International Journal of Reproductive Biomedicine最新文献

{"title":"Correction to \"Insulin-like growth factor-1 on cycle day 2 and assisted reproductive techniques outcome: A cross-sectional study\" [Int J Reprod BioMed 2023; 21: 139-146].","authors":"Fariba Abbasi, Robab Davar, Farimah Shamsi, Saeideh Dashti","doi":"10.18502/ijrm.v22i8.17131","DOIUrl":"https://doi.org/10.18502/ijrm.v22i8.17131","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.18502/ijrm.v21i2.12804.].</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"681"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Role of genetic variations and protein expression of β-Microsemino protein in intrauterine insemination outcome of unexplained infertile men: A case-control study\" [Int J Reprod BioMed 2024; 22: 481-494].","authors":"Elham Bagherian, Sahar Jokari, Parnaz Borjian Boroujeni, Kaveh Haratian, Marjan Sabbaghian, Anahita Mohseni Meybodi","doi":"10.18502/ijrm.v22i8.17185","DOIUrl":"https://doi.org/10.18502/ijrm.v22i8.17185","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.18502/ijrm.v22i6.16799.].</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"682"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possible regulatory role of miR-4463 and its target gene <i>CYP19A1</i> on the ovarian response in the women with diminished ovarian reserve: A case-control study.","authors":"Azam Yazdanian, Marzieh Lotfi, Fateme Montazeri, Saeideh Dashti, Mohammad Hasan Sheikhha","doi":"10.18502/ijrm.v22i8.17237","DOIUrl":"10.18502/ijrm.v22i8.17237","url":null,"abstract":"<p><strong>Background: </strong>Diminished ovarian reserve (DOR) is a condition that affects fertility by reducing the reproductive potential of the ovary. The altered expression profile of cumulus cells (CCs) can negatively affect the quality and quantity of oocytes in the ovaries. Recent studies suggest that circulating miRNAs play a significant role in the ovary function, and their serum expression changes can be valuable biomarkers for predicting ovarian function.</p><p><strong>Objective: </strong>Investigating the expression levels of circulating miRNA-4463 and its target cytochrome P450 19A1 gene (<i>CYP19A1</i>) in DOR-CCs in order to find a molecular pathway involved in DOR.</p><p><strong>Materials and methods: </strong>In this case-control study, a total of 20 DOR-women and 20 women with normal ovarian reservation aged between 20-34 yr referred to Yazd Reproductive Science Institute, Yazd, Iran were included in the study. Serum and CCs were collected, and real time-polymerase chain reaction was performed to investigate the expression level of miR-4463<i>,</i> and its target gene <i>CYP19A1</i>.</p><p><strong>Results: </strong>Our results showed an inverse relationship between miR-4463 and <i>CYP19A1</i> expression levels. Therefore, the increase in the expression of miR-4463 was significantly evident in DOR-women compared to the control group (p = 0.0019), while the expression of its target gene, <i>CYP19A1,</i> has significantly decreased in these women (p = 0.001).</p><p><strong>Conclusion: </strong>The present study suggests that miR-4463 and <i>CYP19A1</i> pathways could regulate ovary function. Therefore, examination of this miRNA could be a promising parameter for predicting ovarian reserve and their response to stimulation protocols.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"639-650"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected early pregnancy during myomectomy followed by successful term delivery: A case report.","authors":"Nasrin Saharkhiz, Mitra Nemati, Nazanin Hajizadeh, Hajar Abbasi","doi":"10.18502/ijrm.v22i8.17242","DOIUrl":"10.18502/ijrm.v22i8.17242","url":null,"abstract":"<p><strong>Background: </strong>Leiomyoma, also known as uterine fibroid, is a non-malignant tumor originating from the uterus's smooth muscles. It is the most common benign tumor in the female genital tract, exhibiting varying size and form that can distort the uterus's shape. Uterine fibroids affect 2.7-10.7% of pregnant women and can lead to increased risks during pregnancy, such as miscarriage, placental abruption, preterm labor, and fetal malpresentation. Myomectomy is a surgical intervention for uterine fibroids, but it has drawbacks, including hemorrhage, fever, infection, ureter ligation, adhesive disorders, and unplanned hysterectomy.</p><p><strong>Case presentation: </strong>In this case report, we present a 32-yr-old woman with a large leiomyoma who underwent laparotomy myomectomy due to abdominal pain and heavy menstrual bleeding. 4 wk after the myomectomy, she was referred to the Obstetric Clinic of Ayatollah Taleghani hospital, Tehran, Iran complaining of delayed menstruation. Her beta-human chorionic gonadotropin test was positive. Ultrasound revealed a fetus with an estimated gestational age of 6 wk and 4 days. The pregnancy continued with no complications. At 38 wk of gestation, she underwent a cesarean section and delivered a healthy newborn.</p><p><strong>Conclusion: </strong>This case report supports previous publications that have demonstrated the safety of myomectomy during pregnancy.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"673-678"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association among cancer-antigen-125 and pre-eclampsia and estimated fetal weight: A case-control study.","authors":"Hamideh Gholami, Lida Garrosi, Shabnam Tofighi, Zahra Ghadimi","doi":"10.18502/ijrm.v22i8.17238","DOIUrl":"10.18502/ijrm.v22i8.17238","url":null,"abstract":"<p><strong>Background: </strong>Although an optimal screening model is still under investigation, pre-eclampsia is a leading cause of perinatal morbidity. The association between cancer-antigen-125 (CA-125) and pre-eclampsia has been discussed in several studies recently.</p><p><strong>Objective: </strong>We aimed to determine the association between CA-125 and preeclampsia and estimated fetal weight.</p><p><strong>Materials and methods: </strong>This case-control study was performed on 30 pregnant women with pre-eclampsia who were homogenized in terms of age, body mass index, and gestational age with 30 normal pregnant women. Participants were recruited via convenience sampling. The level of CA-125 in blood at the time of termination of pregnancy was measured by Enzyme Linked Immunosorbent Assay. The urine sample was used to check proteinuria. Blood pressure and pregnancy outcomes were assessed and recorded.</p><p><strong>Results: </strong>The mean serum CA-125 level in study group was considerably higher than control group (p <math><mo><</mo></math> 0.001). Elevating the level of CA-125 has increased the likelihood of pre-eclampsia by 1.5 times. A significant direct correlation was obtained between CA-125 level and the amount of urinary protein (r = 0.605, p <math><mo><</mo></math> 0.001). Also, a significant but negative correlation was obtained between the CA-125 level and the estimated weight of the fetus (r = -0.593, p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>Increasing the serum level of CA-125 with high sensitivity and specificity is significantly associated with the occurrence of pre-eclampsia and estimated fetal weight.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"651-660"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of L-carnitine in reactive oxygen species reduction and apoptotic gene expression in mice after cyclophosphamide: An experimental study.","authors":"Majid Almasi, Golnaz Shafiei, Hossein Nikzad, Mohammad Karimian, Ghazaleh Moshkdanian","doi":"10.18502/ijrm.v22i8.17262","DOIUrl":"10.18502/ijrm.v22i8.17262","url":null,"abstract":"<p><strong>Background: </strong>Cyclophosphamide (CP), a utilized anticancer drug, is known to cause infertility in women. However, L-carnitine (LC), an antioxidant, has been shown to offer protective benefits against infertility.</p><p><strong>Objective: </strong>This study aimed to evaluate the levels of reactive oxygen species (ROS) and apoptotic gene expression in mice treated with CP and LC.</p><p><strong>Materials and methods: </strong>24 NMRI female mice (6-8 wk, 30 <math><mo>±</mo></math> 5 gr) were divided into 4 groups: control group: received normal saline intraperitoneal (IP) injection for 10 days; CP group: received 75 mg/kg of CP as a single IP on the 10 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> day of the experiment; LC group: received 200 mg/kg of LC IP for 10 days; LC+CP group: received LC for 10 days and CP single IP injection on the 10 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> day of the experiment. After 10 days, mice were superovulated. The oviducts were then removed, and the oocytes of each group were collected for evaluating apoptotic gene expression B-cell lymphoma 2(<i>Bcl2</i>), <i>Bcl2</i>-associated X(<i>Bax</i>), and <i>Caspase3</i> via real-time polymerase chain reaction and intracellular ROS levels by dichloro-dihydro-fluorescein diacetate fluorescence staining.</p><p><strong>Results: </strong>Data revealed that LC in the LC+CP group significantly increased <i>Bcl2</i> gene expression (p = 0.01), and decreased <i>Bax</i> and <i>Caspase3</i> gene expression compared to the CP group (p = 0.03, p = 0.04). LC decreased the ROS level in the LC+CP group compared to the CP group (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>Findings suggest that LC can scavenge the ROS caused by CP and modulate the apoptotic pathway via downregulating the <i>Bax</i> and <i>Caspase3</i> genes and upregulating the <i>Bcl2</i> gene in oocytes of mice exposed to CP.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"661-672"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fixed versus flexible gonadotropin releasing hormone antagonist protocol in women with polycystic ovary syndrome undergoing in vitro fertilization: An RCT.","authors":"Hanieh Fatehi, Robab Davar, Elham Nikfarjam, Fatemeh Bayati","doi":"10.18502/ijrm.v22i8.17230","DOIUrl":"10.18502/ijrm.v22i8.17230","url":null,"abstract":"<p><strong>Background: </strong>Despite the extensive use of the gonadotropin-releasing hormone (GnRH) antagonist protocol in treating infertile women, particularly those with polycystic ovary syndrome (PCOS), there have not been sufficient evidence to compare the flexible and fixed variants in in vitro fertilization (IVF) cycles.</p><p><strong>Objective: </strong>This study aims to assess the treatment outcomes of flexible and fixed types of GnRH-antagonist protocol for IVF in women with PCOS.</p><p><strong>Materials and methods: </strong>In this randomized clinical trial, 150 infertile women with PCOS, who were candidates for IVF, and referred to the Yazd Research and Clinical Center for Infertility, Yazd, Iran between October 2023 and February 2024 were included. Participants were divided into 2 groups (n = 75/each) based on the type of antagonist protocol (fixed or flexible). GnRH antagonist administration started on the 5 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> day of gonadotropin treatment in the fixed group. In the flexible group when there was at least one follicle 12-14 mm, GnRH antagonist was started. Finally, the number of metaphase II oocyte, the quality of embryos, the duration of the stimulation cycle, the dose of gonadotropin, the number of GnRH-antagonist, and the rate of ovarian hyperstimulation syndrome were evaluated.</p><p><strong>Results: </strong>No statistically significant difference was observed in terms of cycle length and the total dose of gonadotropin between groups. Nevertheless, a notable distinction was observed in the total number of oocytes (17.84 vs. 15.5, p = 0.023) and mature oocytes (13.64 vs. 11.83, p = 0.019) in the flexible group compared to the fixed group.</p><p><strong>Conclusion: </strong>In conclusion, the IVF outcomes are more favorable in women with PCOS undergoing the flexible GnRH-antagonist protocol compared to the fixed protocol.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"617-626"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<ArticleTitle xmlns:ns0=\"http://www.w3.org/1998/Math/MathML\">Aspirin before the 11 <ns0:math> <ns0:msup><ns0:mrow><ns0:mi> </ns0:mi></ns0:mrow> <ns0:mtext>th</ns0:mtext></ns0:msup> </ns0:math> week of pregnancy to prevent pre-eclampsia.","authors":"Marie-Laurence Côté, Brielle Demuth, Louise Ghesquière, Emmanuel Bujold","doi":"10.18502/ijrm.v22i8.17245","DOIUrl":"10.18502/ijrm.v22i8.17245","url":null,"abstract":"","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"679-680"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon monoxide refines ovarian structure changes and attenuates oxidative stress via modulating of heme oxygenase system in a rat model of polycystic ovary syndrome: An experimental study.","authors":"Bahareh Asadi, Kamran Rakhshan, Mina Ranjbaran, Arash Abdi, Maryam Vaziripour, Behjat Seifi","doi":"10.18502/ijrm.v22i8.17231","DOIUrl":"10.18502/ijrm.v22i8.17231","url":null,"abstract":"<p><strong>Background: </strong>Carbon monoxide (CO), influences ovarian function, pregnancy, and placental health. Heme oxygenase (HO)-1 and its products, including CO, exhibit protective and anti-inflammatory properties.</p><p><strong>Objective: </strong>This study investigates the protective effects of CO released by the carbon dioxide-releasing molecule (CORM)-2 against oxidative stress, functional and structural changes of the ovaries, and HO-1 expressions in female rats suffering from polycystic ovary syndrome (PCOS).</p><p><strong>Materials and methods: </strong>In this experimental study, 24 <i>Rattus norvegicus var. Albinus</i> female rats (180-200 gr, 8 wk) were randomly divided into 4 groups (n = 6/each): control, CORM-2 (10 mg/kg), PCOS (induced by 4 mg/kg, intramuscular injection and a single dose of estradiol valerate), PCOS + CORM-2. Ovary histological changes were evaluated by crystal violet staining. Malondialdehyde (MDA) level and superoxide dismutase (SOD) activity of ovarian tissue were assessed using enzyme-linked immunosorbent assay. HO-1 expression was evaluated using Western blot.</p><p><strong>Results: </strong>Corpus luteal formation significantly decreased in the PCOS group and was significantly restored with CORM-2 administration compared to the control group (p <math><mo><</mo></math> 0.05). The expression of ovarian HO-1 protein was reduced in the PCOS group compared to controls (p <math><mo><</mo></math> 0.01), and administration of CORM in PCOS rats significantly increased its expression (p <math><mo><</mo></math> 0.0001). In addition, CORM administration markedly reduced ovarian MDA levels and restored SOD activity (p <math><mo><</mo></math> 0.0001).</p><p><strong>Conclusion: </strong>CORM-2 administration to PCOS rats created protective effects by reducing oxidative stress (reducing MDA level and restoring SOD activity) and increasing ovarian HO-1 protein.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 8","pages":"627-638"},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combination of melatonin and L-carnitine on in vitro maturation in mouse oocytes: An experimental study.","authors":"Raziye Chegini, Morteza Sadeghi, Sadegh Shirian, Fatemeh Sabbaghziarani, Ehsan Aali, Pouriya Soleimani, Mohammad Reza Ashtari Majelan, Fariba Zafari, Shahram Darabi","doi":"10.18502/ijrm.v22i7.16961","DOIUrl":"10.18502/ijrm.v22i7.16961","url":null,"abstract":"<p><strong>Background: </strong>Melatonin and L-carnitine are free radical scavengers with antiapoptotic and antioxidant properties that improve oocyte development.</p><p><strong>Objective: </strong>This study aimed to find the possible effect of combining 2 antioxidant agents of melatonin and L-carnitine on oocyte morphology, maturation, apoptosis, and expression of bone morphogenetic protein 15 (<i>BMP-15</i>) and growth differentiation factor 9 (<i>GDF-9</i>) genes in a mice model.</p><p><strong>Materials and methods: </strong>To overstimulation, 60 female NMRI mice were injected intraperitoneally using mare serum gonadotropin. On day 2 post-injection, 70 cumulus-oocyte complexes were collected from each mouse. The collected oocytes randomly were then divided into 4 groups including, the control, melatonin, L-carnitine, and melatonin + L-carnitine groups. The morphology and maturation rate of the oocytes was evaluated using a light microscope. Apoptosis was identified by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay and the expression of <i>BMP-15</i> and growth and differentiation factor <i>GDF-9</i> genes was also evaluated by real-time polymerase chain reaction.</p><p><strong>Results: </strong>Oocyte diameter significantly was increased in combination treatment of L-carnitine and melatonin compared to other groups (p <math><mo><</mo></math> 0.05). L-carnitine group showed the highest mean percentage of oocyte cytoplasmic pattern. Results of the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling indicated that the lowest apoptosis rate belonged to the melatonin + L-carnitine group. Moreover, the combination groups showed the highest number of oocytes and maturation rate. The <i>BMP-15</i> and <i>GDF-9</i> genes were significantly upregulated in all treatment groups compared to the control group.</p><p><strong>Conclusion: </strong>Our results suggested a combination of melatonin + L-carnitine administration as a more effective choice for in vitro promotion of oocyte maturation.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 7","pages":"527-538"},"PeriodicalIF":1.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}