International Journal of Women's Health最新文献

{"title":"Hysteroscopic Myomectomy for Type 2 Submucosal Myoma Pretreated by HIFU and Mifepristone Treatment: A Case Report and Literature Review.","authors":"Junjie Li, Leilei Yang, Yan Wang, Min He, Hongqiu Zhu, Yefang Huang","doi":"10.2147/IJWH.S530879","DOIUrl":"10.2147/IJWH.S530879","url":null,"abstract":"<p><p>Hysteroscopic myomectomy is the first-line treatment for the removal of submucosal myoma in women facing fertility requirements. However, in the face of large diameter type 2 submucosal myoma, patients are at greater risk of complications such as uterine perforation and fluid overload during hysteroscopy. When the diameter of type 2 submucous myoma is greater than 4cm, the three-phase treatment of high intensity focused ultrasound (HIFU), drugs and hysteroscopy is effective and safe. We shared a case of a 30-year-old non-pregnant woman, who had a history of uterine submucous myoma for more than 4 years with symptoms of heavy menstruation, prolonged menstruation and secondary severe anemia. The patient's initial pelvic magnetic resonance results suggested a type 2 uterine submucous myoma with a diameter of more than 4cm. We first performed HIFU on the patient, followed by the patient's oral intake of mifepristone tablets for 3 months, and prior to hysteroscopic surgery, the patient's fibroid type was shifted to type 0, and finally successfully completed hysteroscopic myomectomy (HM). Finally, we conclude that when the diameter of type 2 submucosal myoma exceeds 4 cm, preoperative application of HIFU combined with drug treatment should be considered to maximize the reduction of fibroids, improve symptoms such as anemia and dysmenorrhea, reduce the time required for hysteroscopic surgery, and improve the safety of surgery.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2401-2412"},"PeriodicalIF":2.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative Treatment of Third Trimester Appendicitis Misdiagnosed as Round Ligament Pain. A Case Report and Review of the Literature in a Resource-Limited Setting.","authors":"Rayaan Abdirahman Hassan, Ismail A Ali, Abdullahi Hassan Elmi, Abdullahi Abdirahman Omar","doi":"10.2147/IJWH.S536394","DOIUrl":"10.2147/IJWH.S536394","url":null,"abstract":"<p><strong>Introduction: </strong>Identifying acute appendicitis during pregnancy is particularly challenging, especially in the third trimester, as its symptoms may resemble typical gestational discomfort. While surgery remains the standard treatment, conservative treatment is being considered more often, especially when surgical intervention can pose risks to either the mother or the fetus.</p><p><strong>Case presentation: </strong>We report the case of a 30-year-old woman at 33 weeks of gestation who presented with right lower quadrant pain initially misattributed to round ligament strain. Her condition deteriorated over several days with worsening abdominal pain, fever, and leukocytosis. Imaging confirmed an acute uncomplicated appendicitis. After multidisciplinary evaluation and counseling, the patient declined surgery due to concerns over fetal safety. A conservative approach with intravenous antibiotics was initiated, resulting in complete clinical resolution. The patient delivered a healthy infant at term, without complications or recurrence.</p><p><strong>Conclusion: </strong>This case demonstrates that conservative management of appendicitis during the third trimester can be a safe and effective alternative for highly selected patients. This underscores the importance of individualized care, shared decision-making, and close clinical monitoring, particularly when standard surgical treatment has declined. As the conversation around non-operative strategies evolves, this case adds meaningful support for expanding tailored management options during pregnancy in resource-limited settings.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2413-2420"},"PeriodicalIF":2.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Success Rate of Vaginal Delivery After Cesarean Section and Its Associated Factors in Afghan Women: Insights from a Maternity Hospital in Kabul [Response to Letter].","authors":"Parvin Golzareh, Halima Baha, Fahima Aram, Muhammad Haroon Stanikzai, Razia Rabizada, Massoma Jafari","doi":"10.2147/IJWH.S555432","DOIUrl":"10.2147/IJWH.S555432","url":null,"abstract":"","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2375-2376"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of an Intestinal Spatula in Optimizing a Sacrospinous Ligament Suspension.","authors":"Xiaofan Zhu, Yingfan Chen, Yao Song, Miao Liang, Guangqin Ran, Cheng Chen","doi":"10.2147/IJWH.S526894","DOIUrl":"10.2147/IJWH.S526894","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to investigate the application of an intestinal spatula in a sacrospinous ligament suspension, the effects of this surgical method on the surgical field, and surgical effectiveness.</p><p><strong>Methods: </strong>The clinical data of 33 patients who underwent suspension using intestinal spatula and 33 patients who underwent traditional surgery were collected, and the duration of surgery, amount of intraoperative blood loss, degree of postoperative pain, and degree of preoperative and postoperative uterine prolapse between the two groups were compared.</p><p><strong>Results: </strong>Multivariate analysis revealed that the modified technique significantly reduced anal pain incidence (OR=0.17, <i>P</i>=0.015) and improved anatomical C-point recovery (β=-0.73, <i>P</i><0.001), though no significant differences were observed in operative time or blood loss.</p><p><strong>Conclusion: </strong>This study revealed that the application of an intestinal spatula in a sacrospinous ligament suspension can improve the surgical effect and reduce the incidence of postoperative complications, which is of clinical significance.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2365-2373"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Response Achieved in a Case of Metastatic Triple-Negative Breast Cancer Based on the Patient-Derived Tumor Organoids.","authors":"Yang Liu, Shuai Liang, Jian Li","doi":"10.2147/IJWH.S520867","DOIUrl":"10.2147/IJWH.S520867","url":null,"abstract":"<p><strong>Background: </strong>The prognosis of triple-negative breast cancer (TNBC) is dismal due to aggressive behaviors. Emergence of patient-derived tumor organoids (PDTOs) allows for biomarker identification and drug screening to identify potential drugs at the patient-specific level. Here, we described a case of metastatic TNBC who obtained partial response in the liver metastatic lesions after treatment with sacituzumab govitecan that was identified highly sensitive by the PDTOs.</p><p><strong>Case presentation: </strong>A 50-year-old woman visited our hospital for re-examination due to over 9 years after surgery for the left breast cancer. In February 2024, she experienced liver metastasis. In combination with medical history and immunohistochemistry results, metastatic TNBC was diagnosed. Based on the PDTO drug sensitivity testing, the patient was treated with highly sensitive sacituzumab govitecan. After 6 cycles of treatment, liver metastatic lesions were reduced partially.</p><p><strong>Conclusion: </strong>In our case of TNBC, partial response is achieved in the liver metastatic lesions after treatment based on the PDTOs, unveiling that the PDTO, a potential companion tool for selection of treatment options, can facilitate the personalized treatment in metastatic TNBC patients to improve the prognosis.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2395-2400"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Female Pelvic Floor Muscles: An Integrative Review.","authors":"Laís Bertoldo Frazão, Leticia Assis Couto, Ana Carolina Atanes Mendes Peres, Amélia Pasqual Marques, Anice de Campos Pássaro","doi":"10.2147/IJWH.S532149","DOIUrl":"10.2147/IJWH.S532149","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the function of pelvic floor muscles (PFMs) is important to ensure comprehensive healthcare for women with urogenital and anorectal disorders.</p><p><strong>Objective: </strong>To systematically synthesize the measurement variables used in studies that objectively evaluate female PFMs.</p><p><strong>Methods: </strong>An integrative review was conducted on studies published in Portuguese, Spanish, and English between 2000 and 2020. The databases searched were MEDLINE, EMBASE, Lilacs, Scopus, Web of Science, PEDro, and the Cochrane Library.</p><p><strong>Results: </strong>A total of 54 studies were included. Of these, 13 (24.07%) used multiple instruments to analyze PFMs, and 22 (40.74%) combined manual assessment with other measurement methods. The Oxford Scale was the most frequently used tool (13 studies). Regarding the assessment instruments and variables used to measure PFMs, manometry was the most commonly employed (30 studies, 55.55%), analyzing four variables, with peak pressure being the most frequently assessed (27 studies). Electromyography (EMG) was performed in 21 studies (38.88%), with nine analysis variables and peak contraction being mostly measured (17 studies). Dynamometry was used in nine studies (16.66%) to assess eight variables, with maximal strength being mostly reported (eight studies). Ultrasonography was also used in nine studies (16.66%), with the levator hiatus area at rest being the most frequently evaluated (eight studies).</p><p><strong>Conclusion: </strong>There was no clear standardization of the measurement variables used, with considerable variability in assessment instruments, data collection protocols, and data analysis methods. Advancements in comprehensive healthcare for women with PFMs dysfunction may arise from the development of standardized protocols for data collection and analysis related to the most widely used and established instruments in academic and clinical settings.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2377-2393"},"PeriodicalIF":2.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Diane-35 and Cangfu Daotan Wan Effectively Ameliorates Inflammatory Response, Stress State, and Hormone Levels in Patients with Polycystic Ovary Syndrome (PCOS), Leading to Significant Improvement in Clinical Treatment Outcomes.","authors":"Li Chen, Cai-Ping Fang, Yan Chen, Wei-Hua Gu, Sai-Li Wang, Ning Niu, Qin-Hua Zhang","doi":"10.2147/IJWH.S526092","DOIUrl":"10.2147/IJWH.S526092","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of combining Diane-35 with Cangfu Daotan Wan on inflammatory response, stress response, and hormone levels in patients with polycystic ovary syndrome (PCOS), and to offer insights for clinical management.</p><p><strong>Methods: </strong>A retrospective analysis was conducted from January 2022 to March 2024, encompassing PCOS patients treated at our hospital who fulfilled the inclusion criteria. Patients were categorized into two groups: the study group receiving Diane-35 plus Cangfu Daotan Wan, and the control group receiving Diane-35 alone. Comparisons were made between the two groups regarding inflammatory markers, stress response indicators, hormone levels, and overall treatment efficacy.</p><p><strong>Results: </strong>Post-treatment, the study group exhibited a lower incidence of polycystic ovarian changes and a higher overall efficacy rate compared to the control group (P<0.05). Inflammatory factors IL-6, TNF-α, and MCP-1 were significantly reduced in the study group versus the control group (P<0.05). Oxidative stress markers SOD and GSH were significantly elevated, while GSS was significantly decreased in the study group compared to the control group (P<0.05). No significant differences were observed in FSH, LH, LH/FSH ratio, or testosterone levels between the two groups (P>0.05). The BMI index was significantly lower in the study group than in the control group (P<0.05). Additionally, traditional Chinese medicine symptom scores were significantly reduced in the study group compared to the control group (P<0.05).</p><p><strong>Conclusion: </strong>The combination of Diane-35 and Cangfu Daotan Wan effectively ameliorates inflammatory response and stress state, modulates hormone levels, and enhances clinical treatment outcomes in PCOS patients. This combined therapy is both safe and efficacious, warranting further application in clinical practice.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2353-2364"},"PeriodicalIF":2.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Gauze Tamponade in Preventing Vaginal Bleeding After Transvaginal Oocyte Retrieval: A Retrospective Analysis.","authors":"Qun Wei, Xiufen Wang, Xinyi Yang, Yu He, Xia Hong, Zilian Wang","doi":"10.2147/IJWH.S535786","DOIUrl":"10.2147/IJWH.S535786","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical value of routinely using sterile gauze strips to occlude the vagina after transvaginal ultrasound-guided oocyte retrieval (TVOR) in preventing postoperative vaginal bleeding.</p><p><strong>Methods: </strong>The medical records of 1194 patients who underwent transvaginal oocyte retrieval between March and April 2024 were retrospectively analyzed. Patients with no obvious bleeding at the vaginal puncture site were divided into group A (without gauze packing, 586 cases) and group B (with conventional gauze packing, 608 cases) according to whether gauze was used to control bleeding. The incidence of vaginal bleeding at 30 minutes, 1 hour, 3 hours and bloody discharge at 3 days after oocyte retrieval was compared by the chi-square test between the two groups. Patients in group B were also assessed for their tolerance of gauze tamponade removal and the ease and accuracy of postoperative gauze management.</p><p><strong>Results: </strong>There was no statistical difference in general patient information between the two groups (P>0.05). Compared with group B the incidence of vaginal bleeding at 30 minutes (χ²=8.631, P<0.05) and the incidence of bloody or brown vaginal discharge 3 days (χ²=56.50, P<0.05) postoperatively was significantly higher in group A, and the incidence of vaginal bleeding at 1 hour postoperatively and 3 hours postoperatively was not significantly different in the two groups (P>0.05). Patients in group B tolerated vaginal tamponade and gauze removal better.</p><p><strong>Conclusion: </strong>Routine use of sterile gauze after transvaginal oocyte collection significantly reduces the incidence of vaginal bleeding and is well tolerated by patients.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2327-2333"},"PeriodicalIF":2.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Variants in <i>SIRT1</i> Gene Among Saudi Women Diagnosed with Gestational Diabetes Mellitus: A Case-Control Study.","authors":"Mohammed Alfaifi, Adel Abo Mansour, Bijesh Yadav, Imran Ali Khan","doi":"10.2147/IJWH.S510344","DOIUrl":"10.2147/IJWH.S510344","url":null,"abstract":"<p><strong>Background: </strong>Gestational Diabetes Mellitus (GDM) is defined as impaired glucose intolerance resulting in hyperglycemia. SIRT1 deficiency and single nucleotide polymorphisms (SNPs) were also related to diabetes. No documented studies were carried out between GDM and <i>SIRT1</i> SNPs and it is also not confirmed whether <i>SIRT1</i> SNPs had a role in GDM women.</p><p><strong>Objective: </strong>This study was designed to explore the molecular association carried out between GDM women and <i>SIRT1</i> gene SNPs present in the Saudi Arabia. This is a case-control study carried out in Capital city of Saudi Arabia.</p><p><strong>Methods/design: </strong>Serum samples were used for studying biochemical parameters, genotyping and Sanger sequencings for rs4746720 and rs10823112 SNPs. Statistical analysis was carried out between GDM and non-GDM women for anthropometric, biochemical and molecular data.</p><p><strong>Results: </strong>A total of 120 GDM and 120 non-GDM women were recruited based on inclusion and exclusion criteria. Different forms of glucose values have confirmed the statistical association levels between GDM and non-GDM women (p < 0.05). Penalized logistic regression analysis showed the positive association with FBG, OGTT-2hr and HDLc levels (p < 0.05) in GDM women. The rs4746720 SNP was associated with GDM (p = 0.01). ANOVA analysis has confirmed the strong association with FBG (p = 0.002), PPBG (p = 0.0001) and HDLc (p = 0.0003) levels in rs4746720 SNP; while in rs10823112 SNP, both PPBG (p = 0.0001) and HDLc (p = 0.01) were associated. Linkage disequilibrium and GMDR analysis showed significant associations (p < 0.05).</p><p><strong>Conclusion: </strong>This study confirms rs4746720 SNP and glucose levels played a role in this study.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2335-2352"},"PeriodicalIF":2.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hymen-Sparing Myomectomy: Innovative Laparoscopic Approach for Prolapsed Pedunculated Cervicovaginal Leiomyoma in a Virgin Case.","authors":"Wael Saad Elbanna, Asmaa Khedr Elkaw, Mostafa Mahmoud Elabd","doi":"10.2147/IJWH.S528452","DOIUrl":"10.2147/IJWH.S528452","url":null,"abstract":"<p><p>Leiomyoma is the most common benign tumor of the female genital tract. It may develop subserous, intramural, or submucous. The submucous subtype accounts for 5% of all cases, and it may become pedunculated or prolapse outside the uterine cavity, resulting in vaginal bleeding and pelvic pain, significantly impacting the quality of life, especially for larger leiomyomas. The management of such cases may require vaginal access, which may disrupt hymen integrity and is not accepted in conservative communities. Here, we present an innovative hymen-conserving Laparoscopic-And-Suprapubic Hysteroscopic Approach (LASHA) via anterior colpotomy and myomectomy for endometrial cavity exploration and management of a prolapsed pedunculated cervicovaginal leiomyoma in a virgin patient. A 30-year-old virgin presented to the clinic with heavy menstrual bleeding for the past 6 months. Abdominal ultrasound showed an enlarged uterus with multiple uterine myomas; the largest one was in the cervicovaginal zone, filling the vagina, showing a solid hypo-echoic mass, well delineated, filling the vaginal margins, and suggesting a prolapsed, pedunculated cervicovaginal leiomyoma (5.7x6.6x 8.3 cm). Other subserosal and intramural myomas ranged from 2 to 7 cm. The LASHA approach was decided to preserve the hymen's integrity based on the patient's desire, resulting in a successful tumor excision. In summary, the LASHA approach of a prolapsed, pedunculated cervicovaginal leiomyoma is an adequate, safe, and socially accepted alternative in conservative societies. Therefore, the indications of laparoscopy could be extended to endometrial cavity exploration and managing cervicovaginal leiomyoma in virgin women rejecting vaginal approaches. However, this technique necessitates adequate equipment and skills in laparoscopic surgery.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2313-2323"},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}