封面：可逆交换中α-酮羧酸酯与对氢的碳-13超极化（ChemMedChem 5/2025）

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-03-06 DOI:10.1002/cmdc.202580501

Stephen J. McBride, Keilian MacCulloch, Patrick TomHon, Austin Browning, Samantha Meisel, Mustapha Abdulmojeed, Boyd M. Goodson, Eduard Y. Chekmenev, Thomas Theis

{"title":"封面：可逆交换中α-酮羧酸酯与对氢的碳-13超极化（ChemMedChem 5/2025）","authors":"Stephen J. McBride, Keilian MacCulloch, Patrick TomHon, Austin Browning, Samantha Meisel, Mustapha Abdulmojeed, Boyd M. Goodson, Eduard Y. Chekmenev, Thomas Theis","doi":"10.1002/cmdc.202580501","DOIUrl":null,"url":null,"abstract":"<p>Shown on the cover is the hyperpolarization chemistry of α-ketoglutarate using parahydrogen in reversible exchange. Alpha-ketoglutarate is one example of the broad class of α-ketocarboxylates hyperpolarized in this work. These α-ketocarboxylates represent important biomarkers for the study of in vivo metabolic processes. The NMR and MRI sensitivity of these hyperpolarized biomarkers is enhanced by up to 30000-fold. More details can be found in article 10.1002/cmdc.202400378 by Stephen J. McBride, Thomas Theis, and co-workers. \n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"20 5","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202580501","citationCount":"0","resultStr":"{\"title\":\"Front Cover: Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange (ChemMedChem 5/2025)\",\"authors\":\"Stephen J. McBride, Keilian MacCulloch, Patrick TomHon, Austin Browning, Samantha Meisel, Mustapha Abdulmojeed, Boyd M. Goodson, Eduard Y. Chekmenev, Thomas Theis\",\"doi\":\"10.1002/cmdc.202580501\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Shown on the cover is the hyperpolarization chemistry of α-ketoglutarate using parahydrogen in reversible exchange. Alpha-ketoglutarate is one example of the broad class of α-ketocarboxylates hyperpolarized in this work. These α-ketocarboxylates represent important biomarkers for the study of in vivo metabolic processes. The NMR and MRI sensitivity of these hyperpolarized biomarkers is enhanced by up to 30000-fold. More details can be found in article 10.1002/cmdc.202400378 by Stephen J. McBride, Thomas Theis, and co-workers. \\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":147,\"journal\":{\"name\":\"ChemMedChem\",\"volume\":\"20 5\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202580501\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemMedChem\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202580501\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemMedChem","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202580501","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

封面上显示的是α-酮戊二酸在可逆交换中使用对氢的超极化化学反应。在这项工作中，α-酮戊二酸盐是α-酮羧酸盐超极化的一个例子。这些α-酮羧酸是研究体内代谢过程的重要生物标志物。这些超极化生物标志物的核磁共振和核磁共振灵敏度提高了3万倍。更多细节可以在10.1002/cmdc中找到。202400378作者：Stephen J. McBride， Thomas Theis及其同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange (ChemMedChem 5/2025)

查看原文本刊更多论文

Front Cover: Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange (ChemMedChem 5/2025)

Shown on the cover is the hyperpolarization chemistry of α-ketoglutarate using parahydrogen in reversible exchange. Alpha-ketoglutarate is one example of the broad class of α-ketocarboxylates hyperpolarized in this work. These α-ketocarboxylates represent important biomarkers for the study of in vivo metabolic processes. The NMR and MRI sensitivity of these hyperpolarized biomarkers is enhanced by up to 30000-fold. More details can be found in article 10.1002/cmdc.202400378 by Stephen J. McBride, Thomas Theis, and co-workers.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.