International Journal of Reproductive Biomedicine最新文献

{"title":"Cumulus cells conditioned medium facilitates germ cell differentiation from human embryonic stem cells: An experimental study.","authors":"Somayyeh Sadat Tahajjodi, Ehsan Farashahi Yazd, Azam Agharahimi, Fatemeh Akyash, Fatemeh Hajizadeh-Tafti, Jalal Golzadeh, Reza Aflatoonian, Behrouz Aflatoonian","doi":"10.18502/ijrm.v23i1.18186","DOIUrl":"10.18502/ijrm.v23i1.18186","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown thatembryonic stem cells can differentiate into germ cells either spontaneously or directed by the defined factors or by applying a co-culture method or conditioned medium of stromal cells.</p><p><strong>Objective: </strong>Here, Yazd4 (human embryonic stem cells [hESC] line; 46, XX) was used to evaluate the effect of human cumulus cells conditioned medium (CCCM) on <i>in vitro</i> germ cell production and development.</p><p><strong>Materials and methods: </strong>In this experimental study 2 different complete media were applied, Dulbecco's modified eagle's medium + 20% fetal bovin serum and embryoid body (EB) medium (KnockOut serum replacement- hESC without basal fibroblast growth factor). Thus, there are 2 control groups for spontaneous differentiation (SD) (SD-EB and SD-DM) and 2 types of CCCM (CCCM-DM and CCCM-EB) as test groups. 40% dilution of the conditioned medium was applied according to previous reports.</p><p><strong>Results: </strong>Reverse transcription-quantitative polymerase chain reaction and immunofluorescent staining assays revealed that between groups with similar complete medium, CCCM provides a better condition for <i>in vitro</i> germ cell differentiation from hESCs. Moreover, a comparison between the 2 types of complete media showed that EB medium is more supportive than Dulbecco's modified eagle's medium +20% fetal bovin serum.</p><p><strong>Conclusion: </strong>CCCM with EB medium as a complete medium provides a better condition for <i>in vitro</i> germ cell differentiation from hESCs.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"33-44"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The restorative effect of platelet-rich plasma on estrous cycle disruption induced by arcuate nucleus lesion in female Wistar rats: An experimental study.","authors":"Elham Abbasi, Morteza Behnam Rassouli, Ali Moghimi, Zeinab Neshati","doi":"10.18502/ijrm.v23i1.18185","DOIUrl":"10.18502/ijrm.v23i1.18185","url":null,"abstract":"<p><strong>Background: </strong>Successful reproduction relies on a functioning hypothalamic-pituitary-gonad axis. Damage to this axis disrupts the estrus cycle and reproductive capability.</p><p><strong>Objective: </strong>This study aimed to evaluate the effects of single or multiple platelet-rich plasma (PRP) injections on repairing the damaged hypothalamic arcuate nucleus (ARC) and restoring the estrus cycle in Wistar rats.</p><p><strong>Materials and methods: </strong>90 female Wistar rats (2-3 months old, 250-280 gr) with regular estrous cycles were divided into a control group and 8 experimental groups (n = 10/each). After bilateral stereotaxic chemical surgery of the ARC using quinolinic acid (500 nmol/2 <math><mi>μ</mi></math> l), the experimental rats were categorized into several treatment regimens: ARC <math> <msup><mrow><mi> </mi></mrow> <mo>-</mo></msup> </math> (no treatment), 1 PRP injection (immediately, 24 hr, 48 hr, and 72 hr postsurgery), 2 PRP injections (immediately, 24 hr), 3 PRP injections (immediately, 24 hr, and 48 hr), and 4 PRP injections (immediately, 24 hr, 48 hr, and 72 hr). Vaginal smear cytology was performed daily for 2.5 months. In the end, rats brains were removed and divided for real-time polymerase chain reaction analysis of kisspeptin, neurokinin B, and dynorphin, as well as for ARC cell counting.</p><p><strong>Results: </strong>Vaginal smear cytology indicated that PRP administration gradually restored the estrous cycle. Compared to the ARC <math> <msup><mrow><mi> </mi></mrow> <mo>-</mo></msup> </math> group, PRP treatment significantly increased ARC cell density (p = 0.012) and mRNA levels of kisspeptin, neurokinin B, and dynorphin (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>These findings not only emphasized the importance of the ARC for the regularity of estrous cycle but also showed the potential effects of local PRP treatment in contribution to the protection/reconstruction of ARC.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"55-66"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interlinkage between inflammation, oxidative stress, and endoplasmic reticulum stress in bisphenols-induced testicular steroidogenesis disturbance: A mini review.","authors":"Nur Erysha Sabrina Jefferi, Asma Afifah Shamhari, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib","doi":"10.18502/ijrm.v23i1.18187","DOIUrl":"10.18502/ijrm.v23i1.18187","url":null,"abstract":"<p><p>Bisphenols (BP) are endocrine-disrupting chemicals that cause adverse health effects, including testicular steroidogenesis disturbance. Cyclo-oxygenase-2 and nuclear factor erythroid 2-related factor 2 are the target molecules involved in testicular steroidogenesis disturbance via inflammation and oxidative stress (OS), respectively. Interestingly, endoplasmic reticulum (ER) stress was found to be involved in various pathological conditions. However, the mechanisms involved in BP-induced testicular steroidogenesis disturbance remain unclear. Therefore, this research investigates the key mechanisms underlying BP-induced testicular steroidogenesis disturbances. We focus on 3 critical pathways: inflammation, OS, and ER stress. Our findings demonstrate that BP exposure triggers inflammatory responses by targeting the cyclo-oxygenase-2 molecules that impair Leydig cell function. Concurrently, we observed that BP-increased OS via inhibition of nuclear factor erythroid 2-related factor 2, further disrupting steroidogenic enzyme activity. Additionally, ER stress is activated in response to BP exposure, leading to impaired protein synthesis and exacerbating steroidogenic dysfunction. This review elucidates the interlinkage between inflammation, OS, and ER stress in BP-induced testicular steroidogenesis disturbance in which reactive oxygen species is proposed to be the main culprit in linking these 3 mechanisms. These insights provide a crucial foundation for understanding the reproductive toxicology of BPs and inform future strategies for mitigating their effects on male reproductive health.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"17-32"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of fennel essential oil and manganese in modulating steroidal hormonal imbalance and ovarian alterations in rats with polycystic ovarian syndrome: An experimental study.","authors":"Ensiyeh Mohebbi Kian, Maryam Barancheshmeh, Hossein Najafzadehvarzi, Seyedeh Masoumeh Ghoreishi, Naser Shokrzadeh","doi":"10.18502/ijrm.v23i1.18201","DOIUrl":"10.18502/ijrm.v23i1.18201","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovarian syndrome (PCOS) is a prevalent hormonal disorder among women of reproductive age, resulting in female infertility. Researchers are exploring safe and affordable treatments for this disorder.</p><p><strong>Objective: </strong>This study explored the therapeutic effects of fennel essential oil (FEO) and manganese (Mn) on hormonal and histological markers in rats with estradiol valerate-induced PCOS.</p><p><strong>Materials and methods: </strong>In this experimental study, 35 adult female Wistar rats (9 wk old, 200-250 gr) were divided into 7 groups. For 14 days, groups 1-4 received normal saline intraperitoneally, sesame oil intramuscularly, FEO intraperitoneally, and Mn orally, respectively. PCOS was induced in remaining groups through a single intramuscular injection of estradiol valerate. 60 days after induction, the 6^th and 7^th groups were treated individually with intraperitoneal FEO and oral Mn for 14 days. Blood samples were analyzed for estrogen, progesterone, and malondialdehyde (MDA) markers. The ovarian tissues were histologically examined to assess cyst formation and structural changes.</p><p><strong>Results: </strong>FEO significantly increased estrogen and progesterone levels in PCOS rats compared to the PCOS group (p <math><mo>≤</mo></math> 0.05). Mn also elevated progesterone levels, but the change was not statistically significant (p <math><mo>></mo></math> 0.05). No significant differences in MDA levels were observed between the PCOS and PCOS+FEO groups. Although MDA levels decreased in the PCOS+Mn group, the reduction was not statistically significant (p <math><mo>></mo></math> 0.05). Both FEO and Mn treatments significantly reduced ovarian cyst numbers compared to untreated PCOS rats (p <math><mo>≤</mo></math> 0.05).</p><p><strong>Conclusion: </strong>FEO and Mn demonstrated potential in restoring hormonal balance and improving ovarian histology, offering promise as low-cost treatments for PCOS.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"79-90"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioprotective effect of omeprazole against testicular damage induced by ionizing radiation in mice: An experimental study.","authors":"Ali Nabi, Azam Hassanpour Dehnavi, Fahime Mazaheri, Nastaran Momeni, Habib Nikukar, Mahdie Hemati, Seyed Jalal Hosseinimehr, Masoud Shabani, Fatemeh Sadeghian-Nodoushan, Javad Biabani-Ardakani","doi":"10.18502/ijrm.v23i1.18202","DOIUrl":"10.18502/ijrm.v23i1.18202","url":null,"abstract":"<p><strong>Background: </strong>Radiation-induced normal tissue damage remains a major concern in radiotherapy, particularly affecting rapidly dividing cells, including those in reproductive tissues. Developing effective radioprotective agents to mitigate this damage is crucial for preserving fertility.</p><p><strong>Objective: </strong>The radioprotective effects of omeprazole (OMP) were investigated in adult male mice undergoing external radiation.</p><p><strong>Materials and methods: </strong>In this experimental study, 36 adult male mice (30-35 gr, 6-8 wk old) were divided into 6 groups and orally administered OMP daily via oral gavage for 7 days before whole-body irradiation. On the 8^th day, mice were subjected to a single 6 Gray dose of 6 megavoltage X-ray radiation. Blood samples were collected via cardiac puncture for testosterone level evaluation, while testicular specimens were harvested post-euthanasia for sperm parameters assessment and histological analysis. Additionally, spermatogenic cell density was evaluated.</p><p><strong>Results: </strong>Irradiation of 6 Gray X-ray to the testis of mice significantly affected sperm count, progressive motility, DNA fragmentation, the number of sperm with normal morphology, and the number of immotile sperm. Furthermore, administration of OMP improved progressive motility, DNA fragmentation, and sperm viability. Histopathological findings showed irradiation led to severe testicular atrophy with spermatogenic arrest and abnormal cytoarchitecture vacuolation and interstitial edema, while OMP treatment reversed relative radiation toxicity, especially in the 50 mg OMP treatment group.</p><p><strong>Conclusion: </strong>In conclusion, OMP could act as an effective radioprotector against testicular damage following X-ray irradiation in an animal model. Further studies are needed to investigate OMP potential in protecting human testis tissue.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"91-102"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of diet and food supplements in infertility management in the Eastern Mediterranean Region: A narrative review.","authors":"Kassandra Said Fares, Georges Hani Abi Tayeh, Emile Roger Whaibeh, Romy Jihad Louis, Lina Yasser Jaalouk, Yara Matar Matar, Myriam Andraos Mrad","doi":"10.18502/ijrm.v23i1.18188","DOIUrl":"10.18502/ijrm.v23i1.18188","url":null,"abstract":"<p><p>According to the World Health Organization, 17.5% of the population suffers from infertility. This demonstrates the critical need to expand access to high-quality reproductive care and increase our understanding of the factors that contribute to this issue. This review aims to summarize findings and gaps in the literature regarding diet-related factors and infertility among the Eastern Mediterranean couples poorly studied compared to other populations. The literature search was conducted using PubMed and Scopus databases from January 2012-July 2023. In total, 112 papers described the influence of diet and supplementation on natural and artificial reproductive outcomes in the Eastern Mediterranean Region and were found eligible for the review synthesis. For men, a diet rich in red meat, fatty foods, whole grains, and low in fish, poultry, low-fat dairy products, and vegetables have a positive effect on sperm count. For women, maintaining a healthy weight is crucial for their fertility. Overall, various vitamins and supplements significantly enhance gametes quality, hormonal balance, and antioxidant capacity, despite the results not being consistent across all studies. The findings highlight distinct dietary patterns that mitigate or exacerbate infertility risks, considering macro and micronutrients. Studies unevenly describe potential risk factors, underscoring the need for further exploration across diverse populations.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"23 1","pages":"1-16"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An online intervention relationship enhancement couple therapy program versus systematic desensitization on sexual performance anxiety in women undergoing infertility treatment with timed intercourse: An RCT.","authors":"Maryam Afzal Dehkordi, Tahmineh Farajkhoda, Mahdi Khanabadi, Farimah Shamsi","doi":"10.18502/ijrm.v22i12.18062","DOIUrl":"10.18502/ijrm.v22i12.18062","url":null,"abstract":"<p><strong>Background: </strong>Sexual performance anxiety is common among infertility treatments. Psychological interventions are options for couples who do not tolerate psychiatric medications or like psychotherapy with pharmacotherapy.</p><p><strong>Objective: </strong>This study aimed to compare the effectiveness of relationship enhancement couple therapy program (RECT) vs. systematic desensitization (SD) on sexual anxiety.</p><p><strong>Materials and methods: </strong>A parallel randomized clinical trial was conducted on 68 women with infertility in Shahrekord, Iran, in January 2022. They were randomly allocated to 8 weekly online interventions RECT or SD (control). The main outcome variable, sexual performance anxiety, was assessed via Davis's questionnaire at baseline, completion of the intervention (week 8), and follow-up (week 12). The secondary outcome variable spouse's satisfaction was assessed (weeks 8 and 12, via visual analog scale). Data from 29 women were analyzed in each group.</p><p><strong>Results: </strong>Intra-group comparison RECT and SD showed a significant decrease of sexual anxiety baseline compared to week 12 (p = 0.001, 0.001 for RECT and SD, respectively). No significant difference was observed between the 2 groups in baseline compared to week 12 (RECT vs. SD, p = 0.149). Time-group interaction of spouse's satisfaction showed a significant difference between RECT and SD (p = 0.010).</p><p><strong>Conclusion: </strong>Both RECT and SD were almost equally effective in decreasing sexual anxiety. RECT (couple relationship-centered) by empowering 10 interpersonal skills, and SD (personal-oriented) by learning step-by-step how fight-or-flight response is replaced by relaxation response, helping women perform more adaptive behaviors regarding sexual anxiety. RECT increased spouse satisfaction significantly compared to SD, indicating that males need to participate in positive relationship changes. The results may be applied by therapists and health policymakers.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 12","pages":"963-974"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing sexual dysfunction in cosmetic rhinoplasty candidates and normal population among married women in Shiraz, Iran: A case-control study.","authors":"Ali Sahraian, Masoud Janipour, Atoosa Ebrahimi, Zohre Zareizadeh, Pardis Habibi, Amirhossein Babaei","doi":"10.18502/ijrm.v22i12.18064","DOIUrl":"10.18502/ijrm.v22i12.18064","url":null,"abstract":"<p><strong>Background: </strong>Disturbed self-esteem and self-image can be found in body dysmorphic individuals, and sexual dysfunction is also more frequent among these individuals. Body image concerns may also contribute to the tendency to undergo cosmetic procedures, including rhinoplasty.</p><p><strong>Objective: </strong>This study aimed to compare sexual dysfunction in married women who were candidates for cosmetic rhinoplasty to a control group.</p><p><strong>Materials and methods: </strong>This case-control study was conducted among 342 married women in Shiraz, Iran, from December 2021-2022. The case group included 192 cosmetic rhinoplasty candidates, and the control group comprised 150 women who were not candidates for cosmetic procedures; they were selected from the ear, nose, and throat outpatient department. Data on demographic features, psycho-social history, and quality of marital life were collected by face-to-face interviews. To evaluate their sexual performance, the participants filled out the female sexual function index questionnaire.</p><p><strong>Results: </strong>No significant difference was observed between rhinoplasty subjects and the control group in the female sexual function index (23.63 <math><mo>±</mo></math> 3.6 vs. 23.19 <math><mo>±</mo></math> 4.28, p = 0.43). The prevalence of sexual dysfunction among cosmetic rhinoplasty candidates and the control group was 75% and 76%, respectively (p = 0.60). No significant difference was observed in the sexual dysfunction domains between the groups.</p><p><strong>Conclusion: </strong>Our study indicated a significant sexual dysfunction among the studied population, but the difference was not statistically significant between the rhinoplasty and the control group.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 12","pages":"985-994"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-6-174 G/C transversion might decrease male infertility risk: A case-control study.","authors":"Tayyebeh Zamani-Badi, Mohammad Karimian, Javad Amini Mahabadi, Atieh Rafatmanesh, Hossein Nikzad","doi":"10.18502/ijrm.v22i12.18067","DOIUrl":"10.18502/ijrm.v22i12.18067","url":null,"abstract":"<p><strong>Background: </strong>Genetic predispositions have been identified as important factors in male infertility. Among the many genes related to male reproductive function, interleukin 6 (IL-6) has emerged as a key player. Despite the growing recognition of genetic factors in male infertility, the specific association between the IL-6-174 G/C genetic polymorphism and male infertility remains an area that needs further investigation.</p><p><strong>Objective: </strong>This investigation explores the correlation between the IL-6-174 G/C transversion and male infertility.</p><p><strong>Materials and methods: </strong>In a case-control study, a total of 314 men who referred to the Kashan Infertility Center, Shahid Beheshti hospital, Kashan, Iran, were enrolled for IL-6-174 G/C polymorphism analysis. The study comprised 163 infertile participants as the case group and 151 fertile men as the control group. Following the screening, 2 ml of whole blood was collected from each participant. Cases were categorized into 3 subgroups based on World Health Organization criteria: (i) nonobstructive azoospermia (n = 42), (ii) oligozoospermia (n = 61), and (iii) asthenozoospermia (n = 60). After DNA extraction, genotypes of the samples at the -174 G/C (rs1800795) locus were determined using the polymerase chain reaction-restriction fragment length polymorphism method.</p><p><strong>Results: </strong>Our genetic investigation demonstrated a significant association between the GC genotype and male infertility. Furthermore, a correlation was observed between the heterozygous GC genotype and reduced risk of oligozoospermia and asthenospermia. Additionally, the C allele was correlated with a decreased risk of infertility and specific subgroups such as oligozoospermia and asthenospermia.</p><p><strong>Conclusion: </strong>Our findings suggest that the IL-6-174 G/C transversion could potentially serve as a protective genetic factor against male infertility.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 12","pages":"1015-1024"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing psychological health and reproductive function: Depression, anxiety, and stress in infertile men compared to controls: A case-control study.","authors":"Seyedeh Narjes Roudbaraki, Maryam Ramezani, Bita Saifi, Mostafa Salimi, Massood Issapour Cheshani","doi":"10.18502/ijrm.v22i12.18068","DOIUrl":"10.18502/ijrm.v22i12.18068","url":null,"abstract":"<p><strong>Background: </strong>With the increasing prevalence of infertility and its links to depression, anxiety, and stress, it is essential to compare these mental health levels between infertile men and a control group.</p><p><strong>Objective: </strong>This study aimed to compare depression, anxiety, and stress among infertile and fertile men. Also, assessing demographic factors affecting these challenges among both groups.</p><p><strong>Materials and methods: </strong>This case-control study was conducted on 120 men at Milad Infertility Research Center, Mashhad, Iran from January 2023 to February 2023. Participants were divided into 2 groups: 60 infertile men and 60 healthy men who did not have fertility problems. Demographic information such as age, education, occupation, duration of the marriage, and duration of infertility was collected from their medical records, and they also completed the depression, anxiety, and stress scale 21 questionnaire through a telephonic interview. Finally, the findings were statistically analyzed.</p><p><strong>Results: </strong>Severe and very severe depression, anxiety, and stress were observed in 65%, 60%, and 43.4% of infertile men and 16.7%, 23.3%, and 11.7% of fertile men, respectively. Which was significantly more than the fertile group, and there was a significant relationship between depression (p <math><mo>≤</mo></math> 0.001), anxiety (p = 0.001), stress (p <math><mo>≤</mo></math> 0.001), and infertility. Also, a significant relationship was observed between the duration of infertility and depression (p = 0.031).</p><p><strong>Conclusion: </strong>Our study found infertile men had higher stress, anxiety, and depression than the control group. Limitations included phone-based data collection and the depression, anxiety, and stress scale 21 questionnaire's screening nature. Future studies should involve larger populations and consider economic status as a variable related to mental health.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 12","pages":"1025-1034"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}