Ergosterol and Lanosterol Derivatives: Synthesis and Possible Biomedical Applications.

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-03-09 DOI:10.1002/cmdc.202400948

Joanna Stefaniak-Skorupa, Maria J Milewska

引用次数: 0

Abstract

Lanosterol is the crucial intermediate in ergosterol biosynthesis in fungi. A number of derivatives of natural or synthetic origin of these sterols are portrayed in this review. For the synthetic derivatives, strategies of their syntheses are presented. Biological activities of lanosterol and ergosterol derivatives include antimicrobial, especially antifungal action, anticancer and antiviral effects but also anti-inflammatory and anti-allergic potential. The most promising seems to be the anticancer potential of peroxides, epoxides, and keto- derivatives of both sterols.

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麦角甾醇和羊毛甾醇衍生物：合成和可能的生物医学应用。

羊毛甾醇是真菌麦角甾醇生物合成的重要中间体。这两种甾醇的许多天然或合成衍生物已在本综述中描述。对于合成衍生物，给出了合成策略。羊毛甾醇和麦角甾醇衍生物的生物活性包括抗菌，特别是抗真菌作用，抗癌和抗病毒作用，但也有抗炎和抗过敏的潜力。最有希望的似乎是两种固醇的过氧化物、环氧化物和酮类衍生物的抗癌潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.