Journal of Biomaterials Applications最新文献_第8页

Citrus trifoliata extract -loaded chitosan nanoparticles as a potential treatment for osteoarthritis: An in vitro evaluation. 三叶柑橘提取物负载壳聚糖纳米粒子作为骨关节炎的一种潜在治疗方法：体外评估

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-03-01 Epub Date: 2024-11-19 DOI: 10.1177/08853282241299243

Li Zhang, Mingming Yang, Saman Jalili

{"title":"Citrus trifoliata extract -loaded chitosan nanoparticles as a potential treatment for osteoarthritis: An in vitro evaluation.","authors":"Li Zhang, Mingming Yang, Saman Jalili","doi":"10.1177/08853282241299243","DOIUrl":"10.1177/08853282241299243","url":null,"abstract":"Osteoarthritis (OA) presents a significant global health burden, necessitating innovative therapeutic strategies to address its multifaceted challenges. This study explores the potential of Citrus trifoliata extract-loaded chitosan nanoparticles (CTECNPs) as a novel treatment modality for OA. The encapsulation of Citrus trifoliata extract (CTE) within chitosan nanoparticles offers advantages such as enhanced bioavailability, sustained release kinetics, and targeted delivery to affected joints. In vitro evaluations demonstrate the biocompatibility and anti-inflammatory properties of CTECNPs, with significant anti-inflammatory and antioxidative effects observed. Moreover, in vivo studies in an OA-induced mouse model reveal promising therapeutic outcomes, including improvements in histological features and locomotor function. These findings highlight the potential of CTECNPs as a promising therapeutic approach for OA, offering hope for improved patient outcomes and quality of life. Further research is warranted to elucidate additional signaling pathways and potential synergistic effects of CTECNPs in OA management.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"908-919"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printed sodium alginate/gelatin/tannic acid/calcium chloride scaffolds laden bone marrow mesenchymal stem cells to repair defective thyroid cartilage plate. 三维打印的海藻酸钠/明胶/单宁酸/氯化钙支架富含骨髓间充质干细胞，可修复缺损的甲状软骨板。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-03-01 Epub Date: 2024-11-11 DOI: 10.1177/08853282241300587

Jingzhi Li, Yuelin Chen, Mengru Wei, Ying Tang, Li Zhou, Xiaoxuan Quan, Ruina Ma, Nan Hou

{"title":"3D printed sodium alginate/gelatin/tannic acid/calcium chloride scaffolds laden bone marrow mesenchymal stem cells to repair defective thyroid cartilage plate.","authors":"Jingzhi Li, Yuelin Chen, Mengru Wei, Ying Tang, Li Zhou, Xiaoxuan Quan, Ruina Ma, Nan Hou","doi":"10.1177/08853282241300587","DOIUrl":"10.1177/08853282241300587","url":null,"abstract":"Due to the absence of blood vessels, cartilage exhibits extremely limited self-repair capacity. Currently, repairing laryngeal cartilage defects, resulting from conditions such as laryngeal tumors, injury, and congenital structural abnormalities, remains a significant challenge in the Department of Otolaryngology, Head and Neck Surgery. Previous research has often focused on enhancing the mechanical properties of synthetic materials. However, their low biological activity and weak cell adhesion necessitate compensatory measures. This study aims to capitalize on the advantages of natural materials in cartilage tissue engineering. Sodium alginate, gelatin, tannic acid, and calcium chloride were utilized to prepare bioinks through cross-linking for application in 3D printing cartilage scaffolds. Bone marrow mesenchymal stem cells with multidirectional differentiation potential were chosen as seed cells, with appropriate growth factors incorporated to promote their differentiation into cartilage during in vitro culture. The scaffold laden cells was subsequently implanted into rabbit thyroid cartilage plate defects at the appropriate time. HE staining, toluidine blue staining, Masson staining, and collagen type II staining were employed to assess cartilage defect repair at 4, 8, and 12 weeks, respectively. Results demonstrated that scaffolds made from natural materials could emulate the mechanical properties of fresh cartilage with commendable biocompatibility. Stained sections further confirmed the efficacy of the composite hydrogel scaffolds identified in this study in promoting rabbit thyroid cartilage plate restoration. In summary, this study successfully fabricated a natural material scaffold for rabbit laryngeal cartilage tissue engineering, thereby furnishing a new idea and experience for the clinical application of laryngeal cartilage defect reconstruction.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"891-907"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclodextrins as nanocarriers of hydrophobic silicon phthalocyanine dichloride for the enhancement of photodynamic therapy effect. 以环糊精为纳米载体的疏水二氯化酞菁硅增强光动力治疗效果。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-03-01 Epub Date: 2024-12-07 DOI: 10.1177/08853282241306858

Eleni Georgiopoulou, Eleni Kavetsou, Eleni Alexandratou, Anastasia Detsi, Konstantinos Politopoulos

{"title":"Cyclodextrins as nanocarriers of hydrophobic silicon phthalocyanine dichloride for the enhancement of photodynamic therapy effect.","authors":"Eleni Georgiopoulou, Eleni Kavetsou, Eleni Alexandratou, Anastasia Detsi, Konstantinos Politopoulos","doi":"10.1177/08853282241306858","DOIUrl":"10.1177/08853282241306858","url":null,"abstract":"In this study, silicon phthalocyanine dichloride (SiCl2Pc) was successfully encapsulated in β-cyclodextrin (β-CD) and hydroxy-propyl-β-cyclodextrin (HP-β-CD) using the kneading method. Dynamic Light Scattering (DLS) demonstrated complexes of various hydrodynamic diameters with moderate stability in aqueous solutions. Their structural characterization by Infrared Spectroscopy (FT- IR) indicated that a part of phthalocyanine is located inside the cyclodextrin cavity. Both photophysical and photochemical studies showed that phthalocyanine's encapsulation in cyclodextrins increased its aqueous solubility. The photodynamic studies against A431 cancer cell line indicated that the complexes are more effective than pure SiCl2Pc. Pure SiCl2Pc's photodynamic effect is characterized as dose-dependent, whereas both complexes presented a biphasic dose-response photodynamic effect. For the highest energy dose of 3.24 J/cm2, pure SiCl2Pc induced mild cell toxicity. SiCl2Pc-β-CD complex was the most promising photosensitizer, exhibiting the highest photodynamic effect when irradiated at 2.16 J/cm2.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"933-951"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in the application of auto-concentrated growth factor (CGF) in wound repair. 自体浓缩生长因子（CGF）在创面修复中的应用进展。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-03-01 Epub Date: 2024-12-08 DOI: 10.1177/08853282241305362

Chao Xu, Yuanmin Pei, Yanli Wang, Wenpeng Li, Liu Yang, Aimei Chai, Ying Wang, Wenrong Fan, Huiquan Tan

{"title":"Progress in the application of auto-concentrated growth factor (CGF) in wound repair.","authors":"Chao Xu, Yuanmin Pei, Yanli Wang, Wenpeng Li, Liu Yang, Aimei Chai, Ying Wang, Wenrong Fan, Huiquan Tan","doi":"10.1177/08853282241305362","DOIUrl":"10.1177/08853282241305362","url":null,"abstract":"Auto-concentrated growth factor (CGF) constitutes the latest generation of plasma extract, and has high concentrations of growth factors and white blood cells. Due to the continuous variable speed centrifugation used during preparation, the tensile strength of the fibrin is also higher. CGF preparation does not involve the use of animal serum, minimizing the risk of infection and immune rejection. Therefore, it has wide potential applications in various fields of regenerative medicine. This paper summarizes the history behind CGF development, reviews the clinical applications and research progress concerning single CGF therapy and CGF used in combination with other treatments in multiple wound repair, and summarizes its potential value as therapeutic agent. Finally, some constructive suggestions and research perspectives for the application of CGF in wound healing are put forward. The available evidence indicates that CGF can promote the healing of chronic refractory wounds and acute wound, promote the growth of granulation, accelerate the speed and improve the quality of wound healing, reduce scar formation, minimize the need for repeated wound dressing, and ameliorate the pain experienced by patients.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"819-827"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial nonwoven materials in medicine and healthcare. 医药和保健领域的抗菌无纺材料。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-02-01 Epub Date: 2024-11-06 DOI: 10.1177/08853282241297872

Lijuan Sun, Shixin Jin, Yan Feng, Yanling Liu

{"title":"Antibacterial nonwoven materials in medicine and healthcare.","authors":"Lijuan Sun, Shixin Jin, Yan Feng, Yanling Liu","doi":"10.1177/08853282241297872","DOIUrl":"10.1177/08853282241297872","url":null,"abstract":"Bacterial infection has always been a severe challenge for mankind. The use of antibacterial nonwoven materials provides a lot of convenience in daily life and clinical practice grammar revision, it has become an important solution to avoid bacterial infection in clinical and daily life. This review systematically examines the spin bonding, melt blown, hydroneedling and electrospinning methods of nonwoven fabrication materials, and summarizes the antibacterial nonwoven materials fabrication methods. Finally, the review discusses the applications of antibacterial nonwoven materials for medical protection, external medical and healthcare, external circulation medical care implantable medical and healthcare and intelligent protection and detection. This comprehensive overview aims to provide valuable insights for the advancement of antibacterial nonwoven materials in the domain of medicine and health care. In the future, antibacterial nonwoven materials are expected to evolve towards biodegradability, composite materials, functionalization, minimally invasive techniques, diversification, and intelligence, thereby holding immense potential in healthcare.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"671-695"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibodies against jellyfish collagen. 针对水母胶原蛋白的单克隆抗体。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-02-01 Epub Date: 2024-11-22 DOI: 10.1177/08853282241298354

Keiko Momma, Takeyuki Shimizu, Takahiro Hayashi, Yuki Hirakawa, Masataka Kuroda, Masayuki Oda

{"title":"Monoclonal antibodies against jellyfish collagen.","authors":"Keiko Momma, Takeyuki Shimizu, Takahiro Hayashi, Yuki Hirakawa, Masataka Kuroda, Masayuki Oda","doi":"10.1177/08853282241298354","DOIUrl":"10.1177/08853282241298354","url":null,"abstract":"Collagens are abundant structural proteins found in both mammalian and marine species, and attractive biomaterials used in various fields. Jellyfish collagen-based products have become increasingly popular because of their clinically proven health benefits such as the effects of skin wound healing and immune stimulation. To develop detection tools for jellyfish collagen, we generated four monoclonal antibodies, MCOL1, 2, 3, and 4, by immunizing mice with moon jellyfish collagen. The nucleotide and amino acid sequences of the variable regions of the monoclonal antibodies were determined. The antibody-binding kinetics toward collagens from moon jellyfish were evaluated using a surface plasmon resonance (SPR) biosensor, and the binding specificity was evaluated in comparison with binding to collagens from edible jellyfish, fish scales, and pig and cow skins. MCOL1, 3, and 4 specifically bound to moon jellyfish collagen, whereas MCOL2 bound to both moon and edible jellyfish collagens. Considering the results showing that the SPR responses of MCOL2 binding were greater than those seen with the other antibodies, MCOL2 could recognize the common and repetitive sequences of the two jellyfish collagens. Therefore, this monoclonal antibody will be most applicable for detecting jellyfish collagen.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"807-815"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nanofibrous polycaprolactone/collagen neural guidance channel filled with sciatic allogeneic schwann cells and platelet-rich plasma for sciatic nerve repair. 用于修复坐骨神经的纳米纤维聚己内酯/胶原蛋白神经引导通道，其中填充了坐骨神经异体施旺细胞和富含血小板的血浆。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-02-01 Epub Date: 2024-11-05 DOI: 10.1177/08853282241297446

Wenfeng Chen, Chenxiao Zheng

{"title":"A nanofibrous polycaprolactone/collagen neural guidance channel filled with sciatic allogeneic schwann cells and platelet-rich plasma for sciatic nerve repair.","authors":"Wenfeng Chen, Chenxiao Zheng","doi":"10.1177/08853282241297446","DOIUrl":"10.1177/08853282241297446","url":null,"abstract":"Sciatic nerve damage, a common condition affecting approximately 2.8% of the US population, can lead to significant disability due to impaired nerve signal transmission, resulting in loss of sensation and motor function in the lower extremities. In this study, a neural guidance channel was developed by rolling a nanofibrous scaffold produced via electrospinning. The scaffold's microstructure, biocompatibility, biodegradation rate, porosity, mechanical properties, and hemocompatibility were evaluated. Platelet-rich plasma (PRP) activated with 30,000 allogeneic Schwann cells (SCs) was injected into the lumen of the channels following implantation into a rat model of sciatic nerve injury. Recovery of motor function, sensory function, and muscle re-innervation was assessed using the sciatic function index (SFI), hot plate latency time, and gastrocnemius muscle wet weight loss. Results showed mean hot plate latency times of Autograft: 7.03, PCL/collagen scaffolds loaded with PRP and SCs (PCLCOLPRPSCs): 8.34, polymer-only scaffolds (PCLCOL): 10.66, and untreated animals (Negative Control): 12.00. The mean SFI values at week eight were Autograft: -49.30, PCLCOLPRPSCs: -64.29, PCLCOL: -75.62, and Negative Control: -77.14. The PCLCOLPRPSCs group showed a more negative SFI compared to the Autograft group but performed better than both the PCLCOL and Negative Control groups. These findings suggest that the developed strategy enhanced sensory and functional recovery compared to the negative control and polymer-only scaffold groups.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"797-806"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive oxygen species-responsive nano gel as a carrier, combined with photothermal therapy and photodynamic therapy for the treatment of brucellosis. 以活性氧反应纳米凝胶为载体，结合光热疗法和光动力疗法治疗布鲁氏菌病。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-02-01 Epub Date: 2024-10-23 DOI: 10.1177/08853282241279340

Yuchang Qin, Yuanyuan Xu, Fuli Lin, Yinwei Qiu, Yujie Luo, Xuan Lv, Tianyu Liu, Yongsheng Li, Zhiyong Liu, Shengchao Yang

{"title":"Reactive oxygen species-responsive nano gel as a carrier, combined with photothermal therapy and photodynamic therapy for the treatment of brucellosis.","authors":"Yuchang Qin, Yuanyuan Xu, Fuli Lin, Yinwei Qiu, Yujie Luo, Xuan Lv, Tianyu Liu, Yongsheng Li, Zhiyong Liu, Shengchao Yang","doi":"10.1177/08853282241279340","DOIUrl":"10.1177/08853282241279340","url":null,"abstract":"Brucellosis is an intracellular infectious disease that is primarily treated with antibacterial therapy. However, most antibacterial drugs struggle to penetrate the cell membrane and may be excluded or inactivated within the cell. In a recent study, researchers developed a nanogel coated with polydopamine (PDA) that responds to reactive oxygen species (ROS) and has enhanced adhesion properties. This nanogel encapsulates photosensitized zinc phthalocyanine (ZnPc) and an antibacterial drug, and is further modified with folic acid (FA) for active targeting. The resulting ROS-responsive nanogel, termed PDA@PMAA@ZnPc@DH-FA, can reach temperatures up to 50°C under near-infrared light, leading to a 72.1% improvement in drug release through increased ROS production. Cell staining confirmed a cell survival rate above 75%, with a low hemolysis rate of only 4.633%, indicating excellent biocompatibility. Furthermore, the study's results showed that the nanogel exhibited stronger killing effects against Brucella compared to administering the drug alone. Under near-infrared irradiation, the nanogel achieved a bacteriostatic rate of 99.8%. The combined approach of photothermal therapy and photodynamic therapy offers valuable insights for treating Brucella.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"748-761"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory effect of RGD peptide hydrogel on inflammation and angiogenesis in vitro. RGD 肽水凝胶对体外炎症和血管生成的抑制作用。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-02-01 Epub Date: 2024-11-03 DOI: 10.1177/08853282241296520

Binlin Chen, Licheng Liang, Dadong Jia, Mian Qin, Liye He, Shuai Liu, Yao Lv, Ruping Jiang, Liang Liang

引用次数: 0

Icariin-loaded chitosan/β-glycerophosphate thermosensitive hydrogel enhanced infection control and bone regeneration in canine with infectious bone defects. 淫羊藿苷负载壳聚糖/β-甘油磷酸酯热敏水凝胶增强了犬感染性骨缺损的感染控制和骨再生能力。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-02-01 Epub Date: 2024-10-16 DOI: 10.1177/08853282241288323

Bing Shao, Yang Fu, Bo Li, Siming Huo, Jiayu Du, Xuliang Zhang, Xin Yin, Yanfei Li, Zheng Cao, Miao Song

{"title":"Icariin-loaded chitosan/β-glycerophosphate thermosensitive hydrogel enhanced infection control and bone regeneration in canine with infectious bone defects.","authors":"Bing Shao, Yang Fu, Bo Li, Siming Huo, Jiayu Du, Xuliang Zhang, Xin Yin, Yanfei Li, Zheng Cao, Miao Song","doi":"10.1177/08853282241288323","DOIUrl":"10.1177/08853282241288323","url":null,"abstract":"Faced with infectious bone defects, the development of a thermosensitive hydrogel containing icariin (ICA) represents a promising therapeutic strategy targeting infection control and bone regeneration. In this study, we prepared and evaluated the physicochemical properties, in vitro and in vivo drug release, antimicrobial activity, anti-inflammatory properties, and bone repair effects of ICA/Chitosan/β-Glycerophosphate (ICA/CTS/β-GP) thermosensitive hydrogel. Our findings demonstrate that the ICA/CTS/β-GP thermosensitive hydrogel undergoes a liquid-to-gel transition at body temperature, which is crucial for maintaining local drug release at the defect site. Additionally, the hydrogel exhibited sustained release of ICA over 28 days, showing high antimicrobial activity against Staphylococcus aureus and good biocompatibility in blood compatibility tests. In a canine model of infectious bone defects, the ICA/CTS/β-GP thermosensitive hydrogel showed effective infection control and modulated inflammation, vascular formation, and bone factor expression, while also activating the Wnt/β-catenin signaling pathway. In conclusion, the ICA/CTS/β-GP thermosensitive hydrogel could control infection and repair bone tissue. Its antimicrobial and osteogenic properties provide hope for its clinical application.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"696-713"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0