Stephen J. McBride, Keilian MacCulloch, Patrick TomHon, Austin Browning, Samantha Meisel, Mustapha Abdulmojeed, Boyd M. Goodson, Eduard Y. Chekmenev, Thomas Theis
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引用次数: 0
Abstract
Shown on the cover is the hyperpolarization chemistry of α-ketoglutarate using parahydrogen in reversible exchange. Alpha-ketoglutarate is one example of the broad class of α-ketocarboxylates hyperpolarized in this work. These α-ketocarboxylates represent important biomarkers for the study of in vivo metabolic processes. The NMR and MRI sensitivity of these hyperpolarized biomarkers is enhanced by up to 30000-fold. More details can be found in article 10.1002/cmdc.202400378 by Stephen J. McBride, Thomas Theis, and co-workers.
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