Journal of Applied Biomaterials & Functional Materials最新文献

{"title":"Chitosan-based promising scaffolds for the construction of tailored nanosystems against osteoporosis: Current status and future prospects.","authors":"Ya-Ming Wang, Jiang-Tao Shen","doi":"10.1177/22808000241266487","DOIUrl":"https://doi.org/10.1177/22808000241266487","url":null,"abstract":"<p><p>Despite advancements in therapeutic techniques, restoring bone tissue after damage remains a challenging task. Tissue engineering or targeted drug delivery solutions aim to meet the pressing clinical demand for treatment alternatives by creating substitute materials that imitate the structural and biological characteristics of healthy tissue. Polymers derived from natural sources typically exhibit enhanced biological compatibility and bioactivity when compared to manufactured polymers. Chitosan is a unique polysaccharide derived from chitin through deacetylation, offering biodegradability, biocompatibility, and antibacterial activity. Its cationic charge sets it apart from other polymers, making it a valuable resource for various applications. Modifications such as thiolation, alkylation, acetylation, or hydrophilic group incorporation can enhance chitosan's swelling behavior, cross-linking, adhesion, permeation, controllable drug release, enzyme inhibition, and antioxidative properties. Chitosan scaffolds possess considerable potential for utilization in several biological applications. An intriguing application is its use in the areas of drug distribution and bone tissue engineering. Due to their excellent biocompatibility and lack of toxicity, they are an optimal material for this particular usage. This article provides a comprehensive analysis of osteoporosis, including its pathophysiology, current treatment options, the utilization of natural polymers in disease management, and the potential use of chitosan scaffolds for drug delivery systems aimed at treating the condition.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241266487"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Picoscopy Discoveries of the Binary Atomic Structure","authors":"Olexandr Kucherov, Andrey Mudryk","doi":"10.35745/afm2023v03.02.0001","DOIUrl":"https://doi.org/10.35745/afm2023v03.02.0001","url":null,"abstract":"In this article, we present a discovery of the binary atomic structure. Through picoscopy experiments, it was revealed that electronic structure is divided into core and functional structures. Internal chemically neutral electrons form the core of an atom and are spherical in pink, while the outer functional electrons are elongated in green being chemically active. A spherical yellow layer separates these two parts. It significantly simplifies the Schrödinger equation and leads to a solution for all 118 chemical elements. As a result, the Kucherov-Mudryk formula w = n + ¾l was derived. That formula allowed for organizing the periodic table in ascending order of the whole energy where en electron first fills the level with the lowest energy, according to the Minimum Potential Energy general principle of nature.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ga Concentration on the Output Performance of ZnO Piezoelectric Nanorods Nanogenerator","authors":"Tung-Lung Wu, Teen-Hang Meen, Yu-Chuan Chang","doi":"10.35745/afm2023v03.02.0002","DOIUrl":"https://doi.org/10.35745/afm2023v03.02.0002","url":null,"abstract":"In this study, a self-assembled monolayer of octyltriethoxysilane was grown on ITO glass. Subsequently, a hydrothermal method was employed to grow low-density gallium (Ga)-doped zinc oxide (ZnO) nanorod structures. In this growth process, the undoped pure ZnO nanorods and ZnO nanorods doped with five different Ga concentrations were developed. After growing the nanorods, X-ray diffraction (XRD) analysis was conducted on both undoped pure ZnO and Ga-doped ZnO nanorods to observe the influence of Ga concentration on the crystalline structure of the ZnO nanorods. Additionally, scanning electron microscopy (SEM) was utilized to examine changes in the surface and cross-sectional growth of ZnO nanorods with varying Ga concentrations, thereby investigating the impact of Ga concentration on the growth of ZnO nanorods. Finally, a thin Pt film was sputtered onto the ZnO nanorod structures to assemble nanogenerators. Ultrasonic excitation was applied to develop these nanogenerators for electrical measurements, allowing us to explore the effects of metal doping on the nanorods’ electrical properties.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platinum Nanotubes Calculated Using Relativistic Cylindrical Wave Technique: Chiral Induced Spin Selectivity","authors":"P. D’yachkov, E. D’yachkov","doi":"10.35745/afm2023v03.01.0001","DOIUrl":"https://doi.org/10.35745/afm2023v03.01.0001","url":null,"abstract":"Electronic and spin properties of chiral platinum nanotubes are calculated using the relativistic linear augmented cylindrical waves method. The spin-orbit coupling induces the strong splitting of nonrelativistic dispersion curves for the Fermi energy region. The large differences in spin densities of states for spins up and down can be used to create pure spin currents through the tubules. In the two series Pt (5, n2) and Pt (10, n2), the (5, 3) and (10, 7) nanotubes show the strongest chirality-induced spin selectivity effects.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"165 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76924819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodiesel Production: Agricultural and Economical Aspect in India","authors":"V. Kumar, Sudhaker Dixit, Soni Gautam, Saransh Tiwari, Ajay Singh Yadav","doi":"10.35745/afm2023v03.01.0002","DOIUrl":"https://doi.org/10.35745/afm2023v03.01.0002","url":null,"abstract":"The production of biodiesel attracts attention from scientists and researchers as of its tremendous applications and commercial use. It becomes important as of its eco-friendly nature, too, as it is biodegradable and non-polluting. The advantages of using petro-diesel with biodiesel lie in diminishing air pollution, encouraging the domestic supply of fuel, and creating new opportunities in agriculture. The production of biodiesel provides an alternative for agriculture as well as the industry. Focusing on short-duration annual crops that can generate fuel and oil seed crops provides numerous opportunities for small farmers. The intention of biodiesel concerns for creation and fortification of the environment. It is economically beneficial in several ways, namely by creating new jobs in the food and farming industries. Biodiesel fuel is eco-friendly and replaces petro-diesel. Previous studies showed that pollutants such as CO, CO2, SOX, HC, PAH, PM, and others can be reduced by using blended and pure biodiesel. However, the emission of NOX increases by using biodiesel. Biodiesel also provides a means to recycle CO2 which is mainly responsible for global warming. Biodiesel has been produced using plant oils such as Jatropha oil, Cottonseed oil, Pongamia oil, Palm oils, Rapeseed oil, and Castor oil. Such oils are converted to biodiesel through transesterification. We investigated the potential of Jatropha oil as a source of biodiesel. Biodiesel has become an eco-friendly and alternative fuel with many aspects in industrial use. When the use of biodiesel becomes more popular than petroleum fuel, the supply must be sufficient to meet daily needs. Therefore, the presented review article describes production, properties, agricultural benefits, marketing, and the prospect of biodiesel.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"127 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80087775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slippery lubricant-infused silica nanoparticulate film processing for anti-biofouling applications.","authors":"Yuen Yee Li Sip,&nbsp;Annabel Jacobs,&nbsp;Alejandra Morales,&nbsp;Mengdi Sun,&nbsp;Luke B Roberson,&nbsp;Mary E Hummerick,&nbsp;Herve Roy,&nbsp;Pieter Kik,&nbsp;Lei Zhai","doi":"10.1177/22808000231184688","DOIUrl":"10.1177/22808000231184688","url":null,"abstract":"<p><p>Microbial biofilm build-up in water distribution systems can pose a risk to human health and pipe material integrity. The impact is more devastating in space stations and to astronauts due to the isolation from necessary replacement parts and medical resources. As a result, there is a need for coatings to be implemented onto the inner region of the pipe to minimize the adherence and growth of biofilms. Lubricant-infused surfaces has been one such interesting material for anti-biofouling applications in which their slippery property promotes repellence to many liquids and thus prevents bacterial adherence. Textured and porous films are suitable substrate candidates to infuse and contain the lubricant. However, there is little investigation in utilizing a nanoparticulate thin film as the substrate material for lubricant infusion. A nanoparticulate film has high porosity within the structure which can promote greater lubricant infusion and retention. The implementation as a thin film structure aids to reduce material consumption and cost. In our study, we utilized a well-studied nanoporous thin film fabricated via layer-by-layer assembly of polycations and colloid silica and then calcination for greater stability. The film was further functionalized to promote fluorinated groups and improve affinity with a fluorinated lubricant. The pristine nanoporous film was characterized to determine its morphology, thickness, wettability, and porosity. The lubricant-infused film was then tested for its lubricant layer stability upon various washing conditions and its performance against bacterial biofilm adherence as a result of its slippery property. Overall, the modified silica nanoparticulate thin film demonstrated potential as a base substrate for lubricant-infused surface fabrication that repelled against ambient aqueous solvents and as an anti-biofouling coating that demonstrated low biofilm coverage and colony forming unit values. Further optimization to improve lubricant retention or incorporation of a secondary function can aid in developing better coatings for biofilm mitigation.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231184688"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10238836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation of a self-assembled cell-extracellular complex and its potentials in improving wound healing.","authors":"Danyan Ye,&nbsp;Yaowen Sun,&nbsp;Lujun Yang,&nbsp;Jing Su","doi":"10.1177/22808000221130168","DOIUrl":"https://doi.org/10.1177/22808000221130168","url":null,"abstract":"<p><strong>Background: </strong>To maintain and enhance the wound healing effects of mesenchymal stem cells (MSCs), a scaffold for hosting MSCs is needed, which ought to be completely biocompatible, durable, producible, and of human source.</p><p><strong>Objective: </strong>To build a cell-extracellular matrix (ECM) complex assembled by human umbilical cord mesenchymal stem cells (HuMSCs) and to investigate its clinical potentials in promoting wound healing.</p><p><strong>Method: </strong>HuMSCs were isolated and expanded. When the cells of third passage reached confluency, ascorbic acid was added to stimulate the cells to deposit ECM where the cells grew in. Four weeks later, a cells-loaded ECM sheet was formed. The cell-ECM complex was observed under the scanning electron microscopy (SEM) and subjected to histological studies. The supernatants were collected and the cell-ECM complex was harvested at different time points and processed for enzyme-linked immune sorbent assay (ELISA) and mRNA analysis. The in vivo experiments were performed by means of implanting the cell-ECM complex on the mice back for up to 6 months and the specimens were collected for histological studies.</p><p><strong>Results: </strong>After 4 weeks of cultivation with ascorbic stimulation, a sheet was formed which is mainly composed with HuMSCs, collagen and hyaluronic acid. The cell-ECM complex can sustain to certain tensile force. The mRNA and protein levels of vascular endothelial growth factor-α (VEGF-α), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), and transforming growth factor-β1 (TGF-β1) were remarkably increased compared to monolayer-cultured cells. The implanted cell-ECM complex on mice was still noticeable with host cells infiltration and vascularization on 6 months.</p><p><strong>Conclusion: </strong>Our studies suggested that HuMSCs can be multi-cultivated through adding ascorbic stimulation and ECM containing collagen and hyaluronic acid were enriched around the cells which self-assembly formed a cell-ECM complex. Cell-ECM complex can improve growth factors secretion remarkably which means it may promote wound healing by paracrine.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000221130168"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10516378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a staggered scaffold structure on the mechanical properties and cell response in bone tissue engineering.","authors":"Xiaoli He,&nbsp;Qian Zhao,&nbsp;Ningning Zhang,&nbsp;Junbin Wang,&nbsp;Qingzong Si,&nbsp;Ying Xue,&nbsp;Zhe Xing","doi":"10.1177/22808000231181326","DOIUrl":"https://doi.org/10.1177/22808000231181326","url":null,"abstract":"<p><p>The primary goal of bone tissue engineering is to fabricate scaffolds that can provide a microenvironment similar to that of natural bone. Therefore, various scaffolds have been designed to replicate the bone structure. Although most tissues exhibit complicated structures, their basic structural unit includes stiff platelets arranged in a staggered micro-array. Therefore, many researchers have designed scaffolds with staggered patterns. However, relatively few studies have comprehensively analyzed this type of scaffold. In this review, we have analyzed scientific research pertaining to staggered scaffold designs and summarized their effects on the physical and biological properties of scaffolds. Compression tests or finite element analysis are typically used to evaluate the mechanical properties of scaffolds, and most studies have performed experiments in cell cultures. Staggered scaffolds improve mechanical strength and are beneficial for cell attachment, proliferation, and differentiation in comparison with conventional designs. However, very few have been studied in vivo experiments. Additionally, studies on the effect of staggered structures on angiogenesis or bone regeneration in vivo, particularly in large animals, are required. Currently, with the prevalence of artificial intelligence (AI)-based technologies, highly optimized models can be developed, resulting in better discoveries. In the future, AI can be used to deepen our understanding on the staggered structure, promoting its use in clinical applications.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231181326"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10046957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of filler types on wear and surface hardness of composite resin restorations.","authors":"Fei Chen,&nbsp;Lijuan Sun,&nbsp;Hao Luo,&nbsp;Peng Yu,&nbsp;Jiang Lin","doi":"10.1177/22808000231193524","DOIUrl":"https://doi.org/10.1177/22808000231193524","url":null,"abstract":"<p><strong>Objective: </strong>Wear and surface hardness of resin composites are of relevance from the clinical standpoint. With the incorporation of novel filler system, more studies need to be performed to investigate newly marketed resin composites. The objective of this study was to investigate the abrasive wear and surface hardness of dental restorative with different filler types.</p><p><strong>Methods: </strong>Nanohybrid filled Harmonize (HM) and Tetric N-Ceram (TNC), microhybrid filled Filtek Z250 (Z250), nanofilled Filtek Z350 (Z350) were included in the study. Twelve cylindrical resin composites specimens with 10 mm in diameter and 6 mm in thickness were prepared for abrasive wear test. Eight hundred cycles under 17 kg load were conducted for final wear by CW3-1 wear machine. The specimen was cleaned with an ultrasonic unit for 3 min followed with drying procedure. After measurement of weight loss and the density of specimens, the specimens were kept for measurement of surface hardness. Surface hardness was measured using a micro-hardness tester with a Vickers diamond indenter after polishing. Three specimens of each material were observed by scanning electron microscopy (SEM) after the abrasion to evaluate the morphology of the surface. Data were analyzed using one-way analysis of variance (ANOVA), followed by Tukey HSD test (<i>α</i> = .05).</p><p><strong>Results: </strong>Z250 performed the least volume wear loss (41.1 ± 2.1 mm³), as well as the hardest value (102.7 ± 2.9 HV). There was no significant difference with the volume wear loss (<i>p</i> = 1.000) and surface hardness (<i>p</i> = 0.874) of HM and TNC. SEM images of nanohybrid filled HM and TNC represented smoother surface compared with other types of resin composites.</p><p><strong>Conclusions: </strong>Microhybrid Z250 showed the highest wear resistance and surface hardness, nanofilled and nanohybrid resin composites may still face the insufficient of wear and surface hardness quality.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231193524"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41112140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review.","authors":"Florencia Antunovic, Felipe Tolosa, Catherine Klein, René Ocaranza","doi":"10.1177/22808000231211416","DOIUrl":"10.1177/22808000231211416","url":null,"abstract":"<p><strong>Background: </strong>Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process.</p><p><strong>Methods: </strong>This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. A computerized search of the PubMed, EBSCO, Scielo and Web of Science databases was performed, restricting literature search to published studies in English or Spanish between January 2002 and March 2023. Database search returned 248 studies which were screened based on title, author names and publication dates.</p><p><strong>Results: </strong>Data from 17 studies were reviewed and tabulated. All studies combined PCL with other biomaterials (such as Alginate, hydroxyapatite, bioactive glass, poly (lactic-co-glycolic acid)), growth factors (BMP-2, rhCEMP1), and/or mesenchymal stromal cells (adipose-derived, bone marrow, periodontal ligament or gingiva mesenchymal stromal cells). PCL scaffolds showed higher cell viability and osteoinductive potential when combined with bioactive agents. Complementary, its degradation rates were affected by the addition or exposure to specific substances, such as: Dopamine, Cerium Oxide, PLGA and hydrogen peroxide.</p><p><strong>Conclusions: </strong>PCL is an effective biomaterial for alveolar bone regeneration in periodontally affected teeth. It could be part of a new generation of biomaterials with improved regenerative potential.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231211416"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136397507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}