Journal of Biomaterials Applications最新文献_第9页

Effect of alloying and adding hydroxyapatite on the mechanical and corrosive properties of porous magnesium (Mg). 合金化和羟基磷灰石的加入对多孔镁力学性能和腐蚀性能的影响。

IF 2.4 4区医学

Journal of Biomaterials Applications Pub Date : 2026-06-29 DOI: 10.1177/08853282261466598

Bisma Parveez, Nur Ayuni Jamal, Mohamad Ikhwan Bin Yusuff, Rashed Mustafa Mazarbhuiya, Syed Fouzan Iftekar

{"title":"Effect of alloying and adding hydroxyapatite on the mechanical and corrosive properties of porous magnesium (Mg).","authors":"Bisma Parveez, Nur Ayuni Jamal, Mohamad Ikhwan Bin Yusuff, Rashed Mustafa Mazarbhuiya, Syed Fouzan Iftekar","doi":"10.1177/08853282261466598","DOIUrl":"https://doi.org/10.1177/08853282261466598","url":null,"abstract":"Porous magnesium (Mg) can be a promising material for biomedical application especially implants due to their low density, structure and properties comparable to human bones. In the current work, porous Mg composites were fabricated using powder metallurgy technique with tailored porosities using PMMA particles as space holder (30wt.%, 40wt.%, and 50wt.%.) that decompose on sintering leaving porosity behind. Zinc and manganese were added as alloying elements and hydroxyapatite was added as an additive in proportion of 6wt.%, 8wt.%, 10wt.%, and 12wt.% to influence the mechanical and corrosion properties of porous Mg. The density and porosity were calculated for all samples followed by the compression and corrosion test to evaluate their performance. The porous Mg composites with porosities ranging from 29.64 to 51.34% were developed with compressive strength in the order of 2.63-23.01 MPa and corrosion rate of 1.13-0.6 mm/year. The better performance was exhibited by porous Mg composite with 30wt.% of PMMA and 12wt.% of Hydroxyapatite. The findings indicated that mechanical characteristics and corrosion resistance of porous Mg composites can be successfully controlled by alloying and addition of Hydroxyapatite to make them suitable for biomedical applications.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261466598"},"PeriodicalIF":2.4,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148351651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From leaf to cellulose scaffold: Decellularization and multi-scale characterization of Neolamarckia cadamba leaf for biomedical applications. 从叶片到纤维素支架：用于生物医学应用的新木质素叶片的脱细胞化和多尺度表征。

IF 2.4 4区医学

Journal of Biomaterials Applications Pub Date : 2026-06-25 DOI: 10.1177/08853282261464806

Sangeeta Devi Khangembam, Vipin Kumar Yadav, Anil Kumar Gangwar, Sonal Saxena, Yogendra Singh, Surendra Pratap Chakravarti, Rajesh Kumar Verma, Prafull Kumar Singh, Sameer Shrivastava, Chandra Shekhar, Anil Singh

{"title":"From leaf to cellulose scaffold: Decellularization and multi-scale characterization of Neolamarckia cadamba leaf for biomedical applications.","authors":"Sangeeta Devi Khangembam, Vipin Kumar Yadav, Anil Kumar Gangwar, Sonal Saxena, Yogendra Singh, Surendra Pratap Chakravarti, Rajesh Kumar Verma, Prafull Kumar Singh, Sameer Shrivastava, Chandra Shekhar, Anil Singh","doi":"10.1177/08853282261464806","DOIUrl":"https://doi.org/10.1177/08853282261464806","url":null,"abstract":"Exploring biological \"orthogonality\" between plant and animal kingdoms provides a unique opportunity to mimic biological features of both kingdoms. This novel approach can provide solutions to problems that animal kingdom faces. In this study, we aimed to develop and characterize the Neolamarckia cadamba leaf-derived cellulose scaffolds (NCCS). Fresh Neolamarckia cadamba leaves were decutinized using an n-hexanes-diethyl ether and decellularized using 5% sodium dodecyl sulfate (SDS) for 120h and 2% sodium deoxycholate (SDC) solution for 48h. The leaves incubated in deionized water were acted as controls. Finally, the leaves were bleached in 4% NaOCl solution for 12 h. Histology, DAPI staining, and SEM study of scaffold showed complete decellularization with significantly reduced DNA quantity. Water vapor transmission rate and swelling percentage increased significantly and the scaffolds were hemocompatible. Contact angle revealed a significant increase in hydrophilicity and at maximum load of 2.83 N, percent elongation at break was 0.094 mm/mm. The FT-IR bands were not disturbed, and average roughness (Ra) and root mean square roughness (RMS) (Rq) of NCCS was 193.27 nm and 153.48 nm, respectively. Specific surface area, pore volume, and pore radius of NCCS were increased. The Madin-Darby canine kidney (MDCK) cells were adhered on NCCS and cell viability on decellularized leaf was 88.18% ± 16.12%. Subcutaneously implanted NCCS revealed infiltrated host cells. These characteristics establish NCCS as a sustainable, ethical and cost-effective substitute to mammalian tissue-derived scaffolds for biomedical applications.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261464806"},"PeriodicalIF":2.4,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelatin-based cryogels seeded with exosomes enhance osteogenic activity and bone regeneration in a rabbit femoral defect model. 在兔股骨缺损模型中植入外泌体的明胶冷冻液增强成骨活性和骨再生。

IF 2.4 4区医学

Journal of Biomaterials Applications Pub Date : 2026-06-24 DOI: 10.1177/08853282261463691

Joseph Yang, Daniel Yang, Jhe-Lun Hu, Yong-Ji Chen, Shwu-Jen Chang, Shan-Wei Yang

{"title":"Gelatin-based cryogels seeded with exosomes enhance osteogenic activity and bone regeneration in a rabbit femoral defect model.","authors":"Joseph Yang, Daniel Yang, Jhe-Lun Hu, Yong-Ji Chen, Shwu-Jen Chang, Shan-Wei Yang","doi":"10.1177/08853282261463691","DOIUrl":"https://doi.org/10.1177/08853282261463691","url":null,"abstract":"The development of biomaterial scaffolds that combine structural support with biological activation remains critical for bone defect repair. In this study, gelatin-based cryogels (GBCs) that incorporate β-tricalcium phosphate (β-TCP) and hyaluronic acid (HA) were fabricated and optimized to balance porosity and mechanical stability. Increasing the HA concentration increased the water content, swelling ratio, and porosity while reducing the compressive stiffness. The cryogels that contained 0.3% HA exhibited interconnected macropores (200-300 μm after swelling), ∼30% porosity, and a compressive modulus of 3.67 MPa and were selected for biological evaluation. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC)-derived exosomes were incorporated to increase osteogenic bioactivity. Compared with the control treatment, exosome treatment significantly increased MG-63 proliferation, alkaline phosphatase activity, and mineral deposition (p < 0.05). Notably, compared with exosomes alone, exosome-seeded cryogels synergistically increased osteogenic differentiation (p < 0.001). In a rabbit femoral defect model, compared with cryogels without exosomes, exosome-functionalized cryogels promoted denser bone matrix formation and neovascularization. These findings demonstrate that GBCs seeded with exosomes provide a structurally permissive and biologically active microenvironment that improves bone regeneration. This cell-free strategy represents a promising platform for translational bone repair applications.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261463691"},"PeriodicalIF":2.4,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon monoxide-releasing molecule-3 eradicates mature Enterococcus faecalis biofilms and inhibits recolonization. 一氧化碳释放分子-3根除成熟的粪肠球菌生物膜并抑制再定植。

IF 2.4 4区医学

Journal of Biomaterials Applications Pub Date : 2026-06-23 DOI: 10.1177/08853282261464799

Jiahe Li, Xian He

{"title":"Carbon monoxide-releasing molecule-3 eradicates mature Enterococcus faecalis biofilms and inhibits recolonization.","authors":"Jiahe Li, Xian He","doi":"10.1177/08853282261464799","DOIUrl":"https://doi.org/10.1177/08853282261464799","url":null,"abstract":"Objective: To evaluate the effects of carbon monoxide-releasing molecule-3 (CORM-3) on Enterococcus faecalis biofilm inhibition and eradication, and assess its biosafety. Methods: CO release kinetics were measured by UV spectrophotometry. Mature biofilm eradication was assessed using 72-h biofilm models with crystal violet staining and XTT assay. Colonization inhibition was observed by scanning electron microscopy (SEM). Expression of biofilm-associated genes (esp, gelE, fsrB, cylL) was quantified by RT-qPCR. Cytocompatibility was evaluated in human oral keratinocytes (HOK) and human gingival epithelial cells (HGE). Systemic toxicity was assessed in SD rats through hematological and histopathological analyses. Results: CORM-3 released CO time-dependently with a half-release time of approximately 1.5 min. Treatment with 200 μM and 400 μM CORM-3 achieved biofilm clearance rates of 42.8 ± 5.8% and 65.3 ± 4.7%, with metabolic activity reductions of 38.5 ± 6.2% and 61.7 ± 5.3%, respectively. SEM revealed significantly reduced bacterial adhesion in treated groups. RT-qPCR showed 400 μM CORM-3 downregulated esp, gelE, fsrB, and cylL expression by 64.2%, 68.7%, 55.3%, and 42.1%, respectively. Cell viability remained above 87% after 24 h exposure to 400 μM CORM-3. No hematological abnormalities or organ damage were observed following 7-day intraperitoneal administration. Conclusion: CORM-3 exhibits dual anti-biofilm activity against E. faecalis through controlled CO release, inhibiting bacterial colonization and preventing recolonization while eradicating mature biofilms, with favorable biocompatibility at effective concentrations, supporting its potential as an adjunctive agent in endodontic treatment.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261464799"},"PeriodicalIF":2.4,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural melanin nanoparticles modified with glycol chitosan for enhanced delivery of oxaliplatin. 用乙二醇壳聚糖修饰的天然黑色素纳米颗粒增强奥沙利铂的递送。

IF 2.4 4区医学

Journal of Biomaterials Applications Pub Date : 2026-06-18 DOI: 10.1177/08853282261460756

Güleycan Dedecengiz Varol, Miray Karamese, Seyma Uzum, Kaan Bayer, Rabia Selcen Kuru, Merve Güdül Bacanlı, Sevde Altuntas, Sakip Önder, Gizem Kaleli-Can

{"title":"Natural melanin nanoparticles modified with glycol chitosan for enhanced delivery of oxaliplatin.","authors":"Güleycan Dedecengiz Varol, Miray Karamese, Seyma Uzum, Kaan Bayer, Rabia Selcen Kuru, Merve Güdül Bacanlı, Sevde Altuntas, Sakip Önder, Gizem Kaleli-Can","doi":"10.1177/08853282261460756","DOIUrl":"https://doi.org/10.1177/08853282261460756","url":null,"abstract":"The aim of this study was to investigate the potential of natural melanin nanoparticles (MNPs) as carriers for oxaliplatin (OXP) delivery, with glycol chitosan (GC) surface modification to improve dispersion behavior and drug interaction. The isolated MNPs were spherical with an average diameter of 148 ± 28 nm, which increased to 261 ± 39 nm after GC coating. The particle size decreased to 148 ± 59 nm after OXP loading. Physicochemical characterization confirmed surface modification and drug association. The OXP-loaded GC-MNP formulation showed a loading efficiency of 67.8 ± 4.6% and a biphasic release profile, with an initial rapid release followed by complete drug release within 24 h. Release kinetic analysis showed the best fit with the first-order model, indicating concentration-dependent release behavior. Biological studies demonstrated time-dependent responses in MCF-7 cells. All tested formulations showed low cytotoxicity at 6 h. However, OXP-loaded GC-MNP exhibited higher cytotoxicity than free OXP under selected conditions. Furthermore, concentration-dependent genotoxic effects were observed in comet assay experiments. These findings suggest that GC-coated melanin nanoparticles may serve as a promising carrier platform for short-term modulation of OXP delivery in breast cancer applications.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261460756"},"PeriodicalIF":2.4,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidural thickness of the dura sealants HEMOPATCH® and TACHOSIL® after elective supratentorial craniotomy: A comparative retrospective monocentric cohort study. 选择性幕上开颅术后硬膜外密封剂HEMOPATCH®和TACHOSIL®的硬膜外厚度：一项比较回顾性单中心队列研究。

IF 2.4 4区医学

Journal of Biomaterials Applications Pub Date : 2026-06-17 DOI: 10.1177/08853282261462277

Jakob Rossmann, Andreas Schicho, Julius Höhne, Thomas Eibl, Eduard Yakubov, Johannes Falter, Nils Ole Schmidt, Karl-Michael Schebesch

{"title":"Epidural thickness of the dura sealants HEMOPATCH® and TACHOSIL® after elective supratentorial craniotomy: A comparative retrospective monocentric cohort study.","authors":"Jakob Rossmann, Andreas Schicho, Julius Höhne, Thomas Eibl, Eduard Yakubov, Johannes Falter, Nils Ole Schmidt, Karl-Michael Schebesch","doi":"10.1177/08853282261462277","DOIUrl":"https://doi.org/10.1177/08853282261462277","url":null,"abstract":"This study compares the in vivo behavior (epidural thickness and complication rate including the development of cerebrospinal fluid fistula, CSF-fistula) of the newer dura sealant HEMOPATCH® (HP) with that of the well-established patch TACHOSIL® (TS) in early postoperative magnetic resonance imaging (MRI) and during the clinical course after supratentorial cranial surgery. This retrospective cohort study included 58 patients with complete datasets (HP group n = 39, TS group n = 19). Inclusion criteria were supratentorial surgery, use of one dura sealant (HP or TS), re-implantation of the bone flap, and MRI within 3 months after surgery. We measured the thickness of the used dura sealant in axial T1-weighted sequences of postoperative MRI on the area of suture (central) and on two peripheral spots. Additionally, we examined the incidence of surgical revisions due to hemorrhage, infection, and wound healing disorders. The mean central thickness of HP and TS were 0.49 cm and 0.55 cm, respectively. This difference in size was not statistically significant (p = 0.066). The peripheral epidural thickness of HP (d = 0.36 cm) was significantly smaller than of TS (d = 0.42 cm; p = 0.014) in one of two points of peripheral measurement. Similarly, the two groups did not differ significantly in the complication rate needing surgical revision, including CSF fistula (HP 3/39 vs TS 3/19; p = 0.34). The biological behavior in terms of growth, swelling, induction of wound healing disorders, hemorrhage, and development of CSF-fistula showed no statistically significant difference within this small descriptive cohort.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261462277"},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced skin wound healing using CNC-g-β-glucan/poly(acrylic acid) composite hydrogels: A biocompatible and bioactive scaffold for tissue regeneration. 使用CNC-g-β-葡聚糖/聚丙烯酸复合水凝胶促进皮肤伤口愈合：一种生物相容性和生物活性的组织再生支架。

IF 2.5 4区医学

Journal of Biomaterials Applications Pub Date : 2026-06-11 DOI: 10.1177/08853282261458488

Amir Fallah-Sohy, Mitra Heydari Nasrabadi, Simzar Hosseinzadeh, Roya Rad

{"title":"Enhanced skin wound healing using CNC-g-β-glucan/poly(acrylic acid) composite hydrogels: A biocompatible and bioactive scaffold for tissue regeneration.","authors":"Amir Fallah-Sohy, Mitra Heydari Nasrabadi, Simzar Hosseinzadeh, Roya Rad","doi":"10.1177/08853282261458488","DOIUrl":"https://doi.org/10.1177/08853282261458488","url":null,"abstract":"In this study, composite hydrogel scaffolds of cellulose nanocrystals (CNC) and β-glucan with poly(acrylic acid) (PAA) were synthesized, and their effects on accelerating skin wound healing were investigated. CNC was extracted from hardwood and β-glucan from oat flour, and after chemical crosslinking and photopolymerization, CNC-g-β-glucan/PAA composite hydrogels were prepared. The scaffolds' biological properties were evaluated using MTT assay, in vitro degradation in simulated wound fluid, DAPI staining, FESEM analysis, histological examinations, and immunofluorescence in an animal model. Biocompatibility results indicated that scaffolds containing β-glucan (particularly samples S2 and S3) showed the highest cell viability compared to other groups (p < 0.01). Degradation studies revealed a relatively rapid degradation profile. Moreover, in wound healing assessment, these scaffolds significantly increased epidermal thickness, reduced inflammatory cells, and enhanced the expression of bioactive markers including Col-1, VEGF, and TGF-β. FESEM observations also revealed proper fibroblast spreading and favorable adhesion on the scaffold surface. Overall, the data suggest that incorporating β-glucan into the CNC network improves biological and regenerative performance, likely mediated in part by its immunomodulatory activity, making CNC-g-β-glucan/PAA scaffolds a promising option for wound healing and skin tissue engineering applications.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282261458488"},"PeriodicalIF":2.5,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double emulsion-based encapsulation of iron in amphiphilic block copolymer nanocarriers for controlled release. 铁在两亲嵌段共聚物纳米载体中的双乳化包封控制释放。

IF 2.5 4区医学

Journal of Biomaterials Applications Pub Date : 2026-05-01 Epub Date: 2025-10-31 DOI: 10.1177/08853282251393482

Valentina Camacho, Johan Bermudez, Leon Perez

{"title":"Double emulsion-based encapsulation of iron in amphiphilic block copolymer nanocarriers for controlled release.","authors":"Valentina Camacho, Johan Bermudez, Leon Perez","doi":"10.1177/08853282251393482","DOIUrl":"10.1177/08853282251393482","url":null,"abstract":"In this study, we explored the design of polymeric nanocapsules as vehicles for controlled release of iron. Amphiphilic block copolymers (ABCs) composed of polyethylene glycol (PEG) and poly (ε-caprolactone) (PCL) segments were synthesized via ring-opening polymerization (ROP), using PEG and methoxy-PEG (mPEG) with varying molecular weights as macroinitiators. Structural and molecular characterizations using infrared spectroscopy, proton nuclear magnetic resonance and gel permeation chromatography confirmed successful copolymerization and narrow dispersity indices (Ð <1.5). Iron-loaded nanocapsules were formulated using the double emulsion solvent evaporation (DESE) technique with synthesized PEG-b-PCL copolymers as polymeric precursors. The impact of the copolymer composition on the particle size, morphology, and encapsulation efficiency (EE%) was evaluated. Spherical nanocapsules with diameters below 500 nm were obtained, and a positive correlation was observed between copolymer molecular weight and EE%, with the highest value (74.4%) achieved for the Fe@COP5-96 formulation. Differential scanning calorimetry (DSC) analysis revealed that iron incorporation altered the thermal behavior of the copolymers, resulting in a shift of the melting peaks toward lower temperatures and a decrease in melting enthalpy, consistent with reduced crystallinity arising from ion-polymer interactions. The iron release kinetics exhibited a sustained release behavior. These results demonstrate the potential of PEG-b-PCL nanocapsules as effective carriers for ionic species with promising applications in nutrient delivery and medical therapies.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1263-1273"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of a novel composite hemostatic hydrogel. 一种新型复合止血水凝胶的制备与评价。

IF 2.5 4区医学

Journal of Biomaterials Applications Pub Date : 2026-05-01 Epub Date: 2025-11-01 DOI: 10.1177/08853282251391262

Feng Shen, Qizun Wang, Ruigang Zhu, Yuelei Wang, Chuqiang Yin, Zengshuai Han, Ting Wang, Yanhui Li

{"title":"Preparation and evaluation of a novel composite hemostatic hydrogel.","authors":"Feng Shen, Qizun Wang, Ruigang Zhu, Yuelei Wang, Chuqiang Yin, Zengshuai Han, Ting Wang, Yanhui Li","doi":"10.1177/08853282251391262","DOIUrl":"10.1177/08853282251391262","url":null,"abstract":"Hemostasis is critical for ensuring surgical success over the past few decades. Various topical hemostatic agents have been developed to promote hemostasis in various surgeries, particularly in cases where traditional surgical techniques are not applicable. However, the hemostatic performance of most agents is often limited by their reliance on a single component. Therefore, it is necessary to develop composite hemostatic agents that integrate multiple materials from diverse sources to enhance hemostatic efficacy. In addition, existing hemostatic agents in solid forms are not often effective in scenarios involving irregularly shaped or deep wounds, as well as endoscopic surgical procedures. In this study, a gelatin-chitosan-thrombin (GCT) composite hemostatic hydrogel was prepared using cross-linking method. The agent's properties, including morphology, water absorption ratio, swelling ratio, and cytotoxicity were systematically evaluated. A rabbit spinal laminectomy model and a rat live injury model were used to evaluate the hemostatic efficacy of GCT agent. Histological assessment was performed to investigate its biocompatibility. The three-dimensional porous structure of the GCT agent endows it with a high absorption capacity and a low swelling ratio. The GCT agent demonstrates superior hemostatic performance in terms of blood loss and bleeding time compared to existing agents in vivo. In addition, the GCT agent exhibits excellent biodegradability and biocompatibility in vivo, and minimal hemolytic and cytotoxic effects in vitro. Therefore, the novel composite hemostatic hydrogel would be a strong candidate for surgical hemostasis especially when precise application is required.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1349-1361"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 3D-printed PLA honeycomb-shaped scaffolds for bone tissue engineering. 一种用于骨组织工程的3d打印PLA蜂窝状支架。

IF 2.5 4区医学

Journal of Biomaterials Applications Pub Date : 2026-05-01 Epub Date: 2025-11-10 DOI: 10.1177/08853282251396800

Aochong Zhou, Junwei Liao, Zhishen Huang, Kaicheng Zeng, Yuying Guo, Xuedan Hou, Hongxia Zhao

{"title":"A 3D-printed PLA honeycomb-shaped scaffolds for bone tissue engineering.","authors":"Aochong Zhou, Junwei Liao, Zhishen Huang, Kaicheng Zeng, Yuying Guo, Xuedan Hou, Hongxia Zhao","doi":"10.1177/08853282251396800","DOIUrl":"10.1177/08853282251396800","url":null,"abstract":"Objectives: Polylactic acid (PLA) is widely used as biomedical material due to its good biocompatibility and biodegradability. A PLA honeycomb-shaped porous scaffold as bone graft substitute was printed by 3D-printed. Method:Coating and mineralization treatment was used in order to further improve the properties of the PLA scaffold. The materials were characterized by infrared spectroscopy (IR) and Xray diffraction (XRD). The structure of the scaffolds was observed by electric scanning microscope (SEM). The hydrophilicity of the material was observed by contact angle tester. Compression tests were carried out to evaluate the strength of the scaffolds. The biocompatibility of the scaffolds was evaluated by MTT. The behaviors and responses of preosteoblast cells on the scaffolds were studied as well. Results: The porosity of the 3D-printed PLA scaffold was 82.6%. The compressive strength and compressive modulus value of the PLA scaffolds was 8.22 ± 0.16 MPa and 244.3 ± 5.7 MPa, respectively. Coating and mineralization treatment could improved the hydrophilicity, strength and the biocompatibility of the scaffold. Conclusions: The 3D-printed PLA porous scaffold has a good prospect for application as artificial scaffold for bone tissue engineering.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1323-1331"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0