Journal of Applied Biomaterials & Functional Materials最新文献

{"title":"Controlled release and antibioticeffect of vancomycin-loaded poly(<i>N</i>-isopropylacrylamide) nanoparticles as a smart drug delivery system.","authors":"Liang Lei, Shanlong Li, Xuefeng Kang, Jian Shang","doi":"10.1177/22808000241291824","DOIUrl":"10.1177/22808000241291824","url":null,"abstract":"<p><p>Numerous studies have addressed the use of vancomycin (VA) to effectively treat bacterial infections. However, VA is known to cause side effects when administered intravenously. Herein, monodisperse poly(<i>N</i>-isopropylacrylamide) (PNIPAAm) hollow nanocapsules were synthesized at the interface of a water-in-oil (W/O) single emulsion via Shirasu porous glass (SPG) membrane emulsification and UV-initiated polymerization. In water solutions, the PNIPAAm nanocapsules were able to encapsulate VA and form a new nanoscale water-soluble drug delivery system, namely, PNIPAAm-VA. In vitro experiments showed that PNIPAAm and PNIPAAm-VA had no cytotoxicity toward human bone marrow mesenchymal stem cells. In addition, the slow hydrolysis of PNIPAAm-VA in vitro led to the progressive release of VA, which was discharged at more than 50% and 80% of its initial concentration within 10 days at 37°C and 40°C, respectively; this subsequently inhibited the growth of methicillin-resistant Staphylococcus aureus bacteria. We believe that our PNIPAAm-VA nanoparticles can potentially be used as an effective injectable for temperature-sensitive materials in vivo to achieve the localized controlled release of drugs as safe and specific therapeutic agents.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000241291824"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of printing parameters on the performance of resin occlusal splints for a sustainable dentistry.","authors":"Ashish Kaushik, Ramesh Kumar Garg, Ravinder S Saini, Francesco Bennardo, Artak Heboyan","doi":"10.1177/22808000251333700","DOIUrl":"https://doi.org/10.1177/22808000251333700","url":null,"abstract":"<p><p>Bruxism affects millions worldwide, leading to dental damage like worn teeth and tooth loss. Resin 3D printing presents a promising method for creating intricate, comfortable, and durable occlusal splints. This study examines how printing parameters-layer thickness, orientation angle, and curing time-affect the mechanical (compressive strength, wear rate, impact strength) and physical (water sorption, surface roughness, dimensional accuracy) properties of occlusal splints made from a methacrylate-based resin. A total of 120 specimens were produced according to American Society for Testing and Materials (ASTM) standards using different parametric combinations. The response surface methodology (RSM) was applied to optimize key parameters. The optimum printing parameters for compressive strength include a layer height of 16.5 mm, curing time of 93.6 min, an orientation angle of 12.8º, yielding a compressive strength of 9.05 MPa, wear rate of 159 mm³/min, and impact strength of 71.58 J/m. Similarly, the optimum results for minimum surface roughness (8.013 microns), maximum dimensional accuracy (97.67 and minimum water sorption (0.386%) are achieved at a layer thickness of 16 mm, curing time of 93 min, and orientation angle of 12º. Results show that optimizing resin 3D printing parameters for occlusal splints significantly reduces production costs, particularly in regions with limited access to dental care, while promoting sustainable dental solutions by minimizing the environmental impact of traditional manufacturing methods and enhancing the efficiency of splint production.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251333700"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of stainless steel crowns placed on primary teeth on biochemical parameters in GCF: A systematic review.","authors":"Mario Alberto Alarcón-Sánchez, Julieta Sarai Becerra-Ruiz, Ruth Rodríguez-Montaño, Sarah Monserrat Lomelí-Martínez, Luca Fiorillo, Artak Heboyan","doi":"10.1177/22808000251335403","DOIUrl":"10.1177/22808000251335403","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this systematic review was to investigate, identify, and summarize the existing literature on the levels of proinflammatory cytokines and chemokines present in gingival crevicular fluid (GCF) of primary teeth restored with stainless steel crowns (SSC) versus control teeth.</p><p><strong>Materials and methods: </strong>The systematic review was registered in the Open Science Framework (ID): 10.17605/OSF.IO/39U4D. In addition, it was prepared following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Five electronic databases were used to identify studies for this systematic review: PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar, from January 10, 1999, to September 15, 2024. The risk of bias in the included studies was assessed using Joanna Briggs Institute (cross-sectional studies) and the Cochrane Risk of Bias for Randomized Trials (RoB 2.0) in randomized clinical trials.</p><p><strong>Results: </strong>The review includes four studies (two cross-sectional and two randomized clinical trials). A total of 75 children aged 3 to 10 years were studied. GCF samples were taken from 98 upper and lower molars rehabilitated with SSC and control teeth (without SSC). ELISA analyzed all samples. This way, the levels of four proinflammatory cytokines and chemokines, IL-1β, IL-6, MIP-1α, and MIP-1β, were determined. The studies reported significant differences between both study groups: IL-1β: 27.30 versus 23.56 <i>p</i> < 0.05; MIP-1α: 682.55 versus 197.60 <i>p</i> < 0.05; and MIP-1β: 884.35 versus 287.85, <i>p</i> < 0.05.</p><p><strong>Conclusions: </strong>This systematic review provides a comprehensive and current overview of the concentrations of proinflammatory cytokines and chemokines present in GCF, providing new insights into the pathogenesis of gingival inflammation in children with SSC. IL-1β, MIP-1α, and MIP-1β levels increased in the GCF of upper and lower molars rehabilitated with stainless steel crowns compared to control primary teeth.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251335403"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative effect of human cell-derived BMP-2 cultured within a collagen bone graft in a rat calvaria defect model.","authors":"Keun-Suh Kim, Euna Pi, Sang-Jun Park, Seungyoon Lee, Inyoung Choi, Taeuk Kim, Hyo-Jung Lee, Yang-Jin Yi","doi":"10.1177/22808000251326799","DOIUrl":"https://doi.org/10.1177/22808000251326799","url":null,"abstract":"<p><p>Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor; however, current clinical applications using <i>Escherichia coli</i>-derived recombinant human BMP-2 are constrained by structural deficiencies and high-dose requirements, which increases the risk of adverse effects. In this study, we aimed to address these limitations by developing a novel approach leveraging genetically engineered human retinal pigment epithelial cells (ARPE-19) to synthesize human cell-derived BMP-2 (hBMP-2) within a collagen-based bone graft matrix. ARPE-19 cells were transduced using a lentiviral vector encoding BMP-2 and subsequently cultured in a porcine-collagen mixed graft material. The efficacy of this hBMP-2-enriched graft was evaluated in a rat calvaria defect model over 6 weeks, with comparisons made against empty defects and grafts lacking hBMP-2. Micro-computed tomography analysis revealed improved bone regeneration parameters in the hBMP-2 group compared with those in the graft-only group, although statistical significance was limited to the trabecular number, which approached borderline significance (p < 0.1). Histological analysis corroborated these findings, revealing significantly enhanced new bone formation but only a reducing tendency of residual graft material in the hBMP-2 group. This study presents a promising approach for bone regeneration by utilizing genetically engineered human cells to produce BMP-2 within clinically available bone graft materials, potentially mitigating the high-dose requirements and associated complications of conventional BMP-2 therapies.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251326799"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials in abdominal aortic aneurysm: From targeted therapy to smart vascular repair.","authors":"Xiya Yan, Zhihan You, Weimin Zhou, Wenpeng Zhao, Jiacong Qiu","doi":"10.1177/22808000251379140","DOIUrl":"https://doi.org/10.1177/22808000251379140","url":null,"abstract":"<p><p>Abdominal aortic aneurysm (AAA), defined as a permanent and often asymptomatic dilatation of the abdominal aorta, poses a significant threat of rupture with high mortality, yet lacks effective pharmacological interventions for stabilisation or regression. Current surgical options are invasive or require strict anatomical suitability, leaving patients with small aneurysms under passive surveillance. This critical gap underscores the urgent need for novel therapeutic strategies. Nanomedicine has emerged as a promising approach, offering solutions for targeted drug delivery, precise imaging, and dynamic monitoring of AAA progression. This review comprehensively analyses recent advances in nanomaterial-based systems for AAA management. We classify and discuss key nanocarriers-inorganic nanomaterials, organic nanomaterials, and hybrid nanomaterials-highlighting their unique design strategies, targeting mechanisms, and therapeutic functions. Specific applications include the targeted delivery of anti-inflammatory agents, modulation of matrix metalloproteinase activity via siRNA delivery, protection of vascular smooth muscle cells (VSMCs) from oxidative stress and apoptosis, and strategies for in situ vascular repair and regeneration. Furthermore, the role of nanomaterials in enhanced diagnostics and intelligent sensing for rupture risk prediction is explored. Despite encouraging preclinical results, challenges regarding long-term biosafety, translatability from rodent models to human pathophysiology, and optimisation of hemodynamic delivery remain significant hurdles. Future directions involve closed-loop theranostic systems, artificial intelligence integration, hemodynamic-optimised nanoparticle design, and exploring gene-editing nanocarriers. This review concludes that engineered nanomaterials hold substantial potential to transform AAA management from passive monitoring to active prevention and precision therapy, paving the way for future clinical translation.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251379140"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-coated titanium screws: Enhancing biofilm resistance, mechanical stability, and osseointegration in orthopedic implants.","authors":"Niranjan Ghimire, Manish Rayamajhi, Yuyu Sun, Ying Deng","doi":"10.1177/22808000251358057","DOIUrl":"https://doi.org/10.1177/22808000251358057","url":null,"abstract":"<p><p>Orthopedic implant-associated infections, primarily caused by biofilm-forming <i>Staphylococcus aureus</i>, pose significant clinical challenges. These infections often lead to implant failure, prolonged antibiotic treatments, and an increased risk of revision surgeries, emphasizing the need for effective biofilm-resistant implant materials. In this study, we present a dual-functional titanium screw (Ti-S) grafted with chitosan (Cs), a biocompatible polymer known for its osteogenic and antimicrobial properties while maintaining mechanical integrity. The chitosan-modified titanium screw (Cs-Ti-S) was prepared via chemical immobilization to enhance resistance to biofilm formation while promoting osseointegration and preserving biomechanical integrity. Biomechanical testing confirmed that chitosan modification did not compromise mechanical performance, as Cs-Ti-S exhibited a torsional yield strength of 1.70 ± 0.00 Nm compared to 1.76 ± 0.05 Nm for unmodified titanium screws (Un-Ti-S), and an axial pullout force of 68.66 ± 14.36 N for Cs-Ti-S versus 70.33 ± 9.71 N for Un-Ti-S. Micro-scratch tests revealed similar hardness values (1.26 ± 0.03 GPa for Cs-Ti-S vs. 1.40 ± 0.07 GPa for Un-Ti-S) and scratch resistance, ensuring surface durability. Gene expression analysis showed upregulated β1-integrin on Cs-Ti-S at 24 h post-infection, indicating improved osteoblast adhesion. Scanning electron microscopy (SEM) analysis confirmed significantly reduced bacterial biofilm formation on Cs-Ti-S. Moreover, the combination of povidone-iodide (PI) treatment on Cs-Ti-S surfaces significantly inhibited biofilm formation over 7 days, unlike Un-Ti-S, which retained significant adhesion. These results suggest chitosan grafting as a scalable, non-antibiotic strategy to enhance antimicrobial resistance and osseointegration.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251358057"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel 2D MXenes biocomposite for the removal of emerging organic contaminants from wastewater.","authors":"Sweta Raj, Divya Bajpai Tripathy, Lalit Prasad, Anil Kumar","doi":"10.1177/22808000251360553","DOIUrl":"https://doi.org/10.1177/22808000251360553","url":null,"abstract":"<p><p>Growing ecological and public health issues brought on by the increasing presence of novel organic contaminants in wastewater need the development of innovative remediation solutions. It's usually challenging for conventional treatment methods to effectively collect these contaminants, which include pharmaceuticals, personal care products, and industrial chemicals. Scientists are, therefore, concentrating on innovative material to increase the efficiency of adsorption and removal. Because they facilitate interaction with a range of organic pollutants, 2D MXenes' unique structural and chemical properties have drawn interest from these materials. MXenes are very excellent adsorbents for a variety of contaminants because of their large surface area, many terminal groups, and distinctive 2D layer architectures. Polyfluoroalkyl substances (PFAS), dyes, antibiotics (tetracycline, sulfonamides, and ciprofloxacin), amitriptyline, verapamil, carbamazepine, 17α-ethinyl estradiol, antibiotic resistance genes (ARGs), diclofenac, ibuprofen heavy metals, and other contaminants have all been claimed to be eliminated by MXenes. Recent studies propose the formulation of MXene-based biocomposites, which not only harness the high surface area and electrical conductivity of MXenes but also integrate biodegradable components to promote eco-friendliness. This work explores the potential of novel 2D MXenes biocomposites in addressing the critical challenge of wastewater treatment, focussing on their efficiency, and sustainability in removing emerging contaminants.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251360553"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A composite bioink derived from lacrimal gland extracellular matrix and alginate.","authors":"Luis Kasimir Leo, Katharina Elisabeth Wiebe-Ben Zakour, Julia Matros, Michael Christian Hacker, Florian Kai Groeber-Becker, Gerd Geerling, Joana Witt","doi":"10.1177/22808000251389486","DOIUrl":"https://doi.org/10.1177/22808000251389486","url":null,"abstract":"<p><p>With the high global prevalence of dry eye disease and around 17% attributed to aqueous deficient dry eye (ADDE), there is an urgent need for therapies targeting lacrimal gland (LG) insufficiency. Advancements in in vitro LG analysis are essential for developing effective treatments that allow for efficient, ethical, and comprehensive evaluation of both cell-based therapies and pharmaceuticals. In light of the rapid progress in 3D bioprinting for tissue engineering, this study focuses on creating a composite hydrogel derived from decellularized porcine LG, combined with alginate. This combination leverages the bioactivity of the decellularized extracellular matrix (dECM) with the favorable biomechanical properties of alginate in a single bioink. Our results demonstrate that dECM supports the in vitro culture of LG cell types effectively, while alginate provides enhanced biomechanical stability. We analyzed the biomechanical and rheological properties of the bioink and printed 3D structures containing LG-derived cells, assessing cell viability both immediately post-printing and over a 7-day culture period. The LG-based bioink showed shear-thinning behavior, reduced cell sedimentation, and resilience to shear stresses comparable to pure alginate hydrogels. Additionally, we observed excellent viability of LG epithelial and mesenchymal stromal cells. This composite bioink, combining dECM and alginate, presents improved biomechanical properties while preserving biofunctionality, representing a promising platform for in vitro LG tissue engineering.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251389486"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barium titanate synthesis, mechanism of action and its applications in dentistry: A literature review.","authors":"Rand Naseer Kadhum, Thekra Ismael Hamad","doi":"10.1177/22808000251375714","DOIUrl":"https://doi.org/10.1177/22808000251375714","url":null,"abstract":"<p><strong>Background: </strong>In recent years, barium titanate (BaTiO₃) has demonstrated advancements in the field of dentistry among dental ceramics. This ceramic substance has piezoelectric qualities that are comparable to those of bone, which is crucial for osseointegration. The biomedical field has made extensive use of barium titanate for its affordability, chemical stability, and non-toxicity. The use of barium titanate in dentistry is encouraged by the fact that many widely used metal alloys have unsightly hues and exhibit chemical interactions in the mouth cavity. Because BaTiO₃-based ceramics are more corrosion-resistant, have better color matching that improves esthetics, stronger, and have better radiopacity than traditional biomaterials, their use has grown.</p><p><strong>Purpose: </strong>This review will cover the production techniques, mechanism of action, phases, and dental uses of BaTiO₃.</p><p><strong>Conclusion: </strong>Barium titanate exhibited encouraging qualities for dental uses due to its antibacterial, biocompatible and piezoelectric action.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251375714"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced bone regeneration with cerium-doped bioactive glasses: In vitro and in vivo study.","authors":"Roberta Salvatori, Alexandre Anesi, Luigi Chiarini, Mattia Di Bartolomeo, Arrigo Pellacani, Chiara Cavazzoli, Alfonso Zambon, Gigliola Lusvardi","doi":"10.1177/22808000251326794","DOIUrl":"https://doi.org/10.1177/22808000251326794","url":null,"abstract":"<p><strong>Background: </strong>Bioactive cerium-doped (Ce-BGs) glasses with proven antioxidant properties, which may reduce post-implant oxidative stress, were studied in vitro and in vivo to evaluate their application in bone regeneration. Based on the Kokubo (K) composition, they contain 3.6 and 5.3 mol% cerium (referred to as K3.6 and K5.3, respectively).</p><p><strong>Methods: </strong>Ce-BGs were synthesized by melting and sieved to produce granules (size range = 200-500 µm). In vitro studies were conducted against MLO-Y4 cells using direct Neutral Red (NR) and indirect Bromo-2-deoxyUridine (BrdU) assays to assess cell viability and proliferation respectively. In vivo studies were carried out using a New Zealand white rabbit model to evaluate bone healing potential.</p><p><strong>Results and discussion: </strong>NR results showed a significant increase in cell viability for Ce-BGs: 77% for K and 79 and 85% for K3.6 and K5.3, after 24 h. After 72 h, cell viability decreased for K to 58% and increased for K3.6 and K5.3 (76% and 116% respectively). Cerium inhibits cell proliferation in BrdU assay as explainable by the increased durability of Ce-BGs. In vivo studies, after 30 and 60 days, revealed a delayed degradation for Ce-BGs that can stimulate the osteo-regeneration without inflammatory or degenerative effects. Moreover, the new bone area (NBA) was higher for Ce-BGs compared to control; after 60 days 32% for K5.3 versus 21% for K.</p><p><strong>Conclusions: </strong>Ce-BGs granules show improved direct cytocompatibility in vitro and enhance the long-term bone remodeling process in vivo, contributing to a more controlled and effective bone healing compared to the K granules. This improved behavior can be linked to the antioxidant and anti-inflammatory properties of cerium, that can assist bone regeneration and reduce implant-associated inflammation, and to their slower dissolution rate that supports the controlled release of ions. These results suggest Ce-BGs as a promising device for therapeutic applications on <i>hard</i> tissues.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251326794"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}