Journal of Advanced Research最新文献

{"title":"Associations between specific dietary patterns, gut microbiome composition, and incident subthreshold depression in Chinese young adults","authors":"","doi":"10.1016/j.jare.2024.05.030","DOIUrl":"10.1016/j.jare.2024.05.030","url":null,"abstract":"<div><h3>Introduction</h3><div>The interplay between influential factors and the incidence of subthreshold depression (SD) in young adults remains poorly understood.</div></div><div><h3>Objectives</h3><div>This study sought to understand the dietary habits, gut microbiota composition, etc. among individuals with SD in young adults and to investigate their association with SD occurrence.</div></div><div><h3>Methods</h3><div>Employing a cross-sectional approach, 178 individuals with SD, aged 18–32 years, were matched with 114 healthy counterparts. SD status was evaluated using the Zung Self-rating Depression Scale (SDS), Zung Self-rating Anxiety Scale (SAS), Beck Depression Inventory 2nd version (BDI-II), the 17-item Hamilton Rating Scales of Depression (HAMD-17), and Pittsburgh Sleep Quality Index (PSQI). Metagenomic sequencing was utilized to identify fecal microbial profiles. Dietary patterns were discerned via factor analysis of a 25-item food frequency questionnaire (FFQ). Logistic regression analysis and mediation analysis were performed to explore the potential links between gut microbiota, dietary patterns, and incident SD.</div></div><div><h3>Results</h3><div>Data on dietary habits were available for 292 participants (mean [SD] age, 22.1 [2.9] years; 216 [73.9 %] female). Logistic regression analysis revealed that dietary patterns Ⅰ (odds ratio [OR], 0.34; 95 % CI, 0.15–0.75) and IV (OR, 0.39; 95 % CI, 0.17–0.86 and OR, 0.39; 95 % CI, 0.18–0.84) were associated with reduced risk of SD. Distinct microbial profiles were observed in young adults with SD, marked by increased microbial diversity and taxonomic alterations. Moreover, mediation analysis suggested <em>Veillonella atypica</em> as a potential mediator linking SDS or BDI-II scores with a healthy dietary pattern rich in bean products, coarse grains, nuts, fruits, mushrooms, and potatoes (β = 0.25, 95 % CI: 0.02–0.78 and β = 0.18, 95 % CI: 0.01–0.54).</div></div><div><h3>Conclusions</h3><div>Our findings highlight the complex interplay between dietary patterns, gut microbiota, and the risk of developing SD in young adults, underscoring the potential for dietary interventions and microbiome modulation in mental health promotion.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"65 ","pages":"Pages 183-195"},"PeriodicalIF":11.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies","authors":"","doi":"10.1016/j.jare.2024.05.009","DOIUrl":"10.1016/j.jare.2024.05.009","url":null,"abstract":"<div><h3>Background</h3><div>Autophagy is an evolutionarily conserved turnover process for intracellular substances in eukaryotes, relying on lysosomal (in animals) or vacuolar (in yeast and plants) mechanisms. In the past two decades, emerging evidence suggests that, under specific conditions, autophagy can target particular macromolecules or organelles for degradation, a process termed selective autophagy. Recently, accumulating studies have demonstrated that the abnormality of selective autophagy is closely associated with the occurrence and progression of many human diseases, including neurodegenerative diseases, cancers, metabolic diseases, and cardiovascular diseases.</div></div><div><h3>Aim of Review</h3><div>This review aims at systematically and comprehensively introducing selective autophagy and its role in various diseases, while unravelling the molecular mechanisms of selective autophagy. By providing a theoretical basis for the development of related small-molecule drugs as well as treating related human diseases, this review seeks to contribute to the understanding of selective autophagy and its therapeutic potential.</div></div><div><h3>Key Scientific Concepts of Review</h3><div>In this review, we systematically introduce and dissect the major categories of selective autophagy that have been discovered. We also focus on recent advances in understanding the molecular mechanisms underlying both classical and non-classical selective autophagy. Moreover, the current situation of small-molecule drugs targeting different types of selective autophagy is further summarized, providing valuable insights into the discovery of more candidate small-molecule drugs targeting selective autophagy in the future. On the other hand, we also reveal clinically relevant implementations that are potentially related to selective autophagy, such as predictive approaches and treatments tailored to individual patients.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"65 ","pages":"Pages 297-327"},"PeriodicalIF":11.4,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer","authors":"","doi":"10.1016/j.jare.2024.04.033","DOIUrl":"10.1016/j.jare.2024.04.033","url":null,"abstract":"<div><h3>Introduction</h3><div>Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear.</div></div><div><h3>Objectives</h3><div>To analyze the inhibitory effect of sodium citrate on ovarian cancer cells and the underlying mechanism.</div></div><div><h3>Methods</h3><div>Cell apoptosis was examined by TUNEL staining, flow cytometry, and ferroptosis was examined intracellular Fe²⁺, MDA, LPO assays, respectively. Cell metabolism was examined by OCR and ECAR measurements. Immunoblotting and immunoprecipitation were used to elucidate the mechanism.</div></div><div><h3>Results</h3><div>This study suggested that sodium citrate not only promoted ovarian cancer cell apoptosis but also triggered<!--> <!-->ferroptosis, manifested as elevated levels of Fe²⁺, LPO, MDA and<!--> <!-->lipid ROS production. On one hand, sodium citrate treatment led to a decrease of Ca²⁺ content in the cytosol by chelating<!--> <!-->Ca²⁺, which further inhibited the Ca²⁺/CAMKK2/AKT/mTOR signaling, thereby suppressing HIF1α-dependent glycolysis pathway and inducing cell apoptosis. On the other hand, the chelation of Ca²⁺ by sodium citrate resulted in inactivation of CAMKK2 and AMPK, leading to increase of NCOA4-mediated ferritinophagy, causing increased intracellular Fe²⁺ levels. More importantly, the inhibition of Ca²⁺/CAMKK2/AMPK signaling pathway reduced the activity of the MCU and Ca²⁺ concentration within the mitochondria, resulting in an increase in mitochondrial ROS. Additionally, metabolomic analysis indicated that sodium citrate treatment significantly increased de novo lipid synthesis. Altogether, these factors contributed to ferroptosis. As expected, Ca²⁺ supplementation successfully reversed the cell death and decreased tumor growth induced by sodium citrate. Inspiringly, it was found that coadministration of sodium citrate increased the sensitivity of OC cells to chemo-drugs.</div></div><div><h3>Conclusion</h3><div>These results revealed that the sodium citrate exerted its anti-cancer activity by inhibiting Ca²⁺/CAMKK2-dependent cell apoptosis and ferroptosis. Sodium citrate will hopefully serve as a prospective compound for OC treatment and for improving<!--> <!-->the efficacy of chemo-drugs.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"65 ","pages":"Pages 89-104"},"PeriodicalIF":11.4,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ubiquitin-like protein FAT10 in hepatocellular carcinoma cells limits the efficacy of anti-VEGF therapy","authors":"Yumin Qiu ,&nbsp;Ben Che ,&nbsp;Wenming Zhang ,&nbsp;A.V. Zhang ,&nbsp;Jin Ge ,&nbsp;Dongnian Du ,&nbsp;Jiajuan Li ,&nbsp;Xiaogang Peng ,&nbsp;Jianghua Shao","doi":"10.1016/j.jare.2023.06.006","DOIUrl":"10.1016/j.jare.2023.06.006","url":null,"abstract":"<div><h3>Introduction</h3><p>The efficacy of anti-vascular endothelial growth factor (VEGF) therapy is limited. However, the key factors involved in limiting the efficacy of anti-VEGF therapy and the underlying mechanisms remain unclear.</p></div><div><h3>Objectives</h3><p>To investigate the effects and mechanisms of human leukocyte antigen F locus-adjacent transcript 10 (FAT10), a ubiquitin-like protein, in limiting the efficacy of anti-VEGF therapy in hepatocellular carcinoma (HCC) cells.</p></div><div><h3>Methods</h3><p>FAT10 was knocked out in HCC cells using the clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 technology. Bevacizumab (BV), an anti-VEGF monoclonal antibody, was used to evaluate the efficacy of anti-VEGF therapy <em>in vivo</em>. Mechanisms of FAT10 action were assessed by RNA sequencing, glutathione S-transferase pulldown assays and <em>in vivo</em> ubiquitination assays.</p></div><div><h3>Results</h3><p>FAT10 accelerated VEGF-independent angiogenesis in HCC cells which limited BV efficacy and BV-aggravated hypoxia and inflammation promoted FAT10 expression. FAT10 overexpression increased levels of proteins involved in several signaling pathways in HCC cells, resulting in upregulation of VEGF and multiple non-VEGF proangiogenic factors. Upregulation of multiple FAT10-mediated non-VEGF signals compensated for the inhibition of VEGF signaling by BV, enhancing VEGF-independent angiogenesis and promoting HCC growth.</p></div><div><h3>Conclusions</h3><p>Our preclinical findings identify FAT10 in HCC cells as a key factor limiting the efficacy of anti-VEGF therapy and elucidate its underlying mechanisms. This study provides new mechanistic insights into the development of antiangiogenic therapies.</p></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"59 ","pages":"Pages 97-109"},"PeriodicalIF":10.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2090123223001698/pdfft?md5=afbe4c7f017d86157e7ca4b238211350&pid=1-s2.0-S2090123223001698-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9649179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two aminopeptidase I homologs convergently contribute to pathobiology of fungal entomopathogen Beauveria bassiana via divergent physiology-dependent autophagy pathways for vacuolar targeting","authors":"Jin-Li Ding,&nbsp;Kang Wei,&nbsp;Ming-Guang Feng,&nbsp;Sheng-Hua Ying","doi":"10.1016/j.jare.2023.06.007","DOIUrl":"10.1016/j.jare.2023.06.007","url":null,"abstract":"<div><h3>Introduction</h3><p>In yeast, the cytoplasm-to-vacuole targeting (Cvt) pathway acts as a biosynthetic autophagy-related process, in which vacuolar targeting of hydrolase is mediated by the machineries involved in the selective autophagy. However, the mechanistic insights into vacuolar targeting of hydrolases through the selective autophagy pathway still remain enigmatic in filamentous fungi.</p></div><div><h3>Objectives</h3><p>Our study aims to investigate the mechanisms involved in vacuolar targeting of hydrolases in filamentous fungi.</p></div><div><h3>Methods</h3><p>The filamentous entomopathogenic fungus <em>Beauveria bassiana</em> was used as a representative of filamentous fungi. We identified the homologs of yeast aminopeptidase I (Ape1) in <em>B. bassiana</em> by bioinformatic analyses and characterized their physiological roles by gene function analyses. Pathways for vacuolar targeting of hydrolases were investigated via molecular trafficking analyses.</p></div><div><h3>Results</h3><p><em>B. bassiana</em> has two homologs of yeast aminopeptidase I (Ape1) which are designated as BbApe1A and BbApe1B. The two homologs of yeast Ape1 contribute to starvation tolerance, development, and virulence in <em>B. bassiana</em>. Significantly, BbNbr1 acts as a selective autophagy receptor to mediate the vacuolar targeting of the two Ape1 proteins, in which BbApe1B interacts with BbNbr1 also directly interacting with BbAtg8, and BbApe1A has an additional requirement of the scaffold protein BbAtg11 that interacts with BbNbr1 and BbAtg8. Protein processing occurs at both terminuses of BbApe1A and only at carboxyl terminus of BbApe1B, which is also dependent on the autophagy-related proteins. Together, the functions and translocation processes of the two Ape1 proteins are associated with autophagy in fungal lifecycle.</p></div><div><h3>Conclusion</h3><p>This study reveals the functions and translocation processes for vacuolar hydrolases in the insect-pathogenic fungi and improves our understandings of the Nbr1-mediated vacuolar targeting pathway in the filamentous fungi.</p></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"59 ","pages":"Pages 1-17"},"PeriodicalIF":10.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2090123223001704/pdfft?md5=be4f7d130fecf5ff29c9ba2f1c471a59&pid=1-s2.0-S2090123223001704-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small molecules reprogram reactive astrocytes into neuronal cells in the injured adult spinal cord","authors":"Zijian Tan ,&nbsp;Shangyao Qin ,&nbsp;Hong Liu ,&nbsp;Xiao Huang,&nbsp;Yingyan Pu,&nbsp;Cheng He,&nbsp;Yimin Yuan,&nbsp;Zhida Su","doi":"10.1016/j.jare.2023.06.013","DOIUrl":"10.1016/j.jare.2023.06.013","url":null,"abstract":"<div><h3>Introduction</h3><p>Ectopic expression of transcription factor-mediated <em>in vivo</em> neuronal reprogramming provides promising strategy to compensate for neuronal loss, while its further clinical application may be hindered by delivery and safety concerns. As a novel and attractive alternative, small molecules may offer a non-viral and non-integrative chemical approach for reprogramming cell fates. Recent definitive evidences have shown that small molecules can convert non-neuronal cells into neurons <em>in vitro</em>. However, whether small molecules alone can induce neuronal reprogramming <em>in vivo</em> remains largely unknown.</p></div><div><h3>Objectives</h3><p>To identify chemical compounds that can induce <em>in vivo</em> neuronal reprogramming in the adult spinal cord.</p></div><div><h3>Methods</h3><p>Immunocytochemistry, immunohistochemistry, qRT-PCR and fate-mapping are performed to analyze the role of small molecules in reprogramming astrocytes into neuronal cells <em>in vitro</em> and <em>in vivo</em>.</p></div><div><h3>Results</h3><p>By screening, we identify a chemical cocktail with only two chemical compounds that can directly and rapidly reprogram cultured astrocytes into neuronal cells. Importantly, this chemical cocktail can also successfully trigger neuronal reprogramming in the injured adult spinal cord without introducing exogenous genetic factors. These chemically induced cells showed typical neuronal morphologies and neuron-specific marker expression and could become mature and survive for more than 12 months. Lineage tracing indicated that the chemical compound-converted neuronal cells mainly originated from post-injury spinal reactive astrocytes.</p></div><div><h3>Conclusion</h3><p>Our proof-of-principle study demonstrates that <em>in vivo</em> glia-to-neuron conversion can be manipulated in a chemical compound-based manner. Albeit our current chemical cocktail has a low<!--> <!-->reprogramming efficiency, it will bring <em>in vivo</em> cell fate reprogramming closer to clinical application in brain and spinal cord repair. Future studies should focus on further refining our chemical cocktail and reprogramming approach to boost the reprogramming efficiency.</p></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"59 ","pages":"Pages 111-127"},"PeriodicalIF":10.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2090123223001765/pdfft?md5=f5bd92d2971078e63bc108daeff21cd7&pid=1-s2.0-S2090123223001765-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bile acid and nonalcoholic steatohepatitis: Molecular insights and therapeutic targets","authors":"Zilu Cheng ,&nbsp;Yixiong Chen ,&nbsp;Bernd Schnabl ,&nbsp;Huikuan Chu ,&nbsp;Ling Yang","doi":"10.1016/j.jare.2023.06.009","DOIUrl":"10.1016/j.jare.2023.06.009","url":null,"abstract":"<div><h3>Background</h3><p>Nonalcoholic steatohepatitis (NASH) has been the second most common cause of liver transplantation in the United States. To date, NASH pathogenesis has not been fully elucidated but is multifactorial, involving insulin resistance, obesity, metabolic disorders, diet, dysbiosis, and gene polymorphism. An effective and approved therapy for NASH has also not been established. Bile acid is long known to have physiological detergent function in emulsifying and absorbing lipids and lipid-soluble molecules within the intestinal lumen. With more and more in-depth understandings of bile acid, it has been deemed to be a pivotal signaling molecule, which is capable of regulating lipid and glucose metabolism, liver inflammation, and fibrosis. In recent years, a plethora of studies have delineated that disrupted bile acid homeostasis is intimately correlated with NASH disease severity.</p></div><div><h3>Aims</h3><p>The review aims to clarify the role of bile acid in hepatic lipid and glucose metabolism, liver inflammation, as well as liver fibrosis, and discusses the safety and efficacy of some pharmacological agents targeting bile acid and its associated pathways for NASH.</p></div><div><h3>Key scientific concepts of review</h3><p>Bile acid has a salutary effect on hepatic metabolic disorders, which can ameliorate liver fat accumulation and insulin resistance mainly through activating Takeda G-protein coupled receptor 5 and farnesoid X receptor. Moreover, bile acid also exerts anti-inflammation and anti-fibrosis properties. Furthermore, bile acid has great potential in nonalcoholic liver disease stratification and treatment of NASH.</p></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"59 ","pages":"Pages 173-187"},"PeriodicalIF":10.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S209012322300173X/pdfft?md5=fb53ed9c45b76dd739abcfe49efcbb64&pid=1-s2.0-S209012322300173X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous abscisic acid represses rice flowering via SAPK8-ABF1-Ehd1/Ehd2 pathway","authors":"Liqun Tang ,&nbsp;Guanghao Li ,&nbsp;Huimei Wang ,&nbsp;Juan Zhao ,&nbsp;Zhiyong Li ,&nbsp;Xixi Liu ,&nbsp;Yazhou Shu ,&nbsp;Wanning Liu ,&nbsp;Shuang Wang ,&nbsp;Jie Huang ,&nbsp;Jiezheng Ying ,&nbsp;Xiaohong Tong ,&nbsp;Wenya Yuan ,&nbsp;Xiangjin Wei ,&nbsp;Shaoqing Tang ,&nbsp;Yifeng Wang ,&nbsp;Qingyun Bu ,&nbsp;Jian Zhang","doi":"10.1016/j.jare.2023.06.012","DOIUrl":"10.1016/j.jare.2023.06.012","url":null,"abstract":"<div><h3>Introduction</h3><p>Rice flowering is a major agronomic trait, determining yield and ecological adaptability in particular regions. ABA plays an essential role in rice flowering, but the underlying molecular mechanism remains largely elusive.</p></div><div><h3>Objectives</h3><p>In this study, we demonstrated a “SAPK8-ABF1-<em>Ehd1/Ehd2</em>” pathway, through which exogenous ABA represses rice flowering in a photoperiod-independent manner.</p></div><div><h3>Methods</h3><p>We generated <em>abf1</em> and <em>sapk8</em> mutants using the CRISPR-Cas9 method. Using yeast two-hybrid, Pull down, BiFC and kinase assays, SAPK8 interacted and phosphorylated ABF1. ABF1 directly bound to the promoters of <em>Ehd1</em> and <em>Ehd2</em> using ChIP-qPCR, EMSA, and LUC transient transcriptional activity assay, and suppressed the transcription of these genes.</p></div><div><h3>Results</h3><p>Under both long day and short day conditions, simultaneous knock-out of <em>ABF1</em> and its homolog <em>bZIP40</em> accelerated flowering, while <em>SAPK8</em> and <em>ABF1</em> over-expression lines exhibited delayed flowering and hypersensitivity to ABA-mediated flowering repression. After perceiving the ABA signal, SAPK8 physically binds to and phosphorylates ABF1 to enhance its binding to the promoters of master positive flowering regulators <em>Ehd1</em> and <em>Ehd2</em>. Upon interacting with FIE2, ABF1 recruited PRC2 complex to deposit H3K27me3 suppressive histone modification on <em>Ehd1</em> and <em>Ehd2</em> to suppress these genes transcription, thereby leading to later flowering.</p></div><div><h3>Conclusion</h3><p>Our work highlighted the biological functions of SAPK8 and ABF1 in ABA signaling, flowering control and the involvement of a PRC2-mediated epigenetic repression mechanism in the transcription regulation governed by ABF1 on ABA-mediated rice flowering repression.</p></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"59 ","pages":"Pages 35-47"},"PeriodicalIF":10.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2090123223001753/pdfft?md5=67e9c211dbd630df2d4232dcc1c679cd&pid=1-s2.0-S2090123223001753-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifouling applications and fabrications of biomimetic micro-structured surfaces: A review","authors":"Yuhan Liu ,&nbsp;Xiaoyan He ,&nbsp;Chengqing Yuan ,&nbsp;Pan Cao ,&nbsp;Xiuqin Bai","doi":"10.1016/j.jare.2023.08.019","DOIUrl":"10.1016/j.jare.2023.08.019","url":null,"abstract":"<div><h3>Background</h3><p>Since the inception of the term “Biomimetics” in 1991, the concept of utilizing natural solutions or deriving inspiration from nature to address contemporary engineering challenges has gained significant attention within the scientific community. Organisms, in order to thrive in harsh environments, have evolved a wide range of micro/nanostructured surfaces, which serve as a rich source of inspiration for the development of artificial micro/nano-structured surfaces. These natural adaptations provide valuable insights and novel pathways for fabricating such surfaces.</p></div><div><h3>Aim</h3><p>To conclude recent advances in micro/nano-structured surfaces from four aspects: biomimetic micro-structured surfaces of plants and animals, properties and applications of biomimetic surfaces, methods of preparations, and their limitation.</p></div><div><h3>Key Scientific Concepts:</h3><p>Artificial micro/nano-structured surfaces inspired by animals and plants are classified and demonstrated according to their living environment. The performances, principles and preparation techniques of natural superhydrophobic surfaces, slippery liquid-infused porous surfaces (SLIPS), anisotropic surfaces, etc. are described in detail. Moreover, the pros and cons of each preparation measures are compared and the challenges developing large-scale, cost-effective surface microstructure preparation processes are pointed out. In the end, the development trends of artificial micro/nano-structured surface are forecasted.</p></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"59 ","pages":"Pages 201-221"},"PeriodicalIF":10.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2090123223002357/pdfft?md5=d26edc19ed51786336b83ee6f2fd5f42&pid=1-s2.0-S2090123223002357-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy, a double-edged sword for oral tissue regeneration","authors":"Xinyue Xu ,&nbsp;Jia Wang ,&nbsp;Yunlong Xia ,&nbsp;Yuan Yin ,&nbsp;Tianxiao Zhu ,&nbsp;Faming Chen ,&nbsp;Chunxu Hai","doi":"10.1016/j.jare.2023.06.010","DOIUrl":"10.1016/j.jare.2023.06.010","url":null,"abstract":"<div><h3>Background</h3><p>Oral health is of fundamental importance to maintain systemic health in humans. Stem cell-based oral tissue regeneration is a promising strategy to achieve the recovery of impaired oral tissue. As a highly conserved process of lysosomal degradation, autophagy induction regulates stem cell function physiologically and pathologically. Autophagy activation can serve as a cytoprotective mechanism in stressful environments, while insufficient or over-activation may also lead to cell function dysregulation and cell death.</p></div><div><h3>Aim of review</h3><p>This review focuses on the effects of autophagy on stem cell function and oral tissue regeneration, with particular emphasis on diverse roles of autophagy in different oral tissues, including periodontal tissue, bone tissue, dentin pulp tissue, oral mucosa, salivary gland, maxillofacial muscle, temporomandibular joint, etc. Additionally, this review introduces the molecular mechanisms involved in autophagy during the regeneration of different parts of oral tissue, and how autophagy can be regulated by small molecule drugs, biomaterials, exosomes/RNAs or other specific treatments. Finally, this review discusses new perspectives for autophagy manipulation and oral tissue regeneration.</p></div><div><h3>Key scientific concepts of review</h3><p>Overall, this review emphasizes the contribution of autophagy to oral tissue regeneration and highlights the possible approaches for regulating autophagy to promote the regeneration of human oral tissue.</p></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"59 ","pages":"Pages 141-159"},"PeriodicalIF":10.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2090123223001728/pdfft?md5=a05aa6104d0e573723edca0931a87e5c&pid=1-s2.0-S2090123223001728-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}