Journal of Biomedical Research最新文献_第9页

Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway. 敲低11β-羟基类固醇脱氢酶1型可通过AMPK/SIRT1/PGC-1α途径减轻lps诱导的心肌功能障碍。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2023-05-29 DOI: 10.7555/JBR.36.20220212

Dongmei Zhu, Lingli Luo, Hanjie Zeng, Zheng Zhang, Min Huang, Suming Zhou

{"title":"Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway.","authors":"Dongmei Zhu, Lingli Luo, Hanjie Zeng, Zheng Zhang, Min Huang, Suming Zhou","doi":"10.7555/JBR.36.20220212","DOIUrl":"https://doi.org/10.7555/JBR.36.20220212","url":null,"abstract":"Sepsis-induced myocardial dysfunction is primarily accompanied by severe sepsis, which is associated with high morbidity and mortality. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), encoded by Hsd11b1, is a reductase that can convert inactive cortisone into metabolically active cortisol, but the role of 11β-HSD1 in sepsis-induced myocardial dysfunction remains poorly understood. The current study aimed to investigate the effects of 11β-HSD1 on a lipopolysaccharide (LPS)-induced mouse model, in which LPS (10 mg/kg) was administered to wild-type C57BL/6J mice and 11β-HSD1 global knockout mice. We asscessed cardiac function by echocardiography, performed transmission electron microscopy and immunohistochemical staining to analyze myocardial mitochondrial injury and histological changes, and determined the levels of reactive oxygen species and biomarkers of oxidative stress. We also employed polymerase chain reaction analysis, Western blotting, and immunofluorescent staining to determine the expression of related genes and proteins. To investigate the role of 11β-HSD1 in sepsis-induced myocardial dysfunction, we used LPS to induce lentivirus-infected neonatal rat ventricular cardiomyocytes. We found that knockdown of 11β-HSD1 alleviated LPS-induced myocardial mitochondrial injury, oxidative stress, and inflammation, along with an improved myocardial function; furthermore, the depletion of 11β-HSD1 promoted the phosphorylation of adenosine 5'-monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), and silent information regulator 1 (SIRT1) protein levels both in vivo and in vitro. Therefore, the suppression of 11β-HSD1 may be a viable strategy to improve cardiac function against endotoxemia challenges.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 4","pages":"303-314"},"PeriodicalIF":2.3,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10274602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Circular RNA expression and the competitive endogenous RNA network in pathological, age-related macular degeneration events: A cross-platform normalization study. 病理性年龄相关性黄斑变性事件中的环状RNA表达和竞争性内源性RNA网络：一项跨平台标准化研究。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2023-04-28 DOI: 10.7555/JBR.37.20230010

Ruxu Sun, Hongjing Zhu, Ying Wang, Jianan Wang, Chao Jiang, Qiuchen Cao, Yeran Zhang, Yichen Zhang, Songtao Yuan, Qinghuai Liu

{"title":"Circular RNA expression and the competitive endogenous RNA network in pathological, age-related macular degeneration events: A cross-platform normalization study.","authors":"Ruxu Sun, Hongjing Zhu, Ying Wang, Jianan Wang, Chao Jiang, Qiuchen Cao, Yeran Zhang, Yichen Zhang, Songtao Yuan, Qinghuai Liu","doi":"10.7555/JBR.37.20230010","DOIUrl":"10.7555/JBR.37.20230010","url":null,"abstract":"Age-related macular degeneration (AMD) causes irreversible blindness in people aged over 50 worldwide. The dysfunction of the retinal pigment epithelium is the primary cause of atrophic AMD. In the current study, we used the ComBat and Training Distribution Matching method to integrate data obtained from the Gene Expression Omnibus database. We analyzed the integrated sequencing data by the Gene Set Enrichment Analysis. Peroxisome and tumor necrosis factor-α (TNF-α) signaling and nuclear factor kappa B (NF-κB) were among the top 10 pathways, and thus we selected them to construct AMD cell models to identify differentially expressed circular RNAs (circRNAs). We then constructed a competing endogenous RNA network, which is related to differentially expressed circRNAs. This network included seven circRNAs, 15 microRNAs, and 82 mRNAs. The Kyoto Encyclopedia of Genes and Genomes analysis of mRNAs in this network showed that the hypoxia-inducible factor-1 (HIF-1) signaling pathway was a common downstream event. The results of the current study may provide insights into the pathological processes of atrophic AMD.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"367-381"},"PeriodicalIF":2.3,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10045885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular events in the jaw vascular unit: A traditional review of the mechanisms involved in inflammatory jaw bone diseases. 颌骨血管单位的分子事件：炎症性颌骨疾病相关机制的传统综述。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2023-04-28 DOI: 10.7555/JBR.36.20220266

Ruyu Wang, Haoran Wang, Junyu Mu, Hua Yuan, Yongchu Pang, Yuli Wang, Yifei Du, Feng Han

{"title":"Molecular events in the jaw vascular unit: A traditional review of the mechanisms involved in inflammatory jaw bone diseases.","authors":"Ruyu Wang, Haoran Wang, Junyu Mu, Hua Yuan, Yongchu Pang, Yuli Wang, Yifei Du, Feng Han","doi":"10.7555/JBR.36.20220266","DOIUrl":"10.7555/JBR.36.20220266","url":null,"abstract":"Inflammatory jaw bone diseases are common in stomatology, including periodontitis, peri-implantitis, medication-related osteonecrosis of the jaw, radiation osteomyelitis of the jaw, age-related osteoporosis, and other specific infections. These diseases may lead to tooth loss and maxillofacial deformities, severely affecting patients' quality of life. Over the years, the reconstruction of jaw bone deficiency caused by inflammatory diseases has emerged as a medical and socioeconomic challenge. Therefore, exploring the pathogenesis of inflammatory diseases associated with jaw bones is crucial for improving prognosis and developing new targeted therapies. Accumulating evidence indicates that the integrated bone formation and dysfunction arise from complex interactions among a network of multiple cell types, including osteoblast-associated cells, immune cells, blood vessels, and lymphatic vessels. However, the role of these different cells in the inflammatory process and the 'rules' with which they interact are still not fully understood. Although many investigations have focused on specific pathological processes and molecular events in inflammatory jaw diseases, few articles offer a perspective of integration. Here, we review the changes and mechanisms of various cell types in inflammatory jaw diseases, with the hope of providing insights to drive future research in this field.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":" ","pages":"313-325"},"PeriodicalIF":2.3,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9570481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysfunction of the neurovascular unit in brain aging. 脑老化中神经血管单元的功能障碍。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2023-04-15 DOI: 10.7555/JBR.36.20220105

Shu Liu, Xu Yang, Fei Chen, Zhiyou Cai

引用次数: 0

Improved methodology for efficient establishment of the myocardial ischemia-reperfusion model in pigs through the median thoracic incision. 经胸正中切口建立猪心肌缺血再灌注模型的改进方法。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2023-01-20 DOI: 10.7555/JBR.36.20220189

Liuhua Zhou, Jiateng Sun, Tongtong Yang, Sibo Wang, Tiankai Shan, Lingfeng Gu, Jiawen Chen, Tianwen Wei, Di Zhao, Chong Du, Yulin Bao, Hao Wang, Xiaohu Lu, Haoliang Sun, Meng Lv, Di Yang, Liansheng Wang

{"title":"Improved methodology for efficient establishment of the myocardial ischemia-reperfusion model in pigs through the median thoracic incision.","authors":"Liuhua Zhou, Jiateng Sun, Tongtong Yang, Sibo Wang, Tiankai Shan, Lingfeng Gu, Jiawen Chen, Tianwen Wei, Di Zhao, Chong Du, Yulin Bao, Hao Wang, Xiaohu Lu, Haoliang Sun, Meng Lv, Di Yang, Liansheng Wang","doi":"10.7555/JBR.36.20220189","DOIUrl":"https://doi.org/10.7555/JBR.36.20220189","url":null,"abstract":"To investigate the feasibility and effectiveness of establishing porcine ischemia-reperfusion models by ligating the left anterior descending (LAD) coronary artery, we first randomly divided 16 male Bama pigs into a sham group and a model group. After anesthesia, we separated the arteries and veins. Subsequently, we rapidly located the LAD coronary artery at the beginning of its first diagonal branch through a mid-chest incision. Then, we loosened and released the ligation line after five minutes of pre-occlusion. Finally, we ligated the LAD coronary artery in situ two minutes later and loosened the ligature 60 min after ischemia. Compared with the sham group, electrocardiogram showed multiple continuous lead ST-segment elevations, and ultrasound cardiogram showed significantly lower ejection fraction and left ventricular fractional shortening at one hour and seven days post-operation in the model group. Twenty-four hours after the operation, cardiac troponin T and creatine kinase-MB isoenzyme levels significantly increased in the model group, compared with the sham group. Hematoxylin and eosin staining showed the presence of many inflammatory cells infiltrating the interstitium of the myocardium in the model group but not in the sham group. Masson staining revealed a significant increase in infarct size in the ischemia/reperfusion group. All eight pigs in the model group recovered with normal sinus heart rates, and the survival rate was 100%. In conclusion, the method can provide an accurate and stable large animal model for preclinical research on ischemia/reperfusion with a high success rate and homogeneity of the myocardial infarction area.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 4","pages":"315-325"},"PeriodicalIF":2.3,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis: A multi-omics study. 肠道微生物群与肌萎缩侧索硬化症的认知障碍有关:一项多组学研究。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-12-28 DOI: 10.7555/JBR.36.20220198

Zhenxiang Gong, Li Ba, Jiahui Tang, Yuan Yang, Zehui Li, Mao Liu, Chun Yang, Fengfei Ding, Min Zhang

{"title":"Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis: A multi-omics study.","authors":"Zhenxiang Gong, Li Ba, Jiahui Tang, Yuan Yang, Zehui Li, Mao Liu, Chun Yang, Fengfei Ding, Min Zhang","doi":"10.7555/JBR.36.20220198","DOIUrl":"https://doi.org/10.7555/JBR.36.20220198","url":null,"abstract":"Recently, cognitive impairments (CI) and behavioral abnormalities in patients with amyotrophic lateral sclerosis (ALS) have been reported. However, the underlying mechanisms have been poorly understood. In the current study, we explored the role of gut microbiota in CI of ALS patients. We collected fecal samples from 35 ALS patients and 35 healthy controls. The cognitive function of the ALS patients was evaluated using the Edinburgh Cognitive and Behavioral ALS Screen. We analyzed these samples by using 16S rRNA gene sequencing as well as both untargeted and targeted (bile acids) metabolite mapping between patients with CI and patients with normal cognition (CN). We found altered gut microbial communities and a lower ratio of Firmicutes/ Bacteroidetes in the CI group, compared with the CN group. In addition, the untargeted metabolite mapping revealed that 26 and 17 metabolites significantly increased and decreased, respectively, in the CI group, compared with the CN group. These metabolites were mapped to the metabolic pathways associated with bile acids. We further found that cholic acid and chenodeoxycholic acid were significantly lower in the CI group than in the CN group. In conclusion, we found that the gut microbiota and its metabolome profile differed between ALS patients with and without CI and that the altered bile acid profile in fecal samples was significantly associated with CI in ALS patients. These results need to be replicated in larger studies in the future.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 2","pages":"125-137"},"PeriodicalIF":2.3,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling. 通过单细胞测序和分子建模发现一种SARS-CoV-2中和抗体。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-12-12 DOI: 10.7555/JBR.36.20220221

Zheyue Wang, Qi Tang, Bende Liu, Wenqing Zhang, Yufeng Chen, Ningfei Ji, Yan Peng, Xiaohui Yang, Daixun Cui, Weiyu Kong, Xiaojun Tang, Tingting Yang, Mingshun Zhang, Xinxia Chang, Jin Zhu, Mao Huang, Zhenqing Feng

{"title":"A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling.","authors":"Zheyue Wang, Qi Tang, Bende Liu, Wenqing Zhang, Yufeng Chen, Ningfei Ji, Yan Peng, Xiaohui Yang, Daixun Cui, Weiyu Kong, Xiaojun Tang, Tingting Yang, Mingshun Zhang, Xinxia Chang, Jin Zhu, Mao Huang, Zhenqing Feng","doi":"10.7555/JBR.36.20220221","DOIUrl":"https://doi.org/10.7555/JBR.36.20220221","url":null,"abstract":"Although vaccines have been developed, mutations of SARS-CoV-2, especially the dominant B.1.617.2 (delta) and B.1.529 (omicron) strains with more than 30 mutations on their spike protein, have caused a significant decline in prophylaxis, calling for the need for drug improvement. Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms. The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments, providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies. A total of 128 sequences were obtained after sequencing 196 memory B cells, and 42 sequences were left after merging extremely similar ones and discarding incomplete ones, followed by homology modeling of the antibody variable region. Thirteen candidate sequences were expressed, of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants. The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 3","pages":"166-178"},"PeriodicalIF":2.3,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9536221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers. CpG寡脱氧核苷酸、抗ox40、抗pd1抗体和适配体多靶点原位接种的抗肿瘤效果

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-11-28 DOI: 10.7555/JBR.36.20220052

Anastasia S Proskurina, Vera S Ruzanova, Genrikh S Ritter, Yaroslav R Efremov, Zakhar S Mustafin, Sergey A Lashin, Ekaterina A Burakova, Alesya A Fokina, Timofei S Zatsepin, Dmitry A Stetsenko, Olga Y Leplina, Alexandr A Ostanin, Elena R Chernykh, Sergey S Bogachev

{"title":"Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers.","authors":"Anastasia S Proskurina, Vera S Ruzanova, Genrikh S Ritter, Yaroslav R Efremov, Zakhar S Mustafin, Sergey A Lashin, Ekaterina A Burakova, Alesya A Fokina, Timofei S Zatsepin, Dmitry A Stetsenko, Olga Y Leplina, Alexandr A Ostanin, Elena R Chernykh, Sergey S Bogachev","doi":"10.7555/JBR.36.20220052","DOIUrl":"https://doi.org/10.7555/JBR.36.20220052","url":null,"abstract":"To overcome immune tolerance to cancer, the immune system needs to be exposed to a multi-target action intervention. Here, we investigated the activating effect of CpG oligodeoxynucleotides (ODNs), mesyl phosphoramidate CpG ODNs, anti-OX40 antibodies, and OX40 RNA aptamers on major populations of immunocompetent cells ex vivo. Comparative analysis of the antitumor effects of in situ vaccination with CpG ODNs and anti-OX40 antibodies, as well as several other combinations, such as mesyl phosphoramidate CpG ODNs and OX40 RNA aptamers, was conducted. Antibodies against programmed death 1 (PD1) checkpoint inhibitors or their corresponding PD1 DNA aptamers were also added to vaccination regimens for analytical purposes. Four scenarios were considered: a weakly immunogenic Krebs-2 carcinoma grafted in CBA mice; a moderately immunogenic Lewis carcinoma grafted in C57Black/6 mice; and an immunogenic A20 B cell lymphoma or an Ehrlich carcinoma grafted in BALB/c mice. Adding anti-PD1 antibodies (CpG+αOX40+αPD1) to in situ vaccinations boosts the antitumor effect. When to be used instead of antibodies, aptamers also possess antitumor activity, although this effect was less pronounced. The strongest effect across all the tumors was observed in highly immunogenic A20 B cell lymphoma and Ehrlich carcinoma.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 3","pages":"194-212"},"PeriodicalIF":2.3,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9544167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploration and preliminary clinical investigation of an adhesive approach for primary tooth restoration. 粘接剂在原牙修复中的应用及初步临床研究。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-11-28 DOI: 10.7555/JBR.36.20220188

Xiangqin Xu, Jiansheng Zhu, May Lei Mei, Huaying Wu, Kaipeng Xie, Shoulin Wang, Yaming Chen

{"title":"Exploration and preliminary clinical investigation of an adhesive approach for primary tooth restoration.","authors":"Xiangqin Xu, Jiansheng Zhu, May Lei Mei, Huaying Wu, Kaipeng Xie, Shoulin Wang, Yaming Chen","doi":"10.7555/JBR.36.20220188","DOIUrl":"https://doi.org/10.7555/JBR.36.20220188","url":null,"abstract":"The current study aims to investigate a suitable adhesive for primary tooth enamel. Shear bond strength (SBS) of primary teeth and the length of resin protrusion were analyzed using one-way ANOVA with Bonferroni multiple comparison tests after etching with 35% H 3PO 4. SBS and marginal microleakage tests were conducted with Single Bond Universal (SBU)/Single Bond 2 (SB2) adhesives with or without pre-etching using a nonparametric Kruskal-Wallis test. Clinical investigations were performed to validate the adhesive for primary teeth restoration using Chi-square tests. Results showed that the SBS and length of resin protrusion increased significantly with the etching time. Teeth in the SBU with 35% H 3PO 4 pre-etching groups had higher bond strength and lower marginal microleakage than those in the SB2 groups. Mixed fractures were more common in the 35% H 3PO 4 etched 30 s + SB2/SBU groups. Clinical investigations showed significant differences between the two groups in cumulative retention rates at the 6-, 12- and 18-month follow-up evaluations, as well as in marginal adaptation, discoloration, and secondary caries at the 12- and 18-month follow-up assessments. Together, pre-etching primary teeth enamel for 30 s before SBU treatment improved clinical composite resin restoration, which can provide a suitable approach for restoration of primary teeth.","PeriodicalId":15061,"journal":{"name":"Journal of Biomedical Research","volume":"37 2","pages":"138-147"},"PeriodicalIF":2.3,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9515336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice. 小鼠下丘脑EphA3缺乏可促进高脂肪饮食诱导的肥胖。

IF 2.3 4区医学

Journal of Biomedical Research Pub Date : 2022-11-28 DOI: 10.7555/JBR.36.20220168

Jubiao Zhang, Yang Chen, Lihong Yan, Xin Zhang, Xiaoyan Zheng, Junxia Qi, Fen Yang, Juxue Li

引用次数: 0