Combination of Diane-35 and Cangfu Daotan Wan Effectively Ameliorates Inflammatory Response, Stress State, and Hormone Levels in Patients with Polycystic Ovary Syndrome (PCOS), Leading to Significant Improvement in Clinical Treatment Outcomes.
Li Chen, Cai-Ping Fang, Yan Chen, Wei-Hua Gu, Sai-Li Wang, Ning Niu, Qin-Hua Zhang
{"title":"Combination of Diane-35 and Cangfu Daotan Wan Effectively Ameliorates Inflammatory Response, Stress State, and Hormone Levels in Patients with Polycystic Ovary Syndrome (PCOS), Leading to Significant Improvement in Clinical Treatment Outcomes.","authors":"Li Chen, Cai-Ping Fang, Yan Chen, Wei-Hua Gu, Sai-Li Wang, Ning Niu, Qin-Hua Zhang","doi":"10.2147/IJWH.S526092","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of combining Diane-35 with Cangfu Daotan Wan on inflammatory response, stress response, and hormone levels in patients with polycystic ovary syndrome (PCOS), and to offer insights for clinical management.</p><p><strong>Methods: </strong>A retrospective analysis was conducted from January 2022 to March 2024, encompassing PCOS patients treated at our hospital who fulfilled the inclusion criteria. Patients were categorized into two groups: the study group receiving Diane-35 plus Cangfu Daotan Wan, and the control group receiving Diane-35 alone. Comparisons were made between the two groups regarding inflammatory markers, stress response indicators, hormone levels, and overall treatment efficacy.</p><p><strong>Results: </strong>Post-treatment, the study group exhibited a lower incidence of polycystic ovarian changes and a higher overall efficacy rate compared to the control group (P<0.05). Inflammatory factors IL-6, TNF-α, and MCP-1 were significantly reduced in the study group versus the control group (P<0.05). Oxidative stress markers SOD and GSH were significantly elevated, while GSS was significantly decreased in the study group compared to the control group (P<0.05). No significant differences were observed in FSH, LH, LH/FSH ratio, or testosterone levels between the two groups (P>0.05). The BMI index was significantly lower in the study group than in the control group (P<0.05). Additionally, traditional Chinese medicine symptom scores were significantly reduced in the study group compared to the control group (P<0.05).</p><p><strong>Conclusion: </strong>The combination of Diane-35 and Cangfu Daotan Wan effectively ameliorates inflammatory response and stress state, modulates hormone levels, and enhances clinical treatment outcomes in PCOS patients. This combined therapy is both safe and efficacious, warranting further application in clinical practice.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2353-2364"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317708/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S526092","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To assess the impact of combining Diane-35 with Cangfu Daotan Wan on inflammatory response, stress response, and hormone levels in patients with polycystic ovary syndrome (PCOS), and to offer insights for clinical management.
Methods: A retrospective analysis was conducted from January 2022 to March 2024, encompassing PCOS patients treated at our hospital who fulfilled the inclusion criteria. Patients were categorized into two groups: the study group receiving Diane-35 plus Cangfu Daotan Wan, and the control group receiving Diane-35 alone. Comparisons were made between the two groups regarding inflammatory markers, stress response indicators, hormone levels, and overall treatment efficacy.
Results: Post-treatment, the study group exhibited a lower incidence of polycystic ovarian changes and a higher overall efficacy rate compared to the control group (P<0.05). Inflammatory factors IL-6, TNF-α, and MCP-1 were significantly reduced in the study group versus the control group (P<0.05). Oxidative stress markers SOD and GSH were significantly elevated, while GSS was significantly decreased in the study group compared to the control group (P<0.05). No significant differences were observed in FSH, LH, LH/FSH ratio, or testosterone levels between the two groups (P>0.05). The BMI index was significantly lower in the study group than in the control group (P<0.05). Additionally, traditional Chinese medicine symptom scores were significantly reduced in the study group compared to the control group (P<0.05).
Conclusion: The combination of Diane-35 and Cangfu Daotan Wan effectively ameliorates inflammatory response and stress state, modulates hormone levels, and enhances clinical treatment outcomes in PCOS patients. This combined therapy is both safe and efficacious, warranting further application in clinical practice.
期刊介绍：
International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
