International Journal of Reproductive Biomedicine最新文献

{"title":"Carob extract restores testicular function and sperm quality in cadmium-exposed mice: An experimental study.","authors":"Mojtaba Moradi, Elham Ghanbari, Zahra Rashidi, Saman Moradi, Ali Shakeri, Azita Faramarzi","doi":"10.18502/ijrm.v23i7.19482","DOIUrl":"10.18502/ijrm.v23i7.19482","url":null,"abstract":"<p><strong>Background: </strong>Cadmium (Cd) is a hazardous heavy metal, and its exposure can lead to a range of health issues, including significant adverse effects on reproductive health in animals and humans. Recently, there has been increasing recognition of the antioxidant benefits of <i>Ceratonia siliqua</i> extract (CSE).</p><p><strong>Objective: </strong>To evaluate the therapeutic potential of CSE in mitigating testicular injury and spermatogenesis impairment induced by Cd.</p><p><strong>Materials and methods: </strong>In this experimental study, 40 adult male BALB/c mice (8-12 wk, 30 <math><mo>±</mo></math> 5 gr) were randomly divided into 4 groups (n = 10/each): control, Cd (0.35 mg/kg), CSE (100 mg/kg), and CSE+Cd (100 mg/kg + 0.35 mg/kg). Adult male mice were intraperitoneally injected for one cycle of spermatogenesis (35 days). Sperm parameters, sperm DNA integrity, testicular histopathology status, testosterone hormone level, and testicular levels of malondialdehyde, nitric oxide, and total antioxidant capacity were assessed.</p><p><strong>Results: </strong>CSE restored spermatogenesis by improving sperm count, motility, viability, morphology, and chromatin integrity (p <math><mo><</mo></math> 0.01). Testosterone levels and the histopathology of the testes also showed significant improvement in the CSE-administrated groups (p <math><mo><</mo></math> 0.001). More notably, Cd administration significantly induced oxidative stress in testicular tissue (p <math><mo><</mo></math> 0.001). Also, CSE restored antioxidant status by enhancing total antioxidant capacity levels and ameliorating nitric oxide and malondialdehyde levels (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>Administering CSE could potentially enhance testis function and sperm parameters against chronic Cd exposure-induced reproductive toxicity, likely due to improving testosterone secretion and its antioxidant properties.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 7","pages":"545-558"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial Mediterranean fever and reproductive systems, our experience in two decades: A letter to editor.","authors":"Farhad Salehzadeh, Yousef Mohammadi Kebar, Elham Nezhadseifi","doi":"10.18502/ijrm.v23i7.19491","DOIUrl":"10.18502/ijrm.v23i7.19491","url":null,"abstract":"","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 7","pages":"587-589"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of platelet-rich plasma and nanocurcumin on the sperm quality parameters in frozen-thawed semen of men with asthenoteratozoospermia: A lab trial study.","authors":"Mahsa Soltani, Elham Shojafar, Ali Asghar Ghafarizadeh, Azam Moslemi, Farideh Jalali Mashayekhi, Maryam Baazm","doi":"10.18502/ijrm.v23i7.19481","DOIUrl":"10.18502/ijrm.v23i7.19481","url":null,"abstract":"<p><strong>Background: </strong>Cryopreservation of sperm can adversely affect sperm quality, particularly in individuals with asthenoteratozoospermia. Various substances are added to the cryopreservation medium to prevent cellular damage.</p><p><strong>Objective: </strong>This study aimed to evaluate the effects of platelet-rich plasma (PRP) and nanocurcumin (nCur) on sperm parameters, DNA fragmentation, and oxidative stress levels in cryopreserved semen.</p><p><strong>Materials and methods: </strong>In this lab trial study, semen samples of 20 men with asthenoteratozoospermia who referred to Rastak and Ghavamzadeh Infertility Centers, Arak, Iran from June-August 2024 were collected. Each sample was divided into 5 groups: control (no treatment), PRP₅₀, PRP₁₀₀, nCur₁₀, and nCur₂₀. The control samples underwent freezing without additives. Post-thawing assessments included sperm motility, viability, DNA fragmentation index, and malondialdehyde levels to evaluate oxidative stress.</p><p><strong>Results: </strong>Treatment with PRP₅₀ (p <math><mo><</mo></math> 0.001) and nCur₂₀ (p = 0.001) significantly increased sperm motility compared to the control group. All treatment groups showed a significant increase in viable sperm following freezing (p <math><mo><</mo></math> 0.001), with PRP₅₀ demonstrating the most pronounced effects (p <math><mo><</mo></math> 0.001). While no improvements in sperm morphology were observed after freezing, PRP and nCur significantly reduced DNA fragmentation index after freezing (p <math><mo><</mo></math> 0.001), with PRP₅₀ being the most effective (p <math><mo><</mo></math> 0.001). Additionally, both PRP and nCur significantly decreased malondialdehyde levels compared to the control group (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>PRP and nCur effectively improve sperm parameters in cryopreserved semen from individuals with asthenoteratozoospermia, particularly emphasizing the superior efficacy of PRP at a concentration of 50 in improving sperm quality. These results support the potential use of these agents as additives in sperm cryopreservation protocols to improve reproductive outcomes.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 7","pages":"533-544"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of normal-range fetal heart rate variations during labor with umbilical cord arterial blood gas parameters and neonatal outcomes: A cross-sectional study.","authors":"Mohadese Dashtkoohi, Marjan Ghaemi, Shima Rahimi, Nasim Eshraqi, Mohammad Haddadi, Elham Sedighi, Sedigheh Hantoushzadeh, Fatemeh Golshahi","doi":"10.18502/ijrm.v23i7.19487","DOIUrl":"10.18502/ijrm.v23i7.19487","url":null,"abstract":"<p><strong>Background: </strong>Fetal heart rate (FHR) monitoring is a routine, non-invasive method for assessing fetal well-being during labor. However, its low sensitivity and high false-positive rate often lead to unnecessary cesarean deliveries. While fetal scalp blood sampling offers a more accurate assessment of intrauterine hypoxia, it is invasive, technically challenging, and prone to failure.</p><p><strong>Objective: </strong>To evaluate the association between intrapartum FHR beat-to-beat variability (within the normal range) and umbilical cord arterial blood gas parameters, and to assess their predictive value for neonatal outcomes, such as Apgar scores and acidosis.</p><p><strong>Materials and methods: </strong>This cross-sectional study reviewed medical records of all mothers who had delivered at Yas hospital, Tehran, Iran between August and December 2022. A total of 120 women with term, singleton pregnancies ( <math><mo>≥</mo></math> 37 wk) who were candidates for vaginal delivery were included. FHR monitoring was conducted on admission and 30 min before delivery. Umbilical cord arterial blood gas analysis was performed immediately after birth. Neonates were grouped based on cord pH <math><mo><</mo></math> 7.2 (acidosis) vs. <math><mo>≥</mo></math> 7.2 (non-acidosis).</p><p><strong>Results: </strong>17 neonates (14.2%) had pH <math><mo><</mo></math> 7.2. The acidosis group had significantly lower beat-to-beat variability at both time points (p = 0.002 and p <math><mo><</mo></math> 0.001) and greater variability reduction during labor (p <math><mo><</mo></math> 0.001). Cesarean rates and lower Apgar scores were significantly more frequent. Multiple regression analysis confirmed associations between reduced variability, neonatal acidosis, and lower Apgar scores.</p><p><strong>Conclusion: </strong>Even within normal limits, reduced FHR variability may signal fetal compromise. Monitoring variability trends could enhance intrapartum care and neonatal outcomes.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 7","pages":"569-576"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of inhalation aromatherapy with lemon balm essential oil on perceived stress in infertile women undergoing in vitro fertilization: An RCT.","authors":"Narges Abdollahi Senu, Roshanak Salari, Vahid Ghavami, Kobra Mirzakhani","doi":"10.18502/ijrm.v23i7.19490","DOIUrl":"10.18502/ijrm.v23i7.19490","url":null,"abstract":"<p><strong>Background: </strong>Women undergoing in vitro fertilization (IVF) treatment often experience a lot of stress during treatment cycles. One of the interventions in the field of stress reduction is aromatherapy. Lemon balm is a plant with antistress and antidepressant effects, but its effect on the perceived stress of infertile women has not been studied.</p><p><strong>Objective: </strong>Determining the effect of inhaled aromatherapy with lemon balm essential oil on perceived stress in infertile women undergoing IVF treatment.</p><p><strong>Materials and methods: </strong>The present study was a randomized clinical trial with a pretest/posttest design. A total of 86 infertile women who referred to the Milad Infertility Center in Imam Reza hospital, Mashhad, Iran from July-October 2024 were selected using a convenient sampling method. Women were divided into 2 intervention and control groups using a 4-way random block method. The intervention group received inhaled aromatherapy with lemon balm essential oil for 2 wk, twice a day, in the morning and at night. The control group also received a placebo. The research tools included demographic questionnaires and the fertility-problem inventory. The participants' stress levels were measured with fertility-problem inventory, and both groups completed questionnaires before and after the intervention.</p><p><strong>Results: </strong>Before the intervention, no significant difference was observed in the perceived stress variable between the intervention and control groups (p = 0.112), but after the intervention, a statistically significant difference was observed between the 2 groups (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>The effect of aromatherapy with lemon balm essential oil reduces perceived stress in infertile women undergoing IVF treatment.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 7","pages":"577-586"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of Spirulina platensis and phycocyanin on sperm quality, DNA integrity, and testicular tissue following oxidative stress in rats: An experimental study.","authors":"Katayoun Sedaghatizadeh Candidate, Farkhondeh Nemati, Maryam Gholamitabar Tabari, Fatemeh Peyravii Ghadikolaii, Roya Bishehkolaei","doi":"10.18502/ijrm.v23i7.19485","DOIUrl":"10.18502/ijrm.v23i7.19485","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress significantly contributes to male infertility. Spirulina contains phycocyanin (PC), a protein with significant biological effects, including strong antioxidant activity.</p><p><strong>Objective: </strong>This study investigates the protective effects of Spirulina platensis (Sp) and its active compound, PC, against oxidative damage in sperm and testicular tissue in rats.</p><p><strong>Materials and methods: </strong>This research was an experimental study. 36 male Wistar rats (7-8 wk, 180-220 gr) were randomized into 6 groups (n = 6/each): control, PC (500 mg/kg/day), Sp (300 mg/kg/day), hydrogen peroxide (HP; 0.5%), HP+PC, and HP+Sp. Treatments were given orally for 60 days. Sperm parameters (count, motility, viability) were assessed via Neubauer chamber, motility analysis, and eosin Y staining. Oxidative markers and histopathology were evaluated using colorimetric kits and hematoxylin and eosin staining. DNA fragmentation index (DFI) was measured via acridine orange.</p><p><strong>Results: </strong>HP reduced sperm count (40.2 vs. 55.2 million/mL; p = 0.001), motility (43.4% vs. 87.0%; p = 0.001), and increased DFI (18.5% vs. 4.0%; p = 0.001) versus control. Co-treatment with PC/Sp improved motility (HP-PC: 69.0%, HP-Sp: 61.9%; p = 0.001 vs. HP) and DFI (15.7%; p = 0.001 vs. HP). HP decreased superoxide dismutase and catalase and elevated malondialdehyde (p = 0.001). PC/Sp partially restored superoxide dismutase, reduced malondialdehyde (3.8-3.9 nmol/mL; p = 0.001 vs. HP). PC enhanced total antioxidant capacity (5.6 vs. 3.1 mmol; p = 0.001), while Sp lowered oxidative stress index (0.41 vs. 1.36; p = 0.001) versus HP.</p><p><strong>Conclusion: </strong>Sp and PC protect against oxidative sperm and testicular damage by enhancing antioxidant defenses and reducing oxidative stress. PC demonstrated superior effects on sperm quality, DNA integrity, and testicular histology, indicating its therapeutic potential in male infertility.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 7","pages":"559-568"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitudes toward sexual and reproductive health among youth in Jordan: A cross-sectional study.","authors":"Lina Almahmoud, Laith Altawil, Yazan Shahatit, Rawan Sami, Ayman Abdullah Qatawneh, Zaid Mohannad Alkhdaire, Rajai Zurikat, Akram Mohammad Karmoul, Abdallah Abuawad, Wasan Al-Dalabeeh, Mohammad Abu Khait, Morad Bani-Hani","doi":"10.18502/ijrm.v23i6.19402","DOIUrl":"10.18502/ijrm.v23i6.19402","url":null,"abstract":"<p><strong>Background: </strong>Adolescents constitute 16% of the world's population, among whom critical developmental changes influence their health. Risky sexual behaviors increase the likelihood of contracting sexually transmitted infections, with 40% of global new HIV cases occurring in individuals aged 15-25 yr.</p><p><strong>Objective: </strong>This study aims to assess sexual health attitudes among youth in Jordan.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted from January to April, 2024, involving 864 participants aged between 15 and 22. Data were collected through a validated online survey comprising 43 questions covering socio-demographic factors and knowledge/attitudes toward sexual education, masturbation, pornography, sexual behaviors, and menstruation.</p><p><strong>Results: </strong>Of the participants, 54% were females, 66.4% were university students, and 92.2% resided in urban areas. Most supported sexual education (72.1%) and its inclusion in schools (76.7%). Masturbation was recognized by 88.9%, and pornography had been viewed by 69.9%, with a strong association with male gender (p <math><mo><</mo></math> 0.001). Physical contact with partners was reported by 31.6% while 13.8% opposed it before marriage. Unwanted sexual touch was significantly more reported by females (p <math><mo><</mo></math> 0.001). Additionally, 75.7% would seek expert help for sexual issues. Only 66.7% of females learned about menstruation before its onset.</p><p><strong>Conclusion: </strong>Despite prevailing cultural conservatism, Jordanian youth show considerable openness and awareness regarding sexual health. These findings highlight the need for culturally sensitive, structured sexual education and open dialogue to promote adolescent reproductive well-being.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 6","pages":"493-506"},"PeriodicalIF":1.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 infection on placental histopathology and maternal-perinatal outcomes: A cross-sectional study.","authors":"Seyedeh Mahsa Poormoosavi, Mohammad Amin Behmanesh, Fatemeh Pourmotahari, Kosar Tavvalapour, Sima Janati","doi":"10.18502/ijrm.v23i6.19399","DOIUrl":"10.18502/ijrm.v23i6.19399","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) presents a broad spectrum of clinical outcomes and, unlike other coronaviruses, poses significant risks during pregnancy. A primary concern is the potential for vertical transmission from mother to fetus, affecting both maternal and fetal health.</p><p><strong>Objective: </strong>This study aimed to investigate the placental histopathology and maternal-perinatal outcomes in mothers infected with COVID-19.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 40 pregnant women referred to Ganjavian hospital, Dezful, Iran for delivery from June-October 2021 were enrolled in 2 groups: group I who were women with COVID-19 on the day of delivery (n = 30) and group II who were women without COVID-19 (n = 10). Placental tissue samples were collected post-delivery to assess histopathological changes and placental weight. Additionally, maternal and neonatal characteristics including maternal age, the number of prior deliveries and pregnancies, gestational age, 1- and 5-min Apgar scores, and maternal oxygen administration, mode of delivery, and neonatal COVID-19 test results, were compared between the groups.</p><p><strong>Results: </strong>No significant differences were found between the groups regarding maternal age, gestational age, parity, Apgar scores, placental weight, oxygen therapy, or delivery method. However, group I showed significantly higher rates of placental abnormalities such as intravillous fetal thrombosis (p = 0.002), fibrin deposition, lymphocytic infiltration, chorangiosis, edema, intervillous hemorrhage, syncytial node formation, distal villous hypoplasia, and avascular villi (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>According to our study, the placental tissue of pregnant women who have been infected with COVID-19 during their third trimester indicates tissue changes that can lead to poor exchanges between mother and fetus.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 6","pages":"485-492"},"PeriodicalIF":1.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sperm protamine1 and protamine2 transcript content with paternal age: A cross-sectional study.","authors":"Baharan Dolatshahi, Mehran Dorostghoal, Hamid Galehdari, Masoud Hemadi","doi":"10.18502/ijrm.v23i6.19404","DOIUrl":"10.18502/ijrm.v23i6.19404","url":null,"abstract":"<p><strong>Background: </strong>Over the last decade, there has been a significant increase in average paternal age.</p><p><strong>Objective: </strong>The present study investigated the effects of male age on sperm parameters, DNA fragmentation, andprotamine1 (<i>PRM1</i>) and protamine2(<i>PRM2</i>) transcript content in normozoospermic men.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 106 semen samples from normozoospermic men were obtained. The objects were divided into 3 age groups: 20-25, 30-35, and 40-45 yr. Sperm parameters and DNA fragmentation were assessed, and transcript levels of <i>PRM1</i> and <i>PRM2</i> were analyzed in ejaculated spermatozoa.</p><p><strong>Results: </strong>The highest levels of sperm concentration, motility, and normal morphology were observed in men aged between 20 and 25 yr. Significant declines were seen in sperm total motility (p = 0.006) and normal morphology (p = 0.015) after 40 yr compared to younger men. Significantly (p <math><mo><</mo></math> 0.001) higher levels of DNA damage were seen in 40-45-yr-old men. DNA fragmentation correlated significantly with sperm total motility (r = -0.242, p = 0.012) and normal morphology (r = -0.257, p = 0.008). The lowest levels of <i>PRM1</i> and <i>PRM2</i> transcripts were seen in 40-45-yr-old men. DNA damage was significantly associated with reduced transcript levelsof <i>PRM1</i> (r = -0.453, p = 0.018) and <i>PRM2</i> (r = -0.492, p = 0.009). Transcript levels of <i>PRM1</i> and <i>PRM2</i> in ejaculated spermatozoa were correlated significantly with the age of men.</p><p><strong>Conclusion: </strong>Our findings demonstrate age-related changes in sperm <i>PRM1</i> and <i>PRM2</i> transcript content and their correlations with sperm parameters and DNA fragmentation.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 6","pages":"507-516"},"PeriodicalIF":1.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of intraovarian injection of autologous platelet-rich plasma on outcome of in vitro fertilization in women with poor ovarian response: A systematic review.","authors":"Marzieh Zamaniyan, Sepideh Peivandi, Maryam Pashazadeh, Farnaz Safarloo","doi":"10.18502/ijrm.v23i6.19397","DOIUrl":"10.18502/ijrm.v23i6.19397","url":null,"abstract":"<p><strong>Background: </strong>The beneficial and long-term effects of ovarian platelet-rich plasma (PRP) in assisted reproductive technology cycles are still debatable.</p><p><strong>Objective: </strong>The aim of the current study is to determine the effect of ovarian PRP on the outcome of in vitro fertilization in women with poor ovarian response.</p><p><strong>Materials and methods: </strong>This is a systematic review conducted to address the research question through a structured search process. We searched databases including PubMed, ScienceDirect, Scopus, Web of Science, Embase, Cochrane, and Google Scholar search engine using keywords such as \"clinical pregnancy\", \"live birth\", \"miscarriage\", \"poor ovarian response\", \"platelet-rich plasma\", and \"in vitro fertilization\". The search was conducted without a time limit until December 20, 2024. After screening the titles, abstracts, and full texts of 6646 studies, 14 studies were ultimately selected for inclusion in the review.</p><p><strong>Results: </strong>In 3 studies, no significant effect was observed on abortion rates, but in 1 study, no abortions were reported in the intervention group, raising concerns about the possible role of this procedure. In 5 studies, PRP significantly increased pregnancy success with in vitro fertilization. In contrast, 6 studies found this effect to be non-significant, and 2 reported inconclusive results. In terms of live birth, 5 studies showed a positive effect of PRP, but 3 studies reported non-significant results, and 2 studies reported inconclusive results. One study showed an increase in ongoing pregnancy rates in the PRP group, and 2 studies showed an increase in implantation.</p><p><strong>Conclusion: </strong>The effectiveness of ovarian PRP in infertility treatment remains unclear due to conflicting results.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 6","pages":"459-474"},"PeriodicalIF":1.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}