Chitosan-based promising scaffolds for the construction of tailored nanosystems against osteoporosis: Current status and future prospects.

IF 3.1 4区 医学 Q2 BIOPHYSICS
Ya-Ming Wang, Jiang-Tao Shen
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引用次数: 0

Abstract

Despite advancements in therapeutic techniques, restoring bone tissue after damage remains a challenging task. Tissue engineering or targeted drug delivery solutions aim to meet the pressing clinical demand for treatment alternatives by creating substitute materials that imitate the structural and biological characteristics of healthy tissue. Polymers derived from natural sources typically exhibit enhanced biological compatibility and bioactivity when compared to manufactured polymers. Chitosan is a unique polysaccharide derived from chitin through deacetylation, offering biodegradability, biocompatibility, and antibacterial activity. Its cationic charge sets it apart from other polymers, making it a valuable resource for various applications. Modifications such as thiolation, alkylation, acetylation, or hydrophilic group incorporation can enhance chitosan's swelling behavior, cross-linking, adhesion, permeation, controllable drug release, enzyme inhibition, and antioxidative properties. Chitosan scaffolds possess considerable potential for utilization in several biological applications. An intriguing application is its use in the areas of drug distribution and bone tissue engineering. Due to their excellent biocompatibility and lack of toxicity, they are an optimal material for this particular usage. This article provides a comprehensive analysis of osteoporosis, including its pathophysiology, current treatment options, the utilization of natural polymers in disease management, and the potential use of chitosan scaffolds for drug delivery systems aimed at treating the condition.

基于壳聚糖的有前景的支架可用于构建针对骨质疏松症的定制纳米系统:现状与前景。
尽管治疗技术不断进步,但骨组织受损后的恢复仍是一项具有挑战性的任务。组织工程或靶向给药解决方案旨在通过制造能模仿健康组织结构和生物特性的替代材料,满足临床对替代治疗方法的迫切需求。与人造聚合物相比,从天然来源提取的聚合物通常具有更强的生物相容性和生物活性。壳聚糖是一种独特的多糖,由甲壳素通过脱乙酰化作用提取而成,具有生物降解性、生物相容性和抗菌活性。其阳离子电荷使其有别于其他聚合物,成为各种应用的宝贵资源。通过硫代、烷基化、乙酰化或加入亲水基团等改性措施,壳聚糖的溶胀行为、交联性、粘附性、渗透性、可控药物释放性、酶抑制性和抗氧化性都能得到增强。壳聚糖支架在多种生物应用中具有相当大的利用潜力。壳聚糖支架在药物分布和骨组织工程领域的应用就很引人关注。由于壳聚糖具有良好的生物相容性和无毒性,因此是这种特殊用途的最佳材料。本文全面分析了骨质疏松症,包括其病理生理学、当前的治疗方案、天然聚合物在疾病管理中的应用,以及壳聚糖支架在药物输送系统中的潜在用途,旨在治疗骨质疏松症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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