Journal of Biomedical Research最新文献_第6页

Association between serum 25(OH)D levels and cancer in adults with psoriasis: A cross-sectional study. 成人牛皮癣患者血清25(OH)D与癌症之间的关系：一项横断面研究

IF 2.4 4区医学

Journal of Biomedical Research Pub Date : 2026-03-19 DOI: 10.7555/JBR.39.20250051

Lingquan Deng, Yamei Gao, Chenxingyue Zhang, Zhiqiang Yin

引用次数: 0

The triglyceride-glucose index and obesity: A perspective review. 甘油三酯-葡萄糖指数与肥胖的研究进展

IF 2.4 4区医学

Journal of Biomedical Research Pub Date : 2026-01-25 DOI: 10.7555/JBR.39.20250445

Yury Rosales-Ricardo

引用次数: 0

Immune cell and cytokine profiles in a murine Aspergillus fumigatus extract sensitization model. 小鼠烟曲霉提取物致敏模型的免疫细胞和细胞因子谱。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2026-01-25 DOI: 10.7555/JBR.39.20250479

Long Liang, Ying Luo, Yuqiang Pei, Yongchang Sun

引用次数: 0

Perivascular adipose tissue inflammation in abdominal aortic aneurysm: An underrecognized contributor. 腹主动脉瘤血管周围脂肪组织炎症：一个未被充分认识的因素。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2025-12-25 DOI: 10.7555/JBR.39.20250415

Jiayi Chen, Yang Xue, Liuhua Zhou, Liansheng Wang

{"title":"Perivascular adipose tissue inflammation in abdominal aortic aneurysm: An underrecognized contributor.","authors":"Jiayi Chen, Yang Xue, Liuhua Zhou, Liansheng Wang","doi":"10.7555/JBR.39.20250415","DOIUrl":"10.7555/JBR.39.20250415","url":null,"abstract":"Abdominal aortic aneurysm (AAA) is a life-threatening vascular disorder characterized by localized dilation of the abdominal aorta and a high mortality rate once rupture occurs. At present, therapeutic approaches for AAA are primarily confined to operative repair. Thus, a comprehensive understanding of its pathogenesis is crucial for the development of novel pharmacological interventions. Although the underlying mechanisms remain incompletely defined, several critical pathological features have been identified, including inflammation, extracellular matrix degradation, and loss of vascular smooth muscle cells. In recent years, perivascular adipose tissue (PVAT), an active endocrine and paracrine organ surrounding blood vessels, has emerged as an essential regulator of various cardiovascular diseases. PVAT has been shown to remodel the extracellular matrix and influence vascular smooth muscle cell behavior by establishing a pro-inflammatory milieu, thereby affecting the structural integrity and reactivity of the arterial wall. This review summarizes recent research advances in PVAT-driven inflammation in AAA and highlights the translational potential for clinical applications, aiming to provide new insights for future research.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"1-15"},"PeriodicalIF":3.7,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triglyceride-glucose-uric acid (TyG-UA) index as a superior novel parameter in predicting metabolic syndrome among adult subjects. 甘油三酯-葡萄糖-尿酸（TyG-UA）指数作为预测成人代谢综合征的优越新参数。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2025-11-28 DOI: 10.7555/JBR.39.20250347

Liong Boy Kurniawan, Uleng Bahrun, Mansyur Arif, Agussalim Bukhari, Andi Makbul Aman, Haerani Rasyid

引用次数: 0

Acute kidney injury and postoperative delirium. 急性肾损伤和术后谵妄。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2025-11-28 DOI: 10.7555/JBR.39.20250354

Linyi Yang, Chen Li, Charandip Sandhu, Hong Liu, Chen Chen

引用次数: 0

Glycated albumin and composite glycemic-lipid indices: complementary tools for type 2 diabetes diagnosis. 糖化白蛋白和复合糖脂指数：2型糖尿病诊断的补充工具。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2025-11-25 DOI: 10.7555/JBR.39.20250322

Vera Lukić, Ana Ninić, Gordana Džingalašević, Slađana Menković, Ana Ružanović, Neda Milinković

{"title":"Glycated albumin and composite glycemic-lipid indices: complementary tools for type 2 diabetes diagnosis.","authors":"Vera Lukić, Ana Ninić, Gordana Džingalašević, Slađana Menković, Ana Ružanović, Neda Milinković","doi":"10.7555/JBR.39.20250322","DOIUrl":"10.7555/JBR.39.20250322","url":null,"abstract":"Glycated albumin (GA) is a promising glycemic biomarker that offers advantages over glycated hemoglobin (HbA1c), especially under conditions that affect red blood cell turnover. In type 2 diabetes (T2DM), disturbances in glucose and lipid metabolism often coexist. This study aimed at evalute the diagnostic utility of GA, HbA1c, and their composite indices incorporating high-density lipoprotein cholesterol (HDL-C) in a Serbian cohort. A total of 124 adults (including both T2DM patients and healthy controls) were analyzed for GA, HbA1c, glucose, and lipid profiles. Composite indices, namely, GA/HDL-C and HbA1c/HDL-C, were calculated. Logistic regression and ROC analyses were used to assess diagnostic performance. GA and HbA1c levels were significantly higher in T2DM patients, while HDL-C levels were lower. Both GA/HDL-C and HbA1c/HDL-C showed strong associations with T2DM. HbA1c exhibited the highest AUC (0.966), followed by HbA1c/HDL-C (0.883), GA/HDL-C (0.859), and GA (0.855). The GA/HDL-C index exhibited particularly high specificity (92.06%). GA levels in the control group were consistent with reference values reported in other populations, and this is the first study to provide GA data for a Serbian cohort. The findings highlight GA as a useful complementary marker for T2DM. Composite indices, particularly GA/HDL-C and HbA1c/HDL-C, offer enhanced specificity and may serve as simple, cost-effective tools for integrated metabolic risk evaluation and early T2DM detection.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"1-8"},"PeriodicalIF":3.7,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of dietary magnesium intake and magnesium depletion score with psoriasis among US adults: A cross-sectional NHANES study. 美国成年人膳食镁摄入量和镁耗尽评分与牛皮癣的关系：一项横断面NHANES研究

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2025-11-25 DOI: 10.7555/JBR.39.20250386

Jiliang Lu, Chaojing Zhou, Qinyang Cheng, Chenxingyue Zhang, Ziyue Diao, Zhiqiang Yin

引用次数: 0

Aberrant static and dynamic functional connectivity of auditory processing in migraine: A millisecond-scale magnetoencephalography study. 偏头痛患者听觉加工的异常静态和动态功能连通性：一项毫秒级脑磁图研究。

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2025-11-25 DOI: 10.7555/JBR.39.20250487

Hongxing Liu, Yuanwen Yu, Di Wu, Qiqi Chen, Yingfan Wang, Minghao Li, Xiaoshan Wang

{"title":"Aberrant static and dynamic functional connectivity of auditory processing in migraine: A millisecond-scale magnetoencephalography study.","authors":"Hongxing Liu, Yuanwen Yu, Di Wu, Qiqi Chen, Yingfan Wang, Minghao Li, Xiaoshan Wang","doi":"10.7555/JBR.39.20250487","DOIUrl":"10.7555/JBR.39.20250487","url":null,"abstract":"This study aimed to characterize frequency- and latency-dependent network dysregulation in migraine using magnetoencephalography (MEG)-based static and dynamic functional connectivity analyses during auditory stimulation. Thirty interictal migraine patients and 30 matched healthy controls underwent whole-head MEG recordings during a lateralized auditory task. Static and dynamic functional connectivities were calculated using the corrected amplitude envelope correlation in seven canonical frequency bands (delta 2-120 Hz). Group differences were examined using nonparametric permutation tests, with false discovery rate and Bonferroni correction applied to account for multiple comparisons. Static functional connectivity abnormalities were confined to high-frequency bands (low-gamma, 30-59 Hz; high-gamma, 60-90 Hz; and ripple, 90-120 Hz), showing enhanced frontal-limbic and cross-hemispheric connectivity in migraine patients (Cohen's d = 1.05-1.37). Low-frequency bands showed no significant differences. Dynamic functional connectivity revealed rapid, frequency-specific abnormalities: early (25-50 ms) gamma/ripple hyperconnectivity and late delta/beta alterations, with hemispheric asymmetry. Thus, migraine is characterized by high-frequency oscillatory imbalance during auditory processing, with both persistent (static) and transient (dynamic) network disruptions concentrated in gamma/ripple bands, consistent with impaired predictive coding and sensory hypersensitivity.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"1-14"},"PeriodicalIF":3.7,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new strategy to reduce human influenza infection: creating pigs with partial resistance to influenza A virus infection by targeting ST6GAL1 and ST3GAL4 genes. 减少人类流感感染的新策略：通过靶向ST6GAL1和ST3GAL4基因培育对甲型流感病毒感染具有部分抗性的猪

IF 3.7 4区医学

Journal of Biomedical Research Pub Date : 2025-11-25 DOI: 10.7555/JBR.39.20250300

Lin Li, Shuyi Fang, Xiaoxue Li, Jingjing Liu, Wenhan Lu, Qinyuan Li, Jianghao Chang, Yilin Yuan, Bin Fang, Ying Wang, Yi Rao, Haiyuan Yang, Yifan Dai

{"title":"A new strategy to reduce human influenza infection: creating pigs with partial resistance to influenza A virus infection by targeting ST6GAL1 and ST3GAL4 genes.","authors":"Lin Li, Shuyi Fang, Xiaoxue Li, Jingjing Liu, Wenhan Lu, Qinyuan Li, Jianghao Chang, Yilin Yuan, Bin Fang, Ying Wang, Yi Rao, Haiyuan Yang, Yifan Dai","doi":"10.7555/JBR.39.20250300","DOIUrl":"10.7555/JBR.39.20250300","url":null,"abstract":"A major threat to the global human population is zoonosis, which refers to viral infections transmitted from animals. Pigs are crucial to the transmission of the influenza A virus (IAV) because they express both human-type (α-2,6-linked) and avian-type (α-2,3-linked) sialic acid (SA) receptors, making them a direct source of zoonosis and providing essential \"mixing vessels\" for avian and swine viruses. We aimed to mitigate the IAV threat by disrupting pig influenza infection through gene targeting of the viral receptors in pigs. We utilized CRISPR/Cas9 to knock out the ST6GAL1 and ST3GAL4 genes, which encode enzymes responsible for synthesizing both the human and avian SA receptors in pigs. We observed a significant reduction in these SA receptors in the respiratory tract of the genetically modified pigs. The deletion of these genes conferred partial resistance to IAV infection in vitro, substantially decreasing viral susceptibility. Post-infection transcriptomic analysis revealed distinct expression profiles in ST6GAL1 -/- /ST3GAL4 -/- pigs compared with those of wild-type pig cells. Creating ST6GAL1 -/- /ST3GAL4 -/- pigs provides a large-animal model for studying cross-species transmission of IAV, offering a novel strategy to reduce pandemic risks by disrupting influenza transmission between pigs and humans. This approach suggests a new method for controlling pandemics by targeting animals rather than humans, making it potentially safer than many current alternatives.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"1-15"},"PeriodicalIF":3.7,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0