Impact of a staggered scaffold structure on the mechanical properties and cell response in bone tissue engineering.

IF 3.1 4区 医学 Q2 BIOPHYSICS
Xiaoli He, Qian Zhao, Ningning Zhang, Junbin Wang, Qingzong Si, Ying Xue, Zhe Xing
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引用次数: 0

Abstract

The primary goal of bone tissue engineering is to fabricate scaffolds that can provide a microenvironment similar to that of natural bone. Therefore, various scaffolds have been designed to replicate the bone structure. Although most tissues exhibit complicated structures, their basic structural unit includes stiff platelets arranged in a staggered micro-array. Therefore, many researchers have designed scaffolds with staggered patterns. However, relatively few studies have comprehensively analyzed this type of scaffold. In this review, we have analyzed scientific research pertaining to staggered scaffold designs and summarized their effects on the physical and biological properties of scaffolds. Compression tests or finite element analysis are typically used to evaluate the mechanical properties of scaffolds, and most studies have performed experiments in cell cultures. Staggered scaffolds improve mechanical strength and are beneficial for cell attachment, proliferation, and differentiation in comparison with conventional designs. However, very few have been studied in vivo experiments. Additionally, studies on the effect of staggered structures on angiogenesis or bone regeneration in vivo, particularly in large animals, are required. Currently, with the prevalence of artificial intelligence (AI)-based technologies, highly optimized models can be developed, resulting in better discoveries. In the future, AI can be used to deepen our understanding on the staggered structure, promoting its use in clinical applications.

交错支架结构对骨组织工程中力学性能和细胞反应的影响。
骨组织工程的主要目标是制造能够提供与天然骨相似的微环境的支架。因此,人们设计了各种各样的支架来复制骨结构。尽管大多数组织结构复杂,但其基本结构单位包括排列在交错微阵列中的僵硬血小板。因此,许多研究人员设计了交错模式的支架。然而,对这类支架进行全面分析的研究相对较少。在本文中,我们分析了有关交错支架设计的科学研究,并总结了交错支架设计对支架物理和生物性能的影响。压缩试验或有限元分析通常用于评估支架的力学性能,大多数研究都是在细胞培养中进行的实验。与传统支架设计相比,交错支架提高了机械强度,有利于细胞附着、增殖和分化。然而,很少有体内实验研究。此外,还需要研究交错结构对体内血管生成或骨再生的影响,特别是在大型动物中。目前,随着基于人工智能(AI)技术的普及,可以开发高度优化的模型,从而获得更好的发现。未来,人工智能可以加深我们对交错结构的理解,促进其在临床应用中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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