cGAS-STING信号通路在铁下垂中的作用

IF 13 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Lina Ding , Ruicheng Zhang , Wenqi Du , Qingling Wang , Dongsheng Pei
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引用次数: 0

摘要

环GMP-AMP合成酶(cGAS)-干扰素基因刺激因子(STING)信号通路已被确定为抗病毒防御和先天免疫途径的重要机制。铁下垂以铁依赖和脂质过氧化为特征,是细胞死亡的一种特殊形式。越来越多的研究表明,cGAS-STING信号通路通过调节凋亡相关酶活性或基因表达参与机体的稳态调节。因此,阐明STING信号通路和铁下垂在体内的具体作用对于靶向疾病干预至关重要。本文系统地研究了cGAS-STING信号通路与铁下垂之间的相互作用,强调了它们在炎症、损伤和癌细胞动力学背景下对疾病进展的影响。了解这些相互作用可能会提供新的治疗策略。STING通路参与多种细胞死亡机制的调控,包括凋亡、焦亡、坏死亡、自噬和铁亡。我们主要关注cGAS-STING信号通路和铁凋亡在疾病中的作用和机制,限制了对其他细胞死亡方式的讨论,并排除了对该通路其他功能的全面概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of cGAS-STING signaling pathway in ferroptosis

The role of cGAS-STING signaling pathway in ferroptosis

The role of cGAS-STING signaling pathway in ferroptosis
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence and lipid peroxidation, represents a specialized form of cell death. A burgeoning collection of studies has demonstrated that the cGAS-STING signaling pathway participates in the homeostatic regulation of the organism by modulating ferroptosis-associated enzyme activity or gene expression. Consequently, elucidating the specific roles of the STING signaling pathway and ferroptosis in vivo is vital for targeted disease intervention. This review systematically examines the interactions between the cGAS-STING signaling pathway and ferroptosis, highlighting their influence on disease progression in the contexts of inflammation, injury, and cancerous cell dynamics. Understanding these interactions may provide novel therapeutic strategies. The STING pathway has been implicated in the regulation of various cell death mechanisms, including apoptosis, pyroptosis, necroptosis, autophagy, and ferroptosis. Our focus primarily addresses the role and mechanism of the cGAS-STING signaling pathway and ferroptosis in diseases, limiting discussion of other cell death modalities and precluding a comprehensive overview of the pathway’s additional functions.
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来源期刊
Journal of Advanced Research
Journal of Advanced Research Multidisciplinary-Multidisciplinary
CiteScore
21.60
自引率
0.90%
发文量
280
审稿时长
12 weeks
期刊介绍: Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.
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