Cyclodextrins as nanocarriers of hydrophobic silicon phthalocyanine dichloride for the enhancement of photodynamic therapy effect.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2024-12-07 DOI:10.1177/08853282241306858

Eleni Georgiopoulou, Eleni Kavetsou, Eleni Alexandratou, Anastasia Detsi, Konstantinos Politopoulos

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Abstract

In this study, silicon phthalocyanine dichloride (SiCl₂Pc) was successfully encapsulated in β-cyclodextrin (β-CD) and hydroxy-propyl-β-cyclodextrin (HP-β-CD) using the kneading method. Dynamic Light Scattering (DLS) demonstrated complexes of various hydrodynamic diameters with moderate stability in aqueous solutions. Their structural characterization by Infrared Spectroscopy (FT- IR) indicated that a part of phthalocyanine is located inside the cyclodextrin cavity. Both photophysical and photochemical studies showed that phthalocyanine's encapsulation in cyclodextrins increased its aqueous solubility. The photodynamic studies against A431 cancer cell line indicated that the complexes are more effective than pure SiCl₂Pc. Pure SiCl₂Pc's photodynamic effect is characterized as dose-dependent, whereas both complexes presented a biphasic dose-response photodynamic effect. For the highest energy dose of 3.24 J/cm², pure SiCl₂Pc induced mild cell toxicity. SiCl₂Pc-β-CD complex was the most promising photosensitizer, exhibiting the highest photodynamic effect when irradiated at 2.16 J/cm².

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以环糊精为纳米载体的疏水二氯化酞菁硅增强光动力治疗效果。

本研究将酞菁二氯化硅（SiCl2Pc）成功地用捏合法包封在β-环糊精（β-CD）和羟丙基-β-环糊精（HP-β-CD）中。动态光散射（DLS）证明了在水溶液中具有中等稳定性的各种水动力直径的配合物。红外光谱（FT- IR）表征表明，环糊精腔内存在部分酞菁。光物理和光化学研究表明，环糊精包封酞菁提高了其水溶性。对A431癌细胞的光动力学研究表明，该配合物比纯SiCl2Pc更有效。纯SiCl2Pc的光动力效应是剂量依赖的，而这两种配合物都表现出双相的剂量响应光动力效应。当能量最高剂量为3.24 J/cm2时，纯SiCl2Pc产生轻微的细胞毒性。SiCl2Pc-β-CD配合物是最有前途的光敏剂，当辐照强度为2.16 J/cm2时，其光动力效应最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.