcr/irag160

Katie Coakley, AnnMarie Berry, Irena Helenowski, Joshua Carson

{"title":"Evaluating Patient Perceptions of their Upper Extremity Function and Rehabilitation Outcomes After Acute Burn Injury.","authors":"Katie Coakley, AnnMarie Berry, Irena Helenowski, Joshua Carson","doi":"10.1093/jbcr/irag160","DOIUrl":"https://doi.org/10.1093/jbcr/irag160","url":null,"abstract":"The objective of this study was to describe perceived upper extremity function in patients with acute upper extremity burn injuries, examine changes during hospitalization, and explore relationships among patient perception, ability to perform activities of daily living (ADLs), and pain. This single center, retrospective, observational quantitative study included 110 adult patients with upper extremity burns. Perceived function was measured using the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH). Demographic and clinical data-including burn mechanism, total body surface area, joint involvement, and discharge destination-were collected. AM-PAC Daily Activity scores and pain ratings were analyzed to assess relationships among perceived function, ADL performance, and pain. Patients reported poor perceived upper extremity function following acute burn injury, reflected by high QuickDASH scores. A greater proportion of patients demonstrated improvement than worsening in QuickDASH scores during hospitalization, with 54.3% showing improvement and 30.9% exceeding the minimal clinically important difference of 15.9 points; however, the overall change did not reach statistical significance. AM-PAC Daily Activity scores improved significantly, increasing from a mean of 17.96 at evaluation to 19.86 at discharge (p < .001). QuickDASH scores were moderately correlated with pain (Spearman's r = 0.56, p = 0.004). Patients with upper extremity burns report substantial early functional limitations but demonstrate progress during hospitalization. Improvements in pain were significantly correlated with improvements in perceived upper extremity function. These findings may inform rehabilitation and the design of future research.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pamidronate Dose Response for Hypercalcemia in Burn-Injured Patients. 帕米膦酸钠对烧伤患者高钙血症的剂量反应。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag081

Gisoo Imani, Erin Louie, Sierra Young, Jeremiah J Duby, Samantha VanAcker, Jason Heard

{"title":"Pamidronate Dose Response for Hypercalcemia in Burn-Injured Patients.","authors":"Gisoo Imani, Erin Louie, Sierra Young, Jeremiah J Duby, Samantha VanAcker, Jason Heard","doi":"10.1093/jbcr/irag081","DOIUrl":"10.1093/jbcr/irag081","url":null,"abstract":"Hypercalcemia after a burn injury is attributed to bone resorption secondary to muscle inactivity and prolonged immobilization. Evidence to guide treatment is extremely limited. The purpose of this study was to assess the effect of pamidronate on hypercalcemia in patients with burn injuries. This retrospective, observational study was conducted at a regional burn center. Adult patients admitted to the burn surgery service who received IV pamidronate for hypercalcemia during hospitalization were included. The primary outcome was the change in ionized calcium (iCa) at days 7 and 14 after pamidronate treatment. Secondary outcomes included hypocalcemia and the requirement for calcium replacement. Descriptive statistics were used to evaluate the outcomes. Mixed-effects regression analyses were performed to estimate the direction and magnitude of the effects of clinical factors on changes in iCa. Twenty-seven patients and 37 courses of therapy were included for analysis. The mean age was 44.4 ± 16.0 years, 85% were male, and the mean total body surface area (TBSA) burned was 60.2 ± 22.2%. The majority of IV pamidronate doses were 30 mg (96.2%). The mean peak iCa was 1.45 ± 0.11 mmol/L. The absolute decrease in iCa was -0.26 ± 0.12 mmol/L (-17.1 ± 7.3%) and -0.26 ± 0.13 mmol/L (-17.0 ± 7.5%) at day 7 and day 14, respectively. Hypocalcemia occurred after 5 pamidronate administrations (13.5%). The use of IV pamidronate for the management of hypercalcemia postburn injury appeared effective in decreasing iCa levels. Future studies are needed to further evaluate the clinical implications of these findings.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1491-1495"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Gap in Knowledge: Patient Perspectives and Barriers to Sunscreen Use After Burn Injury. 知识上的差距：烧伤后患者的观点和使用防晒霜的障碍。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag093

Sarah Wang, Dania Johnson, Elizabeth Flores, Karel-Bart Celie, Katrina H Lee, Justin Gillenwater, Maxwell B Johnson, Haig A Yenikomshian

{"title":"A Gap in Knowledge: Patient Perspectives and Barriers to Sunscreen Use After Burn Injury.","authors":"Sarah Wang, Dania Johnson, Elizabeth Flores, Karel-Bart Celie, Katrina H Lee, Justin Gillenwater, Maxwell B Johnson, Haig A Yenikomshian","doi":"10.1093/jbcr/irag093","DOIUrl":"10.1093/jbcr/irag093","url":null,"abstract":"Burned skin remains highly sensitive to UV radiation for years after injury, increasing the risk of damage, pigmentary changes, and carcinogenesis. Although sun protection is crucial, many burn survivors are unsure of necessary measures or how to incorporate them into daily life. This study evaluated survivors' knowledge and use of sun protection to inform future educational efforts. A cross-sectional survey was conducted at a Level 1 American Burn Association (ABA)-verified burn center from June to September 2025. Adult burn patients attending outpatient clinic visits completed a 7-item survey assessing sunscreen use on burn scars, type of sunscreen used, and barriers to adherence. A total of 50 patients were surveyed. The majority of patients were English-speaking (n = 35, 70%). On a scale of 0-10, with 10 being the most important, 68% (n = 34) of patients rated their perceived importance of sunscreen use on burn scars between 7 and 10, but only 28% (n = 14) applied it to healed burn wounds. Sunscreen use on scars was significantly lower among Spanish-speaking patients (6.7%) compared to English-speaking patients (37.1%) (P = .04). The most common reasons for not applying sunscreen were a lack of awareness (n = 13, 36%) and the belief that it was not necessary (n = 9, 25%). Over half of the participants (n = 29, 58%) reported that their healthcare team had not informed them of sunscreen use at prior appointments. Despite recognizing its importance, many burn survivors do not consistently practice sun protection, suggesting a need for reinforced education strategies to improve long-term skin protection.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1543-1548"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Cutaneous Functional Units and Impairment Ratings After Burn Injury. 烧伤后皮肤功能单位与损伤等级的关系。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag100

Maya Andrade, Jenna Kelly, Rupak Mukherjee, Rohit Mittal, Steven A Kahn

{"title":"Association Between Cutaneous Functional Units and Impairment Ratings After Burn Injury.","authors":"Maya Andrade, Jenna Kelly, Rupak Mukherjee, Rohit Mittal, Steven A Kahn","doi":"10.1093/jbcr/irag100","DOIUrl":"10.1093/jbcr/irag100","url":null,"abstract":"Burn injuries can cause lasting functional impairment, often requiring formal impairment ratings for workers' compensation cases. Cutaneous functional units (CFUs), which represent skin areas involved in single-joint motion, may better capture functional impact than TBSA, yet they are not included in current impairment rating guidelines. This study evaluated relationships between initial TBSA, initial CFUs, final scar CFUs, and impairment ratings, hypothesizing that scar burden measured by CFUs would be strongly associated with impairment. A retrospective review was conducted for 78 burn patients with photographically documented TBSA and whole-body impairment ratings at maximum medical improvement at The South Carolina Burn Center at the Medical University of South Carolina. Initial CFUs were calculated from injury photographs using a previously established CFU map, and scar CFUs were calculated from scar photographs obtained at the time of impairment rating. Associations between TBSA, CFUs, and impairment ratings were assessed using Spearman's rho. Initial TBSA was significantly correlated with initial CFUs (rho = 0.471, P < .001) and more strongly correlated with scar CFUs (rho = 0.541, P < .001). Initial TBSA was also significantly correlated with impairment ratings (rho = 0.418, P = .002). Both initial CFUs (rho = 0.307, P = .006) and scar CFUs (rho = 0.569, P < .001) were significantly associated with impairment, with scar CFUs demonstrating the strongest relationship. These findings suggest that scar CFUs may represent a clinically relevant correlate of impairment ratings and warrant further prospective evaluation.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1361-1365"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premorbid Mobility Impairments Increase Likelihood of Shelter Discharge After Burn Hospitalization: A Burn Model System Database Study. 发病前行动障碍增加了烧伤住院后出院的可能性：一项烧伤模型系统数据库研究。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag082

Maya Matheny, Erin Ross, Andrew Humbert, Kristine A Parker, Elizabeth Flores, Karen Kowalske, Jeffrey C Schneider, Haig A Yenikomshian

{"title":"Premorbid Mobility Impairments Increase Likelihood of Shelter Discharge After Burn Hospitalization: A Burn Model System Database Study.","authors":"Maya Matheny, Erin Ross, Andrew Humbert, Kristine A Parker, Elizabeth Flores, Karen Kowalske, Jeffrey C Schneider, Haig A Yenikomshian","doi":"10.1093/jbcr/irag082","DOIUrl":"10.1093/jbcr/irag082","url":null,"abstract":"Burn injuries are functionally limiting, and premorbid mobility impairments may further complicate recovery. Premorbid mobility impairments are associated with worse outcomes in other populations; however, their role in burn recovery remains unclear. This retrospective cohort study included adult burn survivors injured from 2014 to 2025 extracted from the Burn Model System National Burn Database. Premorbid mobility impairment was defined as self-reported preburn physical problems or impairments affecting mobility (difficulty moving the arms, legs, or body). Outcomes included length of stay, discharge disposition, and PROMIS Global Mental Health scores at 6- and 12-month follow-ups postinjury. All regression models were adjusted for age, TBSA, and inhalation injury. The model for Global Mental Health scores additionally adjusted for discharge location, Global Physical Health, preinjury Global Mental Health, and follow-up time. A total of 1372 adult burn survivors were included, with a mean age of 46.2 years. Premorbid mobility impairment was associated with longer hospital stay (incidence rate ratio 1.15; 95% CI, 1.04-1.27; P = .006) and discharge to a shelter (odds ratio 1.75; 95% CI, 1.41-2.19; P < .001). There was also a trend toward lower PROMIS Mental Health scores among survivors with premorbid mobility impairments (β = -1.92, P = .091). Premorbid mobility impairment is associated with poorer burn outcomes, including longer hospital stay and discharge to unstable settings such as shelters, and may also be linked to poorer mental health outcomes. It remains unclear whether shelter discharge reflects premorbid housing instability or a new postburn disposition.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1297-1303"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Burn Injury Consultations: The Influence of Temporal Variables and Weather Conditions. 预测烧伤咨询：时间变量和天气条件的影响。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag084

Claudius Illg, Anna Zoldina, Johann Fontana, Johannes Tobias Thiel, Katarzyna Rachunek-Medved, Adrien Daigeler, Sabrina Krauss

{"title":"Predicting Burn Injury Consultations: The Influence of Temporal Variables and Weather Conditions.","authors":"Claudius Illg, Anna Zoldina, Johann Fontana, Johannes Tobias Thiel, Katarzyna Rachunek-Medved, Adrien Daigeler, Sabrina Krauss","doi":"10.1093/jbcr/irag084","DOIUrl":"10.1093/jbcr/irag084","url":null,"abstract":"Specialized burn centers address the special needs of burn victims. Despite accounting for a small proportion of overall trauma cases, 24-hour specialist availability is required. Identifying periods of increased patient flow may support better allocation of beds and staff. This study examined the influence of temporal and meteorological factors on burn injury consultations. Data of all patients treated for burn injuries in our burn unit within 1 year were analyzed. Temporal variables as well as weather data were correlated with burn injury consultation counts. A total of 466 burn trauma patients (mean age 37.2 ± 18.7 years, 57.9% male, and 34.3% occupational injuries) were included. The highest number of daily consultations was observed in June (2.0 ± 1.3) and July (1.55 ± 1.18). The highest number of burn patients presented at the beginning of the week, particularly on Tuesdays (1.9 ± 1.6). Only 50.9% of patients consulted the clinic during regular working hours. Patient presentation numbers did not correlate significantly with temperature, sunshine duration, precipitation, humidity, and wind speed. The proportion of female patients correlated negatively with daily sunshine duration (r = -0.13, P = .037) and daily mean temperature (r = -0.15, P = .019). Unlike general trauma, the number of burn injury consultations did not correlate with any studied meteorological factor. However, the proportion of female patients showed a negative correlation with favorable weather conditions. Increased patient counts were observed on weekdays in the beginning of the week, notably in June and July. These findings may help improve resource management.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1496-1504"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White Phosphorus Burns: A Comprehensive Review over a Century of Evidence from "Willie Peter" to Modern Clinical Management. 白磷烧伤：从“威利·彼得”到现代临床管理的一个世纪证据的全面回顾。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag114

Paolo Marchica, Luciano Mangiameli, Giuseppe A G Lombardo

{"title":"White Phosphorus Burns: A Comprehensive Review over a Century of Evidence from \"Willie Peter\" to Modern Clinical Management.","authors":"Paolo Marchica, Luciano Mangiameli, Giuseppe A G Lombardo","doi":"10.1093/jbcr/irag114","DOIUrl":"10.1093/jbcr/irag114","url":null,"abstract":"White phosphorus (WP) is a highly reactive incendiary agent capable of causing severe injuries through combined thermal combustion and chemical tissue damage, with potential systemic toxicity disproportionate to burn size. Although traditionally associated with warfare, accidental civilian exposures continue to occur, including in coastal environments where historical military residues may persist. This narrative review synthesizes over a century of evidence on WP burns, integrating findings from experimental studies, clinical reports, military experiences, environmental investigations, and toxicological analyses. A contemporary civilian case of accidental coastal exposure is included to illustrate ongoing non-combat relevance. Available evidence consistently identifies hypocalcemia, hyperphosphatemia, cardiac arrhythmias, renal injury, and hepatocellular damage as major systemic complications of WP exposure. Clinical reports show that retained particles may continue to oxidize and reignite upon oxygen exposure, requiring prompt decontamination, mechanical removal, metabolic monitoring, and repeated evaluation for residual material. Current evidence supports copious irrigation, oxygen exclusion with moist dressings, careful debridement, and avoidance of copper sulfate because of its systemic toxicity. The presented case highlights that even limited exposure may result in full-thickness, burns requiring close observation despite minimal TBSA involvement. Despite over a century of reported experience, evidence guiding WP burn management remains fragmented and largely based on case reports and observational studies. The findings underscore the need for standardized clinical protocols, improved preventive strategies, and collaborative civilian-military approaches to advance recognition and management of this uncommon but potentially life-threatening injury.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1435-1444"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tikkun Olam and the Moral Imperative of Scientific Research. 提昆·奥兰与科学研究的道德要求。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag095

Lauren B Nosanov

引用次数: 0

Therapy Driven Protocol: Early Ambulation for Lower Extremity Grafts. 治疗驱动方案：下肢移植物早期活动。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag104

Audrey M O'Neil, Cassandra Rush, Laura Griffard, David Roggy, Brett Hartman, Rodica I Muraru, Emma Holler, Leigh Spera

{"title":"Therapy Driven Protocol: Early Ambulation for Lower Extremity Grafts.","authors":"Audrey M O'Neil, Cassandra Rush, Laura Griffard, David Roggy, Brett Hartman, Rodica I Muraru, Emma Holler, Leigh Spera","doi":"10.1093/jbcr/irag104","DOIUrl":"10.1093/jbcr/irag104","url":null,"abstract":"Early postoperative (post-op) ambulation benefits burn survivors by expediting return to functional independence, preventing bedrest complications, and shortening hospital admissions. Despite published practice guidelines supporting early ambulation, significant variability in practice continues among burn centers, ranging between 0 and 14 days post-op. A 3-year retrospective review was completed of this 15 bed, adult verified burn center, to identify 149 patients who underwent split thickness skin graft (STSG) placement and/or Autologous Skin Cell Suspension (ASCS) application to their lower extremities (LE). Patients unable to ambulate at baseline or died during admission were excluded. LE involvement ranged from 1% to 28% TBSA (Median: 5%). Autograft placement included 83% meshed (1:1-3:1) STSG (n = 125), 14.8% ASCS (n = 22), and 1.3% sheet STSG (n = 2). Grafts crossed joints on 119 patients including the knee (n = 58), ankle (n = 57), and foot (n = 41). Initial ambulation occurred between postoperative day (POD) 1 and 3 (Avg 1.05) with gait distance ranging from 2 to 1500 ft (Avg 125.4 ft). Twelve patients experienced minor graft loss, which healed conservatively. Additional analysis compared patients with and without graft loss. There was no significance associated between initial POD ambulation and graft loss. However, graft loss was significantly association with history of stroke (P = .006), renal disorder (P = .012), and previous amputation (P = .006). These findings suggest that, within a structured protocol, early ambulation as soon as POD 1 may be safely implemented without increased graft loss risk. Incorporating standardized mobility protocols, including use of compression and individualized clinical assessment, may help reduce practice variability and support earlier functional recovery in burn survivors.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1577-1584"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reuse of the ReCell Enzyme Does Not Decrease the Density of Spray Cell Suspension While Significantly Reducing Costs. ReCell酶的重复使用不会降低喷雾细胞悬浮液的密度，同时显著降低成本。

IF 1.9 4区医学

Journal of Burn Care & Research Pub Date : 2026-09-08 DOI: 10.1093/jbcr/irag086

Derek M Culnan, Alexandria Gudeman, Jay Coates, Elizabeth Blears, Genevieve B Culnan, Guillermo Foncerrada, David N Herndon

{"title":"Reuse of the ReCell Enzyme Does Not Decrease the Density of Spray Cell Suspension While Significantly Reducing Costs.","authors":"Derek M Culnan, Alexandria Gudeman, Jay Coates, Elizabeth Blears, Genevieve B Culnan, Guillermo Foncerrada, David N Herndon","doi":"10.1093/jbcr/irag086","DOIUrl":"10.1093/jbcr/irag086","url":null,"abstract":"Spray cell suspension (SCS) represents a commonplace tool to augment skin grafting; however, the kit required to make the suspension is costly. We hypothesize that repeated use of SCS will result in similar cell counts and graft results while decreasing hospital charges. Our institution used the enzyme from one ReCell kit repeatedly while counting cell dosage and tracking clinical outcomes. Six patients aged 8-86 years, with TBSA 8%-50% and Baux scores of 18-144, had 9 surgeries with SCS. All survived to discharge with 95% wound closure from 7 to 21 days after the first grafting (mode 7 days). Cell dosing was 20 716 ± 2346 cells/cm2. This is 1/3829th the dose of cultured epidermal autograft. Linear regression demonstrated no decrease in cell density when preparing up to 14 biopsies of SCS with a positive slope, indicating further samples are feasible. Analysis of variance and Student's t-test of the first and last enzyme use per surgery found no significant differences. The only factor affecting cell counts was live feedback to surgical technologists preparing samples. Motivation of those performing the isolation had more effect than enzyme reuse, age, or number of surgeries. This modification prevented the hospital from purchasing 19 ReCell kits, saving approximately $130 625 in 1 month. Our results show 1 enzyme can be used at least 7 times without a decrease in cell yield or compromise of clinical outcome, demonstrating repeated use of SCS is a cost-effective, safe, and feasible option to augment skin grafting.","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1516-1523"},"PeriodicalIF":1.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0