Journal of Advanced Research最新文献

{"title":"Challenges and advances in the management of inflammation in atherosclerosis","authors":"Yiming Xing,&nbsp;Xianhe Lin","doi":"10.1016/j.jare.2024.06.016","DOIUrl":"10.1016/j.jare.2024.06.016","url":null,"abstract":"<div><h3>Introduction</h3><div>Atherosclerosis, traditionally considered a lipid-related disease, is now understood as a chronic inflammatory condition with significant global health implications.</div></div><div><h3>Objectives</h3><div>This review aims to delve into the complex interactions among immune cells, cytokines, and the inflammatory cascade in atherosclerosis, shedding light on how these elements influence both the initiation and progression of the disease.</div></div><div><h3>Methods</h3><div>This review draws on recent clinical research to elucidate the roles of key immune cells, macrophages, T cells, endothelial cells, and clonal hematopoiesis in atherosclerosis development. It focuses on how these cells and process contribute to disease initiation and progression, particularly through inflammation-driven processes that lead to plaque formation and stabilization. Macrophages ingest oxidized low-density lipoprotein (oxLDL), which partially converts to high-density lipoprotein (HDL) or accumulates as lipid droplets, forming foam cells crucial for plaque stability. Additionally, macrophages exhibit diverse phenotypes within plaques, with pro-inflammatory types predominating and others specializing in debris clearance at rupture sites. The involvement of CD4⁺ T and CD8⁺ T cells in these processes promotes inflammatory macrophage states, suppresses vascular smooth muscle cell proliferation, and enhances plaque instability.</div></div><div><h3>Results</h3><div>The nuanced roles of macrophages, T cells, and the related immune cells within the atherosclerotic microenvironment are explored, revealing insights into the cellular and molecular pathways that fuel inflammation. This review also addresses recent advancements in imaging and biomarker technology that enhance our understanding of disease progression. Moreover, it points out the limitations of current treatment and highlights the potential of emerging anti-inflammatory strategies, including clinical trials for agents such as p38MAPK, tumor necrosis factor α (TNF-α), and IL-1β, their preliminary outcomes, and the promising effects of canakinumab, colchicine, and IL-6R antagonists.</div></div><div><h3>Conclusion</h3><div>This review explores cutting-edge anti-inflammatory interventions, their potential efficacy in preventing and alleviating atherosclerosis, and the role of nanotechnology in delivering drugs more effectively and safely.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 317-335"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of SPI1/VSIG4/THBS1 on glioblastoma progression through modulation of the PI3K/AKT pathway","authors":"Jie Shen ,&nbsp;Lihui Zhou ,&nbsp;Ke Ye ,&nbsp;Jiangbiao Gong ,&nbsp;Fan Wu ,&nbsp;Kangnan Mo ,&nbsp;Yu Zhu ,&nbsp;Chao Chen ,&nbsp;Renya Zhan","doi":"10.1016/j.jare.2024.06.023","DOIUrl":"10.1016/j.jare.2024.06.023","url":null,"abstract":"<div><h3>Introduction</h3><div>Glioblastoma multiforme (GBM) poses a significant challenge in terms of treatment due to its high malignancy, necessitating the identification of additional molecular targets. VSIG4, an oncogenic gene participates in tumor growth and migration in various cancer types. Nevertheless, the precise process through which VSIG4 facilitates the malignant progression of glioma remains to be elucidated.</div></div><div><h3>Objectives</h3><div>This research aims to explore the function and molecular mechanism involving VSIG4 in the malignant progression of glioma.</div></div><div><h3>Methods</h3><div>The amount of VSIG4 was measured using qPCR, western blotting, and immunohistochemistry. Lentivirus infections were applied for upregulating or downregulating molecules within glioma cells. The incorporation of 5-ethynyl-20-deoxyuridine, Transwell, cell counting kit-8, and clone formation experiments, were applied to assess the biological functions of molecules on glioma cells. Dual luciferase reporter gene, RNA immunoprecipitation, and chromatin immunoprecipitation assays were used to explore the functional relationship among relevant molecules.</div></div><div><h3>Results</h3><div>The upregulation of VSIG4 was observed in GBM tissues, indicating an adverse prognosis. Silencing VSIG4 in glioma cells resulted in a decrease in cell viability, invasion, proliferation, and tumorigenesis, an increase in cell apoptosis, and a stagnation in the cell cycle progression at the G0/G1 phase. Mechanistically, SPI1-mediated upregulation of VSIG4 expression led to binding between VSIG4 and THBS1 protein, ultimately facilitating the malignant progression of glioma cells through the activation of the PI3K/AKT pathway. The inhibited proliferative and invasive capabilities of glioma cells were reversed by overexpressing THBS1 following the knockdown of VSIG4.</div></div><div><h3>Conclusion</h3><div>Our findings provide evidence for the role of VSIG4 as an oncogene and reveal the previously unidentified contribution of the SPI1/VSIG4/THBS1 axis in the malignant progression of glioma. This signaling cascade enhances tumor growth and invasion by modulating the PI3K/AKT pathway. VSIG4 as a potential biomarker may be a viable strategy in the development of tailored molecular therapies for GBM.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 487-500"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alarm: Retracted articles on cancer imaging are not only continuously cited by publications but also used by ChatGPT to answer questions","authors":"Tianshu Gu,&nbsp;Helin Feng,&nbsp;Minghui Li,&nbsp;Weikuan Gu,&nbsp;Guiying Wang","doi":"10.1016/j.jare.2025.03.020","DOIUrl":"10.1016/j.jare.2025.03.020","url":null,"abstract":"","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 1-3"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic evaluation of single-cell RNA-seq analyses performance based on long-read sequencing platforms","authors":"Enze Deng ,&nbsp;Qingmei Shen ,&nbsp;Jingna Zhang ,&nbsp;Yaowei Fang ,&nbsp;Lei Chang ,&nbsp;Guanzheng Luo ,&nbsp;Xiaoying Fan","doi":"10.1016/j.jare.2024.05.020","DOIUrl":"10.1016/j.jare.2024.05.020","url":null,"abstract":"<div><h3>Introduction</h3><div>The rapid development of next-generation sequencing (NGS)-based single-cell RNA sequencing (scRNA-seq) allows for detecting and quantifying gene expression in a high-throughput manner, providing a powerful tool for comprehensively understanding cellular function in various biological processes. However, the NGS-based scRNA-seq only quantifies gene expression and cannot reveal the exact transcript structures (isoforms) of each gene due to the limited read length. On the other hand, the long read length of third-generation sequencing (TGS) technologies, including Oxford Nanopore Technologies (ONT) and Pacific Biosciences (PacBio), enable direct reading of intact cDNA molecules.</div></div><div><h3>Objectives</h3><div>Both ONT and PacBio have been used in conjunction with scRNA-seq, but their performance in single-cell analyses has not been systematically evaluated.</div></div><div><h3>Methods</h3><div>To address this, we generated ONT and PacBio data from the same single-cell cDNA libraries containing different amount of cells.</div></div><div><h3>Results</h3><div>Using NGS as a control, we assessed the performance of each platform in cell type identification. Additionally, the reliability in identifying novel isoforms and allele-specific gene/isoform expression by both platforms was verified, providing a systematic evaluation to design the sequencing strategies in single-cell transcriptome studies.</div></div><div><h3>Conclusion</h3><div>Beyond gene expression analysis, which the NGS-based scRNA-seq only affords, TGS-based scRNA-seq achieved gene splicing analyses, identifying novel isoforms. Attribute to higher sequencing quality of PacBio, it outperforms ONT in accuracy of novel transcripts identification and allele-specific gene/isoform expression.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 141-153"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicon: A valuable soil element for improving plant growth and CO2 sequestration","authors":"Abdul Latif Khan","doi":"10.1016/j.jare.2024.05.027","DOIUrl":"10.1016/j.jare.2024.05.027","url":null,"abstract":"<div><h3>Background</h3><div>Silicon (Si), the second most abundant and quasi-essential soil element, is locked as a recalcitrant silicate mineral in the Earth’s crust. The physical abundance of silicates can play an essential role in increasing plant productivity. Plants store Si as biogenic silica (phytoliths), which is mobilized through a chemical weathering process in the soil.</div></div><div><h3>Aim of review</h3><div>Although Si is a critical element for plant growth, there is still a considerable need to understand its dissolution, uptake, and translocation in agroecosystems. Here, we show recent progress in understanding the interactome of Si, CO₂, the microbiome, and soil chemistry, which can sustainably govern silicate dissolution and cycling in agriculture.</div></div><div><h3>Key scientific concepts of this review</h3><div>Si cycling is directly related to carbon cycling, and the resulting climate stability can be enhanced by negative feedback between atmospheric CO₂ and the silicate uptake process. Improved Si mobilization in the rhizosphere by the presence of reactive elements (for example, Ca, Na, Al, Zn, and Fe) and Si uptake through genetic transporters in plants are crucial to achieving the dual objectives of (i) enhancing crop productivity and (ii) abiotic stress tolerance. Furthermore, the microbiome is a symbiotic partner of plants. Bacterial and fungal microbiomes can solubilize silicate minerals through intriguingly complex bioweathering mechanisms by producing beneficial metabolites and enzymes. However, the interaction of Si with CO₂ and the microbiome’s function in mobilization have been understudied. This review shows that enhancing our understanding of Si, CO₂, the microbiome, and soil chemistry can help in sustainable crop production during climatic stress events.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 43-54"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review and advanced biomolecule-based therapies for osteoporosis","authors":"Maqsood Ali ,&nbsp;Yong-Sik Kim","doi":"10.1016/j.jare.2024.05.024","DOIUrl":"10.1016/j.jare.2024.05.024","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of osteoporosis (OP) on a global scale is significantly elevated that causes life threatening issues. The potential of groundbreaking biomolecular therapeutics in the field of OP is highly encouraging. The administration of biomolecular agents has the potential to mitigate the process of bone demineralization while concurrently augmenting the regenerative capacity of bone tissue, thereby facilitating a personalized therapeutic approach. Biomolecules-based therapies showed promising results in term of bone mass protection and restoration in OP.</div></div><div><h3>Aim of review</h3><div>We summarized the recent biomolecular therapies with notable progress in clinical, demonstrating the potential to transform illness management. These treatments frequently utilize different biomolecule based strategies. Biomolecular therapeutics has a targeted character, which results in heightened specificity and less off-target effects, ultimately leading to increased patient outcomes. These aspects have the capacity to greatly enhance the management of OP, thus resulting in a major enhancement in the quality of life encountered by individuals affected by this condition.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 337-354"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141177153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual effects of vaginal Candida albicans on human papillomavirus infection: A large-scale multicenter study in Chinese women","authors":"Muxuan Chen, Rongdan Chen, Yingxuan Zhang, Wei Qing, Zuyi Zhou, Xiaoxin Song, Yinai Zou, Hongwei Zhou, Cancan Qi, Yan He","doi":"10.1016/j.jare.2025.04.049","DOIUrl":"https://doi.org/10.1016/j.jare.2025.04.049","url":null,"abstract":"<h3>Objectives</h3>Vaginal infections caused by <em>Candida albicans</em> and human papillomavirus (HPV) are common, yet their interactions remain complex and poorly understood.<h3>Methods</h3>We conducted a nationwide, multicenter cohort study in China involving 6,689 women aged 18 to 50 years to examine the association between <em>C. albicans</em> infection and HPV acquisition and persistence. <em>C. albicans</em> infection was defined by positive results on both wet-mount microscopy and culture. HPV genotypes (21 types) and other sexually transmitted infections (STIs, eight types) were detected using polymerase chain reaction. Cervical lesions were assessed via the ThinPrep cytologic test (TCT).<h3>Results</h3>In cross-sectional analyses, <em>C. albicans</em> infection was associated with a lower likelihood of concurrent HPV detection (odds ratio (OR), 0.92, 95 % confidence interval (CI), 0.88–0.96), affecting both high-risk and low-risk genotypes. However, longitudinal follow-up analyses revealed that baseline <em>C. albicans</em> infections was linked to an increased risk of persistent HPV infection among women already infected (hazard ratio (HR), 1.77, 95 % CI, 1.03–3.06). The presence of <em>C. albicans</em> was not significantly associated with other STIs or abnormal cervical cytology. These findings suggest a dual effect of <em>C. albicans</em> on HPV: protection against initial viral acquisition but promotion of viral persistence in those already infected.<h3>Conclusions</h3>Our findings reveal an unexpected dual role of <em>C. albicans</em> in HPV infection: initial protective effects, followed by enhanced viral persistence during co-infection. These results highlight the complexity of host-microbe interactions in the vaginal environment and underscore the need to consider fungal colonization in the natural history of HPV. The contrasting effects of <em>C. albicans</em> on HPV acquisition and persistence provide novel insights into the complex dynamics of polymicrobial interactions in the female reproductive tract.<h3>Significance</h3><strong>Statement:</strong> This study demonstrates for the first time that <em>C. albicans</em> exhibits opposing effects on HPV infection at different stages, suggesting stage-specific host-microbe interactions that may influence viral pathogenesis. These findings have important implications for understanding the role of fungal colonization in viral infections and may inform strategies for HPV management.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"20 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AMPCliff: Quantitative definition and benchmarking of activity cliffs in antimicrobial peptides","authors":"Kewei Li, Yuqian Wu, Yinheng Li, Yutong Guo, Yanwen Kong, Yan Wang, Yiyang Liang, Yusi Fan, Lan Huang, Ruochi Zhang, Fengfeng Zhou","doi":"10.1016/j.jare.2025.04.046","DOIUrl":"https://doi.org/10.1016/j.jare.2025.04.046","url":null,"abstract":"<h3>Introduction</h3>Activity cliff (AC) is a phenomenon that a pair of similar molecules differ by a small structural alternation but exhibit a large difference in their biochemical activities. This phenomenon affects various tasks ranging from virtual screening to lead optimization in drug development. The AC of small molecules has been extensively investigated but limited knowledge is accumulated about the AC phenomenon in pharmaceutical peptides with canonical amino acids.<h3>Objectives</h3>This study introduces a quantitative definition and benchmarking framework AMPCliff for the AC phenomenon in antimicrobial peptides (AMPs) composed by canonical amino acids.<h3>Methods</h3>This study establishes a benchmark dataset of paired AMPs in <em>Staphylococcus aureus</em> from the publicly available AMP dataset GRAMPA, and conducts a rigorous procedure to evaluate various AMP AC prediction models, including nine machine learning, four deep learning algorithms, four masked language models, and four generative language models.<h3>Results</h3>A comprehensive analysis of the existing AMP dataset reveals a significant prevalence of AC within AMPs. AMPCliff quantifies the activities of AMPs by the metric minimum inhibitory concentration (MIC), and defines 0.9 as the minimum threshold for the normalized BLOSUM62 similarity score between a pair of aligned peptides with at least two-fold MIC changes. Our analysis reveals that these models are capable of detecting AMP AC events and the pre-trained protein language model ESM2 demonstrates superior performance across the evaluations. The predictive performance of AMP activity cliffs remains to be further improved, considering that ESM2 with 33 layers only achieves the Spearman correlation coefficient 0.4669 for the regression task of the −log(MIC) values on the benchmark dataset.<h3>Conclusion</h3>Our findings highlight limitations in current deep learning–based representation models. To more accurately capture the properties of antimicrobial peptides (AMPs), it is essential to integrate atomic-level dynamic information that reflects their underlying mechanisms of action.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"43 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of seed germination: ROS, epigenetic, and hormonal aspects","authors":"Yakong Wang ,&nbsp;Xiangyang Sun ,&nbsp;Jun Peng ,&nbsp;Fuguang Li ,&nbsp;Faiza Ali ,&nbsp;Zhi Wang","doi":"10.1016/j.jare.2024.06.001","DOIUrl":"10.1016/j.jare.2024.06.001","url":null,"abstract":"<div><h3>Background</h3><div>The whole life of a plant is regulated by complex environmental or hormonal signaling networks that control genomic stability, environmental signal transduction, and gene expression affecting plant development and viability. Seed germination, responsible for the transformation from seed to seedling, is a key initiation step in plant growth and is controlled by unique physiological and biochemical processes. It is continuously modulated by various factors including epigenetic modifications, hormone transport, ROS signaling, and interaction among them. ROS showed versatile crucial functions in seed germination including various physiological oxidations to nucleic acid, protein, lipid, or chromatin in the cytoplasm, cell wall, and nucleus.</div></div><div><h3>Aim</h3><div><em>of review:</em> This review intends to provide novel insights into underlying mechanisms of seed germination especially associated with the ROS, and considers how these versatile regulatory mechanisms can be developed as useful tools for crop improvement.</div></div><div><h3>Key scientific concepts of review</h3><div>We have summarized the generation and elimination of ROS during seed germination, with a specific focus on uncovering and understanding the mechanisms of seed germination at the level of phytohormones, ROS, and epigenetic switches, as well as the close connections between them. The findings exhibit that ROS plays multiple roles in regulating the ethylene, ABA, and GA homeostasis as well as the Ca²⁺ signaling, NO signaling, and MAPK cascade in seed germination via either the signal trigger or the oxidative modifier agent. Further, ROS shows the potential in the nuclear genome remodeling and some epigenetic modifiers function, although the detailed mechanisms are unclear in seed germination. We propose that ROS functions as a hub in the complex network regulating seed germination.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 107-125"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egypt Genome: Towards an African new genomic era","authors":"Khaled Amer ,&nbsp;Neveen A. Soliman ,&nbsp;Sameh Soror ,&nbsp;Yehia Z. Gad ,&nbsp;Ahmed Moustafa ,&nbsp;Mohamed A. Elmonem ,&nbsp;May Amer ,&nbsp;Ameera Ragheb ,&nbsp;Amira Kotb ,&nbsp;Tarek Taha ,&nbsp;Wael Ali ,&nbsp;Mahmoud Sakr ,&nbsp;Khaled Abdel Ghaffar ,&nbsp;Scientific Committee Consortium","doi":"10.1016/j.jare.2024.06.003","DOIUrl":"10.1016/j.jare.2024.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Studying the human genome is crucial to embrace precision medicine through tailoring treatment and prevention strategies to the unique genetic makeup and molecular information of individuals. After human genome project (1990–2003) generated the first full sequence of a human genome, there have been concerns towards Northern bias due to underrepresentation of other populations. Multiple countries have now established national genome projects aiming at the genomic knowledge that can be harnessed from their populations, which in turn can serve as a basis for their health care policies in the near future<em>.</em></div></div><div><h3>Aim of review</h3><div>The intention is to introduce the recently established Egypt Genome (EG) to delineate the genomics and genetics of both the modern and Ancient Egyptian populations. Leveraging genomic medicine to improve precision medicine strategies while building a solid foundation for large-scale genomic research capacity is the fundamental focus of EG.</div></div><div><h3>Key scientific concepts</h3><div>EG generated genomic knowledge is predicted to enrich the existing human genome and to expand its diversity by studying the underrepresented African/Middle Eastern populations. The insightful impact of EG goes beyond Egypt and Africa as it fills the knowledge gaps in health and disease genomics towards improved and sustainable genomic-driven healthcare systems for better outcomes. Promoting the integration of genomics into clinical practice and spearheading the implementation of genomic-driven healthcare and precision medicine is therefore a key focus of EG. Mining into the wealth of Ancient Egyptian Genomics to delineate the genetic bridge between the contemporary and Ancient Egyptian populations is another excitingly unique area of EG to realize the global vision of human genome.</div></div>","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"71 ","pages":"Pages 415-427"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}