International Journal of Women's Health最新文献

{"title":"Clinical Outcomes of Laparoscopic Folding Suture for Cesarean Scar Defect and Its Impact on Pregnancy Outcomes: A Retrospective Study.","authors":"Xiaoyan Huang, Yurui Wu, Panpan Bei, Shan Li, Yuli Bi, Jidong Wang","doi":"10.2147/IJWH.S585521","DOIUrl":"https://doi.org/10.2147/IJWH.S585521","url":null,"abstract":"<p><strong>Background: </strong>Cesarean scar defect (CSD) is characterized by localized thinning of the myometrium due to defective healing of a previous cesarean section incision. It is frequently associated with abnormal uterine bleeding (AUB) and secondary infertility, and high-quality evidence regarding its surgical management is lacking. As a novel reconstructive technique, the efficacy of laparoscopic CSD folding suture in alleviating AUB and improving fertility outcomes remains to be validated.</p><p><strong>Purpose: </strong>In the absence of high-quality evidence, this study aimed to provide preliminary evidence on the efficacy of laparoscopic folding suture in relieving AUB-related symptoms (assessed by menstrual duration) and optimizing reproductive outcomes, and to assess its feasibility and safety.</p><p><strong>Patients and methods: </strong>This single-centre, retrospective case series included patients who underwent laparoscopic folding suture for CSD at Shandong Provincial Maternal and Child Health Hospital between October 2021 and March 2025. A total of 36 patients were assessed for eligibility; 10 were excluded for the following reasons: lost to follow-up within 3 months postoperatively (n = 3), prior hysteroscopic repair of CSD (n = 2), concurrent endometrial polyps (n = 3), and confirmed tubal factor infertility (n = 2). The remaining 26 women were included in the final analysis. The primary endpoint was change in menstrual duration before and after surgery; secondary endpoints comprised subsequent pregnancy outcomes, change in residual myometrial thickness (RMT), and perioperative adverse events.</p><p><strong>Results: </strong>Menstrual duration was shortened in 96.2% of patients (25/26), with the median menstrual duration significantly decreasing from 14.5 days (IQR 10.0-15.0) preoperatively to 7.0 days (IQR 6.0-9.0) postoperatively (P < 0.001). Sixteen (61.5%) were actively trying to conceive; during follow-up, 12 of these individuals (75%) achieved pregnancy. Intraoperative blood loss was 30 mL (IQR 20-50). The RMT increased significantly from 1.3 mm (IQR 1.0-1.7) preoperatively to 6.5 mm (IQR 5.0-7.0) postoperatively (median increase 5.2 mm; P < 0.001).</p><p><strong>Conclusion: </strong>This single-centre retrospective case series suggests that laparoscopic folding suture is a safe and feasible technique for CSD repair, associated with significant improvement in menstrual symptoms and favorable pregnancy outcomes. However, due to the study design, these preliminary findings warrant confirmation in larger, prospective controlled trials.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"585521"},"PeriodicalIF":2.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrimination, Stigma and Taboo Towards the Three Ms' Working Body: A Systematic Review Around Menstruation, Maternity and Menopause.","authors":"Matteo Cicchetti, Sara Viotti, Alberto Conforti, Lia Corrieri, Daniela Converso, Giulia Bacci, Gloria Guidetti","doi":"10.2147/IJWH.S551155","DOIUrl":"https://doi.org/10.2147/IJWH.S551155","url":null,"abstract":"<p><p>Menstruation, maternity and menopause are three natural and everyday experiences in most women's lives, but they often intersect in complex ways with career paths and workplace dynamics. In this study, the existing literature on these \"three Ms\" is systematically examined in relation to taboo, discrimination and stigma in work context, taking into account the PRISMA guidelines. A total of 84 articles from Pubmed, Scopus and Web of Science databases were analyzed. Most of the articles included refer to studies conducted in post-industrial, English-speaking countries, and only a few of them were conducted in non-post-industrial and low-income countries. The review is structured around the three key phases of the female reproductive life course: menstruation, maternity and menopause. These three Ms are examined using a tripartite framework: (1) the individual and subjective level, which focuses on personal experiences, identity, and psychological responses; (2) the organizational environment, which examines workplace policies, professional cultures, and institutional practices; and (3) attitudes and effects on well-being, including societal perceptions, stigma, and effects on psychological and overall health. This multi-level approach provides a comprehensive understanding of how these transitions are experienced, managed and interpreted both individually and in the socio-organizational environment. Despite the near parity in employment rates between men and women and the prevalence of the three Ms in post-industrial with high income countries, the literature is less extensive than expected, suggesting that there is limited academic engagement with the topic. The study highlights the reciprocal relationship between cultural beliefs and academic research. Increased academic attention to menstruation, maternity and menopause in relation to taboo, stigma and discrimination in the workplace could enhance public discourse and help improve the experiences of women at these life stages throughout their careers.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"551155"},"PeriodicalIF":2.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Polycystic Ovary Syndrome: A Systematic Analysis of Pre- and Post-Pandemic Trends from the 2021 Global Burden of Disease Study (1990-2021).","authors":"Yingwu Guo, Yingrong Du, Lingfang Zhang, Huihui Xu, Jun Liu, Shenghao Li, Zhaoyuan Xu, Junfang Yan, Jie Chen, Huawei Wang","doi":"10.2147/IJWH.S583951","DOIUrl":"https://doi.org/10.2147/IJWH.S583951","url":null,"abstract":"<p><strong>Objective: </strong>The study systematically examines the long-term trends in the global burden of Polycystic ovary syndrome (PCOS) across 204 countries and territories, with a specific focus on comparing pre-pandemic (1990-2019) and post-pandemic (2019-2021) periods.</p><p><strong>Methods: </strong>Using data from the Global Burden of Disease (GBD) 2021 for women aged 15-54, we estimated incidence, prevalence, and years lived with disability (YLDs). Age-standardized rates (ASIR, ASPR, ASYR) and estimated annual percentage change (EAPC) were calculated. Joinpoint, Age-Period-Cohort, and Bayesian models were used to analyze trends from 1990-2021 and project burden to 2050. Mendelian randomization (MR) assessed whether anxiety and guilt contribute to PCOS risk.</p><p><strong>Results: </strong>All burden measures increased globally from 1990 to 2021. Post-2019, the rate of increase (EAPC) accelerated significantly compared to the pre-pandemic period. High-SDI regions showed the lowest pre-pandemic growth but the largest increases during the pandemic. Health inequalities modestly improved by 2021. Projections indicate continued growth, with ASIR, ASPR, and ASYR reaching 73.66, 2104.41, and 18.37 per 100,000 by 2050, respectively. MR supports anxiety and guilt as likely risk factors.</p><p><strong>Conclusion: </strong>The post-pandemic rise in PCOS burden underscores systemic vulnerabilities in women's endocrine healthcare during health emergencies and signals a growing global health challenge.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"583951"},"PeriodicalIF":2.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Health of Female Sex Workers in Six Low- and Middle-Income Countries.","authors":"Heather Thompson, Brian Willis, Swarna D S Weerasinghe, Emily K Perttu, Esther Anne Chin, Wendy L Macias-Konstantopoulos","doi":"10.2147/IJWH.S550242","DOIUrl":"https://doi.org/10.2147/IJWH.S550242","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to examine factors that impact maternal health, including antenatal care and skilled birth attendance, work behavior, and substance use during pregnancy among female sex workers (FSW) across six low- and middle-income countries (LMIC). The added knowledge may inform programs, policies, and funding on a level equivalent to those for HIV prevention to reduce the high numbers of maternal deaths among this population.</p><p><strong>Methods: </strong>This was an exploratory mixed methods study. Quantitative data were gathered from cross-sectional surveys completed by 1352 FSW. The proxy respondent methodology was used to identify behaviors and characteristics related to maternal health in pregnancy among FSW. Descriptive statistics were used to summarize quantitative survey responses, and text analytics to summarize answers to open-ended questions.</p><p><strong>Results: </strong>An estimated 86.1% of FSW were reported to be mothers, but access to antenatal care (ANC) was reported to be only 28.7%. Barriers to ANC included cost, stigma, and accessibility. In some countries the majority of FSW were reported to give birth in brothels. Nearly a quarter (24.4%) of FSW were reported to work until the onset of labor, with most (75.9%) returning to work less than a month postpartum. Consumption of alcohol and other substances during pregnancy was reportedly very high (79.0% and 65.1% respectively), and 70.6% of FSW were reported to experience depression during the postpartum period. Participants expressed the need for respectful FSW-sensitized prenatal, intrapartum, and postpartum care at a location where they felt comfortable.</p><p><strong>Conclusion: </strong>This exploratory study revealed multiple risk factors experienced by pregnant FSW that may contribute to high numbers of maternal deaths reported among FSW, including poor access to affordable, quality maternal healthcare, and lack of service programs to address social determinants of health.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"550242"},"PeriodicalIF":2.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Burden and Trends of Hypertensive Heart Disease Among Women of Childbearing Age from 1992 to 2021.","authors":"Jinglei Huang, Wenkai Jiang, Jiawei Zhai, Kangting Zhang, Guang Yao","doi":"10.2147/IJWH.S588257","DOIUrl":"https://doi.org/10.2147/IJWH.S588257","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive heart disease (HHD) is an important contributor to cardiovascular morbidity among women of childbearing age (WCBA), yet long-term global trends in this population remain insufficiently characterized. We aimed to describe the prevalence, mortality, and disability-adjusted life years (DALYs) of HHD among WCBA at global, regional, and national levels and to assess temporal patterns from 1992 to 2021.</p><p><strong>Methods: </strong>Data were obtained from the Global Burden of Disease (GBD) 2021 study. We estimated numbers and age-standardized rates of prevalence, mortality, and DALYs for women aged 15-49 years. An age-period-cohort (APC) model was applied to disentangle age, period, and cohort effects on mortality trends.</p><p><strong>Results: </strong>From 1992 to 2021, the global burden of HHD among WCBA exhibited a divergent trend: while the prevalence rate increased steadily from 20.09% to 27.94%, mortality and DALY rates generally declined. In 2021, significant regional disparities existed, with the middle-SDI region recording the highest prevalence, whereas the high-middle SDI region achieved the lowest mortality and DALY rates. APC analyses for mortality further clarified these shifts: period-effect risks declined across most SDI groups but notably increased in high-SDI countries. Similarly, while cohort-effect risks significantly reduced in most regions, high-SDI countries exhibited a distinct pattern of an initial risk rise followed by a subsequent decline.</p><p><strong>Conclusion: </strong>Global HHD trends among WCBA are characterized by rising prevalence alongside declining mortality and DALY rates. Marked disparities persisted across SDI regions, with the highest prevalence in middle-SDI settings and more variable mortality patterns in high-SDI settings.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"588257"},"PeriodicalIF":2.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Recurrence After Endometrial Polypectomy in Women of Childbearing Age Based on Machine Learning Algorithm.","authors":"Xiangyu Chen, Guange Chen, Dandan Bao, Jianfei Liu, Xinxin Zhang","doi":"10.2147/IJWH.S591932","DOIUrl":"https://doi.org/10.2147/IJWH.S591932","url":null,"abstract":"<p><strong>Objective: </strong>Research on machine learning (ML) prediction models for recurrence after endometrial polypectomy remains unexplored. In this study, we aim to establish an ML-driven model based on multi-biomarkers to predict recurrence after endometrial polypectomy.</p><p><strong>Methods: </strong>A retrospective cohort of 606 patients who underwent endometrial polypectomy was analyzed. Variables including age, BMI, reproductive history, prior uterine surgery, coexisting uterine disorders, polyp characteristics, and routine blood indices were extracted. Seven ML algorithms (logistic regression, SVM, MLP, random forest, KNN, Naïve Bayes, and decision tree) were trained using 10-fold cross-validation. Performance was evaluated by AUC, accuracy, sensitivity, specificity, PPV, NPV, and F1 score.</p><p><strong>Results: </strong>Of the 606 patients, 179 (29.5%) developed recurrence within one year postoperatively. The cohort was randomly divided into a training set (n = 424) and a validation set (n = 182). In the training set, the random forest (RF) algorithm achieved the best performance (AUC = 0.838, accuracy = 79.5%, specificity = 0.930, F1 score = 0.576). In the validation set, RF remained superior (AUC = 0.760, accuracy = 75.3%, specificity = 0.875, F1 score = 0.526), underscoring its strong generalizability. SHAP analysis identified age, posterior-wall polyp location, prior uterine surgery, histopathological subtype, and hemoglobin level as the most influential predictors of recurrence.</p><p><strong>Conclusion: </strong>The RF-based model, using demographic, clinical, and hematologic features, showed high accuracy in predicting recurrence risk after endometrial polypectomy. This interpretable ML framework can help clinicians identify high-risk patients early and personalize postoperative surveillance.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"591932"},"PeriodicalIF":2.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abortive Tubal Stump Pregnancy: Two Case Reports with Diagnostic Challenges and High Risk of Persistent Ectopic Pregnancy.","authors":"Yanhong Zhao, Jianhong Gao, Donglei Xu, Peipei Sun, Jing Zhang","doi":"10.2147/IJWH.S577301","DOIUrl":"https://doi.org/10.2147/IJWH.S577301","url":null,"abstract":"<p><strong>Background: </strong>Tubal stump pregnancy(TSP) is a rare ectopic pregnancy that occurs in patients after salpingectomy. We report two cases of a distinct clinical subtype characterized by spontaneous detachment of gestational tissue from the tubal stump, which we describe as \"abortive TSP\".</p><p><strong>Cases: </strong>Two patients with a history of salpingectomy presented with abdominal pain and positive β-hCG. Case 1 was conceived naturally, with a history of amenorrhea for 34 days. Case 2 was a pregnancy achieved by in vitro fertilization and embryo transfer (IVF-ET), with two fresh embryos transferred 21 days prior to admission. Preoperative ultrasound showed no intrauterine pregnancy, no obvious mass at the uterine cornua or adnexa, but revealed hemoperitoneum.</p><p><strong>Intervention: </strong>Both patients underwent emergency laparoscopy. Active bleeding from the tubal stump was identified, with no distinct mass visible. Case 1 received evacuation of pelvic hematocele, suture of the tubal stump and uterine cornua. Typical chorionic villi were identified in the pelvic hematocele. Case 2 underwent removal of one intact chorionic villus from the tubal stump surface, evacuation of pelvic hematocele with identification of a second chorionic villus, suture of the tubal stump and uterine cornua.</p><p><strong>Outcomes: </strong>Histopathological examination confirmed chorionic villi in the evacuated pelvic tissue. Primary implantation within the tubal stump wall could not be histologically confirmed. In Case 1, serial β-hCG levels declined steadily to within the normal range during follow-up. In Case 2, β-hCG increased during follow-up, consistent with persistent ectopic pregnancy(PEP), and the condition resolved after treatment with methotrexate (MTX).</p><p><strong>Conclusion: </strong>Abortive TSP is a rare and easily misdiagnosed condition. In post-salpingectomy patients with positive β-hCG and hemoperitoneum, consider TSP and/or abortive TSP; inspect the stump carefully and ensure structured postoperative β-hCG surveillance to detect persistent trophoblastic tissue.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"577301"},"PeriodicalIF":2.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional and Multivariable Mendelian Randomization Study of PCOS and VTE.","authors":"Lifang You, Hongyin Cui, Fen Zhao, Hairong Huang, Wenxuan Xu","doi":"10.2147/IJWH.S586045","DOIUrl":"https://doi.org/10.2147/IJWH.S586045","url":null,"abstract":"<p><strong>Background: </strong>We used bidirectional and multivariable Mendelian randomization (MR) to test whether polycystic ovary syndrome (PCOS) is causally related to venous thromboembolism (VTE).</p><p><strong>Methods: </strong>Using European-ancestry GWAS summary statistics, we performed bidirectional two-sample univariable MR and multivariable MR adjusting for diabetes, body mass index (BMI), hormone replacement therapy, and oral contraceptive use. Robustness was assessed with Cochran's Q, MR-Egger intercept, MR-PRESSO, and leave-one-out analyses.</p><p><strong>Results: </strong>Univariable MR showed no causal effect of PCOS on VTE (IVW OR 1.008, 95% CI 0.974-1.042; <i>p</i> = 0.653), and reverse-direction MR provided no evidence that VTE causally influences PCOS. In multivariable MR, PCOS remained not associated with VTE (IVW OR 1.016, 95% CI 0.987-1.045; <i>p</i> = 0.285), whereas BMI had a clear independent positive effect on VTE risk (IVW OR 1.358, 95% CI 1.262-1.461; <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Genetic evidence does not support a causal relationship between PCOS and VTE. BMI is independently associated with VTE risk and appears to be a key determinant of VTE risk.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"586045"},"PeriodicalIF":2.6,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms Experienced by Breast Cancer Patients Before, During and After Chemotherapy: A Systematic Review.","authors":"Yang Cao, Khuan Lee, Azlina Yusuf, Seong Ting Chen, Xue Dong, Lin Li, Poh Ying Lim","doi":"10.2147/IJWH.S568638","DOIUrl":"https://doi.org/10.2147/IJWH.S568638","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is the most prevalent cancer among women worldwide. Chemotherapy remains a key element of treatment for a large proportion of breast cancer patients. Breast cancer patients undergoing chemotherapy often experience multiple symptoms that can impact their quality of life. This systematic review aimed to identify the symptoms experienced by breast cancer patients before, during and after chemotherapy treatment along with associated factors, to provide an evidence base for healthcare providers.</p><p><strong>Methods: </strong>Five electronic databases were searched from January 2015 to September 2025 encompassing observational studies. Two researchers independently screened the studies and extracted data. The Standard Quality Assessment Criteria for Evaluating Primary Research Papers was used to evaluate the quality of included studies.</p><p><strong>Results: </strong>Out of 5,588 records, 37 studies met the inclusion criteria. Majority of studies were conducted in Asia and the most common study type was cross-sectional studies (n=18, 48.6%). Anxiety, depression, chemotherapy-induced nausea and vomiting (CINV), fatigue and sleep problems were the most common symptoms observed in these studies. The factors reported were divided into non-modifiable factors (sociodemographic and disease related) and modifiable factors (physiological, psychological, lifestyle, nutritional and other related). Younger age was the most frequently reported risk factor for increased anxiety, depression, fatigue, nausea, and menopausal symptoms, followed by having children, greater number of chemotherapy cycles, higher BMI, lower performance status, and limited social support.</p><p><strong>Conclusion: </strong>Breast cancer patients undergoing chemotherapy experience a variety of symptoms. These findings underscore the importance of routine symptom screening and baseline risk assessment to enable early identification of high-risk patients and implementation of targeted interventions to optimize quality of life. Future research should prioritize identifying high-risk populations and implementing targeted early preventive interventions to enhance patient quality of life.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"568638"},"PeriodicalIF":2.6,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Ovarian Cancer in China Attributable to Asbestos Exposure During 1990-2021 and the Projections Through 2050.","authors":"Di Jin, Lei Hua, Qiulin Huang, Ruijiao Lei, Chengyin Xu, Xukai Chen, Pengtao Chen, Tianhui Chen","doi":"10.2147/IJWH.S582043","DOIUrl":"https://doi.org/10.2147/IJWH.S582043","url":null,"abstract":"<p><strong>Objective: </strong>Ovarian cancer is a leading cause of cancer-related mortality among women globally. Occupational asbestos exposure is a well-established risk factor. This study aimed to evaluate and project the burden of ovarian cancer attributable to asbestos exposure in China through 2050.</p><p><strong>Methods: </strong>Data on mortality and disability-adjusted life years (DALYs) for ovarian cancer due to asbestos exposure were obtained from the Global Burden of Disease 2021 study. Temporal trends in age-standardized rates from 1990 to 2021 were analyzed using Joinpoint regression. An age-period-cohort model was applied to disentangle the effects of age, period, and birth cohort. Future disease burden through 2050 was projected using the Bayesian age-period-cohort model.</p><p><strong>Results: </strong>In 2021, asbestos-related ovarian cancer resulted in 357 deaths and 7,621 DALYs in China, accounting for 1.43% and 1.02% of the total ovarian cancer burden, respectively. The burden was highest among individuals aged 70-74 years. Joinpoint analysis identified peaks in the age-standardized mortality and DALY rates around 2011. The age-period-cohort model revealed that rates increased with age. Projections indicate that by 2050, the age-standardized mortality and DALY rates will reach 0.0266 and 0.735 per 100,000, while the deaths and DALYs show an upward trend.</p><p><strong>Conclusion: </strong>The burden of ovarian cancer attributable to asbestos exposure in China has increased substantially and is projected to continue rising through 2050. These findings underscore the imperative for a complete ban on asbestos production and consumption in China.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"18 ","pages":"582043"},"PeriodicalIF":2.6,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13037509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}