International Journal of Reproductive Biomedicine最新文献

{"title":"Comparison of mouse ovarian follicular development and gene expression in the presence of ovarian tissue extract and sodium selenite: An experimental study.","authors":"Hamed Shoorei,&nbsp;Mina Jafarabadi,&nbsp;Shahram PourBayranvand,&nbsp;Mojdeh Salehnia","doi":"10.18502/ijrm.v21i5.13476","DOIUrl":"https://doi.org/10.18502/ijrm.v21i5.13476","url":null,"abstract":"<p><strong>Background: </strong>Ovarian tissue extract (OTE) and sodium selenite (SS) enhance the growth and maturation of preantral follicles in a dose-dependent manner.</p><p><strong>Objective: </strong>The present study was designed to bring more information regarding the mechanism of OTE and SS on the mRNA expression of follicle-stimulating hormone receptors (FSHR) and the proliferation cell nuclear antigens (PCNA) of in vitro matured isolated follicles.</p><p><strong>Materials and methods: </strong>The tissue extract was prepared from adult ovaries. The preantral follicles (n = 266) were isolated from 12-16-day-old mice and cultured in the control, experimental I (10 ng/ml SS), and experimental II (OTE) groups for 12 days. The follicular diameter, survival, and maturation rates, also, the production of 17-β-estradiol and progesterone, and the follicular expression of <i>PCNA</i> and <i>FSH</i> receptor genes were analyzed.</p><p><strong>Results: </strong>The survival rate of follicles in the SS-treated group (84.58%) was significantly higher than that OTE (75.63%; p = 0.023) and control (69.38%; p = 0.032) groups. The mean diameter of culture follicles in experimental group I (403.8 μm) and experimental group II (383.97 μm) increased significantly in comparison with the control group (342.05 μm; p = 0.032). The developmental rate of follicles, percentages of antrum formation, released metaphase II oocytes (p = 0.027; p = 0.019 respectively), production of hormones and the expression of 2 studied genes were significantly increased in both experimental groups in compare with control group (p = 0.021; p = 0.023 respectively).</p><p><strong>Conclusion: </strong>The OTE and SS have a positive effect on development of mouse preantral follicles via over-expression of <i>FSHR</i> and <i>PCNA</i> genes.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis.","authors":"Seyed Sobhan Bahreiny,&nbsp;Elnaz Harooni,&nbsp;Mohammad Reza Dabbagh,&nbsp;Reza Ebrahimi","doi":"10.18502/ijrm.v21i5.13470","DOIUrl":"https://doi.org/10.18502/ijrm.v21i5.13470","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders.</p><p><strong>Objective: </strong>This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity.</p><p><strong>Results: </strong>The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p <math><mo><</mo></math> 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p <math><mo><</mo></math> 0.001) within the subgroup.</p><p><strong>Conclusion: </strong>Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian torsion in a 2-year-old girl: A case report.","authors":"Anahita Haghjoo,&nbsp;Rahil Haghjoo,&nbsp;Marzieh Rahimipour","doi":"10.18502/ijrm.v21i4.13274","DOIUrl":"https://doi.org/10.18502/ijrm.v21i4.13274","url":null,"abstract":"<p><strong>Background: </strong>Ovarian torsion (adnexal torsion) is a rare event in pediatric patients which is primarily managed by pediatric general surgeons.</p><p><strong>Case presentation: </strong>This study presents a case of ovarian torsion in a 2-yr-old girl with a history of episodic lower abdominal pain, nausea, and vomiting for 2 days. Her physical examination was normal except for mild tenderness in the lower abdomen with no palpable mass. A color Doppler ultrasound was performed for further investigation, and an ovarian torsion was reported without sonographic signs of intussusception and acute appendicitis, so she underwent laparotomy. A relatively complete torsion was observed in the left ovarian pedicle. Initially, the left ovary and fallopian tube had a dark appearance, and 10-15% of the ovarian tissue was still normal. Detorsion of ovary was done and it was decided to preserve the ovary. After about 20 min, the color of ovary and fallopian tube returned to relatively normal, indicating normal blood flow. The patient was discharged 2 days later because a follow-up color Doppler ultrasound showed normal ovarian blood flow.</p><p><strong>Conclusion: </strong>The possibility of ovarian torsion must be considered in all female infants with suspicious abdominal pain.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dietary approaches to stop hypertension, and standard diets with and without curcumin on interleukin-1 alpha, 5-alpha reductase gene expressions, and androgenic and glycemic profile in polycystic ovary syndrome women undergoing in vitro fertilization treatment: A study protocol.","authors":"Tayebeh Zohrabi,&nbsp;Mohammad Hasan Sheikhha,&nbsp;Sara Jambarsang,&nbsp;Azadeh Nadjarzadeh,&nbsp;Abbas Aflatoonian,&nbsp;Hassan Mozaffari-Khosravi","doi":"10.18502/ijrm.v21i5.13496","DOIUrl":"https://doi.org/10.18502/ijrm.v21i5.13496","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases with major reproductive and metabolic complications with an impact on public health. Hyperandrogenism and chronic inflammation have been suggested as the leading cause of pathophysiology and clinical manifestations associated with PCOS. It seems that the altered expression of genes involved in the synthesis of pro-inflammatory cytokine and androgens contribute to the promotion of PCOS.</p><p><strong>Objective: </strong>This trial aims to determine the effects of dietary approaches to stop hypertension (DASH) and standard diets with and without curcumin supplementation on the gene expression of interleukin -1 alpha(IL1α), 5α reductase and androgenic and glycemic profile among PCOS patients, who are candidates for in vitro fertilization.</p><p><strong>Materials and methods: </strong>96 infertile women with PCOS, aged 18-40 yr, will participate in this randomized, placebo-controlled clinical trial. Based on treatment conditions and body mass index, the participants will be randomly divided into 4 equal groups using a randomized block design. They will receive a DASH or standard diet containing 52% carbohydrate, 18% protein, and 30% total fat, with the same prescribed sodium, plus 500 mg twice daily curcumin or placebo for 12 wk. The mRNA expression of <i>IL-1</i><math><mi>α</mi></math>, <i>5</i><math><mi>α</mi></math> reductase, and androgenic and glycemic profiles will be measured at baseline and at the end of the study.</p><p><strong>Conclusion: </strong>Concomitant administration of DASH diet and curcumin supplementation may reduce <i>IL-1</i><math><mi>α</mi></math>, <i>5</i><math><mi>α</mi></math> reductase gene expressions, and improve glycemic and androgenic profiles.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9716436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of radioiodine therapy on fertility indicators among men with differentiated thyroid cancer: A cohort study.","authors":"Salman Soltani,&nbsp;Atena Aghaee,&nbsp;Seyed Rasoul Zakavi,&nbsp;Mahdi Mottaghi,&nbsp;Maryam Emadzadeh,&nbsp;Soheil Kasaeian Naeini","doi":"10.18502/ijrm.v21i5.13472","DOIUrl":"https://doi.org/10.18502/ijrm.v21i5.13472","url":null,"abstract":"<p><strong>Background: </strong>Following thyroidectomy, radioiodine therapy is the standard management of differentiated thyroid cancer. The effects of such treatment on testicular function remained a concern for cases and clinicians.</p><p><strong>Objective: </strong>We aimed to observe changes in fertility indicators in men treated with ablation.</p><p><strong>Materials and methods: </strong>In this prospective cohort study, 18 men with differentiated thyroid cancer from June to December 2020 underwent thyroidectomy plus radioiodine therapy. Participants were grouped based on iodine dose (8 men with 30 mCi vs. 10 men with <math><mo>≥</mo></math> 150 mCi). Baseline values (V<math><msub><mrow></mrow><mtext>B</mtext></msub></math>) of the follicular stimulating hormone, luteinizing hormone, testosterone, and sperm analyses were measured 3 wk before iodine ablation and repeated 3 (V<math><msub><mrow></mrow><mn>3</mn></msub></math>) and 12 (V<math><msub><mrow></mrow><mn>12</mn></msub></math>) months later. They were analyzed once as a whole and once based on their groups via ANOVA and Friedman's tests where appropriate.</p><p><strong>Results: </strong>The mean age of participants was 35.61 <math><mo>±</mo></math> 9.74 yr. Follicular stimulating hormone levels showed a significant trend among all participants (V<math><msub><mrow></mrow><mtext>B</mtext></msub></math>: 12.51 <math><mo>±</mo></math> 1.72, V<math><msub><mrow></mrow><mn>3</mn></msub></math>: 13.54 <math><mo>±</mo></math> 1.41, and V<math><msub><mrow></mrow><mn>12</mn></msub></math>: 13.10 <math><mo>±</mo></math> 1.67 IU/mL; p <math><mo><</mo></math> 0.001). Luteinizing hormone showed a similar pattern (V<math><msub><mrow></mrow><mtext>B</mtext></msub></math>: 4.98 <math><mo>±</mo></math> 1.27, V<math><msub><mrow></mrow><mn>3</mn></msub></math>: 5.65 <math><mo>±</mo></math> 1.29, and V<math><msub><mrow></mrow><mn>12</mn></msub></math>: 5.21 <math><mo>±</mo></math> 0.95 IU/mL; p <math><mo><</mo></math> 0.001). Testosterone levels did not differ significantly from baseline. Sperm count decreased at the first checkpoint and returned to normal after 12 months (V<math><msub><mrow></mrow><mtext>B</mtext></msub></math>: 38.22 <math><mo>±</mo></math> 19.40, V<math><msub><mrow></mrow><mn>3</mn></msub></math>: 32.05 <math><mo>±</mo></math> 17.96, and V<math><msub><mrow></mrow><mn>12</mn></msub></math>: 36.66 <math><mo>±</mo></math> 18.81 million/mL; p <math><mo><</mo></math> 0.001). Sperm motility and morphology did not change significantly.</p><p><strong>Conclusion: </strong>Our research showed that even less than 5 GBq irradiation could induce a transient testicular dysfunction in the first 3 months of therapy, but it was mostly reversible after 12 months.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9717245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between dietary micronutrients and endometriosis: A case-control study.","authors":"Ghazal Roshanzadeh,&nbsp;Shahideh Jahanian Sadatmahalleh,&nbsp;Ashraf Moini,&nbsp;Azadeh Mottaghi,&nbsp;Farahnaz Rostami","doi":"10.18502/ijrm.v21i4.13272","DOIUrl":"https://doi.org/10.18502/ijrm.v21i4.13272","url":null,"abstract":"<p><strong>Background: </strong>Fewer studies were on micronutrient intake in women with endometriosis, and the etiology of endometriosis remains unclear between dietary micronutrients and the risk of endometriosis.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between dietary micronutrients and the risk of endometriosis.</p><p><strong>Materials and methods: </strong>This case-control study was conducted on 156 women (18-45 yr) with and without endometriosis in the gynecology clinic of Arash hospital between May 2017 and May 2018 in Tehran, Iran. According to the laparoscopic findings, the participants were divided into 2 groups (n = 78/each), women with pelvic endometriosis as the case group and women without endometriosis pelvic as the control group. Dietary data were collected using a validated 168-item semiquantitative food frequency questionnaire with the standard serving. A logistic regression model was used to determine the association between micronutrients and the risk of endometriosis.</p><p><strong>Results: </strong>Data analysis showed a significant relationship between micronutrients such as: potassium (OR: 0.74; CI: 0.56-0.99; p = 0.01), calcium (OR: 0.70; CI: 0.52-0.94; p = 0.003), and also among the vitamin C (OR: 0.70; CI: 0.52-0.94; p = 0.02), B2 (OR: 0.73; CI: 0.55-0.98; p = 0.01), and B12 (OR: 0.71; CI: 0.53-0.95; p = 0.02) with endometriosis, so those who used fewer micronutrients were at higher risk of endometriosis.</p><p><strong>Conclusion: </strong>The findings showed that the dietary intakes of calcium, potassium, vitamins B12, B2, B6, and C are inversely related to the risk of endometriosis.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The presence, severity, and onset of preeclampsia is associated with maternal interleukin-23 level: A case-control study.","authors":"Forough Forghani,&nbsp;Nasrin Ranjbar,&nbsp;Danial Jahantigh","doi":"10.18502/ijrm.v21i4.13269","DOIUrl":"https://doi.org/10.18502/ijrm.v21i4.13269","url":null,"abstract":"<p><strong>Background: </strong>Scientific evidence support that imbalance between inflammatory and anti-inflammatory cytokines play a critical role in preeclampsia (PE).</p><p><strong>Objective: </strong>To investigate the relationship between the maternal serum level of interleukin (IL)-23, a pro-inflammatory cytokine, PE and its severity risk was investigated.</p><p><strong>Materials and methods: </strong>The case-control study included a total of 145 women counting 75 PE cases, 35 healthy pregnant and 35 healthy non-pregnant controls from Zahedan, southeast of Iran. The maternal levels of IL-23 in circulation were determined via enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>The maternal serum levels of IL-23 were increased in PE and its 2 subgroups severe PE and mild PE, so that these increases were significant in PE and severe PE, but not in mild PE compared with the controls (p <math><mo><</mo></math> 0.001 and p <math><mo><</mo></math> 0.001, p = 0.08, respectively). Besides, the maternal IL-23 serum level was statically significant in the early onset PE, but not in the late onset-PE group compared to healthy pregnant controls (p <math><mo><</mo></math> 0.001, p = 0.46 respectively).</p><p><strong>Conclusion: </strong>The results of our study showed a positive association between IL-23 level and PE, especially in severe type and early onset PE, which suggests that IL-23 may be involved in the pathogenesis of this systemic syndrome.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9566935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the risk factors and management outcomes of ectopic pregnancy: A retrospective case-control study.","authors":"Azadeh Tarafdari,&nbsp;Mahin Bandarian,&nbsp;Sedigheh Hantoushzadeh,&nbsp;Alireza Hadizadeh,&nbsp;Saeedeh Shahsavari,&nbsp;Maryam Alsadat Razavi","doi":"10.18502/ijrm.v21i5.13475","DOIUrl":"https://doi.org/10.18502/ijrm.v21i5.13475","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancy (EP) is the implantation of a fertilized egg outside the uterine cavity or in an unusual location. According to the clinical case reports, hormonal contraceptive failures may be related to emergency contraceptives and EP. EP may be treated medically, surgically, or expectantly. Currently, there is no consensus regarding whether a multiple- or double-dose regimen with methotrexate (MTX) or an additional dose could be more effective than a single-dose regimen.</p><p><strong>Objective: </strong>This study aimed to assess risk factors and treatment outcomes for EP.</p><p><strong>Materials and methods: </strong>This case-control study was conducted in Tehran, Iran from March 2020 to March 2021. The case group was comprised of all EP-diagnosed cases (n = 191). Based on the levels of β-human chorionic gonadotropin, MTX was administered to stable individuals with no surgical indications. Risk factors were assessed through 2 control groups: intrauterine pregnancy (n = 190) and nonpregnant groups (n = 180).</p><p><strong>Results: </strong>The medical treatment significantly improved with an extra dose of MTX, especially in individuals with higher β-human chorionic gonadotropin concentrations and gestational age <math><mo>></mo></math> 7.5 wk (p = 0.002). Considering risk factors, it is assumed that hormonal contraceptive failures, including both oral and emergency contraceptives, may increase the EP likelihood (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>Based on our findings, we recommended an additional dose of MTX for subjects who are further along in their pregnancy. It is also concluded that failure of contraceptive pills increases the chances of EP.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative effect of varicocele on sperm mitochondrial dysfunction: A cross-sectional study.","authors":"Mahshid Elahi,&nbsp;Vida Hojati,&nbsp;Mahmoud Hashemitabar,&nbsp;Mahsa Afrough,&nbsp;Hossain Mohammadpour Kargar,&nbsp;Maryam Dastoorpoor","doi":"10.18502/ijrm.v21i4.13271","DOIUrl":"https://doi.org/10.18502/ijrm.v21i4.13271","url":null,"abstract":"<p><strong>Background: </strong>Varicocele is an abnormal dilation and enlargement of the scrotal venous pampiniform plexus that impairs normal blood drainage and finally leads to infertility if not treated.</p><p><strong>Objective: </strong>This study aimed to figure out the impact of mitochondria status through the mitochondrial membrane potential (MMP) and adenosine triphosphate (ATP) assessment and its correlation with semen parameters to illuminate the impact of sperm mitochondria healthiness on normal sperm functionality.</p><p><strong>Materials and methods: </strong>This analytical cross-sectional study was conducted with 100 men including 50 cases in the normozoospermic group (normal) and 50 in an infertile group with the non-varicocelectomy operation (varicocele) referring to Infertility Research and Treatment Center, ACECR Khuzestan, Iran. Routine semen analysis was performed according to World Health Organization guidelines, DNA fragmentation index, the MMP assay, ATP content, and apoptosis were carried out for all samples.</p><p><strong>Results: </strong>The results showed that the concentration, progressive motility, normal morphology, MMP, and ATP contents of sperm in varicocele were significantly lower than the normal group. In addition, the sperm DNA fragmentation index was significantly higher in the varicocele group in comparison with the normal group.</p><p><strong>Conclusion: </strong>Reduction in MMP and ATP contents, besides the loss of sperm parameters quality and increase in sperm DNA fragmentation, were seriously implicating sperm mitochondria dysfunctionality in varicocele men.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of serum anti-Mullerian hormone levels in a low-prognosis women treated in-vitro fertilization/intracytoplasmic sperm injection: A cohort study.","authors":"Ferdy Royland Marpaung, Amang Surya Priyanto, Fitri Ayu Kusumawati, Sidarti Soehita, Aryati","doi":"10.18502/ijrm.v21i3.13201","DOIUrl":"10.18502/ijrm.v21i3.13201","url":null,"abstract":"<p><strong>Background: </strong>Outcome prediction of participants treated with in-vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) using anti-Mullerian hormone (AMH) concentration has been widely used. According to the patient-oriented strategies encompassing individualized oocyte number (POSEIDON) definition, low prognosis Bologna responders have changed from poor. This definition divides low prognosis into 4 groups.</p><p><strong>Objective: </strong>The purpose of this study was to assess blood AMH levels in the group of women treated with IVF/ICSI who were thought to have a low prognosis.</p><p><strong>Materials and methods: </strong>A retrospective cohort study among 252 suspected low-prognosis group participants was assessed between January 2016 and December 2019 at Morula IVF, National hospital, Surabaya, Indonesia. Observed AMH serum levels and pregnancy rates were compared among 4 subgroups.</p><p><strong>Results: </strong>The AMH cutoff value was 1.7 ng/mL with a sensitivity of 86.7% and a specificity of 70% for diagnosing low-prognosis women using POSEIDON criteria. There was no difference in the pregnancy rate between those groups (p <math><mo>></mo></math> 0.05).</p><p><strong>Conclusion: </strong>AMH levels may indicate a poor prognosis for women having IVF/ICSI in accordance with POSEIDON guidelines. To predict the poor prognosis in women, the cutoff value must be identified.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9397608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}