Cover Feature: Current Context of Designing Phototheranostic Cyclometalated Iridium (III) Complexes to Open a New Avenue in Cancer Therapy (ChemMedChem 5/2025)

The cover art features an iridium complex with distinct cyclometalated ligands that enhance both bioimaging and therapeutic properties. The illustration also highlights the therapeutic function, where the iridium complex, upon light irradiation, induces apoptosis or cellular damage, representing its targeted cancer-fighting capabilities. The review article presents the current advancements and future potential of cyclometalated iridium (III) complexes as a phototheranostic agent. The finding demonstrates that cyclometalated iridium (III) complexes hold significant promise for both bioimaging and therapeutic purposes, showcasing potent anticancer activity that addresses the limitations of conventional cancer therapies by enabling more effective targeted delivery. More details can be found in article 10.1002/cmdc.202400649 by Priyankar Paira and co-workers.