International Journal of Reproductive Biomedicine最新文献

{"title":"Pregnancy and neonatal outcomes of intracytoplasmic sperm injection versus in vitro fertilization in fresh cycles of women with advanced maternal age and nonmale factor infertility: A cross-sectional study.","authors":"Sajad Zare Garizi, Nazanin Sabagh Nezhad Yazd, Nasim Tabibnejad, Razieh Dehghani-Firouzabadi","doi":"10.18502/ijrm.v23i1.18190","DOIUrl":"10.18502/ijrm.v23i1.18190","url":null,"abstract":"<p><strong>Background: </strong>Intracytoplasmic sperm injection (ICSI) was originally developed to facilitate fertilization in situations of severe male infertility. However, it is now frequently used for nonmale factor infertility, such as advanced maternal age or low oocyte count, despite the clinical advantages of this method has not been proven for these situations.</p><p><strong>Objective: </strong>This study aims to compare pregnancy and neonatal outcomes between ICSI and in vitro fertilization (IVF) cycles in women with advanced maternal age and nonmale factor infertility.</p><p><strong>Materials and methods: </strong>This retrospective cross-sectional study included 1090 women with nonmale factor infertility, who underwent fresh embryo transfer cycles of IVF or ICSI at the Yazd Reproductive Sciences Institute, Yazd, Iran between April 2018 and June 2023. Data on demographic characteristics, clinical outcomes, and neonatal outcomes were analyzed from electronic medical records.</p><p><strong>Results: </strong>Women undergoing IVF demonstrated significantly higher outcomes in fertilization, implantation, and chemical pregnancy rate (p <math><mo><</mo></math> 0.05). Neonatal outcomes showed significantly higher twin birth weights and lower prematurity rates in the IVF group compared to the ICSI group (p <math><mo><</mo></math> 0.001 and p = 0.011, respectively).</p><p><strong>Conclusion: </strong>This study suggests that IVF may yield better maternal outcomes and more favorable neonatal results than ICSI for older women with nonmale factor infertility. These results emphasize the significance of tailored treatment plans and the necessity for continued research to enhance assisted reproductive technologies techniques.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"45-54"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of maternal dietary patterns in early pregnancy with gestational weight gain: Yazd Birth Cohort.","authors":"Shahab-Aldin Akbarian, Amin Salehi-Abargouei, Sara Jambarsang, Habib Nikukar, Ph D, Azadeh Nadjarzadeh","doi":"10.18502/ijrm.v23i1.18189","DOIUrl":"10.18502/ijrm.v23i1.18189","url":null,"abstract":"<p><strong>Background: </strong>Abnormal gestational weight gain (GWG) can carry risks for both the mother and the baby. Diet imbalances are the determining factor in the weight gain of pregnant women.</p><p><strong>Objective: </strong>This study aimed to assess the relationship between nutritional patterns and the weight of pregnant mothers living in Yazd, Iran from 2021-2022.</p><p><strong>Materials and methods: </strong>In this cohort study, data from 1497 pregnant women aged 18-45 yr with singleton pregnancy who completed the food frequency questionnaire in the Yazd Birth Cohort Study were extracted. This data included demographic variables, GWG (difference between initial weight at 13-15 wk and 1 wk before the expected delivery date), and food intake information before the 13 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> wk of pregnancy. The women were categorized into 3 groups based on GWG: inadequate, normal, and excessive. Dietary patterns were extracted from the food frequency questionnaire using principal component analysis, and multinomial logistic regression was used to evaluate the relationship between dietary patterns and GWG categories.</p><p><strong>Results: </strong>According to the frequency of food consumption, 3 dietary patterns were obtained: the traditional pattern (cabbage vegetables, fruits, and dried fruits), the unhealthy pattern (processed meats and sweetened drinks), and the vegetable/fruit/olive pattern. The analysis results showed that pregnant women who followed the fruit/vegetable/olive pattern had a lower chance of insufficient weight gain during pregnancy (OR: 0.66, 95% CI: 0.45-0.98).</p><p><strong>Conclusion: </strong>Consuming various fruits and vegetables can help regulate GWG in the population of pregnant women lived in Yazd, Iran. Diet can be considered one of the most effective and safe interventions.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"67-78"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulus cells conditioned medium facilitates germ cell differentiation from human embryonic stem cells: An experimental study.","authors":"Somayyeh Sadat Tahajjodi, Ehsan Farashahi Yazd, Azam Agharahimi, Fatemeh Akyash, Fatemeh Hajizadeh-Tafti, Jalal Golzadeh, Reza Aflatoonian, Behrouz Aflatoonian","doi":"10.18502/ijrm.v23i1.18186","DOIUrl":"10.18502/ijrm.v23i1.18186","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown thatembryonic stem cells can differentiate into germ cells either spontaneously or directed by the defined factors or by applying a co-culture method or conditioned medium of stromal cells.</p><p><strong>Objective: </strong>Here, Yazd4 (human embryonic stem cells [hESC] line; 46, XX) was used to evaluate the effect of human cumulus cells conditioned medium (CCCM) on <i>in vitro</i> germ cell production and development.</p><p><strong>Materials and methods: </strong>In this experimental study 2 different complete media were applied, Dulbecco's modified eagle's medium + 20% fetal bovin serum and embryoid body (EB) medium (KnockOut serum replacement- hESC without basal fibroblast growth factor). Thus, there are 2 control groups for spontaneous differentiation (SD) (SD-EB and SD-DM) and 2 types of CCCM (CCCM-DM and CCCM-EB) as test groups. 40% dilution of the conditioned medium was applied according to previous reports.</p><p><strong>Results: </strong>Reverse transcription-quantitative polymerase chain reaction and immunofluorescent staining assays revealed that between groups with similar complete medium, CCCM provides a better condition for <i>in vitro</i> germ cell differentiation from hESCs. Moreover, a comparison between the 2 types of complete media showed that EB medium is more supportive than Dulbecco's modified eagle's medium +20% fetal bovin serum.</p><p><strong>Conclusion: </strong>CCCM with EB medium as a complete medium provides a better condition for <i>in vitro</i> germ cell differentiation from hESCs.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"33-44"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The restorative effect of platelet-rich plasma on estrous cycle disruption induced by arcuate nucleus lesion in female Wistar rats: An experimental study.","authors":"Elham Abbasi, Morteza Behnam Rassouli, Ali Moghimi, Zeinab Neshati","doi":"10.18502/ijrm.v23i1.18185","DOIUrl":"10.18502/ijrm.v23i1.18185","url":null,"abstract":"<p><strong>Background: </strong>Successful reproduction relies on a functioning hypothalamic-pituitary-gonad axis. Damage to this axis disrupts the estrus cycle and reproductive capability.</p><p><strong>Objective: </strong>This study aimed to evaluate the effects of single or multiple platelet-rich plasma (PRP) injections on repairing the damaged hypothalamic arcuate nucleus (ARC) and restoring the estrus cycle in Wistar rats.</p><p><strong>Materials and methods: </strong>90 female Wistar rats (2-3 months old, 250-280 gr) with regular estrous cycles were divided into a control group and 8 experimental groups (n = 10/each). After bilateral stereotaxic chemical surgery of the ARC using quinolinic acid (500 nmol/2 <math><mi>μ</mi></math> l), the experimental rats were categorized into several treatment regimens: ARC <math> <msup><mrow><mi> </mi></mrow> <mo>-</mo></msup> </math> (no treatment), 1 PRP injection (immediately, 24 hr, 48 hr, and 72 hr postsurgery), 2 PRP injections (immediately, 24 hr), 3 PRP injections (immediately, 24 hr, and 48 hr), and 4 PRP injections (immediately, 24 hr, 48 hr, and 72 hr). Vaginal smear cytology was performed daily for 2.5 months. In the end, rats brains were removed and divided for real-time polymerase chain reaction analysis of kisspeptin, neurokinin B, and dynorphin, as well as for ARC cell counting.</p><p><strong>Results: </strong>Vaginal smear cytology indicated that PRP administration gradually restored the estrous cycle. Compared to the ARC <math> <msup><mrow><mi> </mi></mrow> <mo>-</mo></msup> </math> group, PRP treatment significantly increased ARC cell density (p = 0.012) and mRNA levels of kisspeptin, neurokinin B, and dynorphin (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>These findings not only emphasized the importance of the ARC for the regularity of estrous cycle but also showed the potential effects of local PRP treatment in contribution to the protection/reconstruction of ARC.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"55-66"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interlinkage between inflammation, oxidative stress, and endoplasmic reticulum stress in bisphenols-induced testicular steroidogenesis disturbance: A mini review.","authors":"Nur Erysha Sabrina Jefferi, Asma Afifah Shamhari, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib","doi":"10.18502/ijrm.v23i1.18187","DOIUrl":"10.18502/ijrm.v23i1.18187","url":null,"abstract":"<p><p>Bisphenols (BP) are endocrine-disrupting chemicals that cause adverse health effects, including testicular steroidogenesis disturbance. Cyclo-oxygenase-2 and nuclear factor erythroid 2-related factor 2 are the target molecules involved in testicular steroidogenesis disturbance via inflammation and oxidative stress (OS), respectively. Interestingly, endoplasmic reticulum (ER) stress was found to be involved in various pathological conditions. However, the mechanisms involved in BP-induced testicular steroidogenesis disturbance remain unclear. Therefore, this research investigates the key mechanisms underlying BP-induced testicular steroidogenesis disturbances. We focus on 3 critical pathways: inflammation, OS, and ER stress. Our findings demonstrate that BP exposure triggers inflammatory responses by targeting the cyclo-oxygenase-2 molecules that impair Leydig cell function. Concurrently, we observed that BP-increased OS via inhibition of nuclear factor erythroid 2-related factor 2, further disrupting steroidogenic enzyme activity. Additionally, ER stress is activated in response to BP exposure, leading to impaired protein synthesis and exacerbating steroidogenic dysfunction. This review elucidates the interlinkage between inflammation, OS, and ER stress in BP-induced testicular steroidogenesis disturbance in which reactive oxygen species is proposed to be the main culprit in linking these 3 mechanisms. These insights provide a crucial foundation for understanding the reproductive toxicology of BPs and inform future strategies for mitigating their effects on male reproductive health.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"17-32"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of fennel essential oil and manganese in modulating steroidal hormonal imbalance and ovarian alterations in rats with polycystic ovarian syndrome: An experimental study.","authors":"Ensiyeh Mohebbi Kian, Maryam Barancheshmeh, Hossein Najafzadehvarzi, Seyedeh Masoumeh Ghoreishi, Naser Shokrzadeh","doi":"10.18502/ijrm.v23i1.18201","DOIUrl":"10.18502/ijrm.v23i1.18201","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovarian syndrome (PCOS) is a prevalent hormonal disorder among women of reproductive age, resulting in female infertility. Researchers are exploring safe and affordable treatments for this disorder.</p><p><strong>Objective: </strong>This study explored the therapeutic effects of fennel essential oil (FEO) and manganese (Mn) on hormonal and histological markers in rats with estradiol valerate-induced PCOS.</p><p><strong>Materials and methods: </strong>In this experimental study, 35 adult female Wistar rats (9 wk old, 200-250 gr) were divided into 7 groups. For 14 days, groups 1-4 received normal saline intraperitoneally, sesame oil intramuscularly, FEO intraperitoneally, and Mn orally, respectively. PCOS was induced in remaining groups through a single intramuscular injection of estradiol valerate. 60 days after induction, the 6^th and 7^th groups were treated individually with intraperitoneal FEO and oral Mn for 14 days. Blood samples were analyzed for estrogen, progesterone, and malondialdehyde (MDA) markers. The ovarian tissues were histologically examined to assess cyst formation and structural changes.</p><p><strong>Results: </strong>FEO significantly increased estrogen and progesterone levels in PCOS rats compared to the PCOS group (p <math><mo>≤</mo></math> 0.05). Mn also elevated progesterone levels, but the change was not statistically significant (p <math><mo>></mo></math> 0.05). No significant differences in MDA levels were observed between the PCOS and PCOS+FEO groups. Although MDA levels decreased in the PCOS+Mn group, the reduction was not statistically significant (p <math><mo>></mo></math> 0.05). Both FEO and Mn treatments significantly reduced ovarian cyst numbers compared to untreated PCOS rats (p <math><mo>≤</mo></math> 0.05).</p><p><strong>Conclusion: </strong>FEO and Mn demonstrated potential in restoring hormonal balance and improving ovarian histology, offering promise as low-cost treatments for PCOS.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"79-90"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioprotective effect of omeprazole against testicular damage induced by ionizing radiation in mice: An experimental study.","authors":"Ali Nabi, Azam Hassanpour Dehnavi, Fahime Mazaheri, Nastaran Momeni, Habib Nikukar, Mahdie Hemati, Seyed Jalal Hosseinimehr, Masoud Shabani, Fatemeh Sadeghian-Nodoushan, Javad Biabani-Ardakani","doi":"10.18502/ijrm.v23i1.18202","DOIUrl":"10.18502/ijrm.v23i1.18202","url":null,"abstract":"<p><strong>Background: </strong>Radiation-induced normal tissue damage remains a major concern in radiotherapy, particularly affecting rapidly dividing cells, including those in reproductive tissues. Developing effective radioprotective agents to mitigate this damage is crucial for preserving fertility.</p><p><strong>Objective: </strong>The radioprotective effects of omeprazole (OMP) were investigated in adult male mice undergoing external radiation.</p><p><strong>Materials and methods: </strong>In this experimental study, 36 adult male mice (30-35 gr, 6-8 wk old) were divided into 6 groups and orally administered OMP daily via oral gavage for 7 days before whole-body irradiation. On the 8^th day, mice were subjected to a single 6 Gray dose of 6 megavoltage X-ray radiation. Blood samples were collected via cardiac puncture for testosterone level evaluation, while testicular specimens were harvested post-euthanasia for sperm parameters assessment and histological analysis. Additionally, spermatogenic cell density was evaluated.</p><p><strong>Results: </strong>Irradiation of 6 Gray X-ray to the testis of mice significantly affected sperm count, progressive motility, DNA fragmentation, the number of sperm with normal morphology, and the number of immotile sperm. Furthermore, administration of OMP improved progressive motility, DNA fragmentation, and sperm viability. Histopathological findings showed irradiation led to severe testicular atrophy with spermatogenic arrest and abnormal cytoarchitecture vacuolation and interstitial edema, while OMP treatment reversed relative radiation toxicity, especially in the 50 mg OMP treatment group.</p><p><strong>Conclusion: </strong>In conclusion, OMP could act as an effective radioprotector against testicular damage following X-ray irradiation in an animal model. Further studies are needed to investigate OMP potential in protecting human testis tissue.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"91-102"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of diet and food supplements in infertility management in the Eastern Mediterranean Region: A narrative review.","authors":"Kassandra Said Fares, Georges Hani Abi Tayeh, Emile Roger Whaibeh, Romy Jihad Louis, Lina Yasser Jaalouk, Yara Matar Matar, Myriam Andraos Mrad","doi":"10.18502/ijrm.v23i1.18188","DOIUrl":"10.18502/ijrm.v23i1.18188","url":null,"abstract":"<p><p>According to the World Health Organization, 17.5% of the population suffers from infertility. This demonstrates the critical need to expand access to high-quality reproductive care and increase our understanding of the factors that contribute to this issue. This review aims to summarize findings and gaps in the literature regarding diet-related factors and infertility among the Eastern Mediterranean couples poorly studied compared to other populations. The literature search was conducted using PubMed and Scopus databases from January 2012-July 2023. In total, 112 papers described the influence of diet and supplementation on natural and artificial reproductive outcomes in the Eastern Mediterranean Region and were found eligible for the review synthesis. For men, a diet rich in red meat, fatty foods, whole grains, and low in fish, poultry, low-fat dairy products, and vegetables have a positive effect on sperm count. For women, maintaining a healthy weight is crucial for their fertility. Overall, various vitamins and supplements significantly enhance gametes quality, hormonal balance, and antioxidant capacity, despite the results not being consistent across all studies. The findings highlight distinct dietary patterns that mitigate or exacerbate infertility risks, considering macro and micronutrients. Studies unevenly describe potential risk factors, underscoring the need for further exploration across diverse populations.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"1-16"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An online intervention relationship enhancement couple therapy program versus systematic desensitization on sexual performance anxiety in women undergoing infertility treatment with timed intercourse: An RCT.","authors":"Maryam Afzal Dehkordi, Tahmineh Farajkhoda, Mahdi Khanabadi, Farimah Shamsi","doi":"10.18502/ijrm.v22i12.18062","DOIUrl":"10.18502/ijrm.v22i12.18062","url":null,"abstract":"<p><strong>Background: </strong>Sexual performance anxiety is common among infertility treatments. Psychological interventions are options for couples who do not tolerate psychiatric medications or like psychotherapy with pharmacotherapy.</p><p><strong>Objective: </strong>This study aimed to compare the effectiveness of relationship enhancement couple therapy program (RECT) vs. systematic desensitization (SD) on sexual anxiety.</p><p><strong>Materials and methods: </strong>A parallel randomized clinical trial was conducted on 68 women with infertility in Shahrekord, Iran, in January 2022. They were randomly allocated to 8 weekly online interventions RECT or SD (control). The main outcome variable, sexual performance anxiety, was assessed via Davis's questionnaire at baseline, completion of the intervention (week 8), and follow-up (week 12). The secondary outcome variable spouse's satisfaction was assessed (weeks 8 and 12, via visual analog scale). Data from 29 women were analyzed in each group.</p><p><strong>Results: </strong>Intra-group comparison RECT and SD showed a significant decrease of sexual anxiety baseline compared to week 12 (p = 0.001, 0.001 for RECT and SD, respectively). No significant difference was observed between the 2 groups in baseline compared to week 12 (RECT vs. SD, p = 0.149). Time-group interaction of spouse's satisfaction showed a significant difference between RECT and SD (p = 0.010).</p><p><strong>Conclusion: </strong>Both RECT and SD were almost equally effective in decreasing sexual anxiety. RECT (couple relationship-centered) by empowering 10 interpersonal skills, and SD (personal-oriented) by learning step-by-step how fight-or-flight response is replaced by relaxation response, helping women perform more adaptive behaviors regarding sexual anxiety. RECT increased spouse satisfaction significantly compared to SD, indicating that males need to participate in positive relationship changes. The results may be applied by therapists and health policymakers.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 12","pages":"963-974"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing sexual dysfunction in cosmetic rhinoplasty candidates and normal population among married women in Shiraz, Iran: A case-control study.","authors":"Ali Sahraian, Masoud Janipour, Atoosa Ebrahimi, Zohre Zareizadeh, Pardis Habibi, Amirhossein Babaei","doi":"10.18502/ijrm.v22i12.18064","DOIUrl":"10.18502/ijrm.v22i12.18064","url":null,"abstract":"<p><strong>Background: </strong>Disturbed self-esteem and self-image can be found in body dysmorphic individuals, and sexual dysfunction is also more frequent among these individuals. Body image concerns may also contribute to the tendency to undergo cosmetic procedures, including rhinoplasty.</p><p><strong>Objective: </strong>This study aimed to compare sexual dysfunction in married women who were candidates for cosmetic rhinoplasty to a control group.</p><p><strong>Materials and methods: </strong>This case-control study was conducted among 342 married women in Shiraz, Iran, from December 2021-2022. The case group included 192 cosmetic rhinoplasty candidates, and the control group comprised 150 women who were not candidates for cosmetic procedures; they were selected from the ear, nose, and throat outpatient department. Data on demographic features, psycho-social history, and quality of marital life were collected by face-to-face interviews. To evaluate their sexual performance, the participants filled out the female sexual function index questionnaire.</p><p><strong>Results: </strong>No significant difference was observed between rhinoplasty subjects and the control group in the female sexual function index (23.63 <math><mo>±</mo></math> 3.6 vs. 23.19 <math><mo>±</mo></math> 4.28, p = 0.43). The prevalence of sexual dysfunction among cosmetic rhinoplasty candidates and the control group was 75% and 76%, respectively (p = 0.60). No significant difference was observed in the sexual dysfunction domains between the groups.</p><p><strong>Conclusion: </strong>Our study indicated a significant sexual dysfunction among the studied population, but the difference was not statistically significant between the rhinoplasty and the control group.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 12","pages":"985-994"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}