ChemMedChem最新文献_第9页

Boron-Based Bioisosteres in Medicinal Chemistry: Advances in Heterocycles and Therapeutic 硼基生物同工异构体在药物化学中的应用：杂环和治疗的进展。

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-25 DOI: 10.1002/cmdc.70455

Martin Behringer, Johannes Rainer Kühn, Franz-Josef Meyer-Almes

{"title":"Boron-Based Bioisosteres in Medicinal Chemistry: Advances in Heterocycles and Therapeutic","authors":"Martin Behringer, Johannes Rainer Kühn, Franz-Josef Meyer-Almes","doi":"10.1002/cmdc.70455","DOIUrl":"10.1002/cmdc.70455","url":null,"abstract":"Boron-containing compounds have become an important class of scaffolds in medicinal chemistry, broadening the chemical space available for drug discovery. This review summarizes progress and key advances reported over the past 5 years in the development of bioactive boron-based heterocycles and related systems, including BN-indoles, azaborines, benzoxazaborines, benzodiazaborines, benzoxaborinines, benzoxaboroles, and boronic acid derivatives. These motifs act as bioisosteres of carbon frameworks and impart distinct physicochemical properties such as increased polarity, improved solubility, and enhanced hydrogen-bonding capabilities. Several examples highlight their therapeutic relevance. Azaborine-based histone deacetylase (HDAC) inhibitors and BN-indole derivatives show potent nanomolar enzyme inhibition. Benzoxaboroles have reached clinical relevance, including antifungal drugs such as tavaborole and crisaborole, as well as late-stage candidates like epetraborole and acoziborole. Benzoxaborinines and olaparib isosteres exhibit activity against carbonic anhydrases and PARP enzymes, while boronic acid drugs such as bortezomib and ixazomib are established proteasome inhibitors used in cancer therapy. Additional applications include antiviral, antibacterial, antiparasitic, and anti-inflammatory activities, for example Leishmania CPSF3 inhibitors and P2X7 receptor antagonists. Despite these advances, challenges remain regarding potency, pharmacokinetics, and mechanistic understanding of boron–target interactions. Overall, boron-based bioisosteres represent a versatile platform for developing new therapeutics across diverse disease areas.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-Guided Optimization of a Molecular Glue Targeting the KBTBD4-HDAC1/2 Complex 靶向KBTBD4-HDAC1/2复合物的分子胶的结构导向优化

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-25 DOI: 10.1002/cmdc.70451

Timea Balo, Zhuoyao Chen, Laurine Palluaud, Arpad Kiss, Tibor Novak, Andras Herner, Alex N. Bullock, Virginie Martiny, Andras Kotschy

引用次数: 0

Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling 吡啶-噻唑-硫代氨基脲类抗锥虫药物：设计、合成和硅分析

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-21 DOI: 10.1002/cmdc.70443

Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite

{"title":"Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling","authors":"Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite","doi":"10.1002/cmdc.70443","DOIUrl":"https://doi.org/10.1002/cmdc.70443","url":null,"abstract":"Chagas disease and leishmaniasis are neglected tropical diseases caused by the trypanosomatid protozoa Trypanosoma cruzi and Leishmania spp., respectively. Currently available treatments are often insufficiently effective and lack the characteristics of ideal therapeutics. Here we report the design, synthesis, and antitrypanosomatid evaluation of 20 novel hybrid compounds incorporating pyridine, thiazole, and thiosemicarbazone scaffolds. All compounds were tested against trypomastigote and amastigote forms of T. cruzi, as well as promastigote and amastigote forms of Leishmania infantum and L. amazonensis. Cytotoxicity was assessed in L929 fibroblasts and RAW 264.7 macrophages. Compound 8 emerged as the lead, displaying an IC50 of 1.0 µM against T. cruzi and a selectivity index of 52.8. Despite its potent in vitro activity, Compound 8 exhibited poor in vivo efficacy when administered orally at 150 mg/kg/day. In silico analyses predicted strong binding to cruzain, alongside favorable bioavailability, drug-likeness, and chemical stability. Against Leishmania species, Compound 8 demonstrated selectivity comparable to miltefosine against L. amazonensis amastigotes. Collectively, these findings identify a novel chemical scaffold with promising antitrypanosomatid potential that warrants further optimization to improve in vivo performance.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.70443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible Coordination Modes in Piperazine-Based Ru(II)-p-Cymene Acylthiourea Complexes: Modulating DNA Groove Binding for Selective Antimelanoma Activity 哌嗪基Ru(II)-对聚花烃酰基硫脲配合物的可逆配位模式：调节DNA槽结合选择性抗黑色素瘤活性

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-20 DOI: 10.1002/cmdc.70444

Amir Karim, Xin Wang, Yu-Ting Chu, Rahimeh Eshaghi Malekshah, En-De Shu, Najeeb Ullah, Chien-Chih Chiu, Ching-Ming Chien, Sodio C. N. Hsu

{"title":"Reversible Coordination Modes in Piperazine-Based Ru(II)-p-Cymene Acylthiourea Complexes: Modulating DNA Groove Binding for Selective Antimelanoma Activity","authors":"Amir Karim, Xin Wang, Yu-Ting Chu, Rahimeh Eshaghi Malekshah, En-De Shu, Najeeb Ullah, Chien-Chih Chiu, Ching-Ming Chien, Sodio C. N. Hsu","doi":"10.1002/cmdc.70444","DOIUrl":"https://doi.org/10.1002/cmdc.70444","url":null,"abstract":"Acylthiourea ligands, featuring hard (N, O) and soft (S) donor atoms, enable diverse coordination modes in half-sandwich Ru(II)-p-cymene complexes. Herein, we report the synthesis and full characterization of eight half-sandwich Ru(II)-p-cymene complexes, comprising four monodentate (1m–4m) and four bidentate (1b–4b) species prepared under distinct synthetic conditions. The structures of the complexes 1m, 2m, 3m, 3b, and 4b were confirmed by single-crystal X-ray diffraction, while FT-IR, UV–vis, ESI-MS, and 1H/13C NMR spectroscopy unambiguously distinguish the two binding modes. The reversible coordination mode was monitored by 1H NMR and UV–vis spectroscopy, with base-induced deprotonation favoring bidentate binding and HCl addition regenerating the monodentate form. Cytotoxic assays revealed that metal coordination markedly enhanced the antiproliferative activity of the ligands. Most bidentate complexes exhibited higher cytotoxicity than their monodentate analogues. In particular, 2b displayed a sixfold increase in potency (IC50 = 6.05 μM) compared to 2m (36.4 μM) and showed much lower toxicity toward normal ARPE-19 cells (IC50 = 55.0 μM), indicating greater selectivity toward cancer cells. Molecular docking suggests DNA groove binding as the anticancer mechanism, highlighting the role of bidentate coordination, with 2b identified as the most promising Ru(II)-p-cymene complex.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.70444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus 基于配体的虚拟筛选发现噻吩嘧啶衍生物作为抗西尼罗病毒变构nSMase2调节剂和抗病毒药物

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-19 DOI: 10.1002/cmdc.70452

Hadrián Álvarez-Fernández, Patricia Mingo-Casas, Ana-Belén Blázquez, Flavia Caridi, Miguel A. Martín-Acebes, María-Jesús Pérez-Pérez, Eva-María Priego

{"title":"Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus","authors":"Hadrián Álvarez-Fernández, Patricia Mingo-Casas, Ana-Belén Blázquez, Flavia Caridi, Miguel A. Martín-Acebes, María-Jesús Pérez-Pérez, Eva-María Priego","doi":"10.1002/cmdc.70452","DOIUrl":"https://doi.org/10.1002/cmdc.70452","url":null,"abstract":"Orthoflaviviruses such as West Nile virus (WNV), Zika virus (ZIKV), or dengue virus (DENV) represent a growing global health threat, with millions of annual infections and no approved antiviral therapies. Targeting host pathways represents an alternative antiviral strategy that may overcome limitations associated with direct-acting antivirals, including resistance and narrow antiviral spectra. Neutral sphingomyelinase-2 (nSMase2) plays a central role in sphingolipid metabolism and has emerged as a host factor involved in the replication of several flaviviruses including WNV and ZIKV. Herein, we report a new family of thienopyrimidinone derivatives as nSMase2 inhibitors. A ligand-based virtual screening (LBVS) campaign using DPTIP as a template ligand identified 13 candidates from over 5 million ZINC20 compounds, which were refined through ADMET-properties prediction and molecular docking. Experimental evaluation identified compound 16 as a novel nSMase2 inhibitor. Rational design guided by computational affinity maps enabled the synthesis of several derivatives bearing a thienopyrimidinone core. These compounds inhibited nSMase2 and showed antiviral activity against WNV in cell‑based assays. These results identify thienopyrimidinone derivatives as a new scaffold for nSMase2 inhibition and support host-directed modulation of sphingolipid metabolism as a promising strategy for the development of broad-spectrum antivirals against flaviviruses.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.70452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study 动力学相容性作为PTP1B抑制剂联合结果的预测因子：一项综合实验和计算研究

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-19 DOI: 10.1002/cmdc.70446

Jonathan Trapala, Laura I. Álvarez-Añorve, Nathaly Vasquez-Martínez, Erika Chavira-Suárez, Luz Vásquez-Bochm, Deyamira Matuz-Mares, Francisco Cortés-Benítez, Martin González-Andrade

{"title":"Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study","authors":"Jonathan Trapala, Laura I. Álvarez-Añorve, Nathaly Vasquez-Martínez, Erika Chavira-Suárez, Luz Vásquez-Bochm, Deyamira Matuz-Mares, Francisco Cortés-Benítez, Martin González-Andrade","doi":"10.1002/cmdc.70446","DOIUrl":"https://doi.org/10.1002/cmdc.70446","url":null,"abstract":"Although chlorogenic acid, suramin, ursolic acid, and the glycyrrhetinic acid derivative FC122 are individually known PTP1B inhibitors, no study has systematically characterized how mechanistic diversity determines the pharmacological outcome of their combinations. Here, we integrate experimental enzyme kinetics, molecular docking, molecular dynamics (MD), and membrane permeability simulations to address this question. Individual inhibitory potencies ranked SUR > FC122 > UA > CGA (IC50: 1.82, 3.27, 6.12, and 252 µM, respectively). Fixed-ratio combination experiments showed two distinct profiles: additivity for the uncompetitive + mixed pair (FC122 + UA) and competitive + competitive pairs (SUR + CGA), and antagonism for the competitive + uncompetitive combination (SUR + FC122). Docking and MD provided the structural basis for these results and suggested that each combination imposes a distinct structural flexibility profile on the disordered C-terminal region of PTP1B (residues 300–400). For the first time, the MD-AMBER-Umbrella-COM protocol was applied to generate a comparative membrane permeability profile for mechanistically diverse PTP1B inhibitors, proposing a permeability order (SUR > FC122 > CGA ≈ UA). These results suggest that kinetic compatibility is a more reliable predictor of promising inhibitor combinations than binding-site geography alone, and they offer a rational framework for designing multisite PTP1B inhibition strategies in type 2 diabetes mellitus.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.70446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Docking-Based Virtual Screening Identifies a Small-Molecule Inhibitor of the Translesion Synthesis REV7/REV3 Protein–Protein Interaction 基于对接的虚拟筛选鉴定翻译合成小分子抑制剂REV7/REV3蛋白-蛋白相互作用

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-19 DOI: 10.1002/cmdc.70427

Noah J. Harrahill, Seema M. Patel, Radha Charan Dash, Angela M. Zaino, Vihit Gupta, Dane H. Geddes-Buehre, Colin Brereton, Alessandro A. Rizzo, Nimrat Chatterjee, Dmitry M. Korzhnev, M. Kyle Hadden

{"title":"Docking-Based Virtual Screening Identifies a Small-Molecule Inhibitor of the Translesion Synthesis REV7/REV3 Protein–Protein Interaction","authors":"Noah J. Harrahill, Seema M. Patel, Radha Charan Dash, Angela M. Zaino, Vihit Gupta, Dane H. Geddes-Buehre, Colin Brereton, Alessandro A. Rizzo, Nimrat Chatterjee, Dmitry M. Korzhnev, M. Kyle Hadden","doi":"10.1002/cmdc.70427","DOIUrl":"https://doi.org/10.1002/cmdc.70427","url":null,"abstract":"REV7 is an adaptor protein that mediates protein–protein interactions (PPIs) in DNA damage response and cell cycle control. REV7 functions as a subunit of the translesion synthesis (TLS) DNA polymerase POLζ, which is involved in the replicative bypass of DNA lesions. REV7 is also a component of the shieldin complex, which mediates the choice of pathway for DNA double-stranded break (DSB) repair. TLS promotes cancer cell survival after DNA damage and serves as a mechanism through which cancers develop acquired chemoresistance. DSB repair helps cancers mitigate DNA breaks induced by radiation; therefore, inhibition of REV7 PPIs has emerged as a therapeutic strategy. We performed a docking-based virtual screen to identify compounds predicted to disrupt PPIs between REV7 and the REV7-binding motifs (RBMs) found in the REV3 subunit of POLζ (TLS) and the SHLD3 subunit of shieldin (DSB repair). Biochemical analysis of a promising hit compound and several analogues demonstrated the ability of this scaffold to disrupt the REV7/RBMREV3 PPI. Several REV7 inhibitors sensitize human cancer cells to radiation treatment, identifying these compounds as a new class of TLS and DSB-repair targeted anticancer drugs with potential as adjuvant therapies to improve the efficacy of genotoxic cancer therapies.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crowding Effects on Insulin Aggregation Using Synthetic and Mixed Crowders 拥挤效应对胰岛素聚集的影响

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-19 DOI: 10.1002/cmdc.70445

Satya Ranjan Pallai, Tejas Nikam, Shashi Prakash Patel, Shubhini A. Saraf, Saurabh Awasthi

{"title":"Crowding Effects on Insulin Aggregation Using Synthetic and Mixed Crowders","authors":"Satya Ranjan Pallai, Tejas Nikam, Shashi Prakash Patel, Shubhini A. Saraf, Saurabh Awasthi","doi":"10.1002/cmdc.70445","DOIUrl":"https://doi.org/10.1002/cmdc.70445","url":null,"abstract":"Protein aggregation is implicated in several human diseases and presents an important challenge in the development of stable protein therapeutics. Here, we examine how macromolecular crowding affects insulin amyloid aggregation using polyethylene glycol, Dextran-70, and PVP-10, including binary and ternary mixtures. Aggregation was assessed by Thioflavin-T fluorescence and supported by circular dichroism and atomic force microscopy. PEG 10K showed a biphasic response, with increased ThT intensity at low concentration and markedly reduced signals at higher concentrations, whereas PEG 1, 4, and 6K were largely inhibitory across the tested range. At higher concentration of 100 mg/mL, both Dextran-70 and PVP-10 exhibited reduced ThT intensity, although Dextran-70 showed higher beta-sheet content than PVP-10, as revealed from CD spectroscopic analysis. In mixed crowder systems, Dextran-70 containing binary mixtures produced high ThT signals among the tested binary combinations, while PVP-10-containing mixtures showed lower β-sheet content and short fibrillar structures. Among ternary mixtures, PEG 1K + PEG 10K + PVP-10 produced the lowest aggregation-associated response. Rheology was consistent with a viscosity-linked contribution at higher PEG concentrations, and docking provided supportive, qualitative comparison of crowder–insulin surface contacts. These findings demonstrate that insulin aggregation responses depend on crowder identity, molecular weight, concentration, and mixture composition.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 5-Azetidinyl BODIPY–Olaparib Conjugate for PARP-Targeted Nuclear and Orthotopic Oral Tumor Imaging 5-氮杂二基BODIPY-Olaparib偶联物用于parp靶向核和原位口腔肿瘤成像

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-19 DOI: 10.1002/cmdc.70450

Kaixiang Yan, Hengkai Qi, Xiaochun Dong, Weili Zhao

{"title":"A 5-Azetidinyl BODIPY–Olaparib Conjugate for PARP-Targeted Nuclear and Orthotopic Oral Tumor Imaging","authors":"Kaixiang Yan, Hengkai Qi, Xiaochun Dong, Weili Zhao","doi":"10.1002/cmdc.70450","DOIUrl":"https://doi.org/10.1002/cmdc.70450","url":null,"abstract":"Poly(ADP-ribose) polymerase (PARP) is a clinically validated therapeutic target and an attractive biomarker for fluorescence-guided tumor imaging. However, the nuclear localization of PARP imposes a stringent requirement on probe design, as fluorophore installation must not compromise nuclear entry of the targeting ligand. Herein, we report a focused series of 5-azetidinyl BODIPY–olaparib conjugates as PARP-targeted fluorescent probes. By attaching olaparib-derived ligands to the 5-position of the BODIPY core through flexible linkers, we sought to preserve conformational flexibility while introducing a donor–acceptor fluorophore with an enlarged Stokes shift. Among the synthesized probes, 1a exhibited the most favorable cellular imaging performance, showing efficient nuclear localization in PARP-overexpressing U87 and Cal27 cells. Competitive blocking with olaparib and comparison with HEK293 cells supported PARP-dependent imaging. In Cal27 xenograft and orthotopic oral tumor models, 1a showed rapid tumor accumulation and clear tumor visualization. It provides a wider range of probe options for intraoperative tracking of oral tumors.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"21 16","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenols: From Replacing to Embracing 苯酚：从替代到拥抱

IF 3.5 4区医学

ChemMedChem Pub Date : 2026-08-18 DOI: 10.1002/cmdc.70408

Gilles Ouvry

引用次数: 0