Journal of Biomedical Research最新文献_第10页

Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats. 暴露于铅和膳食呋喃的摄入加重慢性实验大鼠下丘脑-垂体-睾丸轴毒性。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-09-28 DOI: 10.7555/JBR.36.20220108

Solomon E Owumi, Uche O Arunsi, Moses T Otunla, Imisioluwa O Oluwasuji

{"title":"Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats.","authors":"Solomon E Owumi, Uche O Arunsi, Moses T Otunla, Imisioluwa O Oluwasuji","doi":"10.7555/JBR.36.20220108","DOIUrl":"https://doi.org/10.7555/JBR.36.20220108","url":null,"abstract":"Lead (Pb) and furan are toxic agents, and persistent exposure may impair human and animal reproductive function. We therefore explored the effects of Pb and furan on male rat hypothalamic-pituitary-gonadal reproductive status, oxidative stress, inflammation, and genomic integrity. We found that co-exposure to Pb and furan reduced the activities of testicular function enzymes, endogenous antioxidant levels, total sulfhydryl group, and glutathione. Sperm abnormality, biomarkers of oxidative stress, inflammation, and p53 expression were increased in a dose-dependent manner by treatment with furan and Pb. Typical rat gonad histoarchitecture features were also damaged. Conclusively, co-exposure to Pb and furan induced male reproductive function derangement by decreasing the antioxidant defences in rats, increasing abnormalities in spermatozoa morphology, and reducing reproductive hormone in circulation. These pathophysiological alterations, if persistent, might provide a permissive environment for potentiating reproductive dysfunction and infertility.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 2","pages":"100-114"},"PeriodicalIF":2.3,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9517376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Peripheral CD4 ⁺CD8 ⁺ double positive T cells: A potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus. 外周 CD4 +CD8 + 双阳性 T 细胞：评估系统性红斑狼疮肾功能损害易感性的潜在标志物。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-09-28 DOI: 10.7555/JBR.36.20220094

Kai Chang, Wanlin Na, Chenxia Liu, Hongxuan Xu, Yuan Liu, Yanyan Wang, Zhongyong Jiang

{"title":"Peripheral CD4 +CD8 + double positive T cells: A potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus.","authors":"Kai Chang, Wanlin Na, Chenxia Liu, Hongxuan Xu, Yuan Liu, Yanyan Wang, Zhongyong Jiang","doi":"10.7555/JBR.36.20220094","DOIUrl":"10.7555/JBR.36.20220094","url":null,"abstract":"Lupus nephritis (LN) has a high incidence in systemic lupus erythematosus (SLE) patients, but there is a lack of sensitive predictive markers. The purpose of the study was to investigate the association between the CD4 +CD8 + double positive T (DPT) lymphocytes and LN. The study included patients with SLE without renal impairment (SLE-NRI), LN, nephritic syndrome (NS), or nephritis. Peripheral blood lymphocyte subsets were analyzed by flow cytometry. Biochemical measurements were performed with peripheral blood in accordance with the recommendations proposed by the National Center for Clinical Laboratories. The proportions of DPT cells in the LN group were significantly higher than that in the SLE-NRI group ( t=4.012, P<0.001), NS group ( t=3.240, P=0.001), and nephritis group ( t=2.57, P=0.011). In the LN group, the risk of renal impairment increased significantly in a DPT cells proportion-dependent manner. The risk of LN was 5.136 times (95% confidence interval, 2.115-12.473) higher in cases with a high proportion of DPT cells than those whose proportion of DPT cells within the normal range. These findings indicated that the proportion of DPT cells could be a potential marker to evaluate LN susceptibility, and the interference of NS and nephritis could be effectively excluded when assessing the risk of renal impairment during SLE with DPT cell proportion.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"59-68"},"PeriodicalIF":2.3,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of mitophagy in the hallmarks of aging. 线粒体自噬在衰老标志中的作用。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-08-28 DOI: 10.7555/JBR.36.20220045

Jie Wen, Tingyu Pan, Hongyan Li, Haixia Fan, Jinhua Liu, Zhiyou Cai, Bin Zhao

引用次数: 0

Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy. 焦亡是预防不良心脏重构的药物靶点:焦亡、细胞凋亡和自噬之间的串扰。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-08-10 DOI: 10.7555/JBR.36.20220123

Natalia V Naryzhnaya, Leonid N Maslov, Sergey V Popov, Alexandr V Mukhomezyanov, Vyacheslav V Ryabov, Boris K Kurbatov, Alexandra E Gombozhapova, Nirmal Singh, Feng Fu, Jian-Ming Pei, Sergey V Logvinov

{"title":"Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy.","authors":"Natalia V Naryzhnaya, Leonid N Maslov, Sergey V Popov, Alexandr V Mukhomezyanov, Vyacheslav V Ryabov, Boris K Kurbatov, Alexandra E Gombozhapova, Nirmal Singh, Feng Fu, Jian-Ming Pei, Sergey V Logvinov","doi":"10.7555/JBR.36.20220123","DOIUrl":"https://doi.org/10.7555/JBR.36.20220123","url":null,"abstract":"Acute myocardial infarction (AMI) is one of the main reasons of cardiovascular disease-related death. The introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in AMI. Adverse cardiac remodeling is a serious problem in cardiology. An increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac remodeling. Inhibition of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling, and mitigates cardiomyopathy induced by diabetes and metabolic syndrome. Therefore, it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling, diabetes and metabolic syndrome-triggered cardiomyopathy. It was demonstrated that pyroptosis interacts closely with apoptosis and autophagy. Pyroptosis could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors, caspase-1 inhibitors, microRNA, angiotensin-converting enzyme inhibitors, angiotensin Ⅱ receptor blockers, and traditional Chinese herbal medicines.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"36 6","pages":"375-389"},"PeriodicalIF":2.3,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10529077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats. 新型抗氧化剂1-苯甲酰-6-羟基-2,2,4-三甲基-1,2-二氢喹啉对四氯化碳诱导的大鼠肝损伤具有保护作用。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-07-28 DOI: 10.7555/JBR.36.20220098

Evgenii Dmitrievich Kryl'skii, Darya Andreevna Sinitsyna, Tatyana Nikolaevna Popova, Khidmet Safarovich Shikhaliev, Svetlana Mikhajlovna Medvedeva, Larisa Vladimirovna Matasova, Valentina Olegovna Mittova

{"title":"The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats.","authors":"Evgenii Dmitrievich Kryl'skii, Darya Andreevna Sinitsyna, Tatyana Nikolaevna Popova, Khidmet Safarovich Shikhaliev, Svetlana Mikhajlovna Medvedeva, Larisa Vladimirovna Matasova, Valentina Olegovna Mittova","doi":"10.7555/JBR.36.20220098","DOIUrl":"https://doi.org/10.7555/JBR.36.20220098","url":null,"abstract":"Liver diseases with the central pathogenetic mechanism of oxidative stress are one of the main causes of mortality worldwide. Therefore, dihydroquinoline derivatives, which are precursors of hepatoprotectors and have antioxidant activity, are of interest. We have previously found that some compounds in this class have the ability to normalize redox homeostasis under experimental conditions. Here, we initially analyzed the hepatoprotective potential of the dihydroquinoline derivative 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline (BHDQ) for carbon tetrachloride (CCl 4)-induced liver injury in rats. Results suggested that BHDQ normalized the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase in serum. We also observed an improvement in liver tissue morphology related to BHDQ. Animals with CCl 4-induced liver injuries treated with BHDQ had less oxidative stress compared to animals with CCl 4-induced liver injury. BHDQ promoted activation changes in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione transferase on control values in animals with CCl 4-induced liver injury. BHDQ also activated gene transcription in Sod1 and Gpx1 via nuclear factor erythroid 2-related factor 2 and forkhead box protein O1 factors. Therefore, the compound of concern has a hepatoprotective effect by inhibiting the development of necrotic processes in the liver tissue, through antioxidation.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"36 6","pages":"423-434"},"PeriodicalIF":2.3,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10529078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acquired immunity and Alzheimer's disease. 获得性免疫和阿尔茨海默病

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-07-28 DOI: 10.7555/JBR.36.20220083

Weixi Feng, Yanli Zhang, Peng Sun, Ming Xiao

引用次数: 0

Anticoagulation therapy for pulmonary embolism involving a myxoma mimicking, giant type C thrombus: A case report. 肺栓塞伴黏液瘤样巨大C型血栓的抗凝治疗1例。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-07-28 DOI: 10.7555/JBR.36.20220118

Yinhe Feng, Yubin Wang, Xiaolong Li, Hui Mao

引用次数: 0

SIRT3 regulates mitochondrial biogenesis in aging-related diseases. SIRT3调控衰老相关疾病的线粒体生物发生。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-06-28 DOI: 10.7555/JBR.36.20220078

Hong-Yan Li, Zhi-You Cai

{"title":"SIRT3 regulates mitochondrial biogenesis in aging-related diseases.","authors":"Hong-Yan Li, Zhi-You Cai","doi":"10.7555/JBR.36.20220078","DOIUrl":"https://doi.org/10.7555/JBR.36.20220078","url":null,"abstract":"Sirtuin 3 (SIRT3), the main family member of mitochondrial deacetylase, targets the majority of substrates controlling mitochondrial biogenesis via lysine deacetylation and modulates important cellular functions such as energy metabolism, reactive oxygen species production and clearance, oxidative stress, and aging. Deletion of SIRT3 has a deleterious effect on mitochondrial biogenesis, thus leading to the defect in mitochondrial function and insufficient ATP production. Imbalance of mitochondrial dynamics leads to excessive mitochondrial biogenesis, dampening mitochondrial function. Mitochondrial dysfunction plays an important role in several diseases related to aging, such as cardiovascular disease, cancer and neurodegenerative diseases. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) launches mitochondrial biogenesis through activating nuclear respiratory factors. These factors act on genes, transcribing and translating mitochondrial DNA to generate new mitochondria. PGC1α builds a bridge between SIRT3 and mitochondrial biogenesis. This review described the involvement of SIRT3 and mitochondrial dynamics, particularly mitochondrial biogenesis in aging-related diseases, and further illustrated the role of the signaling events between SIRT3 and mitochondrial biogenesis in the pathological process of aging-related diseases.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 2","pages":"77-88"},"PeriodicalIF":2.3,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis: The first case report and narrative review. 水洗菌群移植阻止肌萎缩性侧索硬化症恶化:第一例报告及叙述回顾。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-06-28 DOI: 10.7555/JBR.36.20220088

Gaochen Lu, Quan Wen, Bota Cui, Qianqian Li, Faming Zhang

{"title":"Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis: The first case report and narrative review.","authors":"Gaochen Lu, Quan Wen, Bota Cui, Qianqian Li, Faming Zhang","doi":"10.7555/JBR.36.20220088","DOIUrl":"https://doi.org/10.7555/JBR.36.20220088","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is known as a progressive paralysis disorder characterized by degeneration of upper and lower motor neurons, and has an average survival time of three to five years. Growing evidence has suggested a bidirectional link between gut microbiota and neurodegeneration. Here we aimed to report one female case with ALS, who benefited from washed microbiota transplantation (WMT), an improved fecal microbiota transplantation (FMT), through a transendoscopic enteral tube during a 12-month follow-up. Notedly, the accidental scalp trauma the patient suffered later was treated with prescribed antibiotics that caused ALS deterioration. The subsequent rescue WMTs successfully stopped the progression of the disease with a quick improvement. The plateaus and reversals occurred during the whole course of WMT. The stool and blood samples from the first WMT to the last were collected for dynamic microbial and metabolomic analysis. We observed the microbial and metabolomic changing trend consistent with the disease status. This case report for the first time shows the direct clinical evidence on using WMT for treating ALS, indicating that WMT may be the novel treatment strategy for controlling this so-called incurable disease.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 1","pages":"69-76"},"PeriodicalIF":2.3,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Medical image translation using an edge-guided generative adversarial network with global-to-local feature fusion. 基于全局到局部特征融合的边缘导向生成对抗网络医学图像翻译。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-06-28 DOI: 10.7555/JBR.36.20220037

Hamed Amini Amirkolaee, Hamid Amini Amirkolaee

引用次数: 3