Journal of Biomaterials Applications最新文献

{"title":"Engineered zero-order drug release from degradable PEG hydrogels - A rapamycin case study.","authors":"Lage Ahrenstedt, Anel Oosthuysen, Peter Zilla, Jaco Theron, Deon Bezuidenhout","doi":"10.1177/08853282251410673","DOIUrl":"10.1177/08853282251410673","url":null,"abstract":"<p><p>This study describes the derivatization of Rapamycin (Ra) with acryloyl chloride (AcCl) and iodoacetic acid (IAA), yielding hydrolysis-susceptible esters designed for controlled drug release at physiological pH. These esters were further conjugated to thiolated polyethylene glycols (PEGs), yielding compounds with enhanced water solubility, pendant thiol groups and with variation in the number of methylene groups between the ester and thioether moieties. Hydrogels were subsequently formed via conjugate addition reactions using multi-arm PEG macromers, specifically 8-arm PEG acrylates or vinyl sulphones, alongside thiolated PEG crosslinkers. The primary focus was to elucidate the impact of structural modifications surrounding the thioether ester linker on drug release kinetics. In vitro release studies demonstrated zero-order Ra elution over 7-19 days, modulated by gel architecture. Notably, Ra incorporated via α-thioether ester bonds exhibited significantly faster release than their β-thioether ester counterparts, with release rate increases of 11% and 31%, respectively, across the gel assemblies examined. This behavior was attributed to the electron-withdrawing effect of the adjacent thioether group, which enhanced ester hydrolysis. Additionally, creating a hydrogel more prone to swelling and degradation (by using the PEG acrylate multi-arm instead of the PEG vinyl sulphone equivalent) increased the overall drug release rate due to higher water uptake within the gel matrix. An alternative strategy involved Ra-based crosslinking, where Ra, di-functionalized with IAA, acted as a crosslinker for the PEG thiol multi-arm molecules. This assembly exhibited a biphasic release profile, initially mimicking the linear zero-order release of Ra mono-iodoacetic ester crosslinked with PEG acrylates, followed by an exponential burst phase. These findings provide critical insights into hydrogel design strategies for tailoring drug release kinetics, paving the way for advanced controlled drug delivery applications.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"29-42"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13234310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Core-shell poly(lactide-co-ε-caprolactone)-gelatin fiber scaffolds as pH-sensitive drug delivery systems.","authors":"","doi":"10.1177/08853282261451107","DOIUrl":"10.1177/08853282261451107","url":null,"abstract":"","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"158"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durable bionic hydrogels nanocomposite with cartilage-mimetic charge: Tailoring tribological and mechanical properties with functionalized carbon nanotubes for artificial cartilage.","authors":"Mohammad Javan Almasi, Abdelsalam Abdelhussein, Dangsheng Xiong","doi":"10.1177/08853282251405354","DOIUrl":"10.1177/08853282251405354","url":null,"abstract":"<p><p>Advances in understanding natural articular cartilage have led to the development of bionic repair materials, with hydrogel composites emerging as a promising option due to their low friction, high water content, and customizable mechanical properties. This study investigates PVA/PAMPS/FMWCNT hydrogels, focusing on the role of negatively charged groups in enhancing performance. FTIR analysis confirmed the integration of PVA, PAMPS. SEM revealed a porous structure resembling cartilage, with carboxyl-functionalized samples showing the largest pores and achieved a 1853% swelling ratio, while hydroxyl- and amine-functionalized samples had smaller pores and greater crosslink density. Mechanical tests showed hydroxyl-functionalized samples achieved 1.01 MPa tensile stress and 237% elongation, whereas carboxyl-functionalized samples, despite strong hydrogen bonding, had inferior mechanical properties due to high porosity. Tribological tests demonstrated carboxyl-functionalized samples had the 0.0346 coefficient of friction (COF), attributed to their high negative charge density and hydration lubrication. Long-term friction tests revealed a stable coefficient (0.07), demonstrating sustained frictional stability under extended sliding conditions. These findings highlight the importance of functionalized multiwall carbon nanotubes (FMWCNT) and negatively charged groups in optimizing hydrogels for cartilage repair, offering insights for developing bionic materials.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"43-56"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of hollow manganese dioxide in cancer diagnosis and treatment.","authors":"Xinyu Wang, Jingrui Chang, Xuejiao Ma, Bo Lu","doi":"10.1177/08853282251408712","DOIUrl":"10.1177/08853282251408712","url":null,"abstract":"<p><p>Malignant tumors pose a serious threat to human health. They are characterized by high incidence and indistinct early symptoms. Advances in medical technology have revealed the limitations of conventional therapies. Consequently, precision, minimally invasive, and integrated diagnosis and treatment have become key objectives in modern oncology. Nanomedicine shows considerable potential for precision therapy. However, novel nanocarriers that combine high efficiency, precise targeting, controllable drug release, and excellent biocompatibility are still urgently needed. Hollow manganese dioxide is a promising inorganic nanomaterial. It exhibits high drug loading capacity, responsiveness to the tumor microenvironment, and favorable biocompatibility. These properties make it an excellent drug carrier for cancer therapy. Synthetic methods for constructing MnO₂-based multifunctional nanoplatforms continue to advance. This review highlights promising applications of hollow MnO₂ in drug delivery, bioimaging, and biosensing. Finally, we summarize the associated challenges and future prospects in anticancer applications, aiming to provide meaningful guidance for further research.p.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"3-28"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium silicate-based bone cement incorporated with carbon nanotubes (CNT)<i>: In vitro</i> and <i>in vivo</i>.","authors":"Leonardo Alvares Sobral Silva, Marina Santos Fernandes, Tiago Moreira Bastos Campos, Renata Guimarães Ribas, Nátaly Domingues Almeida, Letícia Adrielly Dias Grisante, Gilmar Patrocínio Thim, Luana Marotta Reis de Vasconcellos","doi":"10.1177/08853282251405355","DOIUrl":"10.1177/08853282251405355","url":null,"abstract":"<p><p>Calcium silicate cements (CaSiO₃) are widely used in bone repair treatments for both medical and dental applications. To meet the demands of tissue engineering, three calcium silicate cements were developed: a control group without carbon nanotubes (CNT) and two experimental groups incorporating CNT nanoparticles at concentrations of 0.2% and 0.5%. The surface topography of the calcium silicate-based cements was analyzed using field emission scanning electron microscopy (FEG-SEM) and X-ray diffraction. Additionally, an <i>in vitro</i> cell viability assay was performed to assess cytotoxicity. An in vivo study was also conducted using 24 Wistar rats, where critical bone defects of 3.0 mm in diameter were surgically created in both tibiae using a trephine drill. A clot group was included as a control. Following euthanasia, the samples were evaluated through histological and histomorphometric analyses, and a three-point flexural biomechanical test was performed. Statistical analysis was conducted using one- and two-way ANOVA, with a significance level set at 5%. The results indicated that none of the cements exhibited cytotoxicity. Regarding bone neoformation, the clot group showed significantly lower values compared to the SiCa and SiCa+0.5%CNT (mass) groups (<i>p</i> < 0.05), while the SiCa+0.2%CNT group did not differ statistically from the others (<i>p</i> > 0.05). The biomechanical test revealed a statistically significant difference between the SiCa+0.2%CNT group and the SiCa and SiCa+0.5%CNT groups, with the SiCa+0.2%CNT group exhibiting lower values (<i>p</i> < 0.05), whereas the clot group showed no statistical difference from the other groups (<i>p</i> > 0.05). These findings indicate that the incorporation of carbon nanotubes (CNT) into calcium silicate cements did not result in significant differences in bone tissue regeneration when compared to cements without CNT.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"96-105"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of the angiogenic properties of borate bioactive glasses supplemented with zinc and copper.","authors":"M N Moll, M Arango-Ospina, E Kunisch, T Walker, T Renkawitz, A R Boccaccini, F Westhauser","doi":"10.1177/08853282251407322","DOIUrl":"10.1177/08853282251407322","url":null,"abstract":"<p><p>In bone tissue engineering (BTE), vascularization can be attracted by application of biomaterials with pro-angiogenic properties like bioactive glasses (BGs). By releasing ions with angiogenesis stimulating activity including boron, zinc or copper, the angiogenic properties of BGs can be enhanced. Borate BGs like the 1393-B3 BG (composition in wt%: 56.6 B₂O₃, 18.5 CaO, 11.1 K₂O, 5.5 Na₂O, 4.6 MgO, 3.7 P₂O₅) constitute an attractive vector to be doped with further pro-angiogenic ions. In this study, the cytocompatiblity and the angiogenic properties of 1393-B3-BG and its copper and/or zinc-doped variants (exchange for CaO) namely B3-Cu BG (wt%: 15.5 CaO, 3.0 CuO), B3-Zn BG (wt%: 17.5 CaO, 1.0 ZnO) and B3-Cu-Zn BG (wt%: 14.5 CaO, 3.0 CuO, 1.0 ZnO) have been evaluated using human bone-marrow derived mesenchymal stromal cells (BMSCs), a human umbilical vein endothelial cells (HUVEC)-tube formation and a chorioallantoic membrane (CAM) assay. All BGs showed excellent cytocompatibility and enhanced the mRNA and protein levels of angiogenesis stimulating factors like VEGF-A. The BGs also enhanced the formation of a tubular network in the HUVEC-based assay and vascularization on the CAM. However, the addition of copper and zinc did not yield an improvement in the enhancement of angiogenesis by the 1393-B3 BG. In conclusion, in the present experimental setting, the unmodified 1393-B3 BG has demonstrated excellent cytocompatibility and strong pro-angiogenic effects with no additional benefit from incorporating zinc or copper in its composition.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"57-70"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional metal organic frameworks for enhancing mild-temperature photothermal therapy via inhibiting HSP expression.","authors":"Fei Li, Yang Zhong, Xi Xia, Chenglong Sun, Xiaopeng Li, Fanfan Li","doi":"10.1177/08853282251405479","DOIUrl":"10.1177/08853282251405479","url":null,"abstract":"<p><p>Hyperthermia induced by photothermal therapy can cause certain damage to surrounding healthy tissues and cells. In contrast, low-temperature photothermal therapy (LTPTT) has emerged as an alternative due to its non-invasiveness and safety. However, tumor cells can upregulate the molecular chaperone heat shock protein upon thermal stimulation, thereby compromising the therapeutic efficacy of LTPTT. Based on this, this study designed and developed ZIF-8 nanoparticles loaded with gambogic acid (GA), and modified the surface of these nanoparticles with Au nanoparticles to obtain the composite nano-system ZIF-8@Au@GA (ZAG). ZAG can accumulate in the tumor site through the enhanced permeability and retention effect and achieve LTPTT in synergy with an 808 nm laser. The loaded GA, as a natural inhibitor of heat-shock protein 90, can directly exert an anti-tumor effect. Meanwhile, the small-sized Au nanoparticles can act as glucose oxidase mimics to consume cellular ATP levels, further reversing the thermal tolerance of tumor cells, and can also upregulate reactive oxygen species such as H₂O₂ to kill tumor cells. Both in vitro and in vivo experiments have demonstrated that the designed ZAG composite system, in combination with an 808 nm laser, can achieve favorable LTPTT efficacy without any toxic side effects. This integrated dual-enhancement strategy for LTPTT designed in this study offers a new perspective for tumor therapy.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"71-79"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon dots crosslinked egg white hydrogel as a effective dressing for accelerated diabetic wound healing.","authors":"Dan Liu, Jungou Zhuang, Junlu Liu, Lifen Peng, Yang Cao, Xiyin Zhang, Xiaoyan Wang, Songnan Qu","doi":"10.1177/08853282251415533","DOIUrl":"10.1177/08853282251415533","url":null,"abstract":"<p><p>Diabetic wounds are a severe complication of diabetes, imposing a significant economic burden on patients and their families. Egg white (EW) is a natural, cost-effective, and easily accessible nutrient that contains various bioactive compounds with anti-inflammatory and pro-angiogenic properties. Carbon dots (CDs) exhibit excellent biocompatibility and low toxicity. This study introduces a CDs-crosslinked EW hydrogel (CEWH), prepared using CDs as crosslinkers for EW. Our previous study has established CEWH as a multifunctional biomaterial for tissue engineering. In this study, we further demonstrate that CEWH acts as a scaffold for diabetic wound healing in a mouse model by recruiting macrophages and promoting their polarization toward the M2 phenotype, thereby improving the local wound microenvironment. Its large pore size and extended degradation profile facilitate vascular infiltration into the wound site. Moreover, CEWH not only enhances the proliferation of skin tissue cells but also promotes the regeneration of hair follicles, sebaceous glands, and nerves while facilitating collagen deposition, ultimately restoring normal skin architecture and accelerating wound closure in diabetic mice. Overall, our findings underscore CEWH's potential as an effective and affordable wound dressing, providing a safe and economically viable solution for diabetic wound treatment.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"149-157"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of alloying and adding hydroxyapatite on the mechanical and corrosive properties of porous magnesium (Mg).","authors":"Bisma Parveez, Nur Ayuni Jamal, Mohamad Ikhwan Bin Yusuff, Rashed Mustafa Mazarbhuiya, Syed Fouzan Iftekar","doi":"10.1177/08853282261466598","DOIUrl":"https://doi.org/10.1177/08853282261466598","url":null,"abstract":"<p><p>Porous magnesium (Mg) can be a promising material for biomedical application especially implants due to their low density, structure and properties comparable to human bones. In the current work, porous Mg composites were fabricated using powder metallurgy technique with tailored porosities using PMMA particles as space holder (30wt.%, 40wt.%, and 50wt.%.) that decompose on sintering leaving porosity behind. Zinc and manganese were added as alloying elements and hydroxyapatite was added as an additive in proportion of 6wt.%, 8wt.%, 10wt.%, and 12wt.% to influence the mechanical and corrosion properties of porous Mg. The density and porosity were calculated for all samples followed by the compression and corrosion test to evaluate their performance. The porous Mg composites with porosities ranging from 29.64 to 51.34% were developed with compressive strength in the order of 2.63-23.01 MPa and corrosion rate of 1.13-0.6 mm/year. The better performance was exhibited by porous Mg composite with 30wt.% of PMMA and 12wt.% of Hydroxyapatite. The findings indicated that mechanical characteristics and corrosion resistance of porous Mg composites can be successfully controlled by alloying and addition of Hydroxyapatite to make them suitable for biomedical applications.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261466598"},"PeriodicalIF":2.4,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148351651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From leaf to cellulose scaffold: Decellularization and multi-scale characterization of <i>Neolamarckia cadamba</i> leaf for biomedical applications.","authors":"Sangeeta Devi Khangembam, Vipin Kumar Yadav, Anil Kumar Gangwar, Sonal Saxena, Yogendra Singh, Surendra Pratap Chakravarti, Rajesh Kumar Verma, Prafull Kumar Singh, Sameer Shrivastava, Chandra Shekhar, Anil Singh","doi":"10.1177/08853282261464806","DOIUrl":"https://doi.org/10.1177/08853282261464806","url":null,"abstract":"<p><p>Exploring biological \"orthogonality\" between plant and animal kingdoms provides a unique opportunity to mimic biological features of both kingdoms. This novel approach can provide solutions to problems that animal kingdom faces. In this study, we aimed to develop and characterize the Neolamarckia cadamba leaf-derived cellulose scaffolds (NCCS). Fresh Neolamarckia cadamba leaves were decutinized using an n-hexanes-diethyl ether and decellularized using 5% sodium dodecyl sulfate (SDS) for 120h and 2% sodium deoxycholate (SDC) solution for 48h. The leaves incubated in deionized water were acted as controls. Finally, the leaves were bleached in 4% NaOCl solution for 12 h. Histology, DAPI staining, and SEM study of scaffold showed complete decellularization with significantly reduced DNA quantity. Water vapor transmission rate and swelling percentage increased significantly and the scaffolds were hemocompatible. Contact angle revealed a significant increase in hydrophilicity and at maximum load of 2.83 N, percent elongation at break was 0.094 mm/mm. The FT-IR bands were not disturbed, and average roughness (Ra) and root mean square roughness (RMS) (Rq) of NCCS was 193.27 nm and 153.48 nm, respectively. Specific surface area, pore volume, and pore radius of NCCS were increased. The Madin-Darby canine kidney (MDCK) cells were adhered on NCCS and cell viability on decellularized leaf was 88.18% ± 16.12%. Subcutaneously implanted NCCS revealed infiltrated host cells. These characteristics establish NCCS as a sustainable, ethical and cost-effective substitute to mammalian tissue-derived scaffolds for biomedical applications.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261464806"},"PeriodicalIF":2.4,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}