International Journal of Reproductive Biomedicine最新文献

{"title":"Circulating nesfatin-1 levels in women with polycystic ovary syndrome: A systematic review and meta-analysis.","authors":"Seyed Sobhan Bahreiny, Akram Ahangarpour, Ali Asghar Hemmati, Razieh Kazemzadeh, Mohammad-Navid Bastani, Mohammad Reza Dabbagh, Mojtaba Aghaei","doi":"10.18502/ijrm.v21i10.14533","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14533","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in females. Nesfatin-1 is a neuropeptide synthesized in the hypothalamus and other peripheral organs, and there are conflicting opinions about its correlation with PCOS.</p><p><strong>Objective: </strong>This study aims to investigate the correlation between nesfatin-1 and PCOS and evaluates the effectiveness of nesfatin-1 as a biomarker for the detection of PCOS in women.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis were conducted to identify pertinent articles from databases such as PubMed, Web of Science, Cochrane, EMBASE, Scopus, and Google Scholar. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random effects model to compare group outcomes. Additionally, meta-regression and subgroup analysis were performed to elucidate sources of heterogeneity.</p><p><strong>Results: </strong>The meta-analysis involved 12 studies with 1222 participants, and the findings revealed a significant relationship between PCOS and nesfatin-1 levels. The pooled (SMD = 0.54; 95% CI: 0.00-1.07; p = 0.04) indicated a significant difference between the evaluated groups. Moreover, a subgroup analysis showed that there was a substantial difference in nesfatin-1 levels among women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 1.46; 95% CI: 0.92-2.00; p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>Our meta-analysis indicates an association between high nesfatin-1 levels and PCOS. This suggests a potential role of nesfatin-1 in the development of PCOS and proposes it as a potential diagnostic biomarker for the disease. However, further research is necessary to validate these findings.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"777-788"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the choice of treatment center by infertile couples: A cross-sectional study in Yazd Reproductive Sciences Institute.","authors":"Mohammad Ranjbar, Ali Mohammad Abdoli, Tahereh Shafaghat, Hasan Jafari, Golnaz Izadpanah, Yibeltal Assefa","doi":"10.18502/ijrm.v21i10.14538","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14538","url":null,"abstract":"<p><strong>Background: </strong>Infertility is one of the critical health issues in Iran. There are more than 70 specialized infertility treatment centers in Iran, of which the Yazd Reproductive Sciences Institute, is one of the most important ones.</p><p><strong>Objective: </strong>This study aimed to determine the factors influencing infertile couples' choice of Yazd Reproductive Sciences Institute.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted on 275 infertile couples aged 18 and older, referring to Yazd Reproductive Sciences Institute, Yazd, Iran from September 2021 to March 2022. Data were gathered using a 2-part questionnaire. Data analysis was done through SPSS software. We used descriptive statistics, Kruskal-Wallis, Mann-Whitney, and <i>t</i> test for data analysis.</p><p><strong>Results: </strong>Most participants were individuals who came from other provinces of Iran (74.9%) and were referred to the Yazd Reproductive Sciences Institute. Among the 4 categories that influenced couples' decision to choose this center, factors related to the personnel and treatment staff received the highest score (75.83), while personal factors received the lowest score (65.76). The average score for factors related to doctors was 72.90, and for factors related to the center, it was 73.65. The satisfaction with personnel and treatment staff varied based on participants' education levels, with those who had lower levels of education reporting higher levels of satisfaction (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>The primary factors contributing to the success of the Yazd Reproductive Sciences Institute in attracting clients were the dedication and expertise of the staff, as well as the esteemed reputation of the doctors at the center.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"827-834"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary inflammatory index and C-reactive protein in plasma and semen with semen quality: A cross-sectional study.","authors":"Ali Taheri Madah, Saeid Hadi, Beheshteh Abouhamzeh, Vahid Hadi, Maasoume Abdollahi, Kiumars Omidi","doi":"10.18502/ijrm.v21i10.14539","DOIUrl":"https://doi.org/10.18502/ijrm.v21i10.14539","url":null,"abstract":"<p><strong>Background: </strong>Infertility affects couples worldwide, with male factors being responsible for half of all cases.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between dietary inflammatory index (DII) and levels of C-reactive protein (CRP) in plasma and semen with the quality of semen in infertile males.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 88 infertile men referring to Besat hospital, Tehran, Iran from December 2021-November 2022 were enrolled. A detailed questionnaire requesting information, and a 168-item semiquantitative food frequency questionnaire, were completed by participants. A food frequency questionnaire was used to calculate the DII. Additionally, semen and blood samples were collected from each participant for semen analysis and CRP-level assessment. Statistical analyses were performed to explore the association between DII and CRP levels with sperm quality. The correlation between DII and serum/semen CRP, besides assessing nutrients in each DII quartile group, was also explored.</p><p><strong>Results: </strong>A significant difference was observed between different DII quartiles considering sperm motility (p = 0.006) and morphology (p = 0.014). Post hoc study revealed a significant difference between the 1<math><msup><mrow></mrow><mtext>st</mtext></msup></math> and 2<math><msup><mrow></mrow><mtext>nd</mtext></msup></math> quartiles and the 1<math><msup><mrow></mrow><mtext>st</mtext></msup></math> and 4<math><msup><mrow></mrow><mtext>th</mtext></msup></math> quartiles of DII regarding sperm motility (p = 0.011, and 0.017 respectively) and a significant difference between the 1<math><msup><mrow></mrow><mtext>st</mtext></msup></math> and 2<math><msup><mrow></mrow><mtext>nd</mtext></msup></math> quartiles of DII considering sperm morphology (p = 0.009). A statistically significant inverse correlation was also observed between DII and sperm motility (p <i>=</i> 0.017). Carbohydrates and β-carotenes were significantly different between the 4 DII quartiles (p = 0.043 and p = 0.026, respectively). Finally, no significant correlation was observed between DII and CRP levels in blood and semen (p <math><mo>></mo></math> 0.05).</p><p><strong>Conclusion: </strong>The findings suggested a notable correlation between DII and semen quality; however, no significant association were observed between DII and CRP levels in blood and semen.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 10","pages":"835-844"},"PeriodicalIF":1.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crucial role of corticotropin-releasing hormone, corticotropin-releasing hormone -binding protein, mir-200c, and mir-181a in preterm delivery: A case-control study.","authors":"Ehsan Mohiti Ardakani, Mahta Mazaheri, Ph D, Mohsen Forouzanfar, Mahdieh Mojibian, Mojtaba Jafarinia","doi":"10.18502/ijrm.v21i9.14398","DOIUrl":"10.18502/ijrm.v21i9.14398","url":null,"abstract":"<p><strong>Background: </strong>Preterm birth before 37<math><msup><mrow></mrow><mtext>th</mtext></msup></math> wk of gestation is called premature birth. Corticotropin-releasing hormone (CRH) and CRH-binding protein (BP) act on various maternal and fetal tissues during pregnancy, such as the myometrium, which regulates the transition from the dormant phase of the uterus to the active phase. Studies have shown that mir-200c and mir-181a interact with CRH and CRH-BP.</p><p><strong>Objective: </strong>The present study aimed to investigate the expression of mir-200c, mir-181a, CRH, and CRH-BP in women with a history of preterm birth.</p><p><strong>Materials and methods: </strong>In this case-control study, the gene expression level of mir-200c, mir-181a, CRH, and CRH-BP in placental tissue samples obtained from 48 women with a history of preterm labor was assessed in the Mojibian hospital of Yazd, Iran, from January to March 2023. Differences between <i>mir-200c</i>, <i>mir-181a CRH</i>, and <i>CRH-BP</i> gene expressions among cases and controls were assessed.</p><p><strong>Results: </strong>The outcomes indicated that the expression of CRH increased with going on to the regular parturition time (p <math><mo><</mo></math> 0.001). While outcomes indicated, CRH-BP decreased with going on to the regular parturition time (p <math><mo><</mo></math> 0.001). In addition, the results showed that the expression of mir-181a increased and mir-200c decreased with approaching the normal delivery time (p <math><mo><</mo></math> 0.001).</p><p><strong>Conclusion: </strong>In conclusion, the expressions of mir-200c, mir-181a, CRH, and CRH-BP were dissimilar in different weeks of gestation. It could be proposed to use mir-200c, mir-181a, CRH, and CRH-BP as biomarkers to weigh the exact delivery time, which could minimize the side effects of preterm labor for the mother and fetus.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"715-722"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to meet marital intimacy needs in women infected with coronavirus 2019: A framework qualitative content analysis research.","authors":"Tahmineh Farajkhoda, Mahmood Kamali Zarch, Saeedeh Najafihedeshi","doi":"10.18502/ijrm.v21i9.14399","DOIUrl":"https://doi.org/10.18502/ijrm.v21i9.14399","url":null,"abstract":"<p><strong>Background: </strong>Separating women with the coronavirus 2019 from family can affect marital life. Considering psychological vulnerability of women for anxiety and depression disorders, these women may experience more stress due to the loss of work at this time or special reproductive health conditions such as pregnancy, having a baby, or other medical conditions.</p><p><strong>Objective: </strong>Considering a limited number of qualitative studies on the need for marital intimacy, this study was conducted to meet marital intimacy needs in women with coronavirus 2019.</p><p><strong>Materials and methods: </strong>Framework qualitative content analysis was conducted through participation of 13 key informants (sex therapist, couple therapist, psychologist, and midwifery counselor) and 18 infected women from Yazd, Iran in July 2020 who were selected purposefully and interviewed through the semi-structured in-depth interviews.</p><p><strong>Results: </strong>3 main categories were: 1) mutual resilience (subcategories: 1. coping strategies; 2. value of marital life; 3. compassionate conflict resolving). 2) skillful relationship (subcategories: 1. assertiveness in sexual expression; 2. self-efficacy in the distance physical connectivity). 3) synergy (subcategories: 1. reframing spirituality closeness; 2. empowering aesthetic creativity; 3. management of family function, and 4. prioritizing).</p><p><strong>Conclusion: </strong>Findings revealed sex and couple therapists, health providers, and policymakers should emphasize on using new forms of digital communication in these couples. Teaching skills that increase partners' creativity and empathy, enable women to fulfill their mental, sexual and reproductive health needs, and lead to more partners responsibility and loyalty, and maintenance of family function. In times of crisis, counseling should be considered in women treatment programs and care guidelines.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"723-736"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of individuals with unconsummated marriage in Iran: A qualitative content analysis.","authors":"Sona Setayesh, Amir Hossein Jalali Nadoushan, Razieh Bakhshandeh, Reza Negarandeh, Mehrdad Eftekhar Ardebili","doi":"10.18502/ijrm.v21i9.14401","DOIUrl":"https://doi.org/10.18502/ijrm.v21i9.14401","url":null,"abstract":"<p><strong>Background: </strong>Sex is one of the important aspects of marriage and a way of expressing intimacy. Unconsummated marriage is a common problem whose prevalence is about 1.5% in Iran and can significantly influence marital life.</p><p><strong>Objective: </strong>This study aimed to assess the unconsummated marriage in a qualitative mode to offer new and beneficial solutions resulting from a better understanding.</p><p><strong>Materials and methods: </strong>In this qualitative study, conventional content analysis was used. Data collection and analysis were done from April 2013 to April 2014 with 11 women and 5 men participating, who were referred to the sexual disorders clinic of Tehran Psychiatric Institute and Rasool Akram hospital of Tehran, Iran. The researchers examined the files of people referred to these clinics with the diagnosis of unconsummated marriage. Our tool for data collection was a semi-structured interview. 2 experienced faculty psychiatrists recorded all the information based on standards for reporting qualitative research guidelines. Data were analyzed using qualitative technique and coding. Guba and Lincoln criteria was used for data validity.</p><p><strong>Results: </strong>The codes of the participants' experiences were classified into 6 main categories, which include self-concept, intrapersonal factors, partner's problem, preparedness for sex, emotional relationship between couples, and the effects of unconsummated marriage on the participant's life.</p><p><strong>Conclusion: </strong>Significant experiences among women included excessive anxiety toward the society and their spouses, and among men were weakness and guilt. Being unable to have sex negatively affected their view of life and caused great harm to their self-perception. Participants personality traits and their self-concept, and attitude toward their partners were important issues.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"745-758"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual function and sexual satisfaction in individuals undergoing infertility: A systematic review.","authors":"Armin Firoozi, Farah Lotfi Kashani, Shahram Vaziri","doi":"10.18502/ijrm.v21i9.14404","DOIUrl":"10.18502/ijrm.v21i9.14404","url":null,"abstract":"<p><strong>Background: </strong>Although sexual function (SF) and sexual satisfaction (SS) are the essential factors influenced negatively by infertility and may be associated with delaying or disrupting infertility treatment, no systematic review has assessed the results of these studies so far.</p><p><strong>Objective: </strong>The present study aimed to systematically review published interventional research regarding SF and SS among infertile individuals.</p><p><strong>Materials and methods: </strong>In this systematic review, the databases of PubMed, MEDLINE, Web of Science, Scopus, ScienceDirect, Cochrane Library, PsycInfo, Google Scholar, and SID were searched to retrieve the relevant studies in Persian and English languages up to August 2021.</p><p><strong>Results: </strong>23 interventional studies were included in this systematic review, of which only 2 were low quality based on the critical appraisal skills program checklist. The interventions of the included studies were classified into 2 main categories: educational and psychological interventions for increasing the SF and SS among infertile women or couples.</p><p><strong>Conclusion: </strong>There was no clear evidence to understand the most effective method for increasing SF and satisfaction among couples with infertility. Based on the results of the included studies, all of them showed the effectiveness of the various interventions performed on sexual health dimensions among couples with infertility. This systematic review showed that most SF studies were educational, whereas the SS were more psychologically interventional. Conducting standardized and high-quality randomized controlled trials focusing on SF and SS is recommended.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"697-714"},"PeriodicalIF":1.6,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in developing 3D culture systems of spermatogonial stem cell preservation and differentiation: A narrative review.","authors":"Leyla Fath-Bayati, Leila Naserpour, Mohadeseh Khoshandam, Rahil Jannatifar, Hoda Fazaeli","doi":"10.18502/ijrm.v21i9.14397","DOIUrl":"https://doi.org/10.18502/ijrm.v21i9.14397","url":null,"abstract":"<p><p>Male infertility has received vast attention in recent years and has no clear etiology in almost 40% of cases. Several methods have been suggested for preserving sperm and spermatogonial stem cells (SSCs) in both in vivo and in vitro conditions. The efficacy of these methods is related to their abilities, including providing an optimal environment for sperm preservation and long-term SSC culture for in vivo and in vitro differentiation of these cells. In this review article, a full MEDLINE/PubMed search was performed using the following search terms: \"Spermatogonial Progenitor Cells, Stem Cells, Fertility Preservations, Sperm Freezing, Cell Differentiations, Tissue Scaffold, 3-Dimensional Cell Culture\", which retrieved results from 1973-2022. Related articles were added to the bibliography of selected articles. Exclusion criteria included non-English language, abstract only, and unrelated articles. The production of functioning male germ cells is suggested by introducing modern bioengineered systems as a new hope for the maintenance of male fertility. Till now, few in vitro spermatogenesis investigations have provided appreciable amounts of mature gametes. Each method had benefits and disadvantages, but the 3-dimensional culture method had the greatest impact on the differentiation and preservation of SSCs. One of the critical elements of research is the preservation of sperm and the differentiation of SSCs. Several methods have been employed in this area. Various scaffolds providing an environment similar to an extracellular matrix and conditions for germ cell development and survival have been employed in recent research.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"681-696"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and perinatal outcomes in pregnant women with COVID-19 in a referral academic center in Iran.","authors":"Paria Boustani, Laleh Eslamian, Ashraf Aleyasin, Ashraf Jamal, Nasim Eshraghi, Marjan Ghaemi","doi":"10.18502/ijrm.v21i9.14403","DOIUrl":"https://doi.org/10.18502/ijrm.v21i9.14403","url":null,"abstract":"The Article Abstract is not available.","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"767-769"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcome in long- versus short-acting gonadotropin-releasing hormone agonist cycles in participants with normal ovarian reserve: An RCT.","authors":"Roya Kabodmehri, Nasrin Ghanami Gashti, Azadeh Raoufi, Marzieh Mehrafza, Zahra Nikpouri, Elmira Hosseinzadeh, Ahmad Hosseini","doi":"10.18502/ijrm.v21i9.14402","DOIUrl":"https://doi.org/10.18502/ijrm.v21i9.14402","url":null,"abstract":"<p><strong>Background: </strong>There is no agreement on which of the 2 gonadotropin-releasing hormone (GnRH) agonist protocols are the most efficient, neither there is any consensus on which one yields a better clinical pregnancy percentage.</p><p><strong>Objective: </strong>The present study aims to compare the effectiveness of reduced dosages of long- and short-acting GnRH agonists on pregnancy outcomes.</p><p><strong>Materials and methods: </strong>In this randomized controlled clinical trial, 400 women were randomly assigned to 2 groups (n = 200/group): the reduced dosage of long-acting GnRH agonist group (group 1, 1.25 mg Decapeptyl) and the short-acting GnRH agonist group (group 2, 0.5 mg/day Buserelin Acetate). The study was conducted at Mehr Medical Institute, Rasht, Iran between July 2019 and July 2020. Biochemical and clinical pregnancy were compared between groups.</p><p><strong>Results: </strong>No significant differences were observed in the endometrial lining, the total number of retrieved and metaphase-II oocytes, progesterone, and serum estradiol levels on human chorionic gonadotropin day, fertilization rate, and top-quality embryos between the groups. The duration of induction (10.8 <math><mo>±</mo></math> 1.7 vs. 10 <math><mo>±</mo></math> 2.1, p <math><mo><</mo></math> 0.001) and the total dosage of gonadotropins (2939.4 <math><mo>±</mo></math> 945.9 vs. 2441 <math><mo>±</mo></math> 1247.1, p <math><mo><</mo></math> 0.001) were significantly greater in group 2 than in group 1. No significant differences were observed between the 2 groups in terms of implantation rate, chemical pregnancy rate, and clinical pregnancy rate. A higher percentage of ovarian hyperstimulation syndrome was observed in group 2 (p = 0.005).</p><p><strong>Conclusion: </strong>Due to a lower percentage of ovarian hyperstimulation syndrome in group 1 and similar assisted reproductive technology outcomes in both groups, the long protocol was found to be superior to the short protocol.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"21 9","pages":"759-766"},"PeriodicalIF":1.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}