Journal of Advanced Research最新文献

{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0165-6147(24)00195-0","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00195-0","url":null,"abstract":"No Abstract","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"20 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0165-6147(24)00192-5","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00192-5","url":null,"abstract":"No Abstract","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"33 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of JNK signaling pathway in organ fibrosis","authors":"Zhouhui Yao, Yandan Lu, Pingping Wang, Ziyan Chen, Licheng Zhou, Xianan Sang, Qiao Yang, Kuilong Wang, Min Hao, Gang Cao","doi":"10.1016/j.jare.2024.09.029","DOIUrl":"https://doi.org/10.1016/j.jare.2024.09.029","url":null,"abstract":"<h3>Background</h3>Fibrosis is a tissue damage repair response caused by multiple pathogenic factors which could occur in almost every apparatus and leading to the tissue structure damage, physiological abnormality, and even organ failure until death. Up to now, there is still no specific drugs or strategies can effectively block or changeover tissue fibrosis. JNKs, a subset of mitogen-activated protein kinases (MAPK), have been reported that participates in various biological processes, such as genetic expression, DNA damage, and cell activation/proliferation/death pathways. Increasing studies indicated that abnormal regulation of JNK signal pathway has strongly associated with tissue fibrosis.<h3>Aim of review</h3>This review designed to sum up the molecular mechanism progresses in the role of JNK signal pathway in organ fibrosis, hoping to provide a novel therapy strategy to tackle tissue fibrosis.<h3>Key scientific concepts of review</h3>Recent evidence shows that JNK signaling pathway could modulates inflammation, immunoreaction, oxidative stress and Multiple cell biological functions in organ fibrosis. Therefore, targeting the JNK pathway may be a useful strategy in cure fibrosis.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"33 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142369653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the role of WRKY transcription factors in leaf senescence: Genetic and molecular insights","authors":"Zishan Ahmad, Muthusamy Ramakrishnan, Chunyue Wang, Shamsur Rehman, Anwar Shahzad, Qiang Wei","doi":"10.1016/j.jare.2024.09.026","DOIUrl":"https://doi.org/10.1016/j.jare.2024.09.026","url":null,"abstract":"<h3>Background</h3>Leaf senescence (LS), the final phase in leaf development, is an important and precisely regulated process crucial for plant well-being and the redistribution of nutrients. It is intricately controlled by various regulatory factors, including <em>WRKY</em> transcription factors (TFs). <em>WRKY</em>s are one of the most significant plant TF families, and several of them are differentially regulated and important during LS. Recent research has enhanced our understanding of the structural and functional characteristics of <em>WRKY</em> TFs, providing insights into their regulatory roles.<h3>Aim of review</h3>This review aims to elucidate the genetic and molecular mechanisms underlying the intricate regulatory networks associated with LS by investigating the role of <em>WRKY</em> TFs. We seek to highlight the importance of <em>WRKY</em>-mediated signaling pathways in understanding LS, plant evolution, and response to varying environmental conditions.<h3>Key scientific concepts of review</h3><em>WRKY</em> TFs exhibit specific DNA-binding activity at the N-terminus and dynamic interactions of the intrinsically disordered domain at the C-terminus with various proteins. These <em>WRKY</em> TFs not only control the activity of other <em>WRKYs</em>, but also interact with either <em>WRKY</em>s or other TFs, thereby fine- tuning the expression of target genes. By unraveling the complex interactions and regulatory mechanisms of <em>WRKY</em> TFs, this review broadens our knowledge of the genetic and molecular basis of LS. Understanding <em>WRKY</em>-mediated signalling pathways provides crucial insights into specific aspects of plant development, such as stress-induced senescence, and offers potential strategies for improving crop resilience to environmental stresses like drought and pathogen attacks. By targeting these pathways, it may be possible to enhance specific productivity traits, such as increased yield stability under adverse conditions, thereby contributing to more reliable agricultural outputs.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"25 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142369654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing therapeutic efficacy of antifungal peptides via strategic terminal amino acid modification","authors":"Jing Song, Shanshan Zhang, Junya Xing, Licong Zhang, Jiajun Wang, Anshan Shan","doi":"10.1016/j.jare.2024.09.017","DOIUrl":"https://doi.org/10.1016/j.jare.2024.09.017","url":null,"abstract":"Antifungal peptides (AFPs) have the potential to treat antifungal-resistant infections; however, their structure–function relationship remains unknown, hindering their rapid development. Therefore, it is imperative to investigate and clarify the structure–function relationships of AFPs.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"54 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142329699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel prognostic scoring system for AML patients undergoing allogeneic hematopoietic stem cell transplantation with real world validation","authors":"Qing Ya Wang, Yi Fan Han, Yu Han Li, Qing Yun Wang, Jin Ye Zhu, Yu Jun Dong, Wei Liu, Na Han, Han Yun Ren, Yuan Li","doi":"10.1016/j.jare.2024.09.014","DOIUrl":"https://doi.org/10.1016/j.jare.2024.09.014","url":null,"abstract":"This study aims to develop a robust predictive model for survival in AML patients undergoing allo-HSCT.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"46 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression reduction and a variant of a P450 gene mediate chlorpyrifos resistance in Tetranychus urticae Koch","authors":"Dandan Xu, Haojie Liao, Chao He, Ke Wang, Rui Dong, Youjun Zhang, Zhaojiang Guo, Xin Yang, Wen Xie, Neil Crickmore, Shaoli Wang","doi":"10.1016/j.jare.2024.09.015","DOIUrl":"https://doi.org/10.1016/j.jare.2024.09.015","url":null,"abstract":"Understanding how insects and mites develop resistance to chlorpyrifos is crucial for effective field management. Although extensive research has demonstrated that <ce:italic>T. urticae</ce:italic> exhibits high resistance to chlorpyrifos, the specific resistance mechanism remains elusive. Investigating this mechanism could provide valuable insights for pest control strategies.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"17 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters","authors":"Yulin Wu, Juan Zhang, Yuanyang Tian, William Chi Shing Cho, Hong-Xi Xu, Zhi-Xiu Lin, Yan-Fang Xian","doi":"10.1016/j.jare.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.jare.2024.09.006","url":null,"abstract":"Gemcitabine (GEM) is the first-line drug for pancreatic ductal adenocarcinoma (PDAC), but drug resistance severely restricts its chemotherapeutic efficacy. Laminin subunit γ2 (LAMC2) plays a crucial role in extracellular matrix formation in the development of GEM-resistance. However, the biological function of LAMC2 in GEM resistance and its molecular mechanisms are still unclear. 20(<ce:italic>S</ce:italic>)-Ginsenoside Rh2 (Rh2), one of the principal active components isolated from Ginseng Radix et Rhizoma, possesses strong anti-tumor effects. However, the effects of Rh2 on overcoming GEM resistance and its action mechanisms remain to be elucidated.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"46 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF","authors":"Nanxi Zheng, Shilin Luo, Xin Zhang, Ling Hu, Muzhi Huang, Mingyu Li, Colin McCaig, Yu-Qiang Ding, Bing Lang","doi":"10.1016/j.jare.2024.08.041","DOIUrl":"https://doi.org/10.1016/j.jare.2024.08.041","url":null,"abstract":"Primary cilia are hair-like solitary organelles growing on most mammalian cells that play fundamental roles in embryonic patterning and organogenesis. Defective cilia often cause a suite of inherited diseases called ciliopathies with multifaceted manifestations. Intraflagellar transport (IFT), a bidirectional protein trafficking along the cilium, actively facilitates the formation and absorption of primary cilia. IFT172 is the largest component of the IFT-B complex, and its roles in Bardet-Biedl Syndrome (BBS) have been appreciated with unclear mechanisms. We performed a battery of behavioral tests with haploinsufficiency () and WT littermates. We use RNA sequencing to identify the genes and signaling pathways that are differentially expressed and enriched in the hippocampus of mice. Using AAV-mediated sparse labeling, electron microscopic examination, patch clamp and local field potential recording, western blot, luciferase reporter assay, chromatin immunoprecipitation, and neuropharmacological approach, we investigated the underlying mechanisms for the aberrant phenotypes presented by mice. mice displayed excessive self-grooming, elevated anxiety, and impaired cognition. RNA sequencing revealed enrichment of differentially expressed genes in pathways relevant to axonogenesis and synaptic plasticity, which were further confirmed by less spine density and synaptic number. mice demonstrated fewer parvalbumin-expressing neurons, decreased inhibitory synaptic transmission, augmented theta oscillation, and sharp-wave ripples in the CA1 region. Moreover, haploinsufficiency caused less BDNF production and less activated BDNF-TrkB signaling pathway through transcription factor Gli3. Application of 7,8-Dihydroxyflavone, a potent small molecular TrkB agonist, fully restored BDNF-TrkB signaling activity and abnormal behavioral phenotypes presented by mice. With luciferase and chip assays, we provided further evidence that Gli3 may physically interact with BDNF promoter I and regulate BDNF expression. Our data suggest that Ift172 drives neurotrophic effects and, when defective, could cause neurodevelopmental disorders reminiscent of autism-like disorders.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"8 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"tsRNA modifications: An emerging layer of biological regulation in disease","authors":"Yaomin Liang, Ding Ji, Xiaoling Ying, Renqiang Ma, Weidong Ji","doi":"10.1016/j.jare.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.jare.2024.09.010","url":null,"abstract":"Transfer RNA (tRNA)-derived small RNA (tsRNA) represents an important and increasingly valued type of small non-coding RNA (sncRNA). The investigation of tRNA and tsRNA modification crosswalks has not only provided novel insights into the information and functions of tsRNA, but has also expanded the diversity and complexity of the tsRNA biological regulation network. Comparing with other sncRNAs, tsRNA biogenesis show obvious correlation with RNA modifications from mature tRNA and harbor various tRNA modifications. In this review, we aim to present the current aspect of tsRNA modifications and that modified tsRNA shape different regulatory mechanisms in physiological and pathological processes. Strategies for studying tsRNA mechanisms include its specific generation and functional effects induced by sequence/RNA modification/secondary structure. tsRNAs could harbor more than one tRNA modifications such as 5-methylcytosine (mC), N1-methyladenosine (mA), pseudouridine (Ψ) and N7-methylguanosine (mG). This review consolidates the current knowledge of tRNA modification regulating tsRNA biogenesis, outlines the functional roles of various modified tsRNA and highlights their specific contributions in various disease pathogenesis. Therefore, the improvement of tsRNA modification detection technology and the introduction of experimental methods of tsRNA modification are conducive to further broadening the understanding of tsRNA function at the level of RNA modification.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"115 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}