International Journal of Reproductive Biomedicine最新文献

{"title":"Renal artery Doppler in fetal sonography: A narrative review.","authors":"Ashraf Sadat Jamal, Mahdieh Modarresi","doi":"10.18502/ijrm.v21i10.14534","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14534","url":null,"abstract":"<p><p>Doppler imaging is a non-invasive method in evaluating fetal circulation. Renal artery doppler (RAD) has been used for assessing fetal well-being in several studies. The aim of this narrative review was to accumulate and classify current evidence on RAD in fetal sonography. Articles until November 2022 were searched. After removing ineligible articles, 51 studies were included. Present articles were about RAD assessment in cases with amniotic fluid level changes, fetal growth restriction, fetal renal diseases, monochorionic twin pregnancies, preeclampsia, and gestational diabetes mellitus. The complex physiology of fetal kidney function may explain different results observed in different studies about the role of RAD in fetal assessment. It seems this factor can be useful in assessing some groups like diabetic pregnant women, and it should be used accompanying other related factors like kidney size. Further research is needed to evaluate the effectiveness of RAD in clinical management.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"789-800"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expressions of vascular endothelial growth factor A, mucin-1, colony-stimulating factor-1, heparin-binding epidermal growth factor-like growth factor, and fibroblast growth factor 2 genes in the female reproductive tracts of women with ectopic pregnancy: A case-control study.","authors":"Sima Golkar, Zahra Chekini, Fatemehsadat Amjadi, Parvaneh Afsharian, Aida Najafian, Firouzeh Ghaffari, Reza Aflatoonian","doi":"10.18502/ijrm.v21i10.14535","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14535","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity.</p><p><strong>Objective: </strong>We aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tubes and endometrial tissue of women with EP.</p><p><strong>Materials and methods: </strong>In this case-control study, 5 women who underwent salpingectomy due to EP, comprised the 5 pseudo-pregnant women as a control group. These participants referred to the Royan Institute, Shariati, and Arash hospital, Tehran, Iran during 2019-2021. We evaluated the expressions of vascular endothelial growth factor A<i>,</i> mucin-1<i>,</i> colony-stimulating factor-1<i>,</i> heparin-binding epidermal growth factor-like growth factor <i>(HBEGF),</i> and fibroblast growth factor 2 genes in the fallopian tube and endometrium of EP cases by real-time polymerase chain reaction using specific primers.</p><p><strong>Results: </strong>The vascular endothelial growth factor expression was significantly higher in the ampulla region of the controls. However, no significant differences were observed in endometrial tissue. Assessments of colony-stimulating factor-1 and fibroblast growth factor 2 showed no significant differences between the case and control groups. <i>HBEGF</i> showed significantly higher expression in the ampulla region of EP cases, but no significant difference was observed in <i>HBEGF</i> expression in the endometrial tissues of the study groups. Mucin-1expression was significantly higher in both study regions of the EP cases.</p><p><strong>Conclusion: </strong>Our results have strongly suggested that these genes play important roles in proper implantation, and disruptions in their expression patterns could lead to EP. However, more studies are needed to confirm the current findings.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"801-808"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of druggable hub genes and key pathways associated with cervical cancer by protein-protein interaction analysis: An in silico study.","authors":"Azizeh Asadzadeh, Nafiseh Ghorbani, Katayoun Dastan","doi":"10.18502/ijrm.v21i10.14536","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14536","url":null,"abstract":"<p><strong>Background: </strong>The uncontrolled growth of abnormal cells in the cervix leads to cervical cancer (CC), the fourth most common gynecologic cancer. So far, many studies have been conducted on CC; however, it is still necessary to discover the hub gene, key pathways, and the exact underlying mechanisms involved in developing this disease.</p><p><strong>Objective: </strong>This study aims to use gene expression patterns and protein-protein interaction (PPI) network analysis to identify key pathways and druggable hub genes in CC.</p><p><strong>Materials and methods: </strong>In this in silico analysis, 2 microarray gene expression datasets; GSE63514 (104 cancer and 24 normal samples), and GSE9750 (42 cancer and 24 normal samples) were extracted from gene expression omnibus to identify common differentially expressed genes between them. Gene ontology and Kyoto encyclopedia of genes and genomes pathway analysis were performed via the Enrichr database. STRING 12.0 database and CytoHubba plugin in Cytoscape 3.9.1 software were implemented to create and analyze the PPI network. Finally, druggable hub genes were screened.</p><p><strong>Results: </strong>Based on the degree method, 10 key genes were known as the hub genes after the screening of PPI networks by the CytoHubba plugin. <i>NCAPG</i>, <i>KIF11</i>, <i>TTK</i>, <i>PBK</i>, <i>MELK</i>, <i>ASPM</i>, <i>TPX2</i>, <i>BUB1</i>, <i>TOP2A</i>, and <i>KIF2C</i> are the key genes, of which 5 genes (<i>KIF11</i>, <i>TTK</i>, <i>PBK</i>, <i>MELK</i>, and <i>TOP2A</i>) were druggable.</p><p><strong>Conclusion: </strong>This research provides a novel vision for designing therapeutic targets in patients with CC. However, these findings should be verified through additional experiments.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"809-818"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of proprotein convertase subtilisin/kexin type 9 protein and oxidative stress indicators in women with preeclampsia: A case-control study.","authors":"Anahita Abbasifard, Shohreh Alimohammadi, Ebrahim Abbasi Oshaghi, Gholamreza Shafiee","doi":"10.18502/ijrm.v21i10.14540","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14540","url":null,"abstract":"<p><strong>Background: </strong>Proprotein convertase subtilisin/kexin type 9 (PCSK9) protein is one of the factors associated with oxidative stress and dyslipidemia disorders.</p><p><strong>Objective: </strong>This study aimed to evaluate the lipid profile, PCSK9 levels, and oxidative stress in preeclampsia.</p><p><strong>Materials and methods: </strong>This case-control study was conducted at Sina hospital in Hamadan University of Medical Sciences, Hamadan, Iran from August 2020-May 2021. The average maternal age of included participants was 30 yr with 30 preeclampsia and 30 healthy pregnant women. After clinical examination, the fasting blood samples were collected, and the serum PCSK9 protein concentration, superoxide dismutase, glutathione peroxidase activities, and glutathione levels were determined by enzyme-linked immunosorbent assay. Total antioxidant capacity, total oxidant status, and malondialdehyde levels were determined manually.</p><p><strong>Results: </strong>The average maternal age of participants were 29.97 <math><mo>±</mo></math> 4.75 and 31.23 <math><mo>±</mo></math> 5.85 yr, respectively. The concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), PCSK9, total antioxidant capacity, and malondialdehyde levels were higher in the preeclampsia group compared with control (p <math><mo><</mo></math> 0.02). Total oxidant status, glutathione levels, superoxide dismutase, glutathione peroxidase activities were lower in the cases group compared with the control group (p <math><mo><</mo></math> 0.01). The PCSK9 variable had a significant negative association with antioxidant parameters; however, a significant positive association was observed between PCSK9 level and parameters of LDL-C.</p><p><strong>Conclusion: </strong>PCSK9 is associated with increased serum levels of LDL-C and oxidative factors in pregnant women that increase the risk of endothelial damage and hypertension in preeclampsia.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"845-852"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating nesfatin-1 levels in women with polycystic ovary syndrome: A systematic review and meta-analysis.","authors":"Seyed Sobhan Bahreiny, Akram Ahangarpour, Ali Asghar Hemmati, Razieh Kazemzadeh, Mohammad-Navid Bastani, Mohammad Reza Dabbagh, Mojtaba Aghaei","doi":"10.18502/ijrm.v21i10.14533","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14533","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in females. Nesfatin-1 is a neuropeptide synthesized in the hypothalamus and other peripheral organs, and there are conflicting opinions about its correlation with PCOS.</p><p><strong>Objective: </strong>This study aims to investigate the correlation between nesfatin-1 and PCOS and evaluates the effectiveness of nesfatin-1 as a biomarker for the detection of PCOS in women.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis were conducted to identify pertinent articles from databases such as PubMed, Web of Science, Cochrane, EMBASE, Scopus, and Google Scholar. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random effects model to compare group outcomes. Additionally, meta-regression and subgroup analysis were performed to elucidate sources of heterogeneity.</p><p><strong>Results: </strong>The meta-analysis involved 12 studies with 1222 participants, and the findings revealed a significant relationship between PCOS and nesfatin-1 levels. The pooled (SMD = 0.54; 95% CI: 0.00-1.07; p = 0.04) indicated a significant difference between the evaluated groups. Moreover, a subgroup analysis showed that there was a substantial difference in nesfatin-1 levels among women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 1.46; 95% CI: 0.92-2.00; p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>Our meta-analysis indicates an association between high nesfatin-1 levels and PCOS. This suggests a potential role of nesfatin-1 in the development of PCOS and proposes it as a potential diagnostic biomarker for the disease. However, further research is necessary to validate these findings.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"777-788"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the choice of treatment center by infertile couples: A cross-sectional study in Yazd Reproductive Sciences Institute.","authors":"Mohammad Ranjbar, Ali Mohammad Abdoli, Tahereh Shafaghat, Hasan Jafari, Golnaz Izadpanah, Yibeltal Assefa","doi":"10.18502/ijrm.v21i10.14538","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14538","url":null,"abstract":"<p><strong>Background: </strong>Infertility is one of the critical health issues in Iran. There are more than 70 specialized infertility treatment centers in Iran, of which the Yazd Reproductive Sciences Institute, is one of the most important ones.</p><p><strong>Objective: </strong>This study aimed to determine the factors influencing infertile couples' choice of Yazd Reproductive Sciences Institute.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted on 275 infertile couples aged 18 and older, referring to Yazd Reproductive Sciences Institute, Yazd, Iran from September 2021 to March 2022. Data were gathered using a 2-part questionnaire. Data analysis was done through SPSS software. We used descriptive statistics, Kruskal-Wallis, Mann-Whitney, and <i>t</i> test for data analysis.</p><p><strong>Results: </strong>Most participants were individuals who came from other provinces of Iran (74.9%) and were referred to the Yazd Reproductive Sciences Institute. Among the 4 categories that influenced couples' decision to choose this center, factors related to the personnel and treatment staff received the highest score (75.83), while personal factors received the lowest score (65.76). The average score for factors related to doctors was 72.90, and for factors related to the center, it was 73.65. The satisfaction with personnel and treatment staff varied based on participants' education levels, with those who had lower levels of education reporting higher levels of satisfaction (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>The primary factors contributing to the success of the Yazd Reproductive Sciences Institute in attracting clients were the dedication and expertise of the staff, as well as the esteemed reputation of the doctors at the center.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"827-834"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary inflammatory index and C-reactive protein in plasma and semen with semen quality: A cross-sectional study.","authors":"Ali Taheri Madah, Saeid Hadi, Beheshteh Abouhamzeh, Vahid Hadi, Maasoume Abdollahi, Kiumars Omidi","doi":"10.18502/ijrm.v21i10.14539","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14539","url":null,"abstract":"<p><strong>Background: </strong>Infertility affects couples worldwide, with male factors being responsible for half of all cases.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between dietary inflammatory index (DII) and levels of C-reactive protein (CRP) in plasma and semen with the quality of semen in infertile males.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 88 infertile men referring to Besat hospital, Tehran, Iran from December 2021-November 2022 were enrolled. A detailed questionnaire requesting information, and a 168-item semiquantitative food frequency questionnaire, were completed by participants. A food frequency questionnaire was used to calculate the DII. Additionally, semen and blood samples were collected from each participant for semen analysis and CRP-level assessment. Statistical analyses were performed to explore the association between DII and CRP levels with sperm quality. The correlation between DII and serum/semen CRP, besides assessing nutrients in each DII quartile group, was also explored.</p><p><strong>Results: </strong>A significant difference was observed between different DII quartiles considering sperm motility (p = 0.006) and morphology (p = 0.014). Post hoc study revealed a significant difference between the 1<math><msup><mrow></mrow><mtext>st</mtext></msup></math> and 2<math><msup><mrow></mrow><mtext>nd</mtext></msup></math> quartiles and the 1<math><msup><mrow></mrow><mtext>st</mtext></msup></math> and 4<math><msup><mrow></mrow><mtext>th</mtext></msup></math> quartiles of DII regarding sperm motility (p = 0.011, and 0.017 respectively) and a significant difference between the 1<math><msup><mrow></mrow><mtext>st</mtext></msup></math> and 2<math><msup><mrow></mrow><mtext>nd</mtext></msup></math> quartiles of DII considering sperm morphology (p = 0.009). A statistically significant inverse correlation was also observed between DII and sperm motility (p <i>=</i> 0.017). Carbohydrates and β-carotenes were significantly different between the 4 DII quartiles (p = 0.043 and p = 0.026, respectively). Finally, no significant correlation was observed between DII and CRP levels in blood and semen (p <math><mo>></mo></math> 0.05).</p><p><strong>Conclusion: </strong>The findings suggested a notable correlation between DII and semen quality; however, no significant association were observed between DII and CRP levels in blood and semen.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"835-844"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crucial role of corticotropin-releasing hormone, corticotropin-releasing hormone -binding protein, mir-200c, and mir-181a in preterm delivery: A case-control study.","authors":"Ehsan Mohiti Ardakani, Mahta Mazaheri, Ph D, Mohsen Forouzanfar, Mahdieh Mojibian, Mojtaba Jafarinia","doi":"10.18502/ijrm.v21i9.14398","DOIUrl":"10.18502/ijrm.v21i9.14398","url":null,"abstract":"<p><strong>Background: </strong>Preterm birth before 37<math><msup><mrow></mrow><mtext>th</mtext></msup></math> wk of gestation is called premature birth. Corticotropin-releasing hormone (CRH) and CRH-binding protein (BP) act on various maternal and fetal tissues during pregnancy, such as the myometrium, which regulates the transition from the dormant phase of the uterus to the active phase. Studies have shown that mir-200c and mir-181a interact with CRH and CRH-BP.</p><p><strong>Objective: </strong>The present study aimed to investigate the expression of mir-200c, mir-181a, CRH, and CRH-BP in women with a history of preterm birth.</p><p><strong>Materials and methods: </strong>In this case-control study, the gene expression level of mir-200c, mir-181a, CRH, and CRH-BP in placental tissue samples obtained from 48 women with a history of preterm labor was assessed in the Mojibian hospital of Yazd, Iran, from January to March 2023. Differences between <i>mir-200c</i>, <i>mir-181a CRH</i>, and <i>CRH-BP</i> gene expressions among cases and controls were assessed.</p><p><strong>Results: </strong>The outcomes indicated that the expression of CRH increased with going on to the regular parturition time (p <math><mo><</mo></math> 0.001). While outcomes indicated, CRH-BP decreased with going on to the regular parturition time (p <math><mo><</mo></math> 0.001). In addition, the results showed that the expression of mir-181a increased and mir-200c decreased with approaching the normal delivery time (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>In conclusion, the expressions of mir-200c, mir-181a, CRH, and CRH-BP were dissimilar in different weeks of gestation. It could be proposed to use mir-200c, mir-181a, CRH, and CRH-BP as biomarkers to weigh the exact delivery time, which could minimize the side effects of preterm labor for the mother and fetus.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"715-722"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to meet marital intimacy needs in women infected with coronavirus 2019: A framework qualitative content analysis research.","authors":"Tahmineh Farajkhoda, Mahmood Kamali Zarch, Saeedeh Najafihedeshi","doi":"10.18502/ijrm.v21i9.14399","DOIUrl":"https://doi.org/10.18502/ijrm.v21i9.14399","url":null,"abstract":"<p><strong>Background: </strong>Separating women with the coronavirus 2019 from family can affect marital life. Considering psychological vulnerability of women for anxiety and depression disorders, these women may experience more stress due to the loss of work at this time or special reproductive health conditions such as pregnancy, having a baby, or other medical conditions.</p><p><strong>Objective: </strong>Considering a limited number of qualitative studies on the need for marital intimacy, this study was conducted to meet marital intimacy needs in women with coronavirus 2019.</p><p><strong>Materials and methods: </strong>Framework qualitative content analysis was conducted through participation of 13 key informants (sex therapist, couple therapist, psychologist, and midwifery counselor) and 18 infected women from Yazd, Iran in July 2020 who were selected purposefully and interviewed through the semi-structured in-depth interviews.</p><p><strong>Results: </strong>3 main categories were: 1) mutual resilience (subcategories: 1. coping strategies; 2. value of marital life; 3. compassionate conflict resolving). 2) skillful relationship (subcategories: 1. assertiveness in sexual expression; 2. self-efficacy in the distance physical connectivity). 3) synergy (subcategories: 1. reframing spirituality closeness; 2. empowering aesthetic creativity; 3. management of family function, and 4. prioritizing).</p><p><strong>Conclusion: </strong>Findings revealed sex and couple therapists, health providers, and policymakers should emphasize on using new forms of digital communication in these couples. Teaching skills that increase partners' creativity and empathy, enable women to fulfill their mental, sexual and reproductive health needs, and lead to more partners responsibility and loyalty, and maintenance of family function. In times of crisis, counseling should be considered in women treatment programs and care guidelines.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"723-736"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of individuals with unconsummated marriage in Iran: A qualitative content analysis.","authors":"Sona Setayesh, Amir Hossein Jalali Nadoushan, Razieh Bakhshandeh, Reza Negarandeh, Mehrdad Eftekhar Ardebili","doi":"10.18502/ijrm.v21i9.14401","DOIUrl":"https://doi.org/10.18502/ijrm.v21i9.14401","url":null,"abstract":"<p><strong>Background: </strong>Sex is one of the important aspects of marriage and a way of expressing intimacy. Unconsummated marriage is a common problem whose prevalence is about 1.5% in Iran and can significantly influence marital life.</p><p><strong>Objective: </strong>This study aimed to assess the unconsummated marriage in a qualitative mode to offer new and beneficial solutions resulting from a better understanding.</p><p><strong>Materials and methods: </strong>In this qualitative study, conventional content analysis was used. Data collection and analysis were done from April 2013 to April 2014 with 11 women and 5 men participating, who were referred to the sexual disorders clinic of Tehran Psychiatric Institute and Rasool Akram hospital of Tehran, Iran. The researchers examined the files of people referred to these clinics with the diagnosis of unconsummated marriage. Our tool for data collection was a semi-structured interview. 2 experienced faculty psychiatrists recorded all the information based on standards for reporting qualitative research guidelines. Data were analyzed using qualitative technique and coding. Guba and Lincoln criteria was used for data validity.</p><p><strong>Results: </strong>The codes of the participants' experiences were classified into 6 main categories, which include self-concept, intrapersonal factors, partner's problem, preparedness for sex, emotional relationship between couples, and the effects of unconsummated marriage on the participant's life.</p><p><strong>Conclusion: </strong>Significant experiences among women included excessive anxiety toward the society and their spouses, and among men were weakness and guilt. Being unable to have sex negatively affected their view of life and caused great harm to their self-perception. Participants personality traits and their self-concept, and attitude toward their partners were important issues.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"745-758"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}