International Journal of Women's Health最新文献

{"title":"Experiences and Perspectives of Women Undergoing Oocyte Cryopreservation in Riyadh, Saudi Arabia: A Mixed-Methods Study.","authors":"Fatimah A Alzahrani, Dania Al-Jaroudi, Hamad Ali Alsufyan, Ali A Alzahrani, Saad Abdullah Alshehri, Sultana S K Jalwi, Elhadi Miskeen","doi":"10.2147/IJWH.S496633","DOIUrl":"10.2147/IJWH.S496633","url":null,"abstract":"<p><strong>Objective: </strong>Women increasingly desire fertility at later ages, yet fertility rates decline with age. Oocyte cryopreservation, offer support for women seeking pregnancy at advanced maternal ages. This mixed-methods study explored the experiences and perspectives of 100 women aged 18-47 in Riyadh, Saudi Arabia who underwent oocyte cryopreservation for social and medical reasons. The research aims to understand the motivations, challenges, and satisfaction levels associated with oocyte cryopreservation within the context of Saudi Arabian society and culture.</p><p><strong>Methods: </strong>Using mixed methods, 100 subjects were enrolled in ten months. Self-administered questionnaires were dispersed to 100 women who underwent oocyte cryopreservation at a private clinic. Fifteen women willing to undergo recorded interviews were interviewed for 11-to 25-minute sessions. The interviews were transcribed entirely and subjected to thematic content analysis. Quantitative data was analyzed on STATA BE Version 18.</p><p><strong>Results: </strong>77 women (77%) froze their oocytes for social reasons, and the women understood the medical/non-medical rationale for freezing. Interestingly, women's reasons for oocyte cryopreservation were highly associated with satisfaction (p=0.050), with women stating social reasons being most satisfied. It can also be seen that factors such as the presence of complications during the oocyte cryopreservation process were tied to low satisfaction (p=0.040). Six thematic areas around oocyte cryopreservation are presented, including freezing concepts and aims, patient experience, challenges in service quality, communication and confidentiality, and -proposals.</p><p><strong>Conclusion: </strong>This research has highlighted how the medical and socio-cultural of women impacted the oocyte cryopreservation intersect. There is a need for improved culturally sensitive healthcare and educational services for better access and awareness. This is better to show that the public policy advocacy that contributes to the unique impacts of oocyte cryopreservation on a woman's reproductive health and why is particularly concerning.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"879-895"},"PeriodicalIF":2.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Septic Shock and Fetal Demise Due to <i>Bacillus cereus</i> Infection Following Mid-Trimester Genetic Amniocentesis.","authors":"Yasong Xu, Yizhen Ji, Liangkai Zheng, Ling Chen, Li Sun, Qichang Wu","doi":"10.2147/IJWH.S511595","DOIUrl":"10.2147/IJWH.S511595","url":null,"abstract":"<p><strong>Background: </strong>The ubiquitous <i>Bacillus cereus</i> bacterium can cause numerous clinical diseases, from transient bacteremia to life-threatening systemic infections. Studies have indicated that non-anthracis <i>Bacillus</i> species, such as <i>Bacillus cereus</i>, may be clinically significant concerning placental infection, and the resulting outcomes for the fetus.</p><p><strong>Case presentation: </strong>We report a woman who developed an acute intrauterine infection following mid-trimester genetic amniocentesis. Twenty-seven hours after the procedure, the mother experienced septic shock, disseminated intravascular coagulation (DIC), and fetal death. Microbiology cultures of placental and fetal swab samples taken during hysterotomy and maternal blood samples taken upon admission revealed the growth of <i>Bacillus cereus</i>. The placental pathological examination revealed a large number of microorganisms in the fetal vessels of the chorionic villi, along with signs of acute villitis and chorioamnionitis.</p><p><strong>Conclusion: </strong>This case study highlights the significance of placental intravascular organisms in acute intrauterine infection caused by <i>Bacillus cereus</i>. It also emphasizes the importance of histological analysis, which offers crucial details about the time of onset of the infection and the causative agents and informs present and future obstetric care of these patients, and the significance of placental intravascular organisms in acute intrauterine infection caused by <i>Bacillus cereus</i>.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"897-902"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Analysis of Maternal Cardiac Autonomic Function in Kazakh Pregnant Women with Gestational Diabetes.","authors":"Aigul Sartayeva, Khatima Kudabayeva, Nurgul Abenova, Yerlan Bazargaliyev, Laura Danyarova, Gulnaz Adilova, Aliya Zhylkybekova, Amin Tamadon","doi":"10.2147/IJWH.S486267","DOIUrl":"10.2147/IJWH.S486267","url":null,"abstract":"<p><strong>Introduction: </strong>Gestational diabetes mellitus (GDM) is a common complication during pregnancy that poses considerable risks to both maternal and fetal health. However, its effect on cardiac autonomic function, measured by heart rate variability (HRV), remains uncertain. This study aims to investigate potential alterations in cardiac autonomic function in women diagnosed with GDM.</p><p><strong>Methods: </strong>In this cross-sectional study, 80 Kazakh pregnant women in their third trimester with GDM were enrolled from the endocrinology department of Aktobe Medical Center between January and April 2023. A control group of 30 third-trimester pregnant women without GDM was also selected from outpatient clinics in Aktobe City. HRV was measured with participants in a seated position. A nomogram was developed to predict GDM risk, integrating relevant parameters associated with the condition.</p><p><strong>Results: </strong>Women with GDM were found to be older than those in the control group (p=0.005), though there were no significant differences in education level, employment status, or parity between the two groups. GDM was associated with larger fetal size (p=0.035) and a higher incidence of miscarriages and abortions (p<0.05) compared to the control group. Additionally, obesity was more prevalent among women with GDM (p<0.05). HRV parameters showed no significant differences between the GDM group and healthy pregnant women. The nomogram demonstrated good predictive accuracy, with an area under the curve of 0.7847 in the training cohort.</p><p><strong>Conclusion: </strong>The nomogram developed in this study may prove useful for clinicians and patients in making informed clinical decisions and assessing outcomes. Notably, no significant differences in HRV were observed between women with uncomplicated pregnancies and those with GDM.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"865-877"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Potential Blood Markers for Endometriosis Through the Integration and Experimental Validation of Immune Cell Traits Genome and Genome-Wide Associated Data.","authors":"Jie Mei, Xi-Ya Jiang, Bin Zhang, Li Wang, Ai-Xi Zhang, Jie-Jie Li, Shun-Xia Chen, Xiao Xu, Jing-Jing Hu, Shu-Guang Zhou","doi":"10.2147/IJWH.S509722","DOIUrl":"10.2147/IJWH.S509722","url":null,"abstract":"<p><strong>Background: </strong>While endometriosis (EM) has been previously associated with multiple immune factors, the causal relationship underlying these associations remains unclear.</p><p><strong>Objective: </strong>In this study, Two-sample Mendelian randomization (MR) method was employed to investigate the causal relationship between 731 immune cell traits and EM based on tabulated data from genome-wide association studies (GWAS).</p><p><strong>Methods: </strong>MR method includes inverse variance weighting (IVW), the weighted median (WM), MR-Egger, the weighted model, and the simple model. IVW is used as the primary method for judging causal effects. Peripheral blood was obtained from EM patients, and the positive immune cell phenotype was confirmed using flow cytometry.</p><p><strong>Results: </strong>After <i>P-value</i> correction, our two-sample MR showed that <i>CD28 on CD28+ DN (CD4-CD8-)</i> had a suggestive causal relationship with EM (β =0.040, 95% CI =1.02-1.06, <i>P</i> =0.00029, <i>P_FDR</i> = 0.1984). The results of the other two main methods were similar: Weighted median (OR =1.031, 95% CI =1.00-1.07, <i>P</i> =0.082); MR-Egger (OR =1.032, 95% CI =1.10-1.06, <i>P</i> =0.044). The flow cytometry results indicated that the expression level of <i>CD28 on CD28+ DN (CD4-CD-8)</i> was significantly increased in the ectopic intima of EM patients.</p><p><strong>Conclusion: </strong>Our study demonstrated a causal relationship between immune traits and EM, and the results were verified by clinical samples. The study may provide new biomarkers for the early diagnosis and immunotherapy of EM.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"845-853"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Subchorionic Hematoma on Pregnancy Outcomes in Obstetric Antiphospholipid Syndrome.","authors":"Rong Cang, Xuelei Ding, Zan Tian, Zijie Fu, Meijuan He, Ying Liang","doi":"10.2147/IJWH.S496848","DOIUrl":"10.2147/IJWH.S496848","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of subchorionic hematoma (SCH) in patients with obstetric antiphospholipid syndrome (OAPS) on pregnancy outcomes, as well as the clinical value of anticoagulant therapy.</p><p><strong>Methods: </strong>This retrospective study included 109 OAPS patients treated at the Fourth Hospital of Shijiazhuang from December 2019 to December 2021. Patients were divided into two groups: SCH group (n=40) and non-SCH group (n=69). Baseline data, laboratory indicators (anti-β2GP I, lupus anticoagulant, ACL, D-D, AA, ADP, ATIII, PS, and PC), complications, and pregnancy outcomes were compared between the groups.</p><p><strong>Results: </strong>There were no significant differences between the two groups concerning the abortion rate, live birth rate (all P>0.05). However, we reported a significantly higher rate of preterm delivery occurring between 34-37 in the SCH group (13.7% vs 1.7%, P=0.027). The proportion of patients with triple-positive antiphospholipid antibodies (aPLs) was significantly higher in the SCH group compared to the non-SCH group (7.5% vs 0.0%, P=0.047). During pregnancy but before routine first-trimester therapy was initiated, the levels of β2GP I, LA, ACL, D-D, AA, and ADP in the SCH group were higher than those in the non-SCH group, while ATIII, PS, and PC levels were lower (all P < 0.05). After treatment, the levels of β2GP I, LA, ACL, D-D, AA, and ADP decreased in both groups compared to their pre-treatment levels (all P < 0.05); however, the levels of D-D and PS in the SCH group remained higher than those in the non-SCH group (all P < 0.05).</p><p><strong>Conclusion: </strong>In patients with OAPS who present with SCH during pregnancy, laboratory indicators suggest more severe immune disorders and coagulopathy, as well as an increased risk of preterm delivery.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"855-863"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting Causal Relationships Between Immune Cells, Plasma Metabolites, and PCOS: Evidence From Mediating Mendelian Randomization Analysis.","authors":"Xia-Li Wang, Yi-Fang He, Shi-Kun Chen, Jing Cheng, Xiu-Ming Wu","doi":"10.2147/IJWH.S508352","DOIUrl":"10.2147/IJWH.S508352","url":null,"abstract":"<p><strong>Background: </strong>The relationship between Polycystic ovary syndrome (PCOS) and immune dysregulation, along with metabolic disturbances, remains unclear. This study used Mendelian Randomization (MR) to investigate causal relationships between immune cells, PCOS, and possible metabolite mediators.</p><p><strong>Methods: </strong>We explored the genetic-level relationship between immune cells and PCOS, focusing on metabolites as potential mediators. Data from genome-wide association studies (GWAS) included 731 immune cell types (n=3757), 1400 plasma metabolites (n=8299), and PCOS cases (n=797) versus controls (n=140,558). Bidirectional MR analysis examined immune-PCOS relationships, while two-step MR and mediation analysis identified metabolites as potential mediators. The inverse variance-weighted (IVW) method was used for primary causal assessment, with sensitivity analysis validating results.</p><p><strong>Results: </strong>We identified a total of 33 immune cells that were associated with increased or decreased risk of PCOS (<i>P</i> < 0.05), and these immune cells were also associated with alterations in certain metabolite levels (<i>P</i> < 0.05). Among them, 12 immune cells were found to influence the occurrence of PCOS through the mediation of 17 metabolites. Notably, the effects of Myeloid DC %DC, NKT AC, CD20 on CD20- CD38-, CD25 on memory B cell, and HLA DR on CD33dim HLA DR+ CD11b+ were mediated by multiple metabolites on PCOS development. Similarly, histidine betaine (hercynine) levels and alpha-ketoglutarate to ornithine ratio mediated the association of more than one immune cell with PCOS.</p><p><strong>Conclusion: </strong>This study highlights 12 immune cells impacting PCOS through 17 metabolites, advancing the understanding of immune mechanisms in PCOS risk and suggesting potential therapeutic approaches targeting immune modulation.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"807-823"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effects of Inflammatory Cytokines and Immune Cell Phenotypes on Spontaneous Abortion: Evidence From Mendelian Randomization.","authors":"Shaochong Lin, Xiangming Tian, Sijia Kong, Bolun Zhang, Sidong Wang, Kongfu Zhu, Xiaomin Liu, William S B Yeung, Dandan Cao, Yuanqing Yao","doi":"10.2147/IJWH.S501620","DOIUrl":"10.2147/IJWH.S501620","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the causal relationship between inflammatory cytokines, immune cells and spontaneous abortion (SA).</p><p><strong>Methods: </strong>A bidirectional two-sample Mendelian randomization (MR) analyses was conducted based on the genetic data of 91 inflammatory cytokines (n=14,824), 731 immune traits (n=3757) and SA (18,680 cases and 162,987 controls) cohorts. Five different MR analysis methods and Bayesian-weighted Mendelian randomization (BWMR) analysis were employed to assess the genetic causal connection. In addition, the robustness of this study results was ensured through comprehensive sensitivity analyses assessing heterogeneity, and potential horizontal pleiotropy and reverse causality.</p><p><strong>Results: </strong>These MR results suggest that higher levels of two inflammatory cytokines and ten immune cells are associated with a lower risk of SA (OR < 1.00). In contrast, fifteen immune cell traits exhibit a positive relationship with SA risk (OR > 1.00). Notably, mediation analysis revealed that the causal effect of programmed death ligand 1 (PDL1) on SA was partially mediated by CD45 expression on Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSCs), and Terminally Differentiated CD4⁻CD8⁻ T cells also acted as mediators in the causal effect of tumor necrosis factor-beta (TNF-β) on SA.</p><p><strong>Conclusion: </strong>This study comprehensively assessed the causal relationship between immune-related exposures and SA, identifying several immune factors associated with SA risk. These finding have implications for clinical guidance in pregnancy preparation.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"793-806"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral Therapy-Induced Changes in Long Non-Coding RNA Expression Profiles in Umbilical Cord Blood and Placental Tissues of Hepatitis B Virus-Infected Pregnant Women.","authors":"Cuimin Wang, Yuting Huang, Lanfeng Li, Xizhen Huang, Yin Huang, Xiang Fang, Yu Long","doi":"10.2147/IJWH.S511524","DOIUrl":"10.2147/IJWH.S511524","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus (HBV) is a major global health concern, with maternal-fetal transmission being the primary route of transmission, which can lead to chronic HBV infection in newborns. Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and immune responses, but their involvement in HBV transmission during pregnancy remains unclear. This study aimed to assess the impact of tenofovir disoproxil fumarate (TDF)-based antiviral therapy on lncRNA expression profiles and immune signaling pathways in umbilical cord blood and placental tissues and to identify potential therapeutic targets for preventing intrauterine HBV infection.</p><p><strong>Materials and methods: </strong>Umbilical cord serum and placental tissues were collected from six HBV carriers. Three carriers received TDF-based antiviral therapy, and the remaining carriers who did not receive antiviral therapy served as controls. LncRNA microarray analysis and bioinformatics were used to evaluate the effects of antiviral therapy on lncRNA expression profiles and signaling pathways.</p><p><strong>Results: </strong>Antiviral therapy exerted minimal effects on lncRNA expression profiles in umbilical cord blood. In placental tissues, significant alterations in lncRNA expression profiles were observed, including 249 upregulated and 381 downregulated lncRNAs. Antiviral therapy activated innate immune pathways, such as intracellular DNA sensing, chemokine signaling, type I interferon, Jak-Stat, and interferon-γ-mediated adaptive immunity. Through intersection analysis, CPED1 was found differentially expressed in both cord blood and placental tissues. KEGG pathway analysis suggested that low CPED1 expression may inhibit virus transmission via the JAK-STAT pathway.</p><p><strong>Conclusion: </strong>This study demonstrated that TDF-based antiviral therapy altered lncRNA expression and activated immune signaling pathways in placental tissues, offering insights into the molecular mechanisms of maternal-fetal HBV transmission.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"835-844"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Hepatic Steatosis Index and Endometrial Cancer Risk: A Cross-Sectional Study.","authors":"Lili Zheng, Huifang Lei, Xiaoyi Tang, Yuanyin Zheng, Qiuzhen Wu, Peixuan Chen, Yanhong Chen, Liangzhi Cai","doi":"10.2147/IJWH.S497621","DOIUrl":"10.2147/IJWH.S497621","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between hepatic steatosis index (HSI) and endometrial cancer (EC) and its diagnostic value for EC.</p><p><strong>Patients and methods: </strong>A total of 114 patients with pathologically diagnosed EC in Mindong Hospital, Ningde City, Fujian Province from 2016 to 2022 were retrospectively included as the EC group. A total of 175 patients with pathologically confirmed benign endometrial lesions (endometrial polyps and uterine submucosal fibroids) in the same hospital during the same period were selected as the control group. Non-parametric test were used to compare the differences in HSI and non-alcoholic fatty liver disease (NAFLD) between the two groups, and the diagnostic value of HSI and NAFLD levels on EC was analysed. The cut-off point of continuous variables was determined by receiver operating characteristic (ROC) curve analysis. Logistic regression analysis was used to calculate odds ratios (ORs).</p><p><strong>Results: </strong>The results showed that compared with the control group, serum GGT, CA125, HDL-C and HSI were significantly increased in the EC group (P<0.05). 27.19% of the EC patients (31/114) and 12% of the control group (21/175) had NAFLD, and the difference between the two groups was statistically significant (P<0.05). The results of univariate logistic regression analysis showed that GGT, CA125, HDL-C, HSI and NAFLD were significantly correlated with the occurrence of EC (P<0.05). Further multivariate logistic regression analysis showed that CA125 and HSI elevation were independent risk factors for EC (P<0.05).</p><p><strong>Conclusion: </strong>NAFLD is closely associated with EC, and elevated HSI is an independent risk factor for EC.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"825-833"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Maternal Attitudes and Depression on Bonding During the Postpartum Period.","authors":"Kumru Şenyaşar Meterelliyoz, Kıymet Çağlar Mengi, Menekşe Sıla Yazar, Ayşe Sevim Akbay Kısa","doi":"10.2147/IJWH.S504763","DOIUrl":"10.2147/IJWH.S504763","url":null,"abstract":"<p><strong>Purpose: </strong>Bonding refers to the development of an emotional relationship between a mother and her baby, which forms a strong and continuous bond that provides the baby with a sense of security and plays an important role in its mental well-being throughout life. The objective of this study was to assess the relationship between cognitive distortions, attitudes towards motherhood and postpartum depression, which have not been studied before, as well as to elucidate their impact on the mother-infant bonding process.</p><p><strong>Patients and methods: </strong>The sample of the study was created between November 2018- June 2019 using the non-discriminatory multiplicity snowball sampling technique through social media. Women with infants aged 0-1 year residing in Turkey were asked to participate in the online survey. A sociodemographic data form, the Edinburgh Postpartum Depression Scale, Attitudes Towards Motherhood Scale (AToM), Postpartum Bonding Questionnaire (PBQ), and Cognitive Distortions Scale (CDS) were applied to the sample via social media.</p><p><strong>Results: </strong>The study sample consisted of 387 women with infants aged 0-1 years, and the rate of impairment bonding was found to be 11.4%. CDS, ATOM and depression scores were significantly higher in the impaired attached group (p < 0.05). The findings indicated that an individual with a psychiatric diagnosis was 2.653 times more likely to exhibit impaired bonding (OR: 2.653, 95% CI: [1.08-6.517]; p = 0.033), and those with a higher AToM score were 1.044 times more likely to display impaired bonding (OR: 1.044, 95% CI: [1.013-1.075]; p = 0.004).</p><p><strong>Conclusion: </strong>The cognitive structure of the mother is associated with impaired mother-baby bonding. Eliminating the mentioned cognitive elements with psychotherapy interventions will be protective in terms of impaired bonding related to psychopathologies and/or interpersonal relationship problems.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"773-784"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}