Journal of Applied Biomaterials & Functional Materials最新文献

{"title":"Fracture resistance of resin endocrowns with and without fiber reinforced composite base material: A preliminary study.","authors":"Işıl Kaya Büyükbayram,&nbsp;Mehmet Esad Güven,&nbsp;Deniz Ayman,&nbsp;Işıl Damla Şener Yamaner,&nbsp;Engin Fırat Cakan","doi":"10.1177/22808000231151832","DOIUrl":"https://doi.org/10.1177/22808000231151832","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the effects of fiber-reinforced composite base material on fracture resistance and fracture pattern of endodontically treated maxillary premolars restored with endocrowns using two different resin nanoceramic computer-aided design and computer-aided manufacturing (CAD/CAM) restorative material.</p><p><strong>Methods: </strong>Forty extracted sound maxillary premolars with an occlusal reduction of 2 mm above the cementoenamel junction (CEJ) was performed following root canal treatment. Mesial interproximal box was prepared for each tooth at the margin of the CEJ and randomly distributed into four groups (<i>n</i> = 10) as follows: Group A, no resin build-up in the pulp chamber; Group B, 2 mm of fiber-reinforced composite (FRC) build-up (EverX Posterior, GC).; Group C, no resin build-up in pulp chamber; Group D, 2 mm of FRC build-up. Groups A and B were prepared with resin nanoceramic (RNC) consisting ceramic nanofillers (Lava Ultimate 3 M ESPE), while Group C and D were prepared with RNC consisting ceramic nanohybrid fillers (Cerasmart GC Corp). All samples were subjected to 1,200,000 chewing cycles (1.6 Hz, 50 N) and 5000 thermal cycles (5°C-55°C) for artificial aging on a chewing simulator with thermal cycles (CSTC). Samples that survived the CSTC test without being damaged were subjected to a load-to-fracture test.</p><p><strong>Results: </strong>The highest mean fracture strength was found in Group D (936.0 ± 354.7) and lowest in Group A (684.2 ± 466.9). Fracture strength was higher in groups where FRC was used as a base material than plain restorations. However, there were no significant differences between the Lava and Cerasmart groups with and without FRC (<i>p</i> > 0.05). Most of the samples were irreparably fractured under CEJ.</p><p><strong>Conclusion: </strong>Using short FRCs as a resin base material did not significantly improve fracture resistance. Cerasmart and Lava blocks had similar fracture resistance and fracture pattern.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231151832"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10588898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of broken screws on implant abutment by digital guide plate: A case report and literature review.","authors":"Honglan Huang,&nbsp;Zhisheng Zhang,&nbsp;Pingting Lin,&nbsp;Yan Xiang,&nbsp;Yuchen Xu,&nbsp;Yayun Chen,&nbsp;Yanru Hong,&nbsp;Qianhuang Cheng,&nbsp;Lu Yin","doi":"10.1177/22808000231186226","DOIUrl":"10.1177/22808000231186226","url":null,"abstract":"<p><p>Implant restoration is currently the most mainstream method for repairing missing teeth. With the increasing number of plantings, various planting complications begin to be paid attention to. Among them, there are many reports of disability phenomena such as loose and broken abutment screws and broken top screws, which cause the implant to fail or fail to function. In recent years, with the development of computer-aided software and its application in the field of oral treatment, digital guide plates based on 3D printing of oral CBCT scanning data are widely used in oral implants. Therefore, we explore the application prospect of post-core crown restoration after removing broken screws from the implant abutment with a digital guide plate. We reported a case of upper right first molar implant abutment screws broken, which were removed by a digital guide plate and customized turning bur. The resin-matrix ceramics crown post core was prepared, and then the occlusal force was tested by the T-ScanIII system. It provides a reference for the application of digital guide plates in special cases such as broken screws of implant abutment.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231186226"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the role of oral cavity physiological factors into the viscoelastic model of denture adhesives for numerical implementation.","authors":"Anantha Narayanan Ramakrishnan, Oliver Röhrle, Christopher Ludtka, Josephine Koehler, Andreas Kiesow, Stefan Schwan","doi":"10.1177/22808000231201460","DOIUrl":"10.1177/22808000231201460","url":null,"abstract":"<p><p>Physiological parameters of the oral cavity have a profound impact on any restorative solutions designed for edentulous patients including denture adhesives. This study aims to mathematically quantify the influence of three such variables, namely: the temperature, pH, and the swelling of such adhesives under the influence of saliva on its mechanical behavior. The mathematical quantification is further aimed to implement a material model for such adhesives which considers the impact of such physiological factors. The denture adhesive is experimentally investigated by means of rheological steady state frequency sweep tests to obtain the relaxation spectrum of the material. The relaxation behavior is measured for a wide range of oral cavity temperatures and pH. Also, the adhesive is hydrated and upon swelling to different levels again tested to understand the impact of swelling on the mechanical behavior. The experimentally measured continuous relaxation spectrum is modeled as a viscoelastic material using a discrete set of points based on the Prony series discretization technique. The relaxation spectrums for various temperatures are compared and the possibility of a time-temperature superposition is explored for the model. Similarly, the measured values of Storage and loss modulus are investigated to understand the role of pH and swelling. The results in this study clearly indicated a horizontal shift in the relaxation behavior with increase in temperature. And hence, the time-temperature shift factor was calculated for the adhesive. The relaxation spectrum also showed a strong correlation with swelling of the adhesive and the pH. The influence of these two parameters were captured into the model based on the relaxation time parameter in the Prony series approach. Based on this study the impact of these parameters could be appreciated on the performance and mechanical behavior of denture adhesives and implemented into a Prony series based viscoelastic material model which can be used with numerical simulations.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231201460"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel selenium and/or copper substituted hydroxyapatite-gelatin-chitosan-eggshell membrane nanocomposite scaffolds for bone tissue engineering applications.","authors":"Sara Ibrahim Korowash,&nbsp;Nik Sa Nik Sharifulden,&nbsp;Doreya Mohamed Ibrahim,&nbsp;David Ys Chau","doi":"10.1177/22808000231187959","DOIUrl":"https://doi.org/10.1177/22808000231187959","url":null,"abstract":"<p><p>Limitations with the majority of bone therapeutic treatments include low availability, ethical constraints and low biological compatibility. Although a number of choice materials have been exploited successfully, there has always been scope for improvement as well as development of the next-generation of materials. Herein, scaffolds - developed from gelatin, chitosan and eggshell membranes - were crosslinked using tannic acid, and further infused with selenium and/or copper substituted hydroxyapatite nanoparticles to generate a novel nanocomposite substrate. FESEM images of the nanocomposite scaffolds revealed the presence of interconnected pores, mostly spread over the whole surface of the scaffold, alongside XRD and FTIR profiling that detailed the formation of hydroxyapatite as a sole phase. Moreover, physical characterisation of the nanocomposite confirmed that the hydroxyapatite particulates and the eggshell membrane fibres were uniformly distributed and contributed to the surface roughness of the scaffold. Biocompatibility and cytotoxicity of the novel constructs were assessed using the mouse-derived osteoblastic cell line, MC3T3-E1, and standard cell culture assays. Metabolic activity assessment (i.e. MTS assay), LDH-release profiles and Live/Dead staining demonstrated good cell adhesion, viability, and proliferation rates. Accordingly, this work summarises the successful development of a novel construct which may be exploited as a clinical/therapeutic treatment for bone repair as well as a possible translational application as a novel biomaterial for the drug development pipeline.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231187959"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41131042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of organic and antioxidant agents to regain bond strength to bleached enamel in different dental adhesive solvents.","authors":"Satheesh B Haralur, Renad Mohammed Al-Ibrahim, Faten Abdullah Al-Shahrani, Rahaf Abdullah Al-Qahtani, Saurabh Chaturvedi, Naseer M Alqahtani","doi":"10.1177/22808000231198807","DOIUrl":"10.1177/22808000231198807","url":null,"abstract":"<p><p>Materials like carbamide peroxide or hydrogen peroxide are commonly used for vital teeth bleaching. However, there have been concerns regarding their effect on composite-to-bleached enamel bonding strength. The study investigated the impact of organic and antioxidant agents on composite bond strength in bleached enamel with different dental adhesive solvents. Human third molar teeth were sectioned into buccal and lingual halves. The two main adhesive solvent groups evaluated were acetone and alcohol. Each main group was divided into six groups. The positive control group received no bleaching, the negative control group consisted of bleaching with no surface deoxidization; and other experimental categories involved post-bleach treatments with 95% ethanol, sodium ascorbate (10%), acetone solution, or sodium fluoride solution (1.1%). Following the surface treatment and enamel bonding procedure, nano-hybrid composite cylinders measuring 3 × 2 mm were directly cured over the bleached enamel substrate. The shear bond test was performed after 24-h storage and 12,000 thermocycles on a universal testing machine. In this study, one-way ANOVA was used along with Tukey's HSD tests at a significance level of 0.05. The negative control groups showed significantly lower bond strength than the positive control group. Ethanol surface treatment had superior mean bonding strength in acetone and alcohol-based adhesive solvent groups. The utilization of sodium ascorbate for surface treatment resulted in a significant enhancement of adhesion between the composite material and bleached enamel surface. Sodium fluoride application showed no significant recovery in shear bond strength in both dental adhesive groups. It was concluded that hydrogen peroxide severely compromised the immediate bond strength of composite resin. Surface treatment of bleached enamel with ethanol, sodium ascorbate, and acetone solutions is an effective option for restoring bond strength.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231198807"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of mineral trioxide aggregate in dentistry: A bibliometric analysis using Scopus database.","authors":"Muhammad Arqam Najmi, Talha Nayab, Beenish Fatima Alam, Tanveer Abbas, Shama Ashgar, Talib Hussain, Syed Saad Bin Qasim, Artak Heboyan","doi":"10.1177/22808000231154065","DOIUrl":"10.1177/22808000231154065","url":null,"abstract":"<p><strong>Objectives: </strong>Mineral trioxide aggregate (MTA) has a long history of providing predictable clinical outcomes in dental applications especially in endodontic procedures. This bibliometric analysis aimed at evaluating the advancements of research in mineral trioxide aggregate and its use in the field of dentistry, together with the detection of most significant authors, organizations, countries, journals, papers, and the exploration of commonly used keywords using a structured approach.</p><p><strong>Materials and method: </strong>The search was conducted using the Elsevier's Scopus database, gathering publication information related to MTA published from 1993 and 2021 July. Metadata comprising of titles, abstracts, keywords, authors, organizations, and countries were obtained. Bibliometric evaluators with respect to authors, articles published, journals, keywords, and top countries were scrutinized. Data was analyzed using VOS viewer.</p><p><strong>Results: </strong>Between 1993 and 2021, an uptrend in the research performed on MTA was identified. Researchers from United States, Brazil, and Iran actively contributed on MTA, while papers from USA were highly cited. The Journal of Endodontics along with International Endodontic Journal were the top contributing academic journals. Hacettepe University, Turkey and Cardiff University from United Kingdom were the top most contributing organizations. Mahmoud Torabinejad was the most cited author. Most commonly used keywords included Mineral trioxide aggregate, silicate, oxide, root canal filling material.</p><p><strong>Conclusion: </strong>The global rise in the number of publications on mineral trioxide aggregate, tremendous networking and citations have been identified amongst various organizations, authors, and nations through this bibliometric analysis.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231154065"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10721764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of bleaching on surface roughness and gloss of different CAD/CAM ceramic and hybrid ceramic materials.","authors":"Ruwaida Z Alshali, Mohammed A AlQahtani, Dalea M Bukhary, Mlak A Alzahrani, Shatha S Alsoraihi, Majed A Alqahtani","doi":"10.1177/22808000231152566","DOIUrl":"10.1177/22808000231152566","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effect of bleaching on surface roughness and gloss of different CAD/CAM ceramic materials.</p><p><strong>Methods: </strong>The ceramic materials included IPS e.max CAD (lithium disilicate), VITA ENAMIC (polymer infiltrated ceramic), and Celtra Duo CAD (zirconia reinforced lithium silicate). Samples of each material were randomly divided into four groups (<i>n</i> = 10); a control group immersed in distilled water, the second and third groups were treated with 20% carbamide peroxide (20% CP) and 35% carbamide peroxide (35% CP) bleaching agents for 4 h/day and 60 min/day respectively for 7 days. The fourth group was treated with 40% hydrogen peroxide (40% HP) applied twice, each turn for 20 min. After treatment, the surface roughness (using 3D non-contact profilometry) and surface gloss were assessed followed by imaging with a scanning electron microscope. The data were analyzed using multiple linear regression and Kruskal-Wallis one-way ANOVA tests (α = 0.05).</p><p><strong>Results: </strong>The surface roughness (<i>p</i> = 0.157) and gloss (<i>p</i> = 0.073) of IPS e.max CAD were not significantly affected by the different bleaching treatments. Similarly, no significant effect on surface roughness (<i>p</i> = 0.162) and gloss (<i>p</i> = 0.965) were shown for Celtra Duo CAD. On the other hand, VITA ENAMIC was significantly affected when treated with 20% CP and 35% CP showing increased roughness (<i>p</i> = 0.001) and gloss (<i>p</i> = 0.008).</p><p><strong>Conclusions: </strong>Home bleaching treatments (20% CP and 35% CP) significantly affected the surface roughness and gloss of VITA ENAMIC while IPS e.max CAD and Celtra Duo CAD were not affected by the different bleaching treatments.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231152566"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro and in vivo evaluation of effects of high-purity magnesium on tight junction of intestinal epithelial cell.","authors":"Ting Shan,&nbsp;Jun Yan,&nbsp;Xiaonong Zhang,&nbsp;Yigang Chen","doi":"10.1177/22808000231165281","DOIUrl":"https://doi.org/10.1177/22808000231165281","url":null,"abstract":"<p><p>After anastomosis of sutures or pins, the restoration of intestinal barrier function can avoid several complications, such as tissue damage and inflammation. Our previous studies demonstrated the feasibility of biodegradable magnesium (Mg) pins as novel anastomosing implants to spontaneously absorb in the body, avoiding secondary removal surgery and long-term inflammation. However, the effect of Mg pins on the intestinal tight junction barrier is rarely investigated. In this study, we conducted high-purity Mg pins inserted in the intestine of rats and prepared Mg extracts cultured intestinal epithelial cell line to investigate the biological effect on the intestinal barrier associated with tight junction protein expression. We discovered that the concentration of released Mg ions over 1.7 mM was the critical threshold, above which mRNA expression of intestinal tight junction and cell apoptosis were affected considerably. Results of the immunohistochemical analysis revealed that Mg functions to stimulate ZO-1, caspase-3, occluding, and claudin-3 expressions. We offer new insight into the effectiveness of biodegradable Mg materials as the next generation of intestinal anastomosis pins, which effectively filters toxins as well as bacteria, and reduces inflammation.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231165281"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomedical properties and hemostatic efficacy of polyvinyl alcohol (PVA) based hydrogel in experimental rat liver injury model.","authors":"Erfan Dorkhani,&nbsp;Ali Faryabi,&nbsp;Yasmin Noorafkan,&nbsp;Asieh Heirani,&nbsp;Behnam Behboudi,&nbsp;Mohammad Sadegh Fazeli,&nbsp;Alireza Kazemeini,&nbsp;Mohammad Reza Keramati,&nbsp;Amir Keshvari,&nbsp;Seyed Mohsen Ahmadi Tafti","doi":"10.1177/22808000231198803","DOIUrl":"10.1177/22808000231198803","url":null,"abstract":"<p><strong>Purpose: </strong>Bleeding is a leading cause of mortality and morbidity in the trauma and surgery field, using effective hemostatic agents can help us reduce bleeding especially in parenchymal hemorrhage. Nowadays polyvinyl alcohol (PVA) is known as a safe candidate for wound dressing and maybe a hemostatic agent. PVA-based hydrogel is a popular biocompatible material in the biomedical field especially when it has high water absorption. In this study, we investigated the PVA hydrogel's mechanical and biological properties as well as its hemostatic potential in parenchymal bleeding.</p><p><strong>Methods: </strong>PVA hydrogel had made by the freeze-thawing approach, we used PVA hydrogel in comparison to standard treatment to investigate hemostatic potency. Also, we performed MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) tests to survey PVA cellular toxicity. After an acute liver injury, two groups of 12 rats were treated with PVA hydrogel or standard treatment with sterile gauze. The results including the time and volume of bleeding, and the time and survival rate of the rats were measured and compared.</p><p><strong>Results: </strong>We saw that PVA hydrogel was safe with no cellular toxicity in the MTT assay. Regarding efficacy, PVA hydrogel increased rats' survival after bleeding from 75% to 91.7%, and decreased bleeding time (<i>p</i>: 0.015), and bleeding volume (<i>p</i>: 0.03) compared to the control group.</p><p><strong>Conclusion: </strong>Polyvinyl alcohol is safe. It has good biological properties with no cellular toxicity and has a significant hemostatic effect and can be regarded in control of parenchymal hemorrhage.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231198803"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41131412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and evaluation of <i>Bletilla striata</i> polysaccharide/konjac glucomannan blend hydrogel for wound healing.","authors":"Jin Shang,&nbsp;Liangliang Duan,&nbsp;Weimin Zhang,&nbsp;Xiangwen Li,&nbsp;Cheng Ma,&nbsp;Bao Xin","doi":"10.1177/22808000231176202","DOIUrl":"10.1177/22808000231176202","url":null,"abstract":"<p><p><i>Bletilla striata</i> polysaccharide (BSP) is effective for wound healing and has important applications in health care. A series of blend hydrogels was designed with BSP and konjac glucomannan (KGM) in this study to overcome the deficient mechanical performance caused by the excessive dissolution of BSP without affecting its physiological activity. The interplay between them, as well as the effects of KGM concentration on the physical properties and microstructures of hydrogels, were also explored. It was proved that the frame of the hydrogel was primarily formed by KGM. BSP was dispersed uniformly and linked to KGM through hydrogen bonding, which effectively improved the physical properties, such as increasing the water-holding capacity, improving the swelling degree, and enhancing the mechanical properties. Blend hydrogel BK2-2 (containing 1.0% BSP and 1.0% KGM, w/v) was found to be the optimal formulation based on the thermal stability and microstructure, which was used for further research. <i>In vitro</i> experiments revealed the L929 cell proliferative effects of the blend hydrogel, and no difference was found with BSP sponge extract after 72 h of exposure. <i>In vivo</i> animal studies indicated that the BK2-2 accelerated wound healing compared with the control group; however, no difference was found with dressings only made of BSP. These results demonstrated that KGM improved the physical properties of BSP-based material without negatively affecting its physiological properties. Also, the BSP/KGM blend hydrogel had good comprehensive properties and is expected to be used as a wound healing material in the future.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231176202"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}