Endometrial compaction can improve assisted reproductive technology outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy: A cross-sectional study.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
International Journal of Reproductive Biomedicine Pub Date : 2025-05-01 eCollection Date: 2024-05-01 DOI:10.18502/ijrm.v23i2.18484
Shahrzad Moeinaddini, Saeideh Dashti, Zahra Amini Majomerd, Nooshin Hatamizadeh
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引用次数: 0

Abstract

Background: Endometrial compaction (EC) is an ultrasound evaluation method that may predict assisted reproductive technology outcomes.

Objective: This study aimed to assess the impact of EC on assisted reproductive technology outcomes in frozen embryo transfer cycles with hormone replacement therapy.

Materials and methods: In this cross-sectional study, 100 women who underwent first or second frozen embryo transfer cycle at Yazd Reproductive Sciences Institute, Yazd, Iran from June to October 2024 were included. Endometrial thickness was compared between the day of starting progesterone and embryo transfer day. Then participants were divided into 2 groups, no compaction and compaction group. Biochemical, clinical, and ongoing pregnancy rates (OPR) were assessed between the 2 groups.

Results: Statistically significant differences were observed in biochemical, clinical, and OPR between the compaction and no compaction groups. Logistic regression analysis demonstrated significantly higher pregnancy rates in EC 10-15% and > 15%. We found a significant influence of EC 10-15% (p = 0.02, p = 0.01, p = 0.01), and EC > 15% (p = 0.002, p = 0.001, and p = 0.002) on biochemical, clinical, and OPR, respectively.

Conclusion: EC after progesterone administration in hormone replacement therapy-frozen embryo transfer cycles can increase biochemical, clinical, and OPR. The percentage of EC changes also influence the outcomes of these cycles.

子宫内膜压实可以改善使用激素替代疗法的冷冻解冻胚胎移植周期的辅助生殖技术结果:一项横断面研究。
背景:子宫内膜压实(EC)是一种可以预测辅助生殖技术结果的超声评估方法。目的:本研究旨在评估EC对激素替代疗法冷冻胚胎移植周期辅助生殖技术结果的影响。材料和方法:在这项横断面研究中,纳入了2024年6月至10月在伊朗亚兹德亚兹德生殖科学研究所进行第一次或第二次冷冻胚胎移植周期的100名妇女。比较孕激素起始日和胚胎移植日子宫内膜厚度。然后将受试者分为不压实组和压实组。评估两组患者的生化、临床及持续妊娠率(OPR)。结果:压实组与未压实组在生化、临床、OPR等指标上均有统计学差异。Logistic回归分析显示,EC组妊娠率10-15%,>组妊娠率15 -15%。我们发现EC 10-15% (p = 0.02, p = 0.01, p = 0.01)和EC > 15% (p = 0.002, p = 0.001, p = 0.002)分别对生化、临床和OPR有显著影响。结论:在激素替代疗法-冷冻胚胎移植周期中,给予孕酮后EC可提高生化、临床和OPR。欧共体变化的百分比也影响这些周期的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.40
自引率
7.70%
发文量
93
审稿时长
16 weeks
期刊介绍: The International Journal of Reproductive BioMedicine (IJRM), formerly published as "Iranian Journal of Reproductive Medicine (ISSN: 1680-6433)", is an international monthly scientific journal for who treat and investigate problems of infertility and human reproductive disorders. This journal accepts Original Papers, Review Articles, Short Communications, Case Reports, Photo Clinics, and Letters to the Editor in the fields of fertility and infertility, ethical and social issues of assisted reproductive technologies, cellular and molecular biology of reproduction including the development of gametes and early embryos, assisted reproductive technologies in model system and in a clinical environment, reproductive endocrinology, andrology, epidemiology, pathology, genetics, oncology, surgery, psychology, and physiology. Emerging topics including cloning and stem cells are encouraged.
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