International Journal of Reproductive Biomedicine最新文献

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The protective effects of melatonin on testis, sperm parameters quality, and in-vitro fertilization in mice following treatment with aflatoxin B1: An experimental study. 褪黑素对黄曲霉毒素B1治疗小鼠睾丸、精子参数质量和体外受精的保护作用:一项实验研究。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18492
Maryam Sabahi, Mojtaba Karimipour, Abass Ahmadi, Bagher Pourheydar, Gholamhossein Farjah
{"title":"The protective effects of melatonin on testis, sperm parameters quality, and in-vitro fertilization in mice following treatment with aflatoxin B1: An experimental study.","authors":"Maryam Sabahi, Mojtaba Karimipour, Abass Ahmadi, Bagher Pourheydar, Gholamhossein Farjah","doi":"10.18502/ijrm.v23i2.18492","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18492","url":null,"abstract":"<p><strong>Background: </strong>Aflatoxin B1 (AFB1) contamination of foods and animal feeds is a public health issue. Exposure to AFB1 induces oxidative stress and can cause male reproductive toxicity. Melatonin (MLT) is a neuro-hormone produced by the pineal gland and the testis and is known as a potent antioxidant.</p><p><strong>Objective: </strong>This study aims to determine the protective effect of MLT on testicular tissue alterations, sperm parameter indexes, and in vitro fertility assays in mice treated with AFB1.</p><p><strong>Materials and methods: </strong>In this experimental study, 28 adult male NMRI mice (8-10 wk old, 25-27 gr) were divided randomly into 4 groups: control, MLT (20 mg/kg/day, intraperitoneally), AFB1 (50 <math><mi>μ</mi></math> g/kg/day, intraperitoneally) and MLT+AFB1. After 35 consecutive days, testis histological changes, sperm quality parameters, the rate of sperm with DNA damage, and in vitro fertilization outcomes up to the blastocyst stage were surveyed and compared between groups.</p><p><strong>Results: </strong>Our results showed that AFB1 administration induced histological alterations in the testis and significantly decreased all the sperm parameters and in vitro fertility (fertilization and blastocyst formation rates) compared to control. Additionally, the percentages of immature sperms and sperms with DNA damage significantly (p <math><mo><</mo></math> 0.001) increased in the AFB1-treated group. MLT treatment in the MLT+AFB1group significantly increased testis quality and sperm parameters and improved in vitro fertilizaton rate and in vitro embryonic development.</p><p><strong>Conclusion: </strong>These findings demonstrated that MLT can compensate for the adverse effects of AFB1 on the quality of testicular tissue, sperm parameters, sperm DNA, and in vitro fertilization outcomes.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"185-198"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic potential of cell-free fetal nucleic acids in predicting pregnancy complications: A systematic review and meta-analysis on trisomy, pre-eclampsia, and gestational diabetes. 无细胞胎儿核酸预测妊娠并发症的诊断潜力:一项关于三体、先兆子痫和妊娠糖尿病的系统回顾和荟萃分析。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18476
Jiut Ram Keshari, Pritam Prakash, Seema Rani Sinha, Prem Prakash, Kirti Rani, Tarique Aziz, Shaily Shilpa
{"title":"Diagnostic potential of cell-free fetal nucleic acids in predicting pregnancy complications: A systematic review and meta-analysis on trisomy, pre-eclampsia, and gestational diabetes.","authors":"Jiut Ram Keshari, Pritam Prakash, Seema Rani Sinha, Prem Prakash, Kirti Rani, Tarique Aziz, Shaily Shilpa","doi":"10.18502/ijrm.v23i2.18476","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18476","url":null,"abstract":"<p><strong>Background: </strong>Recent studies reveal an association between increased cell-free fetal (cff) nucleic acid in maternal blood and pregnancy challenges like loss, pre-eclampsia, growth restriction, and preterm labor.</p><p><strong>Objective: </strong>This article assesses the role of cff nucleic acids as potential diagnostic markers for the prediction and monitoring progression of severe pregnancy-related complications.</p><p><strong>Materials and methods: </strong>In this systematic review and meta-analysis, various databases were searched. Original articles reporting on the role of cff nucleic acids in predicting the complications of pregnancy were included. I square test and funnel plot were used to analyze heterogeneity and publication bias, respectively. The quality of studies was assessed using the critical appraisal checklists for studies created by the Joanna Briggs Institute.</p><p><strong>Results: </strong>70 publications were selected for the final qualitative analysis. Articles were published between 2010 and 2023, and most studies were conducted in the USA and China. The majority of studies were conducted on the quantity of cff-DNA (n = 40), and the remaining on microRNA (n = 18), messenger RNA (n = 11), and cell-free RNA (n = 1). The pooled sensitivity of cff nucleic acids for detecting trisomy was found to be 90.9 (95% CI: 80.9-100%). MicroRNA levels were significantly increased in participants with gestational diabetes mellitus, with a standardized mean difference of 1.22 (95% CI: -0.90-3.34).</p><p><strong>Conclusion: </strong>Fetal nucleic acids can serve as accurate noninvasive diagnostic tools for predicting serious complications during pregnancy.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"111-130"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometrial compaction can improve assisted reproductive technology outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy: A cross-sectional study. 子宫内膜压实可以改善使用激素替代疗法的冷冻解冻胚胎移植周期的辅助生殖技术结果:一项横断面研究。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18484
Shahrzad Moeinaddini, Saeideh Dashti, Zahra Amini Majomerd, Nooshin Hatamizadeh
{"title":"Endometrial compaction can improve assisted reproductive technology outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy: A cross-sectional study.","authors":"Shahrzad Moeinaddini, Saeideh Dashti, Zahra Amini Majomerd, Nooshin Hatamizadeh","doi":"10.18502/ijrm.v23i2.18484","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18484","url":null,"abstract":"<p><strong>Background: </strong>Endometrial compaction (EC) is an ultrasound evaluation method that may predict assisted reproductive technology outcomes.</p><p><strong>Objective: </strong>This study aimed to assess the impact of EC on assisted reproductive technology outcomes in frozen embryo transfer cycles with hormone replacement therapy.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 100 women who underwent first or second frozen embryo transfer cycle at Yazd Reproductive Sciences Institute, Yazd, Iran from June to October 2024 were included. Endometrial thickness was compared between the day of starting progesterone and embryo transfer day. Then participants were divided into 2 groups, no compaction and compaction group. Biochemical, clinical, and ongoing pregnancy rates (OPR) were assessed between the 2 groups.</p><p><strong>Results: </strong>Statistically significant differences were observed in biochemical, clinical, and OPR between the compaction and no compaction groups. Logistic regression analysis demonstrated significantly higher pregnancy rates in EC 10-15% and <math><mo>></mo></math> 15%. We found a significant influence of EC 10-15% (p = 0.02, p = 0.01, p = 0.01), and EC <math><mo>></mo></math> 15% (p = 0.002, p = 0.001, and p = 0.002) on biochemical, clinical, and OPR, respectively.</p><p><strong>Conclusion: </strong>EC after progesterone administration in hormone replacement therapy-frozen embryo transfer cycles can increase biochemical, clinical, and OPR. The percentage of EC changes also influence the outcomes of these cycles.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"141-152"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An investigation of the therapeutic potential of the testicular tissue encapsulated in amnion membrane in mouse model: An experimental study. 羊膜包封睾丸组织治疗小鼠模型的实验研究。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18489
Keykavoos Gholami, Elahe Asheghmadine, Fateme Guitynavard, Leila Zareian Baghdadabad, Diana Taheri, Parisa Zahmatkesh, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir
{"title":"An investigation of the therapeutic potential of the testicular tissue encapsulated in amnion membrane in mouse model: An experimental study.","authors":"Keykavoos Gholami, Elahe Asheghmadine, Fateme Guitynavard, Leila Zareian Baghdadabad, Diana Taheri, Parisa Zahmatkesh, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir","doi":"10.18502/ijrm.v23i2.18489","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18489","url":null,"abstract":"<p><strong>Background: </strong>Restoring fertility in male cancer individuals through testicular tissue transplantation faces challenges due to hypoxia-induced loss of spermatogonial stem cells (SSCs). Hydrogel encapsulation was explored to minimize hypoxic damage in testicular tissue transplantation. For this purpose, human amnion membrane (hAM)-derived hydrogel could be an alternative.</p><p><strong>Objective: </strong>The potential of hAM-derived hydrogel to support testis tissue grafts was evaluated.</p><p><strong>Materials and methods: </strong>In this experimental study, testicular tissue samples (1-3 mm<sup>3</sup>) were obtained from 16 male NMRI mice (4-5 wk, 22 <math><mo>±</mo></math> 2 gr). These tissue fragments were either encapsulated within a hydrogel derived from a hAM or left unencapsulated (control) prior to being autologously transplanted beneath the dorsal skin of mice subjected to hemilateral or bilateral orchiectomy. The grafted testicular tissues were histologically evaluated for key parameters, including the integrity of seminiferous tubules, survival of SSCs, Sertoli cell functionality, as well as hypoxia and apoptosis on day 21.</p><p><strong>Results: </strong>No significant differences were observed between groups regarding ST integrity, number of SSCs, Sertoli cell functionality, or the rate of hypoxia-inducible factor 1-alpha and apoptosis (p <math><mo>≤</mo></math> 0.05).</p><p><strong>Conclusion: </strong>In conclusion, this study demonstrated no effect of hAM hydrogel encapsulation on the outcomes of testicular tissue transplantation.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"171-184"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of laparoscopic surgery effects on pain severity and quality of life in different subtypes of endometriosis: A follow-up study. 腹腔镜手术对不同亚型子宫内膜异位症患者疼痛程度和生活质量的影响:一项随访研究
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18494
Mania Kaveh, Haniye Malakouti, Shahla Chaichian, Abolfazl Mehdizadeh Kashi, Mahdi Afshari, Kambiz Sadegi
{"title":"Evaluation of laparoscopic surgery effects on pain severity and quality of life in different subtypes of endometriosis: A follow-up study.","authors":"Mania Kaveh, Haniye Malakouti, Shahla Chaichian, Abolfazl Mehdizadeh Kashi, Mahdi Afshari, Kambiz Sadegi","doi":"10.18502/ijrm.v23i2.18494","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18494","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that endometriosis significantly has a negative impact on women's mental health and quality of life (QoL), resulting in these participants experiencing a diminished QoL.</p><p><strong>Objective: </strong>This study aimed to evaluate the effect of laparoscopic surgery on the severity of pain and the QoL of women with different types of endometriosis.</p><p><strong>Materials and methods: </strong>In this follow-up study 50 women with endometriosis, who underwent laparoscopic surgery, who met a high visual analog score ( <math><mo>></mo></math> 6) with impaired QoL, lack of response to analgesics, infertility with pain unresponsive to assisted reproductive therapy, and involvement of other organs such as the bowel or ureter at the Amir Al Momenin hospital, Zabol, Iran, from August 2022 to January 2023 were enrolled. The participants were categorized into 2 groups: those with stage IV endometriosis and those with lower stages (I-III). Groups according to the higher occurrence of grade 4 endometriosis, as 55.1% were affected by it. The pain score was measured using the visual analog score, and the participants' QoL score was measured using the endometriosis health profile questionnaire.</p><p><strong>Results: </strong>The mean age of participants was 32 yr, with a standard deviation of 8.6 yr. Participants were divided into 2 groups: those with grade 4 endometriosis (55.1%) and those with a grade lower than 4, as classified by the American Society for Reproductive Medicine. Over 12 months, both groups experienced a significant decrease in pain severity and QoL scores (p <math><mo><</mo></math> 0.0001). However, the changes in pain and QoL scores between the 2 groups were not statistically significant (p = 0.520 and p = 0.984, respectively).</p><p><strong>Conclusion: </strong>Laparoscopic treatment can reduce pain and QoL scores (increase the QoL indices) in women with endometriosis, regardless of the disease's severity.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"199-206"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of ovarian hyperstimulation syndrome on intracytoplasmic sperm injection outcomes in poly-cystic ovarian syndrome women: A cross-sectional study. 卵巢过度刺激综合征对多囊卵巢综合征患者卵浆内单精子注射结果的影响:一项横断面研究。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18496
Mufeda Ali Jwad, Maryam Hussein Khaleefah, Ramih Abd AlFattah Naser
{"title":"Impact of ovarian hyperstimulation syndrome on intracytoplasmic sperm injection outcomes in poly-cystic ovarian syndrome women: A cross-sectional study.","authors":"Mufeda Ali Jwad, Maryam Hussein Khaleefah, Ramih Abd AlFattah Naser","doi":"10.18502/ijrm.v23i2.18496","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18496","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovarian syndrome (PCOS) is a complex disorder that affects the endocrine, metabolic, and reproductive systems. While controlled ovarian hyperstimulation can increase the number of oocytes retrieved and improve the number of good-quality embryos, it may also negatively affect oocyte maturity, embryo quality, endometrial receptivity, and pregnancy outcomes.</p><p><strong>Objective: </strong>This study aimed to find out if ovarian hyperstimulation syndrome (OHSS) has negative effects on intracytoplasmic sperm injection outcomes in a sample of PCOS women.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, data of 84 PCOS women who underwent controlled ovarian stimulation using a flexible antagonist protocol-treated intracytoplasmic sperm injection cycles referred to the Infertility Department of Higher Institute for the Diagnosis of Infertility and Assisted Reproduction Techniques, Baghdad, Iraq between January 2020 and December 2023 was extracted from their medical records. Participants were categorized into 2 groups after undergoing controlled ovarian hyperstimulation protocol: PCOS with OHSS (n = 54) and PCOS without OHSS (n = 30). The dosage was tailored based on age, body mass index, and response to previous stimulation cycles, if applicable. The trigger was administered using decapeptyl 0.2 mg alone or in combination with recombinant human chorionic gonadotrophin, depending on the estradiol levels at the time of the trigger.</p><p><strong>Results: </strong>Significant differences were observed in the duration of stimulation (p = 0.005), oocyte yield (p = 0.001), mature oocytes (p = 0.001), and fertilized oocytes (p = 0.036); however, no significant difference was observed, neither in number of good quality embryos (p = 0.52) nor in pregnancy rate (p = 0.54) after fresh and frozen embryo transfer between the 2 groups.</p><p><strong>Conclusion: </strong>OHSS does not affect the embryo quality or pregnancy rate in PCOS women.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"207-216"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetic pregnancy: A literature review of maternal and neonatal adverse outcomes. 糖尿病妊娠:孕产妇和新生儿不良结局的文献综述。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18482
Sara Mohamed, Waverly Kundysek, Niraj Vora, Vinayak Govande, Raza Bajwa, Mohammad Nasir Uddin
{"title":"Diabetic pregnancy: A literature review of maternal and neonatal adverse outcomes.","authors":"Sara Mohamed, Waverly Kundysek, Niraj Vora, Vinayak Govande, Raza Bajwa, Mohammad Nasir Uddin","doi":"10.18502/ijrm.v23i2.18482","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18482","url":null,"abstract":"<p><p>Of all pregnant women in the United States an average of 1.5% reported to have type 1 or type 2 diabetes mellitus. Our review article will discuss and explore the relationship between pre-pregnancy diabetes and its adverse outcomes in mothers and neonates. Diabetes in pregnancy can cause a myriad of complications, many of which are related to microvascular changes, including diabetic nephropathy and retinopathy associated with preterm delivery, cesarean sections, and intrauterine growth restriction. Pregnant patients with diabetes also have an increased risk of pre-eclampsia, likely due to complications related to abnormal structure and function of the placenta. In addition, cardiovascular complications are more common and may present antepartum, intrapartum, or postpartum. Adverse neonatal outcomes that have been observed in diabetic pregnancies include fetal stillbirth and perinatal death, macrosomia, congenital malformations, respiratory distress, and neurological impairments. These complications explain the increased morbidity and mortality rate of infants of diabetic mothers, and the increased frequency of neonatal intensive care unit hospitalizations after birth. Diabetes in pregnancy causes a spectrum of changes in the maternal-fetal interface. This review addresses the placental changes during pregnancy and its adverse maternal and neonatal outcomes. We strongly believe the material discussed in this article can help in understanding the effects of diabetes during pregnancy which will ultimately aid in designing interventions to prevent these adverse outcomes.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"131-140"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of addiction behavior and spermatogenesis in glial cell line-derived neurotrophic factor-treated cannabis-addicted rats: An experimental study. 神经营养因子治疗大麻成瘾大鼠神经胶质细胞系来源的成瘾行为和精子发生的评估:一项实验研究。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI: 10.18502/ijrm.v23i2.18487
Rozhina Laleh, Mitra Heydari Nasrabadi, Parvin Khodarahmi, Jamshid Soltani
{"title":"Assessment of addiction behavior and spermatogenesis in glial cell line-derived neurotrophic factor-treated cannabis-addicted rats: An experimental study.","authors":"Rozhina Laleh, Mitra Heydari Nasrabadi, Parvin Khodarahmi, Jamshid Soltani","doi":"10.18502/ijrm.v23i2.18487","DOIUrl":"https://doi.org/10.18502/ijrm.v23i2.18487","url":null,"abstract":"<p><strong>Background: </strong>Cannabis addiction poses risks to male fertility by lowering levels of glial cell line-derived neurotrophic factor (GDNF), which is vital for spermatogenesis.</p><p><strong>Objective: </strong>This research aimed to determine if the injection of exogenous GDNF into the brain of cannabis-addicted rats has a positive impact on their behavior and spermatogenesis.</p><p><strong>Materials and methods: </strong>This study involved 15 male Wistar rats divided into 3 equal groups: control, model, and experimental. Cannabis addiction was induced in the model and experimental groups using a smoking machine with a 0.25 gr dose per 5 rats, and the experimental group received a 0.5 mg GDNF treatment via stereotaxic injection. Behavioral changes were assessed through plus maze, open field, and sucrose preference tests before and after treatments. Sperm parameters were evaluated with H&E staining, sperm morphology with Diff-Quik staining, DNA damage and viability with acridine orange and trypan blue staining.</p><p><strong>Results: </strong>Addicted rats displayed increased anxiety, which was improved by GDNF treatment (p <math><mo><</mo></math> 0.05). Although cannabis significantly reduced germ cells and the size of the testis and epididymis compared to controls (p = 0.0006, p = 0.003), GDNF had a limited effect on these aspects. Cannabis significantly altered sperm morphology (p = 0.0016), but GDNF reversed abnormal sperms. GDNF improves sperm quality, reverses cannabis-induced sperm grading alterations (grade C, p = 0.0295), reduces DNA damage significantly (p = 0.0242), and enhances sperm viability, highlighting its potential to counteract some of cannabis's harmful effects on male reproductive health.</p><p><strong>Conclusion: </strong>The findings of this experiment suggest that exogenous GDNF could be a potential therapeutic agent for cannabis addiction and sperm parameters.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 2","pages":"153-170"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy and neonatal outcomes of intracytoplasmic sperm injection versus in vitro fertilization in fresh cycles of women with advanced maternal age and nonmale factor infertility: A cross-sectional study. 高龄产妇和非男性因素不孕症的新鲜周期中,卵浆内单精子注射与体外受精的妊娠和新生儿结局:一项横断面研究。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.18502/ijrm.v23i1.18190
Sajad Zare Garizi, Nazanin Sabagh Nezhad Yazd, Nasim Tabibnejad, Razieh Dehghani-Firouzabadi
{"title":"Pregnancy and neonatal outcomes of intracytoplasmic sperm injection versus in vitro fertilization in fresh cycles of women with advanced maternal age and nonmale factor infertility: A cross-sectional study.","authors":"Sajad Zare Garizi, Nazanin Sabagh Nezhad Yazd, Nasim Tabibnejad, Razieh Dehghani-Firouzabadi","doi":"10.18502/ijrm.v23i1.18190","DOIUrl":"10.18502/ijrm.v23i1.18190","url":null,"abstract":"<p><strong>Background: </strong>Intracytoplasmic sperm injection (ICSI) was originally developed to facilitate fertilization in situations of severe male infertility. However, it is now frequently used for nonmale factor infertility, such as advanced maternal age or low oocyte count, despite the clinical advantages of this method has not been proven for these situations.</p><p><strong>Objective: </strong>This study aims to compare pregnancy and neonatal outcomes between ICSI and in vitro fertilization (IVF) cycles in women with advanced maternal age and nonmale factor infertility.</p><p><strong>Materials and methods: </strong>This retrospective cross-sectional study included 1090 women with nonmale factor infertility, who underwent fresh embryo transfer cycles of IVF or ICSI at the Yazd Reproductive Sciences Institute, Yazd, Iran between April 2018 and June 2023. Data on demographic characteristics, clinical outcomes, and neonatal outcomes were analyzed from electronic medical records.</p><p><strong>Results: </strong>Women undergoing IVF demonstrated significantly higher outcomes in fertilization, implantation, and chemical pregnancy rate (p <math><mo><</mo></math> 0.05). Neonatal outcomes showed significantly higher twin birth weights and lower prematurity rates in the IVF group compared to the ICSI group (p <math><mo><</mo></math> 0.001 and p = 0.011, respectively).</p><p><strong>Conclusion: </strong>This study suggests that IVF may yield better maternal outcomes and more favorable neonatal results than ICSI for older women with nonmale factor infertility. These results emphasize the significance of tailored treatment plans and the necessity for continued research to enhance assisted reproductive technologies techniques.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"45-54"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of maternal dietary patterns in early pregnancy with gestational weight gain: Yazd Birth Cohort. 妊娠早期产妇饮食模式与妊娠期体重增加的关系:亚兹德出生队列。
IF 1.6
International Journal of Reproductive Biomedicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.18502/ijrm.v23i1.18189
Shahab-Aldin Akbarian, Amin Salehi-Abargouei, Sara Jambarsang, Habib Nikukar, Ph D, Azadeh Nadjarzadeh
{"title":"Association of maternal dietary patterns in early pregnancy with gestational weight gain: Yazd Birth Cohort.","authors":"Shahab-Aldin Akbarian, Amin Salehi-Abargouei, Sara Jambarsang, Habib Nikukar, Ph D, Azadeh Nadjarzadeh","doi":"10.18502/ijrm.v23i1.18189","DOIUrl":"10.18502/ijrm.v23i1.18189","url":null,"abstract":"<p><strong>Background: </strong>Abnormal gestational weight gain (GWG) can carry risks for both the mother and the baby. Diet imbalances are the determining factor in the weight gain of pregnant women.</p><p><strong>Objective: </strong>This study aimed to assess the relationship between nutritional patterns and the weight of pregnant mothers living in Yazd, Iran from 2021-2022.</p><p><strong>Materials and methods: </strong>In this cohort study, data from 1497 pregnant women aged 18-45 yr with singleton pregnancy who completed the food frequency questionnaire in the Yazd Birth Cohort Study were extracted. This data included demographic variables, GWG (difference between initial weight at 13-15 wk and 1 wk before the expected delivery date), and food intake information before the 13 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> wk of pregnancy. The women were categorized into 3 groups based on GWG: inadequate, normal, and excessive. Dietary patterns were extracted from the food frequency questionnaire using principal component analysis, and multinomial logistic regression was used to evaluate the relationship between dietary patterns and GWG categories.</p><p><strong>Results: </strong>According to the frequency of food consumption, 3 dietary patterns were obtained: the traditional pattern (cabbage vegetables, fruits, and dried fruits), the unhealthy pattern (processed meats and sweetened drinks), and the vegetable/fruit/olive pattern. The analysis results showed that pregnant women who followed the fruit/vegetable/olive pattern had a lower chance of insufficient weight gain during pregnancy (OR: 0.66, 95% CI: 0.45-0.98).</p><p><strong>Conclusion: </strong>Consuming various fruits and vegetables can help regulate GWG in the population of pregnant women lived in Yazd, Iran. Diet can be considered one of the most effective and safe interventions.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"67-78"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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