International Journal of Reproductive Biomedicine最新文献

{"title":"Follicular fluid meiosis activating sterol supplementation enhances oocyte maturation and fertilization in a microfluidic system: A lab trial study.","authors":"Hossein Torkashvand, Ronak Shabani, Tayebe Artimani, Shamim Pilehvari, Mahdi Moghimi, Mehdi Mehdizadeh","doi":"10.18502/ijrm.v22i10.17663","DOIUrl":"10.18502/ijrm.v22i10.17663","url":null,"abstract":"<p><strong>Background: </strong>In vitro maturation (IVM) is a promising technique in assisted reproductive technologies, offering benefits such as reducing the risk of ovarian hyperstimulation syndrome.</p><p><strong>Objective: </strong>This study aimed to evaluate the effects of timed follicular fluid meiosis-activating sterol (FF-MAS) supplementation on the IVM of germinal vesicle oocytes using a dynamic microfluidic system.</p><p><strong>Materials and methods: </strong>In this lab trial study, 266 germinal vesicle oocytes were collected from the Infertility Center of Fatemieh hospital, Hamedan, Iran between June 2023 and January 2024. The oocytes were allocated into 3 groups for dynamic microfluidic culture. Each group received culture medium at a flow rate of 0.36 µL/min for 24 hr through inlet A and FF-MAS supplementation through inlet B for 1, 2, and 6 hr. The study evaluated maturation and fertilization rates, embryo development, and mitochondrial status, which was assessed using the JC-1 mitochondrial membrane potential assay.</p><p><strong>Results: </strong>Maturation rates were significantly higher in the medium-term FF-MAS exposure (MTG) and long-term FF-MAS exposure groups compared to the short-term FF-MAS group (STG) (p <math><mo><</mo></math> 0.05). Fertilization rates were also higher in the MTG and long-term FF-MAS group compared to the STG (p <math><mo><</mo></math> 0.05). Embryo formation rates and the proportion of good-quality embryos were higher in the MTG compared to the STG (100% vs. 75%; p = 0.03) and (83.3% vs. 33.3%; p = 0.01), respectively. Mitochondrial peripheral distribution was significantly higher in the MTG than in the STG (p = 0.04).</p><p><strong>Conclusion: </strong>Optimizing FF-MAS exposure duration enhances IVM efficiency, offering a promising strategy to increase oocyte utilization in in vitro fertilization programs.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 10","pages":"781-792"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secretome of human amniotic membrane stem cells promote recovery and testicular functions through modulating <i>SIRT1/NRF2/TNF-α</i> pathway in mice testicular torsion: An experimental study.","authors":"Roghayeh Esfehani, Farnaz Khadivi, Jamal Valipour, Maryam Shabani, Mahya Ramesh, Parinaz Javanbakht, Davood Zarini, Sina Mojaverrostami, Masih Hoseini","doi":"10.18502/ijrm.v22i10.17670","DOIUrl":"10.18502/ijrm.v22i10.17670","url":null,"abstract":"<p><strong>Background: </strong>Testicular ischemia/reperfusion injury, a significant result of testicular torsion, can lead to the risk of male infertility.</p><p><strong>Objective: </strong>The current study aimed to evaluate the effect of human amniotic membrane-derived mesenchymal stem cells (hAMSCs) secretome on testicular torsion/detorsion (T/D) in mice.</p><p><strong>Materials and methods: </strong>All the experiments were performed in the Anatomy Department of Tehran University of Medical Sciences, Tehran, Iran, during the period of March 2023 to December 2023. 40 male NMRI mice (5-7 wk, 25-30 gr) were randomized into: 1) the sham group: mice received sham operations with no other interventions, 2) T/D group, 3) negative control group; torsion detorsion + intratesticular injection of Dulbecco's Modified Eagle Medium/Nutrient Mixture F-12, and 4) the T/D group + hAMSCs secreted factors. Serum testosterone levels, hematoxylin and eosin staining, and sperm quality parameters were used to evaluate the therapeutic effects of hAMSCs secreted factors on the testicular structure and function. Tissue oxidative stress was measured by determining malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase-1. Nuclear factor erythroid 2-related factor 2, Kelch-like ECH-associated protein 1, NAD-dependent deacetylase sirtuin-1, tumor necrosis factor-alpha and tumor protein P53 mRNA expressions were assessed in testis via real-time polymerase chain reaction.</p><p><strong>Results: </strong>The results showed that hAMSCs secreted factors alleviated testicular T/D injury by attenuating oxidative stress, inflammatory response, and apoptosis via modulating the sirtuin-1/ nuclear factor erythroid 2-related factor 2/tumor necrosis factor-alpha signaling pathway.</p><p><strong>Conclusion: </strong>hAMSCs secreted factors increased antioxidative, anti-inflammatory, and antiapoptotic properties which consequently increased testosterone levels, spermatogenesis, and sperm quality parameters.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 10","pages":"821-836"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing intra-uterine injection of mononuclear cells and platelet-rich plasma on the pregnancy rate of women with recurrent implantation failure: An RCT.","authors":"Hoda Fazaeli, Azar Sheikholeslami, Zahra Ebrahimi, Naser Kalhor, Leila Naserpour","doi":"10.18502/ijrm.v22i10.17668","DOIUrl":"10.18502/ijrm.v22i10.17668","url":null,"abstract":"<p><strong>Background: </strong>Recurrent implantation failure (RIF) can be explained mainly by improper crosstalk between the embryo and endometrium. The T-helper1/T-helper2 profile balance influences effective embryo implantation. Endometrial immunomodulation via intrauterine injection of activated peripheral blood mononuclear cells (PBMCs) or autologous platelet-rich plasma (PRP) is a potentially efficient treatment option.</p><p><strong>Objective: </strong>This study aims to examine the biochemical and clinical pregnancies resulting from the intrauterine administering of activated PBMCs and PRP in RIF women.</p><p><strong>Materials and methods: </strong>This randomized clinical trial study was done in the Rooya Infertility Treatment Center, Qom, Iran from November 2022 to April 2024. 96 women with at least 2 RIFs were randomized into control, PBMC, and PRP groups. Briefly, 3 ml of blood sample was collected and PBMCs were isolated using Ficoll separation solution, and cultured for 72 hr. PRP was separated from 10 ml of peripheral blood through centrifugation. 2 days before embryo transfer PBMCs or PRP were transferred into the endometrial cavity.</p><p><strong>Results: </strong>Except for the duration of infertility, which was higher in the PBMC group, all other baseline characteristics were not statistically different. Moreover, a significantly higher rate of biochemical pregnancy was observed in the PRP (10/32) and PBMC (12/32) groups compared to the control (3/32) (p = 0.027), while the rate of clinical pregnancy was only significantly higher in the PBMC group (10/32) than in the control group (2/32) (p = 0.038).</p><p><strong>Conclusion: </strong>Neither PBMC nor PRP interventions exhibited a substantial advantage over one another regarding biochemical and clinical pregnancy rates.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 10","pages":"801-810"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and neonatal outcomes in women with COVID-19: A retrospective cohort study.","authors":"Malihe Nourollahpour Shiadeh, Ommolbanin Zare, Mahmood Moosazadeh, Azadeh Kiapour, Sima Elyasi","doi":"10.18502/ijrm.v22i10.17667","DOIUrl":"10.18502/ijrm.v22i10.17667","url":null,"abstract":"<p><strong>Background: </strong>Considering the conflicting evidence that exists regarding the effect of the coronavirus disease 2019 (COVID-19) on pregnancy and newborn outcomes, it is necessary to conduct this research during the first year in the north of Iran, a highly visited and trafficked place, which increases the possibility of contracting the virus and severity of the infection.</p><p><strong>Objective: </strong>This study aimed to compare maternal and neonatal outcomes in pregnant women with and without COVID-19.</p><p><strong>Materials and methods: </strong>In this retrospective cohort study, data from 160 pregnant women referred to 3 hospitals in Mazandaran, Iran from April 2020 to March 2021 were extracted from their medical records using checklists. Participants were divided into 2 groups: group A) 80 pregnant women with COVID-19 and group B) 80 noninfected pregnant women. All information related to maternal and neonatal outcomes were extracted and compared from the files of the 2 groups. The results obtained from comparing 2 groups of pregnant women from the result of the reverse-transcription polymerase chain reaction test were analyzed.</p><p><strong>Results: </strong>The most common symptoms in the COVID-19 group were fever and cough. Pregnancy complications such as abortion, pre-eclampsia, and premature birth were not significant between groups (p = 0.4, 0.45, 0.45, respectively). No statistically significant difference was observed between groups regarding maternal and neonatal outcomes.</p><p><strong>Conclusion: </strong>Despite the peak and severity of the COVID-19 disease in the first year of the pandemic, it seems that it had no effect on maternal and neonatal outcomes in each trimester of pregnancy in affected women.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 10","pages":"793-800"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between menstrual disorders and anti-Müllerian hormone with COVID-19: A prospective cohort study.","authors":"Ziba Haghipour, Shahideh Jahanian Sadatmahalleh, Fatemeh Razavinia, Malihe Nasiri","doi":"10.18502/ijrm.v22i10.17669","DOIUrl":"10.18502/ijrm.v22i10.17669","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus 2019 (COVID-19) has affected almost all communities throughout the world. It affects different systems in the body, which causes irreparable consequences.</p><p><strong>Objective: </strong>This study aimed to investigate the effect of the COVID-19 virus on menstrual disorders, anti-Mullerian hormone (AMH), thyroid peroxidase (TPO), thyroid stimulating hormone (TSH), and prolactin levels in women with COVID-19 disease.</p><p><strong>Materials and methods: </strong>This prospective cohort study was conducted on 201 women (101 healthy, and 100 women with COVID-19) in Nomadic hospital, Khorramabad, Iran from February-October 2021. After recovery from COVID-19, participants were interviewed about their menstrual cycle in their 1 <math> <msup><mrow><mi> </mi></mrow> <mtext>st</mtext></msup> </math> and 4 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> months. Blood samples were collected during 1 <math> <msup><mrow><mi> </mi></mrow> <mtext>st</mtext></msup> </math> and 4 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> months, and AMH, TSH, TPO, and prolactin levels were assessed.</p><p><strong>Results: </strong>No significant differences were observed in the 1 <math> <msup><mrow><mi> </mi></mrow> <mtext>st</mtext></msup> </math> and 4 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> months regarding menstrual disorders, TPO, and prolactin levels in the patient group (p <math><mo>></mo></math> 0.05). The mean level of AMH in the healthy group was higher than the patient group in both times (p <math><mo><</mo></math> 0.001). A relationship between TSH and COVID-19 was observed in the 1 <math> <msup><mrow><mi> </mi></mrow> <mtext>st</mtext></msup> </math> month (p <math><mo><</mo></math> 0.001); however, no significant relationship was observed in the 4 <math> <msup><mrow><mi> </mi></mrow> <mtext>th</mtext></msup> </math> month, in this regard.</p><p><strong>Conclusion: </strong>Endocrine dysfunction in the form of low AMH and high TSH were common among COVID-19 patients. Due to the importance of menstrual and hormonal disorders, especially AMH and TSH, and their association with COVID-19, health policymakers should find appropriate solutions to reduce complications.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 10","pages":"811-820"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental pathological findings and their association with maternal and fetal clinical outcomes: A cross-sectional study.","authors":"Soheila Sarmadi, Elham Mirzaian, Fatemeh Nili, Fatemeh Khalafrezaei","doi":"10.18502/ijrm.v22i10.17662","DOIUrl":"10.18502/ijrm.v22i10.17662","url":null,"abstract":"<p><strong>Background: </strong>Placental pathological changes can occur in both normal and high-risk pregnancies, leading to adverse maternal and neonatal outcomes.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between placental histopathological findings and maternal and fetal clinical outcomes, as well as to determine if there is an association between maternal comorbidities and placental pathologies.</p><p><strong>Materials and methods: </strong>In this study, 250 placenta samples were evaluated. The slides and paraffin blocks were retrieved from the archive of the pathology department of Shariati and Yas hospitals, Tehran, Iran. The placental histopathological findings were analyzed in relation to maternal and fetal clinical data.</p><p><strong>Results: </strong>The average age of pregnant women was 31.84 yr. The average gestational age at birth was 28 wk. The most prevalent pathological finding was maternal vascular malperfusion, observed in 59.6% of cases. The presence of nucleated red blood cells (NRBC) in umbilical cord blood vessels was observed in 16.4% of cases. Fetal vascular malperfusion was significantly associated with intrauterine fetal demise. Maternal inflammatory response was associated with premature rupture of membranes. Maternal vascular malperfusion and the presence of NRBC in umbilical cord blood vessels was significantly associated with pre-eclampsia and preterm labor. Furthermore, a history of maternal malignancy was associated with placental infarction and the presence of NRBC in umbilical cord blood vessels.</p><p><strong>Conclusion: </strong>The findings of this study underscore the importance of evaluating placental histopathological findings in relation to maternal and fetal clinical outcomes. Therefore, understanding these placental pathological changes will be crucial in predicting and preventing complications in subsequent pregnancies.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 10","pages":"771-780"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of hydatidiform moles using <i>p57 immunohistochemistry</i> and <i>chromogenic insitu hybridization</i>: A retrospective study.","authors":"Mojgan Akbarzadeh-Jahromi, Tara Taheri, Fatemeh Sari Aslani, Akbar Safaei, Fatemeh Pouraminaee, Marjan Zare","doi":"10.18502/ijrm.v22i9.17478","DOIUrl":"https://doi.org/10.18502/ijrm.v22i9.17478","url":null,"abstract":"<p><strong>Background: </strong>Chromogenic in situ hybridization(<i>CISH</i>) and immunohistochemistry analysis for <i>p57</i> are ancillary studies discriminating partial hydatidiform mole (PHM), complete hydatidiform mole (CHM), and non-molar hydropic abortion (HA).</p><p><strong>Objective: </strong>It aimed to study <i>CISH</i> with a probe to chromosome 17(<i>CISH17</i>) and chromosome 2(<i>CISH2</i>) discriminating chromosomal ploidy of PHM, CHM, and HA; in addition, their surrogacy value in the evaluation of triploid and diploid in product of conception specimens (POCs) was evaluated.</p><p><strong>Materials and methods: </strong>44 statistically significant POCs were selected retrospectively. The Kappa agreement coefficients, sensitivity, specificity, and accuracy with 95% confidence interval (95% CI) were reported.</p><p><strong>Results: </strong>PHM, CHM, and HA were diagnosed to be 23, 17, and 3 cases based on both <i>CISH2</i> and <i>CISH17</i> resulting in their complete discrimination between PHM and HA (23 vs. 3). The Kappa agreement coefficient was 95.4% (p <math><mo><</mo></math> 0.001) when diagnosing the PHM (23), CHM (20), and HA (1). In addition, the accuracy, sensitivity, and specificity were 95.26% (95% CI: 84.25-99.38), 100% (95% CI: 85.18-100), and 95% (95% CI: 76.18-99.88), respectively. The power analysis on <i>CISH2</i> and <i>CISH17</i> tests discriminating between triploid and diploid in POCs was estimated to be 100%.</p><p><strong>Conclusion: </strong>Based on the current finding, <i>CISH2</i> and <i>CISH17</i> enjoyed perfect agreement in diagnosing chromosomal ploidy; in addition, their absolute power discriminating between triploid and diploid revealed that they could be used as surrogate markers for ploidy. Prospective studies on fresh specimens are suggested comparing the <i>CISH</i> method's accuracy with flow cytometry karyotyping and fluorescence in situ hybridization.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 9","pages":"727-738"},"PeriodicalIF":1.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The report of ovarian tissue transplant in Iran: A case report\" [Int J Reprod BioMed 2024; 22: 323-328].","authors":"Fatemeh Anbari, Mohammad Ali Khalili, Mahboubeh Vatanparast, Saeid Haghdani, Maryam Eftekhar","doi":"10.18502/ijrm.v22i9.17481","DOIUrl":"https://doi.org/10.18502/ijrm.v22i9.17481","url":null,"abstract":"<p><p>[This corrects the article on p. 323 in vol. 22.].</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 9","pages":"755"},"PeriodicalIF":1.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dietary approaches to stop hypertension and curcumin co-administration on glycemic parameters in polycystic ovary syndrome: An RCT.","authors":"Tayebeh Zohrabi, Azadeh Nadjarzadeh, Sara Jambarsang, Mohammad Hasan Sheikhha, Abbas Aflatoonian, Hassan Mozaffari-Khosravi","doi":"10.18502/ijrm.v22i9.17473","DOIUrl":"https://doi.org/10.18502/ijrm.v22i9.17473","url":null,"abstract":"<p><strong>Background: </strong>olycystic ovary syndrome (PCOS) is an endocrine disorder that can lead to major reproductive and metabolic complications. Management of glycemic parameters is an important step to improve the symptoms of PCOS.</p><p><strong>Objective: </strong>This study aims to evaluate the effects of the dietary approaches to stop hypertension (DASH) diet and curcumin (Cur) co-administration on glycemic parameters in normal weight and overweight/obese women with PCOS undergoing in vitro fertilization.</p><p><strong>Materials and methods: </strong>In this double-blind randomized clinical study, 104 infertile women with PCOS were divided into 4 intervention groups considering treatment conditions and body mass index. They received 500 mg twice daily of Cur or placebo (Pls) along with DASH or a standard diet (St) based on macronutrient composition (52% carbohydrate, 18% protein, and 30% fat) for 12 wk, (DASH + Cur, DASH + Pls, St + Cur, St + Pls). The effect of these interventions on fasting blood sugar and insulin levels, insulin resistance (IR), and insulin sensitivity were determined.</p><p><strong>Results: </strong>Participants adhered to the intervention protocol ( <math><mo>></mo></math> 80%). Insulin levels in the supplement intervention (Cur + diet) decreased significantly in the crude model. They remained significant even after adjusting for confounding variables in adjusted models (body mass index classification, energy difference, age, and physical activity levels at the baseline) ( <math><mi>β</mi></math> = -45.3, 95% CI [-73.23, -17.46], p = 0.002). Homeostasis model assessment of IR decreased significantly in the supplement intervention even after controlling for confounding factors in adjusted models. Changes in fasting blood sugar and insulin sensitivity were not significant in either the crude or adjusted models.</p><p><strong>Conclusion: </strong>The study results show that adding Cur to the diet can positively reduce insulin levels, improve IR, and lead to faster recovery of hyperinsulinemia. Cur supplementation with a healthy diet has synergistic beneficial effects on glycemic parameters. Larger clinical trials with longer durations are needed to confirm these results.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 9","pages":"689-700"},"PeriodicalIF":1.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between emotional intelligence, quality of life, and infertility stigma in infertile woman: A descriptive-correlational study.","authors":"Mobina Anari, Mahboube Taebi, Mohammad Javad Tarrahi, Masoume Pirhadi","doi":"10.18502/ijrm.v22i9.17479","DOIUrl":"https://doi.org/10.18502/ijrm.v22i9.17479","url":null,"abstract":"<p><strong>Background: </strong>Infertility is one of the major crises in couples' lives, affecting both mental and physical health. One of the most significant consequences of infertility is stigma; moreover, emotional intelligence and women's coping style with these consequences can affect the quality of this disorder.</p><p><strong>Objective: </strong>This study aimed to investigate emotional intelligence, infertility stigma, quality of life, and the relationship between these variables in infertile women.</p><p><strong>Materials and methods: </strong>This descriptive-correlational study was conducted from April 2023 to February 2024 on 349 infertile women referred to \"Hazrat Maryam Infertility Center in Shahid Beheshti hospital\" and \"Isfahan Fertility and Infertility Center\" in Isfahan, Iran. Sampling was done using a convenience sampling method, and tools included 4 questionnaires, a demographic and midwifery information form, the quality of life questionnaire, the female-infertility-stigma-questionnaire, and the Schutte-Emotional-Intelligence scale.</p><p><strong>Results: </strong>The results showed that the women's mean age was 35.08 <math><mo>±</mo></math> 7.60 yr. The mean score for emotional intelligence was 109.06 <math><mo>±</mo></math> 6.12, and the infertility stigma's was 56.1 <math><mo>±</mo></math> 14.73. The results indicated a positive correlation between emotional intelligence and infertility stigma (r = 0.13, p <math><mo><</mo></math> 0.001). Only the mean score of social well-being and general health dimensions had a significant relationship with the total score of emotional intelligence (r = 0.037, p <math><mo><</mo></math> 0.02).</p><p><strong>Conclusion: </strong>Infertile women have a lower quality of life and experience higher stigma. Since the quality of life and overall mental health affect the treatment process, also emotional intelligence plays an important role in human life, educational sessions and counseling should be considered in the treatment programs to improve the quality of life, thereby facilitating the treatment process with greater ease and speed.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 9","pages":"739-748"},"PeriodicalIF":1.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}